Discharge patterns of human genioglossus motor units during arousal from sleep

Sleep

Volumn 33, Issue 3, 2010, Pages 379-387

  Wilkinson, Vanessa ^a   Malhotra, Atul ^b   Nicholas, Christian L ^a   Worsnop, Christopher ^a   Jordan, Amy S ^b   Butler, Jane E ^c   Saboisky, Julian P ^b   Gandevia, Simon C ^c   White, David P ^b   Trinder, John ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

Lung; Motoneuron; Motor control; Obstructive sleep apnea; Single motor units; Upper airway

Indexed keywords

ADULT; AROUSAL; ARTICLE; BREATHING; ELECTRODE; ELECTROMYOGRAPHY; FEMALE; GENIOGLOSSUS MUSCLE; HUMAN; HUMAN EXPERIMENT; MALE; MOTOR UNIT; MUSCLE; MUSCLE CONTRACTION; NERVE CONDUCTION; NORMAL HUMAN; PRIORITY JOURNAL; SLEEP;

EID: 77649246560     PISSN: 01618105     EISSN: 15509109     Source Type: Journal    
DOI: 10.1093/sleep/33.3.379     Document Type: Article

References (22)

1. White DP. Pathogenesis of obstructive and central sleep apnea. Am J Respir Crit Care Med 2005;172:1363-70.
2. Young T, Palta M, Dempsey J, Skatrud J, Weber S, Badr S. The occurrence of sleep disordered breathing among middle-aged adults. N Engl J Med 1993;328:1230-5.
3. Malhotra A, White DP. Obstructive sleep apnoea. Lancet 2002;360: 237-45.
4. Cheng S, Butler JE, Gandevia SC, Bilston LE. Movement of the tongue during normal breathing in awake healthy humans. J Physiol 2008;586:4283-94.
5. Saboisky JP, Butler JE, Fogel RB, et al. Tonic and phasic respiratory drives to human genioglossus motorneurons during breathing. J Neurophysiol 2006;95:2213-21.
6. Saboisky JP, Butler JE, McKenzie DK, et al. Neural drive to human genioglossus in obstructive sleep apnoea. J Physiol 2007;585:134-46.
7. Worsnop CJ, Kay A, Pierce R, Kim Y, Trinder J. Activity of respiratory pump and upper airway muscles during sleep onset. J Appl Physiol 1998;85:908-20.
8. Wilkinson V, Malhotra A, Nicholas CL, et al. Discharge patters on human genioglossus motor units during sleep onset. Sleep 2008;31:525-33.
9. Bailey EF, Fridel KW, Rice AD. Sleep/wake firing patterns of human genioglossus motor units. J Neurophysiol 2007;98:3284-91.
10. EEG arousals: scoring rules and examples. An American Sleep Disorders Association Report. Sleep 1992;15:174-84.
11. Eastwood PR, Allison GT, Shepherd KL, Szollosi I, Hillman DR. Heterogenious activity of the human genioglossus muscle assessed by multiple bipolar fine-wire electrodes. J Appl Physiol 2003;94:1849-58.
12. Day SJ, Hulliger M. Experimental simulation of cat electromyograms: evidence for algebraic summation of motor-unit action-potential trains. J Neurophysiol 2001;86:2144-58.
13. Jordan AS, Eckert DJ, Catcheside PG, McEvoy RD. Ventilatory response to brief arousal from non-rapid eye movement sleep is greater in men than in women. Am J Respir Crit Care Med 2003;168:1512-9.
14. Trinder J, Whitworth F, Kay A, Wilken P. Respiratory instability during sleep onset. J Appl Physiol 1992;73:2462-9.
15. Kay A, Trinder J, Bowes G, Kim Y. Changes in airway resistance during sleep onset. J Appl Physiol 1994;76:1600-7.
16. Trinder J, Allen N, Kleiman J, et al. On the nature of cardiovascular activation at an arousal from sleep. Sleep 2003;26:543-51.
17. 2. J Sleep Res 2006;15:174-82.
18. Horner RL, Sanford LD, Pack AI, Morrison AR. Activation of a distinct arousal state immediately after spontaneous awakening from sleep. Brain Res 1997;778:126-33.
19. De Troyer A, Gorman RB, Gandevia SC. Distribution of inspiratory drive to the external intercostal muscles in humans. J Physiol 2003;546:943-54.
20. Binder MD. Integration of synaptic and intrinsic dendritic currents in cat spinal motoneurons. Brain Res Rev 2002;40:1-8.
21. Henneman, E. Relation between size of neurons and their susceptibility to discharge. Science 1957;126:1345-7.
22. Butler JE, McKenzie DK, Gandevia SC. Discharge properties and recruitment of human diaphragmatic motor units during voluntary inspiratory task. J Physiol 1999;518:907-20.