Urinary exosomes

TheScientificWorldJournal

Volumn 9, Issue , 2009, Pages 1107-1118

  Dimov, Irena ^a   Velickovic, Ljubinka Jankovic ^a   Stefanovic, Vladisav ^a  

^a UNIVERSITY OF NI   (Serbia)

Author keywords

Biomarkers; Exosome; Kidney disease; Proteomics; Urine

Indexed keywords

CISPLATIN;

BIOGENESIS; CELL FUNCTION; CLINICAL RESEARCH; EXOSOME; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; KIDNEY DISEASE; LIPIDOMICS; NONHUMAN; PROTEOMICS; REVIEW; TREATMENT RESPONSE; URINARY EXOSOME;

ANIMALS; BIOLOGICAL MARKERS; EXOSOMES; HIV INFECTIONS; HUMANS; LIPIDS; PROTEOMICS; URINALYSIS;

EID: 77649243438     PISSN: None     EISSN: 1537744X     Source Type: Journal    
DOI: 10.1100/tsw.2009.128     Document Type: Review

References (68)

1. Johnstone, R.M., Adam, M., Hammond, J.R., Orr, L., and Turbide, C. (1987) Vesicle formation during reticulocyte maturation. Association of plasma membrane activities with released vesicles (exosomes). J. Biol. Chem. 262, 9412-9420.
2. Schorey, J. and Bhatnagar, S. (2008) Exosome function: from tumor immunology to pathogen biology. Traffic 9, 871-881.
3. Keller, S., Sanderson, M.P., Stoeck, A., and Altevogt, P. (2006) Exosomes: from biogenesis and secretion to biological function. Immunol. Lett. 107, 102-108.
4. Gruenberg, J. and Stenmark, H. (2004) The biogenesis of multivesicular endosomes. Nat. Rev. Mol. Cell. Biol. 5, 317-322.
5. Sotelo, J.R. and Porter, K.R. (1959) An electron microscope study of the rat ovum. J. Biophys. Biochem. Cytol. 5, 327-342.
6. Katzmann, D.J., Babst, M., and Emr, S.D. (2001) Ubiquitin dependent sorting into the multivesicular body pathway requires the function of the conserved endosomal protein sorting complex, ESCRT-I. Cell 106, 145-155.
7. Denzer, K., Kleijmeer, M., Heijnen, H.F.G., Stoorvegel, W., and Geuze, J. (2002) Exosome: from internal vesicle of the multivesicular body to intercellular signaling device. J. Cell Sci. 113, 3365-3374.
8. Van Niel, G., Porto-Carreiro, I., Simoes, S., and Raposo, K. (2006) Exosomes: a common pathway for a specialized function. J. Biochem. 140, 13-21.
9. Xiao, Z., Blonder, J., Zhou, M., and Veenstra, T.D. (2008) Proteomic analysis of extracellular matrix and vesicles. J. Proteomics 72, 34-45.
10. Woodman, P. and Futter, C. (2008). Multivesicular bodies: co-ordinated progression to maturity. Curr. Opin. Cell Biol. 20, 408-414.
11. Williams, R.L. and Urbe, S. (2007) The emerging shape of the ESCRT machinery. Nat. Rev. Mol. Cell. Biol. 8, 355-368.
12. Razi, M. and Futter, C. (2006) Distinct roles for Tsg101 and Hrs in multivesicular body formation and inward vesiculation. Mol. Biol. Cell 17, 3469-3483.
13. Slagsvold, T., Pattni, K., Malerod, L., and Stenmark, H. (2006) Endosomal and non-endosomal functions of ESCRT proteins. Trends. Cell Biol. 16, 317-326.
14. Wurmser, A.E. and Emr, S.D. (1998) Phosphoinositide signaling and turnover: Ptdins(3)P, a regulator of membrane traffic, is transported to the vacuole and degraded by a process that requires lumenal vacuolar hydrolase activities. EMBO J. 17, 4930-4942.
15. Kobayashi, T., Stang, E., Fang, K.S., de Moerloose, P., Parton, R.G., and Gruenberg, J. (1998) A lipid associated with the antiphospholipid syndrome regulates endosome structure and function. Nature 392, 193-197.
16. De Gassart, A., Geminard, C., Fevrier, B., Raposo, G., and Vidal, M. (2003) Lipid raft-associated protein sorting in exosomes. Blood 102, 4336-4344.
17. Trajkovic, K., Hsu, C., Chiantia, S., and Rajendran, L. (2008) Ceramide triggers budding of exosome vesicles into multivesicular endosomes. Science 319, 1244-1247.
