Overview of the physiological control of eating

Forum of Nutrition

Volumn 63, Issue , 2010, Pages 9-53

  Langhans, Wolfgang ^a   Geary, Nori ^a  

^a ETH ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL; BODY WEIGHT; EATING; HOMEOSTASIS; HUMAN; OBESITY; PATHOPHYSIOLOGY; PHYSIOLOGY; REVIEW; SATIETY;

ANIMALS; BODY WEIGHT; EATING; HOMEOSTASIS; HUMANS; OBESITY; SATIATION;

EID: 77649226732     PISSN: 16600347     EISSN: None     Source Type: Book Series    
DOI: 10.1159/000264392     Document Type: Review

References (282)

1. James W: The Principles of Psychology. London, Dover Press, 1878.
2. Neary NT, Batterham RL: Gaining new insights into food reward with functional neuroimaging; in Langhans W, Geary N (eds): Frontiers in Eating and Weight Regulation. Forum Nutr. Basel, Karger, 2010, vol 63, pp 152-163.
3. Kringelbach ML, Stein A: Cortical mechanisms of human eating; in Langhans W, Geary N (eds): Frontiers in Eating and Weight Regulation. Forum Nutr. Basel, Karger, 2010, vol 63, pp 164-175.
4. Stice E, Dagher A: Genetic variation in dopaminergic reward in humans; in Langhans W, Geary N (eds): Frontiers in Eating and Weight Regulation. Forum Nutr. Basel, Karger, 2010, vol 63, pp 176-185.
5. Hillebrand JJG, Geary N: Do leptin and insulin signal adiposity; in Langhans W, Geary N (eds): Frontiers in Eating and Weight Regulation. Forum Nutr. Basel, Karger, 2010, vol 63, pp 111-122.
6. Kringelbach ML: The human orbitofrontal cortex: Linking reward to hedonic experience. Nature Rev Neurosci 2005;6:691-702.
7. Davis JD, Smith GP: The Conditioned Satiating Effect of Orosensory Stimuli. Physiol Behav 2009.
8. Klein DA, Schebendach JS, Devlin MJ, Smith G P, Walsh BT: Intake, sweetness and liking during modified sham feeding of sucrose solutions. Physiol Behav 2006;87:602-606.
9. Berridge KC, Robinson TE: Parsing reward. Trends Neurosci 2003;26:507-513.
10. Gibson EL, Brunstrom JM: Learned influences on appetite and food intake: evidence in human beings; in Cooper SJ, Kirkham TC (eds): Appetite and Body Weight: Integrative Systems and the Development of Anti-Obesity Drugs. London, Academic Press/Elsevier, 2007, pp 271-300.
11. Rozin PN, Schulkin J: Food selection; in Stricker E (ed): Handbook of Behavioral Neurobiology. New York, Plenum Press, 1990, vol 10, Neurobiology of Food and Fluid Intake, pp 297-328.
12. Bowen DJ: Taste and food preference changes across the course of pregnancy. Appetite 1992;19:233-242.
13. Zellner DA, Garriga-Trillo A, Centeno S, Wadsworth E: Chocolate craving and the menstrual cycle. Appetite 2004;42:119-121.
14. Rozin P, Hanko K, Durlach P: Self-prediction of hedonic trajectories for repeated use of body products and foods: poor performance, not improved by a full generation of experience. Appetite 2006;46:297-303.
15. Bartoshuk LM, Duffy VB, Hayes JE, Moskowitz HR, Snyder DJ: Psychophysics of sweet and fat perception in obesity: problems, solutions and new perspectives. Phil Trans Royal Soc [B] 2006;361:1137-1148.
16. Drewnowski A, Kurth C, Holden-Wiltse J, Saari J: Food preferences in human obesity: carbohydrates versus fats. Appetite 1992;18:207-221.
17. Macdiarmid JI, Vail A, Cade JE, Blundell JE: The sugar-fat relationship revisited: differences in consumption between men and women of varying BMI. Int J Obes Relat Metab Disord 1998;22:1053-1061.
18. Rolls BJ: Sensory-specific satiety. Nutr Rev 1986;44:93-101.
19. Rolls BJ, Vanduijvenvoorde PM, Rowe EA: Variety in the diet enhances intake in a meal and contributes to the development of obesity in the rat. Physiol Behav 1983;31:21-27.
20. Banks WA: Blood-brain barrier as a regulatory interface; in Langhans W, Geary N (eds): Frontiers in Eating and Weight Regulation. Forum Nutr. Basel, Karger, 2010, vol 63, pp 102-110.
21. Geary N: Endocrine controls of eating: CCK, leptin, and ghrelin. Physiol Behav 2004;81:719-733.
22. Gibbs J, Young RC, Smith GP: Cholecystokinin decreases food intake in rats. J Comp Physiol Psychol 1973;84:488-495.
23. Smith GP: Introduction to the reviews on peptides and the control of food intake and body weight. Neuropeptides 1999;33:323-328.
24. Beglinger C, Degen L: Gastrointestinal satiety signals in humans: physiologic roles for GLP-1 and PYY? Physiol Behav 2006;89:460-464.
