메뉴 건너뛰기




Volumn 166, Issue 3, 2010, Pages 284-288

Blood-brain barrier Part III: Therapeutic approaches to cross the blood-brain barrier and target the brain;Barrière hématoencéphalique Partie III : approche thérapeutique pour franchir la barrière hématoencéphalique

Author keywords

Blood brain barrier; Drug delivery; Drug targeting; Receptors; Transporters

Indexed keywords

ABC TRANSPORTER; VIRUS VECTOR; XENOBIOTIC AGENT;

EID: 77649232029     PISSN: 00353787     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neurol.2009.06.005     Document Type: Review
Times cited : (2)

References (44)
  • 1
    • 44449175178 scopus 로고    scopus 로고
    • A pilot randomized clinical safety study of sonothrombolysis augmentation with ultrasound-activated perflutren-lipid microspheres for acute ischemic stroke
    • Alexandrov A.V., Mikulik R., Ribo M., et al. A pilot randomized clinical safety study of sonothrombolysis augmentation with ultrasound-activated perflutren-lipid microspheres for acute ischemic stroke. Stroke 39 (2008) 1464-1469
    • (2008) Stroke , vol.39 , pp. 1464-1469
    • Alexandrov, A.V.1    Mikulik, R.2    Ribo, M.3
  • 2
    • 37549007090 scopus 로고    scopus 로고
    • Adenovirus-based strategies overcome temozolomide resistance by silencing the O6-methylguanine-DNA methyltransferase promoter
    • Alonso M.M., Gomez-Manzano C., Bekele B.N., Yung W.K., and Fueyo J. Adenovirus-based strategies overcome temozolomide resistance by silencing the O6-methylguanine-DNA methyltransferase promoter. Cancer Res 67 (2007) 11499-11504
    • (2007) Cancer Res , vol.67 , pp. 11499-11504
    • Alonso, M.M.1    Gomez-Manzano, C.2    Bekele, B.N.3    Yung, W.K.4    Fueyo, J.5
  • 3
    • 1642454475 scopus 로고    scopus 로고
    • ABC transporters and the blood-brain barrier
    • Begley D.J. ABC transporters and the blood-brain barrier. Curr Pharm Des 10 (2004) 1295-1312
    • (2004) Curr Pharm Des , vol.10 , pp. 1295-1312
    • Begley, D.J.1
  • 4
    • 0035292828 scopus 로고    scopus 로고
    • Delivery of peptides and proteins through the blood-brain barrier
    • Bickel U., Yoshikawa T., and Pardridge W.M. Delivery of peptides and proteins through the blood-brain barrier. Adv Drug Deliv Rev 46 (2001) 247-279
    • (2001) Adv Drug Deliv Rev , vol.46 , pp. 247-279
    • Bickel, U.1    Yoshikawa, T.2    Pardridge, W.M.3
  • 5
    • 0034454980 scopus 로고    scopus 로고
    • Endocytosis and transcytosis of an immunoliposome-based brain drug delivery system
    • Cerletti A., Drewe J., Fricker G., Eberle A.N., and Huwyler J. Endocytosis and transcytosis of an immunoliposome-based brain drug delivery system. J Drug Target 8 (2000) 435-446
    • (2000) J Drug Target , vol.8 , pp. 435-446
    • Cerletti, A.1    Drewe, J.2    Fricker, G.3    Eberle, A.N.4    Huwyler, J.5
  • 6
    • 22944434897 scopus 로고    scopus 로고
    • Quantitative in vivo microdialysis study on the influence of multidrug transporters on the blood-brain barrier passage of oxcarbazepine: concomitant use of hippocampal monoamines as pharmacodynamic markers for the anticonvulsant activity
    • Clinckers R., Smolders I., Meurs A., Ebinger G., and Michotte Y. Quantitative in vivo microdialysis study on the influence of multidrug transporters on the blood-brain barrier passage of oxcarbazepine: concomitant use of hippocampal monoamines as pharmacodynamic markers for the anticonvulsant activity. J Pharmacol Exp Ther 314 (2005) 725-731
    • (2005) J Pharmacol Exp Ther , vol.314 , pp. 725-731
    • Clinckers, R.1    Smolders, I.2    Meurs, A.3    Ebinger, G.4    Michotte, Y.5
  • 8
    • 4644292545 scopus 로고    scopus 로고
    • Potential role of ABC transporters as a detoxification system at the blood-CSF barrier
    • de Lange E.C. Potential role of ABC transporters as a detoxification system at the blood-CSF barrier. Adv Drug Deliv Rev 56 (2004) 1793-1809
