Polycyclic N-heterocyclic compounds. Part 621: Reaction of N-(quinazolin-4-yl)amidine derivatives with hydroxylamine hydrochloride and anti-platelet aggregation activity of the products

Chemical and Pharmaceutical Bulletin

Volumn 58, Issue 3, 2010, Pages 369-374

  Okuda, Kensuke ^a   Zhang, Ying Xue ^b   Ohtomo, Hiromi ^b   Hirota, Takashi ^b   Sasaki, Kenji ^b  

^a GIFU PHARMACEUTICAL UNIVERSITY   (Japan)

^b OKAYAMA UNIVERSITY   (Japan)

Author keywords

1,2,4 oxadiazole; Amide oxime; Anti platelet aggregation; Hydroxylamine hydrochloride; N (quinazolin 4 yl)amidine; Rearrangement

Indexed keywords

1,2,4 OXADIAZOLE DERIVATIVE; AMIDINE; FORMAMIDE DERIVATIVE; HYDROXYLAMINE; N (QUINAZOLIN 4 YL)AMIDINE DERIVATIVE; N [2 (3 ETHYL[1,2,4]OXADIAZOL 5 YL)CYCLOHEXEN 1 YL]FORMAMIDE OXIME; N [2 (3 ETHYL[1,2,4]OXADIAZOL 5 YL)PHENYL]FORMAMIDE OXIME; N [2 (3 METHYL[1,2,4]OXADIAZOL 5 YL)CYCLOHEXEN 1 YL]FORMAMIDE OXIME; N [2 (3 METHYL[1,2,4]OXADIAZOL 5 YL)PHENYL]FORMAMIDE OXIME; N [2 (3 PHENYL[1,2,4]OXADIAZOL 5 YL)CYCLOHEXEN 1 YL]FORMAMIDE OXIME; N [2 (3 PHENYL[1,2,4]OXADIAZOL 5 YL)PHENYL]FORMAMIDE OXIME; N [2 ([1,2,4]OXADIAZOL 5 YL)CYCLOHEXEN 1 YL]FORMAMIDE OXIME; N [2 ([1,2,4]OXADIAZOL 5 YL)PHENYL]FORMAMIDE OXIME; N [2 [3 (3 METHYLPHENYL)[1,2,4]OXADIAZOL 5 YL]CYCLOHEXEN 1 YL]FORMAMIDE OXIME; N [2 [3 (4 CHLOROPHENYL)[1,2,4]OXADIAZOL 5 YL]CYCLOHEXEN 1 YL]FORMAMIDE OXIME; N [2 [3 (4 CHLOROPHENYL)[1,2,4]OXADIAZOL 5 YL]PHENYL]FORMAMIDE OXIME; N [2 [3 (4 FLUOROPHENYL)[1,2,4]OXADIAZOL 5 YL]CYCLOHEXEN 1 YL]FORMAMIDE OXIME; N [2 [3 (4 FLUOROPHENYL)[1,2,4]OXADIAZOL 5 YL]PHENYL]FORMAMIDE OXIME; N [2 [3 (4 METHYLPHENYL)[1,2,4]OXADIAZOL 5 YL]PHENYL]FORMAMIDE OXIME; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL REACTION; CONTROLLED STUDY; CYCLIZATION; DRUG ACTIVITY; DRUG INHIBITION; DRUG SYNTHESIS; ISOMERIZATION; STRUCTURE ACTIVITY RELATION; THROMBOCYTE AGGREGATION;

AMIDINES; ANIMALS; HETEROCYCLIC COMPOUNDS; HYDROXYLAMINE; MALE; MOLECULAR STRUCTURE; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; POLYCYCLIC COMPOUNDS; QUINAZOLINES; RABBITS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77649265069     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.58.369     Document Type: Article

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