25. Cummings DE, Overduin J: Gastrointestinal regulation of food intake. J Clin Invest 2007;117:13-23.
26. Moran TH: Gut peptide signaling in the controls of food intake. Obesity 2006;14:250-253.
27. Murphy KG, Bloom SR: Gut hormones and the regulation of energy homeostasis. Nature 2006;444:854-859.
28. Ritter RC: Gastrointestinal mechanisms of satiation for food. Physiol Behav 2004;81:249-273.
29. Strader AD, Woods SC: Gastrointestinal hormones and food intake. Gastroenterology 2005;128:175-191.
30. Wölnerhanssen B, Beglinger C: Therapeutic potential of gut peptides; in Langhans W, Geary N (eds): Frontiers in Eating and Weight Regulation. Forum Nutr. Basel, Karger, 2010, vol 63, pp 54-63.
31. Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K: Ghrelin is a growth-hormonereleasing acylated peptide from stomach. Nature 1999;402:656-660.
32. Cummings DE, Foster-Schubert KE, Overduin J: Ghrelin and energy balance: Focus on current controversies. Current Drug Targets 2005;6:153-169.
33. Ueno H, Yamaguchi H, Kangawa K, Nakazato M: Ghrelin: a gastric peptide that regulates food intake and energy homeostasis. Regul Peptides 2005;126:11-19.
34. Zhao HY: Growth hormone secretagogue receptor antagonists as potential therapeutic agents for obesity. Drug Dev Res 2005;65:50-54.
35. Helmling S, Maasch C, Eulberg D, Buchner K, Schroder W, Lange C, et al: Inhibition of ghrelin action in vitro and in vivo by an RNA-Spiegelmer. Proc Natl Acad Sci USA 2004;101:13174-13179.
36. Monnikes H, Helmling S, Stengel A, Wlotzka B, Andresen V, Klapp BF, et al: Anti-ghrelin Spiegelmer NOX-B11 inhibits neurostmoulatory and crexigenic effects of peripheral ghrelin in rats. Gastroenterology 2005;128: A374.
37. Wang S P, Helmling S, Stribling DS, et al: Ghrelin neutralization by an RNA-Spiegelmer yields body weight loss in diet-induced obese mice. Obes Res 2005;13: A32.
38. Gardiner JV, Kong WM, Ward H, Murphy KG, Dhillo WS, Bloom SR: AAV mediated expression of anti-sense neuropeptide Y cRNA in the arcuate nucleus of rats results in decreased weight gain and food intake. Biochem Biophys Res Commun 2005;327:1088-1093.
39. Gualillo O, Lago F, Dieguez C: Introducing GOAT: a target for obesity and anti-diabetic drugs? Trends Pharmacol Sci 2008;29:398-401.
40. Kirchner H, Gutierrez JA, Solenberg PJ, Pfluger PT, Czyzyk TA, Willency JA, et al: GOAT links dietary lipids with the endocrine control of energy balance. Nat Med 2009;15:741-745.
41. Yang J, Brown MS, Liang G, Grishin N V, Goldstein JL: Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone. Cell 2008;132:387-396.
42. Date Y, Murakami N, Toshinai K, Matsukura S, Niijima A, Matsuo H, et al: The role of the gastric afferent vagal nerve in ghrelin-induced feeding and growth hormone secretion in rats. Gastroenterology 2002;123:1120-1128.
43. Date Y, Toshinai K, Koda S, Miyazato M, Shimbara T, Tsuruta T, et al: Peripheral interaction of ghrelin with cholecystokinin on feeding regulation. Endocrinology 2005;146:3518-3525.
44. Arnold M, Mura A, Langhans W, Geary N: Gut vagal afferents are not necessary for the eating-stimulatory effect of intraperitoneally injected Ghrelin in the rat. J Neurosci 2006;26:11052-11060.
45. Cowley MA, Grove KL: Ghrelin-satisfying a hunger for the mechanism. Endocrinology 2004;145:2604-2606.
46. Eisen S, Davis JD, Rauhofer E, Smith GP: Gastric negative feedback produced by volume and nutrient during a meal in rats. Am J Physiol 2001;281: R1201-R1214.
47. Kaplan JMM, Moran TH: Gastrointestinal signaling in the control of food intake; in Stricker EM, Woods SC (eds): Handbook of Behavioral Neurobiology. Neurobiology of Food and Fluid Intake, ed 2. New York, Kluwer Academic, 2004, vol 14, pp 275-305.
48. Phillips RJ, Powley TL: Gastric volume rather than nutrient content inhibits food intake. Am J Physiol 1996;271: R766-R779.
49. Schwartz GJ: Brainstem integrative function in the central nervous system control of food intake; in Langhans W, Geary N (eds): Frontiers in Eating and Weight Regulation. Forum Nutr. Basel, Karger, 2010, vol 63, pp 141-151.
50. Geliebter A, Westreich S, Gage D: Gastric distention by balloon and test-meal intake in obese and lean subjects. Am J Clin Nutr 1988;48:592-594.
