Occurrence and tissue distribution of porcine circovirus type 2 identified by immunohistochemistry in danish finishing pigs at slaughter

Journal of Comparative Pathology

Volumn 142, Issue 2-3, 2010, Pages 109-121

  Hansen, M S ^a,b   Pors, S E ^a   Bille Hansen, V ^b   Kjerulff, S K J ^a   Nielsen, O L ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

PORCINE CIRCOVIRUS TYPE 2 ANTIGEN; PROTEIN CNA.42; PROTEIN S 100; UNCLASSIFIED DRUG; VIRUS ANTIGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY LABELING; ARTICLE; CELL ISOLATION; CELL STRUCTURE; CIRCOVIRIDAE; CONTROLLED STUDY; DENMARK; DISEASE ASSOCIATION; DISEASE PREDISPOSITION; EPITHELIUM CELL; FOLLICULAR DENDRITIC CELL; HISTIOCYTE; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; KIDNEY; LUNG; LYMPH FOLLICLE; LYMPHOCYTE DEPLETION; NONHUMAN; PATHOPHYSIOLOGY; PORCINE CIRCOVIRUS TYPE 2; PORCINE CIRCOVIRUS TYPE 2 INFECTION; PRIORITY JOURNAL; SLAUGHTERHOUSE; SPLEEN; STELLATE CELL; SWINE; TISSUE DISTRIBUTION; VIRUS DETECTION; VIRUS IDENTIFICATION; VIRUS INFECTION;

ANIMALS; CIRCOVIRIDAE INFECTIONS; CIRCOVIRUS; IMMUNOHISTOCHEMISTRY; KIDNEY; LUNG; LYMPH NODES; SPLEEN; SWINE; TISSUE DISTRIBUTION;

ANIMALIA; PORCINE CIRCOVIRUS; PORCINE CIRCOVIRUS 2; SUIDAE; SUS;

EID: 77649271208     PISSN: 00219975     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jcpa.2009.07.059     Document Type: Article

References (80)