    • (2004) Adv Drug Deliv Rev , vol.56 , pp. 1793-1809
    • de Lange, E.C.1
  • 9
    • 29144442863 scopus 로고    scopus 로고
    • Gene transfer of human acid sphingomyelinase corrects neuropathology and motor deficits in a mouse model of Niemann-Pick type A disease
    • Dodge J.C., Clarke J., Song A., et al. Gene transfer of human acid sphingomyelinase corrects neuropathology and motor deficits in a mouse model of Niemann-Pick type A disease. Proc Natl Acad Sci U S A 102 (2005) 17822-17827
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 17822-17827
    • Dodge, J.C.1    Clarke, J.2    Song, A.3
  • 10
    • 0035669389 scopus 로고    scopus 로고
    • Overexpression of multiple drug resistance genes in endothelial cells from patients with refractory epilepsy
    • Dombrowski S.M., Desai S.Y., Marroni M., et al. Overexpression of multiple drug resistance genes in endothelial cells from patients with refractory epilepsy. Epilepsia 42 (2001) 1501-1506
    • (2001) Epilepsia , vol.42 , pp. 1501-1506
    • Dombrowski, S.M.1    Desai, S.Y.2    Marroni, M.3
  • 11
    • 23644452944 scopus 로고    scopus 로고
    • Efficient in vivo protection of nigral dopaminergic neurons by lentiviral gene transfer of a modified Neurturin construct
    • Fjord-Larsen L., Johansen J.L., Kusk P., et al. Efficient in vivo protection of nigral dopaminergic neurons by lentiviral gene transfer of a modified Neurturin construct. Exp Neurol 195 (2005) 49-60
    • (2005) Exp Neurol , vol.195 , pp. 49-60
    • Fjord-Larsen, L.1    Johansen, J.L.2    Kusk, P.3
  • 12
    • 0000933610 scopus 로고    scopus 로고
    • Trans-skull ultrasound therapy: the feasibility of using image-derived skull thickness information to correct the phase distortion
    • Hynynen K., and Sun J. Trans-skull ultrasound therapy: the feasibility of using image-derived skull thickness information to correct the phase distortion. IEEE Trans Ultrason Ferroelectr Freq Control 46 (1999) 752-755
    • (1999) IEEE Trans Ultrason Ferroelectr Freq Control , vol.46 , pp. 752-755
    • Hynynen, K.1    Sun, J.2
  • 13
    • 0032855497 scopus 로고    scopus 로고
    • Multifaceted activities of the HIV-1 transactivator of transcription, Tat
    • Jeang K.T., Xiao H., and Rich E.A. Multifaceted activities of the HIV-1 transactivator of transcription, Tat. J Biol Chem 274 (1999) 28837-28840
    • (1999) J Biol Chem , vol.274 , pp. 28837-28840
    • Jeang, K.T.1    Xiao, H.2    Rich, E.A.3
  • 14
    • 0032518290 scopus 로고    scopus 로고
    • The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors
    • Kim R.B., Fromm M.F., Wandel C., et al. The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors. J Clin Invest 101 (1998) 289-294
    • (1998) J Clin Invest , vol.101 , pp. 289-294
    • Kim, R.B.1    Fromm, M.F.2    Wandel, C.3
  • 15
    • 33746851261 scopus 로고    scopus 로고
    • Noninvasive localized delivery of Herceptin to the mouse brain by MRI-guided focused ultrasound-induced blood-brain barrier disruption
    • Kinoshita M., McDannold N., Jolesz F.A., and Hynynen K. Noninvasive localized delivery of Herceptin to the mouse brain by MRI-guided focused ultrasound-induced blood-brain barrier disruption. Proc Natl Acad Sci U S A 103 (2006) 11719-11723
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 11719-11723
    • Kinoshita, M.1    McDannold, N.2    Jolesz, F.A.3    Hynynen, K.4
  • 17
    • 0031965788 scopus 로고    scopus 로고
    • Outwitting the blood-brain barrier for therapeutic purposes: osmotic opening and other means
    • [discussion 1099-100]
    • Kroll R.A., and Neuwelt E.A. Outwitting the blood-brain barrier for therapeutic purposes: osmotic opening and other means. Neurosurgery 42 (1998) 1083-1099 [discussion 1099-100]
    • (1998) Neurosurgery , vol.42 , pp. 1083-1099
    • Kroll, R.A.1    Neuwelt, E.A.2
  • 18