18. Theos, A.C., Truschel, S.T., Tenza, D., Hurbain, I., Harper, D.C., Berson, J.F., Thomas, P.C., Raposo, G., and Marks, M.S. (2006) A novel pathway for sorting to intralumenal vesicles of multivesicular endosomes involved in organelle morphogenesis Dev. Cell 10, 343-354.
19. Thery, C., Zitvogel, L., and Amigorena, S. (2002) Exosomes: composition, biogenesis and function. Nat. Rev. Immunol. 2, 569-578.
20. Simpson, R.J., Jensen, S.S., and Lim, J.W. (2008) Proteomic profiling of exosomes: current perspectives. Proteomics 8, 4083-4099.
21. Andre, F., Schartz, N.E., Movassagh, M., Flament, C., Pautier, P., Morice, P., Pomel, C., Lhomme, C., Escudier, B., Le Chevalier, T., Turzs, T., Amigorena, S., Raposo, G., Angevin, E., and Zitvogel, L. (2002) Malignant effusions and immunogenic tumour-derived exosomes. Lancet 360, 295-305.
22. Pisitkun, T., Shen, R.-F., and Knepper, M.A. (2004) Identification and proteomic profiling of exosomes in human urine. Proc. Natl. Acad. Sci. U. S. A. 101, 13368-13373.
23. Mears, R., Craven, R.A., Hanrahan, S., Totty, N., Upton, C., Young, S.L., Patel, P., Selby, P.J., and Banks, R.E. (2004) Proteomic analysis of melanoma-derived exosomes by two-dimensional polyacrylamide gel electrophoresis and mass spectrometry. Proteomics 4, 4019-4031.
24. Cheruvanky, A., Zhou, H., Pisitkun, T., Kopp, J.B., Knepper, M.A., Peter, S.T., Yuen, P.S.T., and Star, R.A. (2007) Rapid isolation of urinary exosomal biomarkers using a nanomembrane ultrafiltration concentrator. Am. J. Physiol. Renal Physiol. 292, 1657-1661.
25. Olver, C. and Vidal, M. (2007) Proteomic analysis of secreted exosomes. Subcell. Biochem. 43, 99-131.
26. Gonsales, P.A., Pisitkun, T., Hoffert, J.D., Tchapyjnikov, D., Star, R.A., Kleta, R., Wang, S., and Knepper, M.A. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20, 363-379.
27. Hu, C., van der Heijden, R., Wang, M., van der Greef, J., Hankemeier, T., and Xu, G.(2009) Analytical strategies in lipidomics and applications in disease biomarker discovery. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 877, 2836-2846.
28. Wenk, M.R. (2005) The emerging field of lipidomics. Nat. Rev. Drug. Discov. 4, 594-610.
29. Simons, M. and Raposo, G. (2009) Exosomes - vesicular carriers for intercellular communication. Curr. Opin. Cell Biol. 21, 575-581.
30. Subra, C., Laulagnier, K., Perret, B., and Record, M. (2007) Exosome lipidomics unravels lipid sorting at the level of multivesicular bodies. Biochemie 89, 205-212.
31. Wubbolts, R., Leckie, R.S., Veenhuizen, P.T., Schwarzmann, G., Mobius, W., Hoernschemeyer, J., Slot, J.W., Geuze, H.J., and Stoorvogel, W.(2003) Proteomic and biochemical analyses of human B cell-derived exosomes. Potential implications for their function and multivesicular body formation. J. Biol. Chem. 278, 10963-10972.
32. Zhou, H., Yuen, P.S., Pisitkun, T., Gonzales, P.A., Yasuda, H., Dear, J.W., Gross, P., Knepper, M.A., and Star, R.A. (2006) Collection, storage, preservation, and normalization of human urinary exosomes for biomarker discovery . Kidney Int. 69, 1471-1476.
33. Hoorn, E.J., Pisitkun, T., Zeitse, R., Gross, P., Frokiaer, J., Wang, N.S., Gonsales, P.A., Star, R.A., and Knepper, M.A. (2005) Prospects for urinary proteomics: exosomes as a source of urinary biomarkers. Nephrology 10, 283-290.
34. Huber, V., Filipazzi, P., Iero, M., Fais, S., and Rivoltini, L. (2008) More insights into the immunosuppressive potential of tumor exosomes. J. Transl. Med. 6, 63.