1. Allen C.D., Cyster J.G. Follicular dendritic cell networks of primary follicles and germinal centers: phenotype and function. Seminars in Immunology 2008, 20:14-25.
2. Allan G, McNeilly F (2006) PMWS/PCVD: diagnosis, disease, and control: what do we knowq In: Proceedings of the 19th International Pig Veterinary Society Congress, Copenhagen, Denmark, pp. 1-9.
3. Bodewadt-Radzun S., Wacker H.H., Radzun H.J., Parwaresch M.R. Phenotypic characterization of macrophages in non-neoplastic lymph nodes. Current Topics in Pathology 1990, 84:247-264.
4. Bolin S.R., Stoffregen W.C., Nayar G.P., Hamel A.L. Postweaning multisystemic wasting syndrome induced after experimental inoculation of cesarean-derived, colostrum-deprived piglets with type 2 porcine circovirus. Journal of Veterinary Diagnostic Investigation 2001, 13:185-194.
5. Brunborg I.M., Moldal T., Jonassen C.M. Quantitation of porcine circovirus type 2 isolated from serum/plasma and tissue samples of healthy pigs and pigs with postweaning multisystemic wasting syndrome using a TaqMan-based real-time PCR. Journal of Virological Methods 2004, 122:171-178.
6. Burton G.F., Keele B.F., Estes J.D., Thacker T.C., Gartner S. Follicular dendritic cell contributions to HIV pathogenesis. Seminars in Immunology 2002, 14:275-284.
7. Carasova P., Celer V., Takacova K., Trundova M., Molinkova D., et al. The levels of PCV2 specific antibodies and viremia in pigs. Research in Veterinary Science 2007, 83:274-278.
8. Carman S., Cai H.Y., DeLay J., Youssef S.A., McEwen B.J., et al. The emergence of a new strain of porcine circovirus-2 in Ontario and Quebec swine and its association with severe porcine circovirus associated disease - 2004-2006. Canadian Journal of Veterinary Research 2008, 72:259-268.
9. Chae C. Postweaning multisystemic wasting syndrome: a review of aetiology, diagnosis and pathology. Veterinary Journal 2004, 168:41-49.
10. Chae C. A review of porcine circovirus 2-associated syndromes and diseases. Veterinary Journal 2005, 169:326-336.
11. Charles J.A. Lymph nodes and thymus. Pathology of the Pig. A Diagnostic Guide 1996, 185-210. The Pig Research and Development Corporation and Agriculture Victoria, Victoria. L.D. Sims, J.R.W. Glastonbury (Eds.).
12. Chianini F., Majo N., Segalés J., Dominguez J., Domingo M. Immunohistochemical characterisation of PCV2 associated lesions in lymphoid and non-lymphoid tissues of pigs with natural postweaning multisystemic wasting syndrome (PMWS). Veterinary Immunology and Immunopathology 2003, 94:63-75.
13. Chiou MT, Lin CN, Chuang MS, Chiang HC, Tsai CP (2004) Etiological and epidemiological survey of PRDC associated pathogens in Taiwan. In: Proceedings of the 18th International Pig Veterinary Society Congress, Hamburg, Germany, p. 191.
14. D'Allaire S., Moore C., Cote G. A survey on finishing pig mortality associated with porcine circovirus diseases in Quebec. Canadian Veteterinary Journal 2007, 48:145-146.
15. Darwich L., Segalés J., Resendes A., Balasch M., Plana-Duran J., et al. Transient correlation between viremia levels and IL-10 expression in pigs subclinically infected with porcine circovirus type 2 (PCV2). Research in Veterinary Science 2008, 84:194-198.
16. Denzer K., van Eijk M., Kleijmeer M.J., Jakobson E., de Groot C., et al. Follicular dendritic cells carry MHC class II-expressing microvesicles at their surface. Journal of Immunology 2000, 165:1259-1265.
17. Desrosiers R. Overview of PCVD - the disease in Eastern Canada and US vs. Europe. Proceedings of the 2007 Banff Pork Seminar 2007, 35-48. Alberta, Canada.
18. Drolet R., D'Allaire S., Larochelle R., Magar R., Ribotta M., et al. Infectious agents identified in pigs with multifocal interstitial nephritis at slaughter. Veterinary Record 2002, 150:139-143.
19. Fachinger V., Bischoff R., Jedidia S.B., Saalmuller A., Elbers K. The effect of vaccination against porcine circovirus type 2 in pigs suffering from porcine respiratory disease complex. Vaccine 2008, 26:1488-1499.
20. Fray M.D., Supple E.A., Morrison W.I., Charleston B. Germinal centre localization of bovine viral diarrhoea virus in persistently infected animals. Journal of General Virology 2000, 81:1669-1673.