    • 56149124382 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling controls development of the blood-brain barrier
    • Liebner S., Corada M., Bangsow T., et al. Wnt/beta-catenin signaling controls development of the blood-brain barrier. J Cell Biol 183 (2008) 409-417
    • (2008) J Cell Biol , vol.183 , pp. 409-417
    • Liebner, S.1    Corada, M.2    Bangsow, T.3
  • 19
    • 23044500398 scopus 로고    scopus 로고
    • Drug resistance in brain diseases and the role of drug efflux transporters
    • Loscher W., and Potschka H. Drug resistance in brain diseases and the role of drug efflux transporters. Nat Rev Neurosci 6 (2005) 591-602
    • (2005) Nat Rev Neurosci , vol.6 , pp. 591-602
    • Loscher, W.1    Potschka, H.2
  • 20
    • 33751312312 scopus 로고    scopus 로고
    • Ultrasound, microbubbles and the blood-brain barrier
    • Meairs S., and Alonso A. Ultrasound, microbubbles and the blood-brain barrier. Prog Biophys Mol Biol 93 (2007) 354-362
    • (2007) Prog Biophys Mol Biol , vol.93 , pp. 354-362
    • Meairs, S.1    Alonso, A.2
  • 21
    • 0038660123 scopus 로고    scopus 로고
    • Serum from patients with multiple sclerosis downregulates occludin and VE-cadherin expression in cultured endothelial cells
    • Minagar A., Ostanin D., Long A.C., et al. Serum from patients with multiple sclerosis downregulates occludin and VE-cadherin expression in cultured endothelial cells. Mult Scler 9 (2003) 235-238
    • (2003) Mult Scler , vol.9 , pp. 235-238
    • Minagar, A.1    Ostanin, D.2    Long, A.C.3
  • 22
    • 0028881233 scopus 로고
    • Comparison of intracerebral inoculation and osmotic blood-brain barrier disruption for delivery of adenovirus, herpes virus, and iron oxide particles to normal rat brain
    • Muldoon L.L., Nilaver G., Kroll R.A., et al. Comparison of intracerebral inoculation and osmotic blood-brain barrier disruption for delivery of adenovirus, herpes virus, and iron oxide particles to normal rat brain. Am J Pathol 147 (1995) 1840-1851
    • (1995) Am J Pathol , vol.147 , pp. 1840-1851
    • Muldoon, L.L.1    Nilaver, G.2    Kroll, R.A.3
  • 23
    • 38049144280 scopus 로고    scopus 로고
    • Glioblastoma multiforme: evidence-based approach to therapy
    • [Suppl.]
    • Nicholas M.K. Glioblastoma multiforme: evidence-based approach to therapy. Expert Rev Anticancer Ther 7 (2007) S23-S27 [Suppl.]
    • (2007) Expert Rev Anticancer Ther , vol.7
    • Nicholas, M.K.1
  • 24
    • 0033526159 scopus 로고    scopus 로고
    • Vector-mediated drug delivery to the brain
    • Pardridge W.M. Vector-mediated drug delivery to the brain. Adv Drug Deliv Rev 36 (1999) 299-321
    • (1999) Adv Drug Deliv Rev , vol.36 , pp. 299-321
    • Pardridge, W.M.1
  • 25
    • 0029079310 scopus 로고
    • Vector-mediated delivery of a polyamide ("peptide") nucleic acid analogue through the blood-brain barrier in vivo
    • Pardridge W.M., Boado R.J., and Kang Y.S. Vector-mediated delivery of a polyamide ("peptide") nucleic acid analogue through the blood-brain barrier in vivo. Proc Natl Acad Sci U S A 92 (1995) 5592-5596
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 5592-5596
    • Pardridge, W.M.1    Boado, R.J.2    Kang, Y.S.3
  • 26
    • 0023227218 scopus 로고
    • Human blood-brain barrier transferrin receptor
    • Pardridge W.M., Eisenberg J., and Yang J. Human blood-brain barrier transferrin receptor. Metabolism 36 (1987) 892-895
    • (1987) Metabolism , vol.36 , pp. 892-895
    • Pardridge, W.M.1    Eisenberg, J.2    Yang, J.3
  • 27
    • 0026784945 scopus 로고
    • Antennapedia homeobox as a signal for the cellular internalization and nuclear addressing of a small exogenous peptide
    • Perez F., Joliot A., Bloch-Gallego E., Zahraoui A., Triller A., and Prochiantz A. Antennapedia homeobox as a signal for the cellular internalization and nuclear addressing of a small exogenous peptide. J Cell Sci 102 (1992) 717-722