35. Adachi, J., Kumar, C., Zhang, Y., Olsen, J.V., and Mann, M. (2006) The human urinary proteome contains more than 1500 proteins, including a large proportion of membrane proteins. Genome Biol. 7, R80.
36. Mayr, M., Zhang, J., Greene, A.S., Gutterman, D., Perloff, J., and Ping, P. (2006) Proteomics-based development of biomarkers in cardiovascular disease: mechanistic, clinical, and therapeutic insights. Mol. Cell. Proteomics 5, 1853-1864.
37. Pisitkun, T., Johnstone, R., and Knepper, M.A. (2006) Discovery of urinary biomarkers. Mol. Cell. Proteomics 5, 1760-1771.
38. Keller, S., Rupp, C., Stoeck, A., Runy, S., Fogel, M., Lugert, S., Hager, H.-D., Abdel-Bakky, M.S., Gutwein, P., and Altevog, P. (2007) CD24 is a marker of exosomes secreted into urine and amniotic fluid. Kidney Int. 72, 1095-1102.
39. Knepper, M.A. and Pisitkun, T. (2007) Exosomes in urine: who would have thought...? Kidney Int. 72, 1043-1045.
40. Simpson, R.J., Jensen, S.S., and Lim, J.W.E. (2008) Proteomic profiling of exosomes: current perspectives. Proteomics 8, 4083-4099.
41. Valadi, H., Ekström, K., Bossios, A., Sjöstrand, M., Lee, J.J., and Lötvall, J.O. (2007) Exosome-mediated transfer of mRNA and microRNAs is a novel mechanism of genetic exchange between cells. Nat. Cell Biol. 9, 654-659.
42. Fevrier, B. and Raposo, G. (2004) Exosomes: endosomal derived vesicles shipping extracellular messages. Curr. Opin. Cell Biol. 16, 415-421.
43. Goligorsky, M.S., Addabbo, F., and O'Riordan, E. (2007) Diagnostic potential of urine proteomics: a broken mirror of renal diseases. J. Am. Soc. Nephrol. 18, 2233-2239.
44. Kanno, K., Sasaki, S., Hirata, Y., Ishikawa, S., Fushimi, K., Nakanishi, S., Bichet, D.G., and Marumo, F. (1995) Urinary excretion of aquaporin-2 in patients with diabetes insipidus. N. Engl. J. Med. 332, 1540-1545.
45. Elliot, S., Goldsmith, P., Knepper, M., Haughey, M., and Olson, B. (1996) Urinary excretion of aquaporin- 2 in humans: a potential marker of collecting duct responsiveness to vasopressin. J. Am. Soc. Nephrol. 7, 403-409.
46. Valenti, G., Laera, A., Pace, G., Aceto, G., Lospalluti, M.L., Penza, R., Selvaggi, F.P., Chiozza, M.L., and Svelto, M. (2000) Urinary aquaporin 2 and calciuria correlate with the severity of enuresis in children. J. Am. Soc. Nephrol. 11, 1873-1881.
47. Ishikawa, S.E. and Schrier, R.W. (2003) Pathophysiological roles of arginine vasopressin and aquaporin-2 in impaired water excretion. Clin. Endocrinol. 58, 1-17.
48. + exchanger isoform 3 (NHE3) protein as new marker of tubule injury in critically ill patients with ARF. Am. J. Kidney Dis. 42, 497-506.
49. Zhou, H., Pisitkun, T., Aponte, A., Yuen, P.S., Hoffert, J.D., Yasuda, H., Hu, X., Chawla, L., Shen, R.-F., Knepper, M.A., and Star, R.A. (2006) Exosomal fetuin-A identified by proteomics: a novel urinary biomarker for detecting acute kidney injury. Kidney Int. 70, 1847-1857.
50. Bennett, W.M. (2005) V2 receptor antagonists in cystic kidney diseases: an exciting step towards a practical treatment. J. Am. Soc. Nephrol. 16, 838-839.
51. Ruf, R., Rensing, C., Topaloglu, R., Woodford, L.G., Klein, C., Vollmer, M., Otto, E., Beekmann, F., Haller, M., Wiedensohler, A., Leumann, E., Antignac, C., Rizzoni, G., Filler, G., Brandis, M., Weber, J.L., and Hildebrant, F. (2003) Confirmation of the ATP6B1 gene as responsible for distal renal tubular acidosis. Pediatr. Nephrol. 18,105-109.