21. Grau-Roma L., Segalés J. Detection of porcine reproductive and respiratory syndrome virus, porcine circovirus type 2, swine influenza virus and Aujeszky's disease virus in cases of porcine proliferative and necrotizing pneumonia (PNP) in Spain. Veteterinary Microbiolology 2007, 119:144-151.
22. Gray D., Kosco M., Stockinger B. Novel pathways of antigen presentation for the maintenance of memory. International Immunology 1991, 3:141-148.
23. Harder TC, Huebert P (2004) Development and application of a nonaplex RT-PCR for simultaneous detection of mycoplasmal and viral agents associated with the porcine respiratory disease complex. In: Proceedings of the 18th International Pig Veterinary Society Congress, Hamburg, Germany, p. 341.
24. Harding JC, Halbur PG (2002) PMWS or a group of PCV2-associated syndromes: ever-growing concerns. In: PMWS and PCV2 Diseases, Beyond the Debate, Keynotes on the Merial Symposium and Brief Epidemiological Updates. Proceedings of the17th International Pig Veterinary Society Congress, Ames, Iowa, USA, pp. 19-31.
25. Harding J.C.S., Clark E.G. Recognizing and diagnosing postweaning multisystemic wasting syndrome (PMWS). Journal of Swine Health and Production 1997, 5:201-203.
26. Harding J.C.S., Clark E.G., Strokappe J.H., Willson P.I., Ellis J.A. Postweaning multisystemic wasting syndrome: epidemiology and clinical presentation. Journal of Swine Health and Production 1998, 6:249-254.
27. Jaffe E.S. Histiocytoses of lymph nodes: biology and differential diagnosis. Seminars in Diagnostic Pathology 1988, 5:376-390.
28. Janeway C.A., Travers P., Walport M., Shlomchik M.J. Immunobiology: the Immune System in Health and Disease 2005, Garland Science Publishing, New York, pp. 382-383. 6th Edit.
29. Jensen T.K., Vigre H., Svensmark B., Bille-Hansen V. Distinction between porcine circovirus type 2 enteritis and porcine proliferative enteropathy caused by Lawsonia intracellularis. Journal of Comparative Pathology 2006, 135:176-182.
30. Kasajima-Akatsuka N., Maeda K. Development, maturation and subsequent activation of follicular dendritic cells (FDC): immunohistochemical observation of human fetal and adult lymph nodes. Histochemistry and Cell Biology 2006, 126:261-273.
31. Kim J., Chae C. Necrotising lymphadenitis associated with porcine circovirus type 2 in pigs. Veterinary Record 2005, 156:177-178.
32. Kim J., Chung H.K., Chae C. Association of porcine circovirus 2 with porcine respiratory disease complex. Veterinary Journal 2003, 166:251-256.
33. Krakowka S., Ellis J.A., McNeilly F., Gilpin D., Meehan B., et al. Immunologic features of porcine circovirus type 2 infection. Viral Immunology 2002, 15:567-582.
34. Larochelle R., Magar R., D'Allaire S. Comparative serologic and virologic study of commercial swine herds with and without postweaning multisystemic wasting syndrome. Canadian Journal of Veterinary Research 2003, 67:114-120.
35. Lindhout E., Lakeman A., Mevissen M.L., de Groot C. Functionally active Epstein-Barr virus-transformed follicular dendritic cell-like cell lines. Journal of Experimental Medicine 1994, 179:1173-1184.
36. Liu Q., Wang L., Willson P., O'Connor B., Keenliside J., et al. Seroprevalence of porcine circovirus type 2 in swine populations in Canada and Costa Rica. Canadian Journal of Veterinary Research 2002, 66:225-231.
37. Mabbott N.A., Bruce M.E. Follicular dendritic cells as targets for intervention in transmissible spongiform encephalopathies. Seminars in Immunology 2002, 14:285-293.
38. Maeda K., Matsuda M., Suzuki H., Saitoh H.A. Immunohistochemical recognition of human follicular dendritic cells (FDCs) in routinely processed paraffin sections. Journal of Histochemistry and Cytochemistry 2002, 50:1475-1486.
39. Mandrioli L., Sarli G., Panarese S., Baldoni S., Marcato P.S. Apoptosis and proliferative activity in lymph node reaction in postweaning multisystemic wasting syndrome (PMWS). Veterinary Immunology and Immunopathology 2004, 97:25-37.
40. Martinez J., Segalés J., Aduriz G., Atxaerandio R., Jaro P., et al. Pathological and aetiological studies of multifocal interstitial nephritis in wasted pigs at slaughter. Research in Veterinary Science 2006, 81:92-98.