51. Rigaud D, Trostler N, Rozen R, Vallot T, Apfelbaum M: Gastric distension, hunger and energy intake after balloon implantation in severe obesity. Int J Obes Relat Metab Disord 1995;19:489-495.
52. Jones KL, Doran SM, Hveem K, et al: Relation between postprandial satiation and antral area in normal subjects. Am J Clin Nutr 1997;66:127-132.
53. Sturm K, Parker B, Wishart J, et al: Energy intake and appetite are related to antral area in healthy young and older subjects. Am J Clin Nutr 2004;80:656-667.
54. Oesch S, Ruegg C, Fischer B, Degen L, Beglinger C: Effect of gastric distension prior to eating on food intake and feelings of satiety in humans. Physiol Behav 2006;87:903-910.
55. Wang GJ, Tomasi D, Backus W, et al: Gastric distention activates satiety circuitry in the human brain. Neuroimage 2008;39:1824-1831.
56. Beglinger C, Degen L: Fat in the intestine as a regulator of appetite: role of CCK. Physiol Behav 2004;83:617-621.
57. Moran TH, Ameglio PJ, Schwartz GJ, Mchugh PR: Blockade of type-A, not type-B, CCK receptors attenuates satiety actions of exogenous and endogenous CCK. Am J Physiol 1992;262: R46-R50.
58. Moran TH, Kinzig KP: Gastrointestinal satiety signals. II. Cholecystokinin. Am J Physiol 2004;286: G183-G188.
59. Ballinger AB, Clark ML: L-Phenylalanine releases cholecystokinin (CCK) and is associated with reduced food-intake in humans: evidence for a physiological role of CCK in control of eating. Metab Clin Exp 1994;43:735-738.
60. Lieverse RJ, Jansen JBMJ, Vandezwan A, Samson L, Masclee AAM, Lamers CBHW: Effects of a physiological dose of cholecystokinin on food Intake and postprandial satiation in man. Regul Peptides 1993;43:83-89.
61. Jordan J, Greenway FL, Leiter LA, Li Z, Jacobson P, Murphy K, et al: Stimulation of cholecystokinin-A receptors with GI181771X does not cause weight loss in overweight or obese patients. Clin Pharmacol Ther 2008;83:281-287.
62. West DB, Fey D, Woods SC: Cholecystokinin persistently suppresses meal size but not food intake in free-feeding rats. Am J Physiol 1984;246: R776-R787.
63. Bi S, Moran TH: Actions of CCK in the controls of food intake and body weight: Lessons from the CCK-A receptor deficient OLETF rat. Neuropeptides 2002;36:171-181.
64. Cox JE: Cholecystokinin satiety involves CCKA receptors perfused by the superior pancreaticoduodenal artery. Am J Physiol 1998;274: R1390-R1396.
65. Blevins JE, Baskin DG: Hypothalamic-brainstem circuits controlling eating; in Langhans W, Geary N (eds): Frontiers in Eating and Weight Regulation. Forum Nutr. Basel, Karger, 2010, vol 63, pp 133-140.
66. Batterham RL, Cowley MA, Small CJ, Herzog H, Cohen MA, Dakin CL, et al: Gut hormone PYY3-36 physiologically inhibits food intake. Nature 2002;418:650-654.
67. Karra E, Chandarana K, Batterham RL: The role of peptide YY in appetite regulation and obesity. J Physiol 2009;587:19-25.
68. Neary MT, Batterham RL: Peptide YY: food for thought. Physiol Behav 2009;97:616-619.
69. Vincent R P, le Roux CW: The satiety hormone peptide YY as a regulator of appetite. J Clin Pathol 2008;61:548-552.
70. Ruttimann EB, Arnold M, Hillebrand JJ, Geary N, Langhans W: Intrameal hepatic portal and intraperitoneal infusions of glucagon-like peptide-1 reduce spontaneous meal size in the rat via different mechanisms. Endocrinology 2009;150:1174-1181.
71. Williams DL, Baskin DG, Schwartz MW: Evidence that intestinal glucagon-like peptide-1 plays a physiological role in satiety. Endocrinology 2009;150:1680-1687.
72. Hayes MR, Skibicka KP, Grill HJ: Caudal brainstem processing is sufficient for behavioral, sympathetic, and parasympathetic responses driven by peripheral and hindbrain glucagon-like-peptide-1 receptor stimulation. Endocrinology 2008;149:4059-4068.
73. Scott KA, Moran TH: The GLP-1 agonist exendin-4 reduces food intake in nonhuman primates through changes in meal size. Am J Physiol 2007;293:R983-R987.
74. Sandoval DA, Bagnol D, Woods SC, D'Alessio DA, Seeley RJ: Arcuate glucagon-like peptide 1 receptors regulate glucose homeostasis but not food intake. Diabetes 2008;57:2046-2054.
75. Kim W, Egan JM: The role of incretins in glucose homeostasis and diabetes treatment. Pharmacol Rev 2008;60:470-512.
76. Woods SC, Lutz TA, Geary N, Langhans W: Pancreatic signals controlling food intake; insulin, glucagon and amylin. Phil Trans Royal Soc [B] 2006;361:1219-1235.