    • (1992) J Cell Sci , vol.102 , pp. 717-722
    • Perez, F.1    Joliot, A.2    Bloch-Gallego, E.3    Zahraoui, A.4    Triller, A.5    Prochiantz, A.6
  • 28
    • 0037388250 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled, phase 2 study of RMP-7 in combination with carboplatin administered intravenously for the treatment of recurrent malignant glioma
    • Prados M.D., Schold S.J.S., Fine H.A., et al. A randomized, double-blind, placebo-controlled, phase 2 study of RMP-7 in combination with carboplatin administered intravenously for the treatment of recurrent malignant glioma. Neuro Oncol 5 (2003) 96-103
    • (2003) Neuro Oncol , vol.5 , pp. 96-103
    • Prados, M.D.1    Schold, S.J.S.2    Fine, H.A.3
  • 29
    • 0022531272 scopus 로고
    • Pharmacological modification of bradykinin induced breakdown of the blood-brain barrier
    • Raymond J.J., Robertson D.M., and Dinsdale H.B. Pharmacological modification of bradykinin induced breakdown of the blood-brain barrier. Can J Neurol Sci 13 (1986) 214-220
    • (1986) Can J Neurol Sci , vol.13 , pp. 214-220
    • Raymond, J.J.1    Robertson, D.M.2    Dinsdale, H.B.3
  • 30
    • 0034126420 scopus 로고    scopus 로고
    • New advances in the transport of doxorubicin through the blood-brain barrier by a peptide vector-mediated strategy
    • Rousselle C., Clair P., Lefauconnier J.M., Kaczorek M., Scherrmann J.M., and Temsamani J. New advances in the transport of doxorubicin through the blood-brain barrier by a peptide vector-mediated strategy. Mol Pharmacol 57 (2000) 679-686
    • (2000) Mol Pharmacol , vol.57 , pp. 679-686
    • Rousselle, C.1    Clair, P.2    Lefauconnier, J.M.3    Kaczorek, M.4    Scherrmann, J.M.5    Temsamani, J.6
  • 31
    • 4143081639 scopus 로고    scopus 로고
    • Cellular mechanisms of the blood-brain barrier opening induced by ultrasound in presence of microbubbles
    • Sheikov N., McDannold N., Vykhodtseva N., Jolesz F., and Hynynen K. Cellular mechanisms of the blood-brain barrier opening induced by ultrasound in presence of microbubbles. Ultrasound Med Biol 30 (2004) 979-989
    • (2004) Ultrasound Med Biol , vol.30 , pp. 979-989
    • Sheikov, N.1    McDannold, N.2    Vykhodtseva, N.3    Jolesz, F.4    Hynynen, K.5
  • 32
    • 0036156280 scopus 로고    scopus 로고
    • Drug resistance in epilepsy: expression of drug resistance proteins in common causes of refractory epilepsy
    • Sisodiya S.M., Lin W.R., Harding B.N., Squier M.V., and Thom M. Drug resistance in epilepsy: expression of drug resistance proteins in common causes of refractory epilepsy. Brain 125 (2002) 22-31
    • (2002) Brain , vol.125 , pp. 22-31
    • Sisodiya, S.M.1    Lin, W.R.2    Harding, B.N.3    Squier, M.V.4    Thom, M.5
  • 33
    • 0035839257 scopus 로고    scopus 로고
    • Chemically modified polyacrylamide-g-guar gum-based crosslinked anionic microgels as pH-sensitive drug delivery systems: preparation and characterization
    • Soppimath K.S., Kulkarni A.R., and Aminabhavi T.M. Chemically modified polyacrylamide-g-guar gum-based crosslinked anionic microgels as pH-sensitive drug delivery systems: preparation and characterization. J Control Release 75 3 (2001) 331-345
    • (2001) J Control Release , vol.75 , Issue.3 , pp. 331-345
    • Soppimath, K.S.1    Kulkarni, A.R.2    Aminabhavi, T.M.3
  • 34
    • 11244349670 scopus 로고    scopus 로고
    • Transduction of human glial and neuronal tumor cells with different lentivirus vector pseudotypes
    • Steffens S., Tebbets J., Kramm C.M., Lindemann D., Flake A., and Sena-Esteves M. Transduction of human glial and neuronal tumor cells with different lentivirus vector pseudotypes. J Neurooncol 70 (2004) 281-288
    • (2004) J Neurooncol , vol.70 , pp. 281-288
    • Steffens, S.1    Tebbets, J.2    Kramm, C.M.3    Lindemann, D.4    Flake, A.5    Sena-Esteves, M.6
  • 35
    • 4644269603 scopus 로고    scopus 로고