41. McNeilly F., McNair I., Mackie D.P., Meehan B.M., Kennedy S., et al. Production, characterisation and applications of monoclonal antibodies to porcine circovirus 2. Archives of Virology 2001, 146:909-922.
42. Melot F., Defaweux V., Jolois O., Collard A., Robert B., et al. FDC-B1: a new monoclonal antibody directed against bovine follicular dendritic cells. Veterinary Immunology and Immunopathology 2004, 97:1-9.
43. Nielsen E.O., Enoe C., Jorsal S.E., Barfod K., Svensmark B., et al. Postweaning multisystemic wasting syndrome in Danish pig herds: productivity, clinical signs and pathology. Veterinary Record 2008, 162:505-508.
44. Opriessnig T., Meng X.J., Halbur P.G. Porcine circovirus type 2 associated disease: update on current terminology, clinical manifestations, pathogenesis, diagnosis, and intervention strategies. Journal of Veterinary Diagnostic Investigation 2007, 19:591-615.
45. Opriessnig T., Thacker E.L., Yu S., Fenaux M., Meng X.J., et al. Experimental reproduction of postweaning multisystemic wasting syndrome in pigs by dual infection with Mycoplasma hyopneumoniae and porcine circovirus type 2. Veterinary Pathology 2004, 41:624-640.
46. Palmieri C., Brunetti M., Della S.L. Immunohistochemical characterization of Kisselev nodules (ectopic lymphoid follicles) in wild boar (Sus scrofa L.). Research in Veterinary Science 2007, 83:109-115.
47. Palzer A., Ritzmann M., Wolf G., Heinritzi K. Associations between pathogens in healthy pigs and pigs with pneumonia. Veterinary Record 2008, 162:267-271.
48. Park C.S., Choi Y.S. How do follicular dendritic cells interact intimately with B cells in the germinal centre?. Immunology 2005, 114:2-10.
49. Park J.S., Ha Y., Kwon B., Cho K.D., Lee B.H., et al. Detection of porcine circovirus 2 in mammary and other tissues from experimentally infected sows. Journal of Comparative Pathology 2009, 140:208-211.
50. Perez J., Garcia P.M., Mozos E., Bautista M.J., Carrasco L. Immunohistochemical characterization of hepatic lesions associated with migrating larvae of Ascaris suum in pigs. Journal of Comparative Pathology 2001, 124:200-206.
51. Quintana J., Segalés J., Rosell C., Calsamiglia M., Rodriguez-Arrioja G.M., et al. Clinical and pathological observations on pigs with postweaning multisystemic wasting syndrome. Veterinary Record 2001, 149:357-361.
52. Ramamoorthy S., Meng X. Porcine circoviruses: a minuscule yet mammoth paradox. Animal Health Research Reviews 2008, 10.1017/S1466252308001461.
53. Rangel-Moreno J., Hartson L., Navarro C., Gaxiola M., Selman M., et al. Inducible bronchus-associated lymphoid tissue (iBALT) in patients with pulmonary complications of rheumatoid arthritis. Journal of Clinical Investigation 2006, 116:3183-3194.
54. Raymond I., Al S.T., Tkaczuk J., Chittal S., Delsol G. CNA.42, a new monoclonal antibody directed against a fixative-resistant antigen of follicular dendritic reticulum cells. American Journal of Pathology 1997, 151:1577-1585.
55. Resendes A.R., Majo N., Segalés J., Mateu E., Calsamiglia M., et al. Apoptosis in lymphoid organs of pigs naturally infected by porcine circovirus type 2. Journal of General Virology 2004, 85:2837-2844.
56. Rosell C., Segalés J., Plana-Duran J., Balasch M., Rodriguez-Arrioja G.M., et al. Pathological, immunohistochemical and in-situ hybridization studies of natural cases of postweaning multisystemic wasting syndrome (PMWS) in pigs. Journal of Comparative Pathology 1999, 120:59-78.
57. Rosell C., Segalés J., Ramos-Vara J.A., Folch J.M., Rodriguez-Arrioja G.M., et al. Identification of porcine circovirus in tissues of pigs with porcine dermatitis and nephropathy syndrome. Veterinary Record 2000, 146:40-43.
58. Rütten M., Stephan R., Pospischil A., Sydler T. Porcine circovirus type 2 infections in healthy pigs at slaughter. Proceedings of the 24th Congress of the European Society of Veterinary Pathology, Edinburgh, Scotland 2006, 108-109.
59. Sarli G, Bacci B, Brunetti B, Panarese S, Mandroli L et al. (2006) PCV2 detection in 170 submaxillary lymph nodes of regularly slaughtered pigs in Northern Italy. In: Proceedings of the 19th International Pig Veterinary Society Congress, Copenhagen, Denmark, p. 85.
60. Sarli G., Mandrioli L., Laurenti M., Sidoli L., Cerati C., et al. Immunohistochemical characterisation of the lymph node reaction in pig post-weaning multisystemic wasting syndrome (PMWS). Veterinary Immunology and Immunopathology 2001, 83:53-67.