77. Lutz TA: Roles of amylin in satiation, adiposity and brain development; in Langhans W, Geary N (eds): Frontiers in Eating and Weight Regulation. Forum Nutr. Basel, Karger, 2010, vol 63, pp 64-74.
78. Lutz TA, Del Prete E, Scharrer E: Reduction of food intake in rats by intraperitoneal injection of low doses of amylin. Physiol Behav 1994;55:891-895.
79. Lutz TA, Geary N, Szabady MM, Del Prete E, Scharrer E: Amylin decreases meal size in rats. Physiol Behav 1995;58:1197-1202.
80. Lutz TA: Pancreatic amylin as a centrally acting satiating hormone. Curr Drug Targets 2005;6:181-189.
81. Arnelo U, Reidelberger R, Adrian TE, Larsson J, Permert J: Sufficiency of postprandial plasma levels of islet amyloid polypeptide for suppression of feeding in rats. Am J Physiol 1998;275: R1537-R1542.
82. Mollet A, Gilg S, Riediger T, Lutz TA: Infusion of the amylin antagonist AC 187 into the area postrema increases food intake in rats. Physiol Behav 2004;81:149-155.
83. Reidelberger RD, Haver AC, Arnelo U, Smith DD, Schaffert CS, Permert J: Amylin receptor blockade stimulates food intake in rats. Am J Physiol 2004;287: R568-R574.
84. Langhans W: Metabolic and glucostatic control of feeding. Proc Nutr Soc 1996;55:497-515.
85. Langhans W: The enterocyte as an energy flow sensor in the control of eating; in Langhans W, Geary N (eds): Frontiers in Eating and Weight Regulation. Forum Nutr. Basel, Karger, 2010, vol 63, pp 75-83.
86. Moran TH: Hypothalamic nutrient sensing and energy balance; in Langhans W, Geary N (eds): Frontiers in Eating and Weight Regulation. Forum Nutr. Basel, Karger, 2010, vol 63, pp 94-101.
87. LouisSylvestre J, LeMagnen J: A fall in blood-glucose level precedes meal onset in free-feeding rats. Neurosci Biobehav Rev 1980;4:13-15.
88. Melanson KJ, Westerterp-Plantenga MS, Campfield LA, Saris WHM: Blood glucose and meal patterns in time-blinded males, after aspartame, carbohydrate, and fat consumption, in relation to sweetness perception. Br J Nutr 1999;82:437-446.
89. Campfield LA, Smith FJ: Blood glucose dynamics and control of meal initiation: a pattern detection and recognition theory. Physiol Rev 2003;83:25-58.
90. MacLagan N: The role of appetite in the control of body weight. J Physiol (London) 1937;90:385-394.
91. Bady I, Marty N, Dallaporta M, et al: Evidence from Glut2-null mice that glucose is a critical physiological regulator of feeding. Diabetes 2006;55:988-995.
92. Russek M: Participation of hepatic glucoreceptors in control of intake of food. Nature 1963;197:79-81.
93. Tordoff MG, Friedman MI: Hepatic portal glucose infusions decrease food-intake and increase food preference. Am J Physiol 1986;251: R192-R196.
94. Tordoff MG, Friedman MI: Hepatic control of feeding: effect of glucose, fructose, and mannitol infusion. Am J Physiol 1988;254: R969-R976.
95. Tordoff MG, Tluczek J P, Friedman MI: Effect of hepatic portal glucose-concentration on food-intake and metabolism. Am J Physiol 1989;257: R1474-R1480.
96. Langhans W, Grossmann F, Geary N: Intrameal hepatic-portal infusion of glucose reduces spontaneous meal size in rats. Physiol Behav 2001;73:499-507.
97. Niijima A: Afferent impulse discharges from glucoreceptors in liver of guinea pig. Ann NY Acad Sci 1969;157:690-697.
98. Levin BE: Metabolic sensors: viewing glucosensing neurons from a broader perspective. Physiol Behav 2002;76:397-401.
99. Niijima A: Glucose-sensitive afferent nerve-fibers in the liver and their role in food-intake and bloodglucose regulation. J Auton Nerv Syst 1983;9:207-220.
100. Li B, Xi XC, Roane DS, Ryan DH, Martin RJ: Distribution of glucokinase, glucose transporter GLUT2, sulfonylurea receptor-1, glucagon-like peptide-1 receptor and neuropeptide Y messenger RNAs in rat brain by quantitative real time RT-PCR. Mol Brain Res 2003;113:139-142.
101. Navarro M, de Fonseca FR, Alvarez EA, et al: Colocalization of glucagon-like peptide-1 (GLP-1) receptors, glucose transporter GLUT-2, and glucokinase mRNAs in rat hypothalamic cells: evidence for a role of GLP-1 receptor agonists as an inhibitory signal for food and water intake. J Neurochem 1996;67:1982-1991.
102. Marty N, Bady I, Thorens B: Distinct classes of central GLUT2-dependent sensors control counterregulation and feeding. Diabetes 2006;55: S108-S113.