52. Jang, H.R., Lee, J.W., Oh, Y.K., Joo, K.W., Jeon, U.S., Cheong, H.I., Kim, J., and Han, J.S. (2006) From bench to bedside: diagnosis of Gitelman's syndrome - defect of sodium-chloride cotransporter in renal tissue. Kidney Int. 70, 813-817.
53. Knoers, N.V. and Levtchenko, E.N. (2008) Gitelman syndrome. Orphanet. J. Rare Dis. 30, 22.
54. Hogan, M.C., Manganlli, L., Woollard, J.R., Masyuk, A.I., Masyuk, T.V., Tammachote, R., Huang, B.Q., Leontovich, A.A., Beito, T.G., Madden, B.J., Charlesworth, M.C., Torres, V.E., LaRusso, N.F., Harris, P.C., and Ward, C.J. (2009) Characterization of PKD protein-positive exosome-like vesicles. J. Am. Soc. Nephrol. 20, 278-288.
55. Ariztia, E.V., Lee, C.J., Gogoi, R., and Fishman, D.A. (2006) The tumor microenvironment: key to early detection. Crit. Rev. Clin. Lab. Sci. 43, 393-426.
56. Rivoltini, L., Canese, P., Huber, V., Iero, M., Pilla, L., Valenti, R., Fais, S., Lozupone, F., Casati, C., Castelli, C., and Parmiani, G. (2005) Escape strategies and reasons for failure in the interaction between tumour cells and the immune system: how can we tilt the balance towards immune-mediated cancer control? Expert Opin. Biol. Ther. 5, 463-476.
57. Segura, E., Amigorena, S., and Thery, C. (2005) Mature dendritic cells secrete exosomes with strong ability to induce antigen-specific effector immune responses. Blood Cells Mol. Dis. 35, 89-93.
58. Smith, S.C. and Theodoresu, D. (2009) The Ral GTPase in metastatic bladder cancer: key mediator and therapeutic target. Urol. Oncol. 27, 42-47.
59. Winkler, A., Zigeuner, R., Rehak, P., Hutterer, G., Chromecki, T., and Lagner, C. (2007) CD24 expression in urothelial carcinoma of the upper urinary tract correlates with tumor progression. Virchovs Arch. 450, 59-64.
60. Smalley, D.M., Sheman, E.S., Nelson, K., and Theodorescu, D., (2008) Isolation and identification of potential urinary microparticle biomarkers of bladder cancer. J. Proteome Res. 7, 2088-2096.
61. Ceccarelli, S., Visco, V., Raffa, S., Wakisaka, N., Pagano, J.S., and Torrisi, M.R. (2007) Epstein-Barr virus latent membrane protein 1 promotes concentration in multivesicular bodies of fibroblast growth factor 2 and its release through exosomes. Int. J. Cancer 121, 1494-1506.
62. Mitchell, P.J., Welton, J., Staffurth, J., Court, J., Mason, M.D., Tabi1, Z., and Clayton, A. (2009) Can urinary exosomes act as treatment response markers in prostate cancer? J. Transl. Med.7, 4.
63. Jansen, F.H., Krijgsveld, J., van Rijswik, A., van den Bemt, G.-J., van den Berg, M.S., van Weerden, W.M., Williemsen, R., Dekker, L.J., Luider, T.M., and Jenster, G. (2009) Exosomal secretion of cytoplasmic prostate cancer xenograft-derived proteins. Mol. Cell. Proteomics 8(6), 1192-1205.
64. Gould, S.J., Booth, A.M., and Hildreth, J.E. (2003) The Trojan exosome hypothesis. Proc. Natl. Acad. Sci. U. S. A. 100, 10592-10597.
65. Fang, Y., Wu, N., Gan, X., Yan, W., Morrell, J.C., and Gould, S.J. (2007) Higher-order oligomerization targets plasma membrane proteins and HIV gag to exosomes. PLoS. Biol. 5, e158.
66. Chen, B.J. and Lamb, R.A. (2007) Mechanisms for enveloped virus budding: can some viruses do without an ESCRT? Virology 372, 221-232.
67. Kramer, B., Pelchen-Matthews, A., Deneka, M., Garcia, E., Piguet, V., and Marsh, M. (2005) HIV interaction with endosomes in macrophages and dendritic cells. Blood Cells Mol. Dis. 35, 111-115.
68. Baumgartner, C., Rejtar, T., Kullolli, M., Akella, L.M., and Karger, B.L. (2008) SeMoP: a new computational strategy for the unrestricted search for modified peptides using LC-MS/MS data. J. Proteome Res. 7, 4199-4208.