61. Sarli G., Mandrioli L., Panarese S., Brunetti B., Segalés J., et al. Characterization of interstitial nephritis in pigs with naturally occurring postweaning multisystemic wasting syndrome. Veterinary Pathology 2008, 45:12-18.
62. Sarradell J., Andrada M., Ramirez A.S., Fernandez A., Gomez-Villamandos J.C., et al. A morphologic and immunohistochemical study of the bronchus-associated lymphoid tissue of pigs naturally infected with Mycoplasma hyopneumoniae. Veterinary Pathology 2003, 40:395-404.
63. Sato H., Dobashi M. Ultrastructural localization of S-100 protein in rat popliteal lymph nodes, and very slight proliferative activity of follicular dendritic cells. Histology and Histopathology 1996, 11:703-709.
64. Schmoll F., Lang C., Steinrigl A.S., Schulze K., Kauffold J. Prevalence of PCV2 in Austrian and German boars and semen used for artificial insemination. Theriogenology 2008, 69:814-821.
65. Segalés J. Update on postweaning multisystemic wasting syndrome and porcine dermatitis and nephropathy syndrome diagnostics. Journal of Swine Health and Production 2002, 10:277-281.
66. Segalés J., Allan G.M., Domingo M. Porcine circovirus diseases. Animal Health Research Reviews 2005, 6:119-142.
67. Segalés J., Calsamiglia M., Olvera A., Sibila M., Badiella L., et al. Quantification of porcine circovirus type 2 (PCV2) DNA in serum and tonsillar, nasal, tracheo-bronchial, urinary and faecal swabs of pigs with and without postweaning multisystemic wasting syndrome (PMWS). Veterinary Microbiology 2005, 111:223-229.
68. Segalés J., Domingo M., Chianini F., Majo N., Dominguez J., et al. Immunosuppression in postweaning multisystemic wasting syndrome affected pigs. Veterinary Microbiology 2004, 98:151-158.
69. Shibahara T., Sato K., Ishikawa Y., Kadota K. Porcine circovirus induces B lymphocyte depletion in pigs with wasting disease syndrome. Journal of Veterinary Medical Science 2000, 62:1125-1131.
70. Shibata I., Okuda Y., Kitajima K., Asai T. Shedding of porcine circovirus into colostrum of sows. Journal of Veterinary Medicine B. Infectious Diseases and Veterinary Public Health 2006, 53:278-280.
71. Shoji J., Inada N., Saito K., Takaura N., Iwasaki Y., et al. Immunohistochemical study on follicular dendritic cell of conjunctiva-associated lymphoid tissue. Japanese Journal of Ophthalmology 1998, 42:1-7.
72. Sibila M., Calsamiglia M., Segalés J., Blanchard P., Badiella L., et al. Use of a polymerase chain reaction assay and an ELISA to monitor porcine circovirus type 2 infection in pigs from farms with and without postweaning multisystemic wasting syndrome. American Journal of Veterinary Research 2004, 65:88-92.
73. Soerensen C.M., Holmskov U., Aalbaek B., Boye M., Heegaard P.M., et al. Pulmonary infections in swine induce altered porcine surfactant protein D expression and localization to dendritic cells in bronchial-associated lymphoid tissue. Immunology 2005, 115:526-535.
74. Stevens A., Wilson I.G. The haematoxylins and eosin. Theory and Practice of Histological Techniques 1996, 99-112. Churchill Livingstone, New York. 4th Edit. J.D. Bancroft, A. Stevens (Eds.).
75. Stevenson G.W., Kiupel M., Mittal S.K., Choi J., Latimer K.S., et al. Tissue distribution and genetic typing of porcine circoviruses in pigs with naturally occurring congenital tremors. Journal of Veterinary Diagnostic Investigation 2001, 13:57-62.
76. Thacker E.L. Mycoplasmal diseases. Diseases of Swine 2006, 701-717. Blackwell Publishing, Oxford. 9th Edit. B.E. Straw, J.J. Zimmerman, S. D'Allaire, D.J. Taylor (Eds.).
77. + T cells. Journal of Virology 2009, 83:150-158.
78. Winkler M.T., Doster A., Jones C. Persistence and reactivation of bovine herpesvirus 1 in the tonsils of latently infected calves. Journal of Virology 2000, 74:5337-5346.
79. Woda B.A., Sullivan J.L. Reactive histiocytic disorders. American Journal of Clinical Pathology 1993, 99:459-463.
80. Yu S., Opriessnig T., Kitikoon P., Nilubol D., Halbur P.G., et al. Porcine circovirus type 2 (PCV2) distribution and replication in tissues and immune cells in early infected pigs. Veterinary Immunology and Immunopathology 2007, 115:261-272.