103. Levin BE: Metabolic sensing neurons and the control of energy homeostasis. Physiol Behav 2006;89:486-489.
104. Leonhardt M, Langhans W: Fatty acid oxidation and control of food intake. Physiol Behav 2004;83:645-651.
105. Dobbins RL, Szczepaniak LS, Bentley B, Esser V, Myhill J, McGarry JD: Prolonged inhibition of muscle carnitine palmitoyltransferase-1 promotes intramyocellular lipid accumulation and insulin resistance in rats. Diabetes 2001;50:123-130.
106. Wanders RJA, Vreken P, den Boer MEJ, Wijburg FA, van Gennip AH, Ijlst L: Disorders of mitochondrial fatty acyl-CoA beta-oxidation. J Inherited Metabol Dis 1999;22:442-487.
107. Wood PA: Genetically modified mouse models for disorders of fatty acid metabolism: pursuing the, nutrigenomics of insulin resistance and type 2 diabetes. Nutrition 2004;20:121-126.
108. Scharrer E: Control of food intake by fatty acid oxidation and ketogenesis. Nutrition 1999;15:704-714.
109. Langhans W: Fatty acid oxidation in the energostatic control of eating: a new idea. Appetite 2008;51:446-451.
110. Brandt K, Arnold M, Geary N, Langhans W, Leonhardt M: Vagal afferents mediate the feeding response to mercaptoacetate but not to the beta (3) adrenergic receptor agonist CL 316, 243. Neurosci Lett 2007;411:104-107.
111. Lam TK, Schwartz GJ, Rossetti L: Hypothalamic sensing of fatty acids. Nat Neurosci 2005;8:579-584.
112. Andersson U, Filipsson K, Abbott CR, Woods A, Smith K, Bloom SR, et al: AMP-activated protein kinase plays a role in the control of food intake. J Biol Chem 2004;279:12005-12008.
113. Minokoshi Y, Alquier T, Furukawa N, et al: AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus. Nature 2004;428:569-574.
114. Cota D, Proulx K, Smith KA, et al: Hypothalamic mTOR signaling regulates food intake. Science 2006;312:927-930.
115. Keesey RE, Hirvonen MD: Body weight set-points: determination and adjustment. Journal of Nutrition 1997;127: S1875-S1883.
116. Langhans W, Geary N: Regulation of body weight; in Munsch S, Beglinger C (eds): Obesity and Binge Eating Disorder. Basel, Karger, 2006, pp 21-40.
117. Kennedy GC: The role of depot fat in the hypothalamic control of food intake in the rat. Proc R Soc Lond [B] 1953;140:578-596.
118. Coleman DL, Hummel KP: Effects of parabiosis of normal with genetically diabetic mice. Am J Physiol 1969;217:1298.
119. Coleman DL: Effects of parabiosis of obese with diabetes and normal mice. Diabetologia 1973;9:294-298.
120. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM: Positional cloning of the mouse obese gene and its human homologue. Nature 1994;372:425-432.
121. Chua SC, Chung WK, Wupeng XS, et al: Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor. Science 1996;271:994-996.
122. Tartaglia LA, Dembski M, Weng X, et al: Identification and expression cloning of a leptin receptor, OB-R. Cell 1995;83:1263-1271.
123. Campfield LA, Smith FJ, Guisez Y, Devos R, Burn P: Recombinant mouse ob protein: evidence for a peripheral signal linking adiposity and central neural networks. Science 1995;269:546-549.
124. Halaas JL, Gajiwala KS, Maffei M, et al: Weightreducing effects of the plasma-protein encoded by the obese gene. Science 1995;269:543-546.
125. Pelleymounter MA, Cullen MJ, Baker MB, et al: Effects of the obese gene-product on body-weight regulation in ob/ob mice. Science 1995;269:540-543.
126. Ahima RS, Lazar MA: Adipokines and the peripheral and neural control of energy balance. Mol Endocrinol 2008;22:1023-1031.
127. Grill HJ, Schwartz M W, Kaplan JM, Foxhall JS, Breininger J, Baskin DG: Evidence that the caudal brainstem is a target for the inhibitory effect of leptin on food intake. Endocrinology 2002;143:239-246.
128. Malik KF, Young WS: Localization of binding sites in the central nervous system for leptin (OB protein) in normal, obese (ob/ob), and diabetic (db/db) C57BL/6J mice. Endocrinology 1996;137:1497-1500.
129. Eckel LA, Langhans W, Kahler A, Campfield LA, Smith FJ, Geary N: Chronic administration of OB protein decreases food intake by selectively reducing meal size in female rats. Am J Physiol 1998;275: R186-R193.
130. Kahler A, Geary N, Eckel LA, Campfield LA, Smith FJ, Langhans W: Chronic administration of OB protein decreases food intake by selectively reducing meal size in male rats. Am J Physiol 1998;275:R180-R185.
131. Zhang J, Matheny MK, Tumer N, Mitchell MK, Scarpace PJ: Leptin antagonist reveals that the normalization of caloric intake and the thermic effect of food after high-fat feeding are leptin dependent. Am J Physiol 2007;292: R868-R874.