    • Use of verapamil as a potential P-glycoprotein inhibitor in a patient with refractory epilepsy
    • Summers M.A., Moore J.L., and McAuley J.W. Use of verapamil as a potential P-glycoprotein inhibitor in a patient with refractory epilepsy. Ann Pharmacother 38 (2004) 1631-1634
    • (2004) Ann Pharmacother , vol.38 , pp. 1631-1634
    • Summers, M.A.1    Moore, J.L.2    McAuley, J.W.3
  • 36
    • 2342439868 scopus 로고    scopus 로고
    • Anti-HIV drug distribution to the central nervous system
    • Thomas S.A. Anti-HIV drug distribution to the central nervous system. Curr Pharm Des 10 (2004) 1313-1324
    • (2004) Curr Pharm Des , vol.10 , pp. 1313-1324
    • Thomas, S.A.1
  • 37
    • 12344273724 scopus 로고    scopus 로고
    • Small molecular drug transfer across the blood-brain barrier via carrier-mediated transport systems
    • Tsuji A. Small molecular drug transfer across the blood-brain barrier via carrier-mediated transport systems. NeuroRx 2 (2005) 54-62
    • (2005) NeuroRx , vol.2 , pp. 54-62
    • Tsuji, A.1
  • 38
    • 33744494277 scopus 로고    scopus 로고
    • Gene therapy in epilepsy
    • Vezzani A. Gene therapy in epilepsy. Epilepsy Curr 4 (2004) 87-90
    • (2004) Epilepsy Curr , vol.4 , pp. 87-90
    • Vezzani, A.1
  • 39
    • 0033827147 scopus 로고    scopus 로고
    • The disposition of saquinavir in normal and P-glycoprotein deficient mice, rats, and in cultured cells
    • Washington C.B., Wiltshire H.R., Man M., et al. The disposition of saquinavir in normal and P-glycoprotein deficient mice, rats, and in cultured cells. Drug Metab Dispos 28 (2000) 1058-1062
    • (2000) Drug Metab Dispos , vol.28 , pp. 1058-1062
    • Washington, C.B.1    Wiltshire, H.R.2    Man, M.3
  • 40
    • 0037705377 scopus 로고    scopus 로고
    • Characterization of the MRP4- and MRP5-mediated transport of cyclic nucleotides from intact cells
    • Wielinga P.R., van der Heijden I., Reid G., Beijnen J.H., Wijnholds J., and Borst P. Characterization of the MRP4- and MRP5-mediated transport of cyclic nucleotides from intact cells. J Biol Chem 278 (2003) 17664-17671
    • (2003) J Biol Chem , vol.278 , pp. 17664-17671
    • Wielinga, P.R.1    van der Heijden, I.2    Reid, G.3    Beijnen, J.H.4    Wijnholds, J.5    Borst, P.6
  • 41
    • 70350710063 scopus 로고    scopus 로고
    • Weiss N, Miller F, Cazaubon S, Couraud PO. Part I: Biology of the blood-brain barrier. Rev Neurol (Paris) doi:10.1016/j.neurol.2009.03.004.
    • Weiss N, Miller F, Cazaubon S, Couraud PO. Part I: Biology of the blood-brain barrier. Rev Neurol (Paris) doi:10.1016/j.neurol.2009.03.004.
  • 42
    • 0036627211 scopus 로고    scopus 로고
    • Tight junctions of the blood-brain barrier: development, composition and regulation
    • Wolburg H., and Lippoldt A. Tight junctions of the blood-brain barrier: development, composition and regulation. Vascul Pharmacol 38 (2002) 323-337
    • (2002) Vascul Pharmacol , vol.38 , pp. 323-337
    • Wolburg, H.1    Lippoldt, A.2
  • 43
    • 34548130700 scopus 로고    scopus 로고
    • Quantitative evaluation of focused ultrasound with a contrast agent on blood-brain barrier disruption
    • Yang F.Y., Fu W.M., Yang R.S., Liou H.C., Kang K.H., and Lin W.L. Quantitative evaluation of focused ultrasound with a contrast agent on blood-brain barrier disruption. Ultrasound Med Biol 33 (2007) 1421-1427
    • (2007) Ultrasound Med Biol , vol.33 , pp. 1421-1427
    • Yang, F.Y.1    Fu, W.M.2    Yang, R.S.3    Liou, H.C.4    Kang, K.H.5    Lin, W.L.6
  • 44
    • 38149090292 scopus 로고    scopus 로고
    • The blood-brain barrier in health and chronic neurodegenerative disorders
    • Zlokovic B.V. The blood-brain barrier in health and chronic neurodegenerative disorders. Neuron 57 (2008) 178-201
    • (2008) Neuron , vol.57 , pp. 178-201
    • Zlokovic, B.V.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.