132. Rosenbaum M, Goldsmith R, Bloomfield D, et al: Low-dose leptin reverses skeletal muscle, autonomic, and neuroendocrine adaptations to maintenance of reduced weight. J Clin Invest 2005;115:3579-3586.
133. Schwartz M W, Woods SC, Seeley RJ, Barsh GS, Baskin DG, Leibel RL: Is the energy homeostasis system inherently biased toward weight gain? Diabetes 2003;52:232-238.
134. Velkoska E, Morris MJ, Burns P, Weisinger RS: Leptin reduces food intake but does not alter weight regain following food deprivation in the rat. Int J Obes 2003;27:48-54.
135. Woods SC, Decke E, Vasselli JR: Metabolic hormones and regulation of body-weight. Psychol Rev 1974;81:26-43.
136. Woods SC, Seeley RJ: Insulin as an adiposity signal. Int J Obes 2001;25: S35-S38.
137. Bruning JC, Gautam D, Burks DJ, et al: Role of brain insulin receptor in control of body weight and reproduction. Science 2000;289:2122-2125.
138. Woods SC, Seeley RJ, Baskin DG, Schwartz MW: Insulin and the blood-brain barrier. Curr Pharmaceut Design 2003;9:795-800.
139. Benoit SC, Air EL, Coolen LM, et al: The catabolic action of insulin in the brain is mediated by melanocortins. J Neurosci 2002;22:9048-9052.
140. Flynn MC, Scott TR, Pritchard TC, Plata-Salaman CR: Mode of action of OB protein (leptin) on feeding. Am J Physiol 1998;275: R174-R179.
141. Plata-Salaman CR, Oomura Y, Shimizu N: Dependence of food intake on acute and chronic ventricular administration of insulin. Physiol Behav 1986;37:717-734.
142. Emond M, Schwartz GJ, Ladenheim EE, Moran TH: Central leptin modulates behavioral and neural responsivity to CCK. Am J Physiol 1999;276:R1545-R1549.
143. Riedy CA, Chavez M, Figlewicz DP, Woods SC: Central insulin enhances sensitivity to cholecystokinin. Physiol Behav 1995;58:755-760.
144. Bouret SG: Development of hypothalamic neural networks controlling appetite; in Langhans W, Geary N (eds): Frontiers in Eating and Weight Regulation. Forum Nutr. Basel, Karger, 2010, vol 63, pp 84-93.
145. Sullivan EL, Grove KL: Metabolic imprinting in obesity; in Langhans W, Geary N (eds): Frontiers in Eating and Weight Regulation. Forum Nutr. Basel, Karger, 2010, vol 63, pp 186-194.
146. Anand BK, Brobeck JR: Localization of a feeding center in the hypothalamus of the rat. Proc Soc Exp Biol Med 1951;77:323-324.
147. Hetherington AW, Ranson SW: Hypothalamic lesions and adiposity in the rat. Anatom Rec 1940;78:149-172.
148. Stellar E: The physiology of motivation. Psychol Rev 1954;61:5-22.
149. Duggan J P, Booth DA: Obesity, Overeating, and rapid gastric-emptying in rats with ventromedial hypothalamic-lesions. Science 1986;231:609-611.
150. Epstein AN, Teitelbaum P: Specific loss of hypoglycemic control of feeding in recovered lateral rats. Am J Physiol 1967;213:1159-1167.
151. Powley TL: Ventromedial hypothalamic syndrome, satiety, and a cephalic phase hypothesis. Psychol Rev 1977;84:89-126.
152. Bernardis LL, Bellinger LL: The lateral hypothalamic area revisited: neuroanatomy, body-weight regulation, neuroendocrinology and metabolism. Neurosci Biobehav Rev 1993;17:141-193.
153. Leibowitz SF: Paraventricular nucleus: primary site mediating adrenergic-stimulation of feeding and drinking. Pharmacol Biochem Behav 1978;8:163-175.
154. Olney JW: Brain lesions obesity and other disturbances in mice treated with monosodium glutamate. Science 1969;164:719.
155. Dahlstrom A, Fuxe K: The autonomic nervous system and the histochemical fluorescence method for the microscopical localization of catecholamines and serotonin. Brain Res Bull 1999;50:365-367.
156. Hillarp NA, Fuxe K, Dahlstrom A: Demonstration and mapping of central neurons containing dopamine noradrenaline and 5-hydroxytryptamine and their reactions to psychopharmaca. Pharmacol Rev 1966;18:727-741.
157. Simerly RB: Anatomical substrates of hypothalamic integration; in Paxinos G (ed): The Rat Nervous System. Amsterdam, Elsevier, 2004, pp 335-368.
158. Swanson LW: The neuroanatomy revolution of the 1970s and the hypothalamus. Brain Res Bull 1999;50:397.
159. Leibowitz SF: Reciprocal hunger-regulating circuits involving alpha-and beta-adrenergic receptors located, respectively, in ventromedial and lateral hypothalamus. Proc Natl Acad Sci USA 1970;67:1063.
160. Ungerstedt U: Adipsia and aphagia after 6-hydroxydopamine induced degeneration of the nigro-striatal dopamine system. Acta Physiol Scand Suppl 1971;367:95-122.
161. Kirchgessner AL, Sclafani A: PVN-hindbrain pathway involved in the hypothalamic hyperphagiaobesity syndrome. Physiol Behav 1988;42:517-528.
162. Grill HJ, Kaplan JM: The neuroanatomical axis for control of energy balance. Front Neuroendocrinol 2002;23:2-40.
163. Norgren R, Grill HJ: Brain-stem control of ingestive behavior; in Pfaff D (ed): The Physiological Mechanisms of Motivation. New York, Springer, 1982, pp 99-132.
164. Banks WA, Kastin AJ, Huang W, Jaspan JB, Maness LM: Leptin enters the brain by a saturable system independent of insulin. Peptides 1996;17:305-311.
165. Schwartz M W, Seeley RJ, Campfield LA, Burn P, Baskin DG: Identification of targets of leptin action in rat hypothalamus. J Clin Invest 1996;98:1101-1106.
166. Mercer JG, Hoggard N, Williams LM, et al: Coexpression of leptin receptor and preproneuropeptide Y mRNA in arcuate nucleus of mouse hypothalamus. J Neuroendocrinol 1996;8:733-735.
167. Seeley RJ, Yagaloff KA, Fisher SL, et al: Melanocortin receptors in leptin effects. Nature 1997;390:349.
168. Berthoud HR: Multiple neural systems controlling food intake and body weight. Neurosci Biobehav Rev 2002;26:393-428.
169. Cowley MA, Cone RD, Enriori P, Louiselle I, Williams SM, Evans AE: Electrophysiological actions of peripheral hormones on melanocortin neurons. Melanocortin Syst 2003;994:175-186.
170. Ellacott KLJ, Cone RD: The central melanocortin system and the integration of short-and long-term regulators of energy homeostasis. Rec Progr Horm Res 2004;59:395-408.
171. Elmquist JK, Coppari R, Balthasar N, Ichinose M, Lowell BB: Identifying hypothalamic pathways controlling food intake, body weight, and glucose homeostasis. J Comp Neurol 2005;493:63-71.
172. Heisler LK, Jobst EE, Sutton GM, et al: Serotonin reciprocally regulates melanocortin neurons to modulate food intake. Neuron 2006;51:239-249.
173. Hillebrand JJG, de Wied D, Adan RAH: Neuropeptides, food intake and body weight regulation: a hypothalamic focus. Peptides 2002;23:2283-2306.
174. Craig AD: How do you feel? Interoception: the sense of the physiological condition of the body. Nature Rev Neurosci 2002;3:655-666.
175. Rolls ET: Brain mechanisms underlying flavour and appetite. Phil Trans Roy Soc [B] 2006;361:1123-1136.
176. Uher R, Treasure J, Heining M, Brammer MJ, Campbell IC: Cerebral processing of food-related stimuli: effects of fasting and gender. Behav Brain Res 2006;169:111-119.
177. Broberger C, Landry M, Wong H, Walsh JN, Hokfelt T: Subtypes Y1 and Y2 of the neuropeptide Y receptor are respectively expressed in pro-opiomelanocortin- and neuropeptide-Y-containing neurons of the rat hypothalamic arcuate nucleus. Neuroendocrinology 1997;66:393-408.
178. Csiffary A, Gorcs TJ, Palkovits M: Neuropeptide-Y innervation of ACTH-immunoreactive neurons in the arcuate nucleus of rats: a correlated light and electron-microscopic double immunolabeling study. Brain Res 1990;506:215-222.
179. Beck B: Neuropeptide Y in normal eating and in genetic and dietary-induced obesity. Phil Trans Roy Soc [B] 2006;361:1159-1185.
180. Billington CJ, Briggs JE, Grace M, Levine AS: Effects of intracerebroventricular injection of neuropeptide-Y on energy-metabolism. Am J Physiol 1991;260: R321-R327.
181. Stanley BG, Magdalin W, Seirafi A, Thomas WJ, Leibowitz SF: The perifornical area: the major focus of (a) patchy distributed hypothalamic neuropeptide Y-sensitive feeding system (s). Brain Res 1993;604:304-317.
182. Widdowson PS: Regionally-selective down-regulation of NPY receptor subtypes in the obese Zucker rat. Relationship to the Y5 'feeding' receptor. Brain Res 1997;758:17-25.
183. Balthasar N, Dalgaard LT, Lee CE, Yu J, Funahashi H, Williams T, et al: Divergence of melanocortin pathways in the control of food intake and energy expenditure. Cell 2005;123:493-505.
184. Heymsfield SB, Greenberg AS, Fujioka K, Dixon RM, Kushner R, Hunt T, et al: Recombinant leptin for weight loss in obese and lean adults: a randomized, controlled, dose-escalation trial. J Am Med Assoc 1999;282:1568-1575.
185. Münzberg H: Leptin-signaling pathways and leptin resistance; in Langhans W, Geary N (eds): Frontiers in Eating and Weight Regulation. Forum Nutr. Basel, Karger, 2010, vol 63, pp 123-132.
186. Fan W, Boston BA, Kesterson RA, Hruby VJ, Cone RD: Role of melanocortinergic neurons in feeding and the agouti obesity syndrome. Nature 1997;385:165-168.
187. Harrold JA, Widdowson PS, Williams G: Altered energy balance causes selective changes in melanocortin-4 (MC4-R), but not melanocortin-3 (MC3-R), receptors in specific hypothalamic regions: further evidence that activation of MC4-R is a physiological inhibitor of feeding. Diabetes 1999;48:267-271.
188. Mountjoy KG, Mortrud MT, Low MJ, Simerly RB, Cone RD: Localization of the melanocortin-4 receptor (Mc4-R) in neuroendocrine and autonomic control-circuits in the brain. Mol Endocrinol 1994;8:1298-1308.
189. Moran TH: Neural and hormonal controls of food intake and satiety; in Johnson LR (ed): Physiology of the Gastrointestinal Tract. Burlington, Elsevier Academic Press, 2006, pp 877-894.
190. Campbell RE, Smith MS, Allen SE, Grayson BE, ffrench-Mullen JMH, Grove KL: Orexin neurons express a functional pancreatic polypeptide Y4 receptor. J Neurosci 2003;23:1487-1497.
191. Flynn MC, Turrin NP, Plata-Salaman CR, Ffrench-Mullen JMH: Feeding response to neuropeptide Y-related compounds in rats treated with Y5 receptor antisense or sense phosphothio-oligodeoxynucleotide. Physiol Behav 1999;66:881-884.
192. Kanatani A, Ishihara A, Asahi S, Tanaka T, Ozaki S, Ihara M: Potent neuropeptide YY1 receptor antagonist, 1229U91: blockade of neuropeptide Y-induced and physiological food intake. Endocrinology 1996;137:3177-3182.
193. Kanatani A, Mashiko S, Murai N, et al: Role of the Y1 receptor in the regulation of neuropeptide Y-mediated feeding: comparison of wild-type, Y1 receptor-deficient, and Y5 receptor-deficient mice. Endocrinology 2000;141:1011-1016.
194. Naveilhan P, Hassani H, Canals JM, et al: Normal feeding behavior, body weight and leptin response require the neuropeptide YY2 receptor. Nat Med 1999;5:1188-1193.
195. Blevins JE, Eakin TJ, Murphy JA, Schwartz M W, Baskin DG: Oxytocin innervation of caudal brainstem nuclei activated by cholecystokinin. Brain Res 2003;993:30-41.
196. Blevins JE, Schwartz M W, Baskin DG: Evidence that paraventricular nucleus oxytocin neurons link hypothalamic leptin action to caudal brain stem nuclei controlling meal size. Am J Physiol 2004;287: R87-R96.
197. Costello JF, Brown MR, Gray TS: Bombesin immunoreactive neurons in the hypothalamic paraventricular nucleus innervate the dorsal vagal complex in the rat. Brain Res 1991;542:77-82.
198. Rinaman L: Oxytocinergic inputs to the nucleus of the solitary tract and dorsal motor nucleus of the vagus in neonatal rats. J Comp Neurol 1998;399:101-109.
199. Broberger C, De Lecea L, Sutcliffe JG, Hokfelt T: Hypocretin/orexin-and melanin-concentrating hormone-expressing cells form distinct populations in the rodent lateral hypothalamus: relationship to the neuropeptide Y and Agouti gene-related protein systems. J Comp Neurol 1998;402:460-474.
200. Chen CT, Dun SL, Kwok EH, Dun NJ, Chang JK: Orexin A-like immunoreactivity in the rat brain. Neurosci Lett 1999;260:161-164.
201. Elias CF, Saper CB, Maratos-Flier E, et al: Chemically defined projections linking the mediobasal hypothalamus and the lateral hypothalamic area. J Comp Neurol 1998;402:442-459.
202. Qu DQ, Ludwig DS, Gammeltoft S, et al: A role for melanin-concentrating hormone in the central regulation of feeding behaviour. Nature 1996;380:243-247.
203. Borowsky B, Durkin MM, Ogozalek K, et al: Antidepressant, anxiolytic and anorectic effects of a melanin-concentrating hormone-1 receptor antagonist. Nature Med 2002;8:825.
204. Marsh DJ, Weingarth DT, Novi DE, et al: Melaninconcentrating hormone 1 receptor-deficient mice are lean, hyperactive, and hyperphagic and have altered metabolism. Proc Natl Acad Sci USA 2002;99:3240-3245.
205. Haynes AC, Jackson B, Overend P, et al: Effects of single and chronic intracerebroventricular administration of the orexins on feeding in the rat. Peptides 1999;20:1099-1105.
206. Sakurai T: Roles of orexins in regulation of feeding and wakefulness. Neuroreport 2002;13:987-995.
207. Obici S, Feng ZH, Morgan Y, Stein D, Karkanias G, Rossetti L: Central administration of oleic acid inhibits glucose production and food intake. Diabetes 2002;51:271-275.
208. Routh VH: Glucose-sensing neurons: are they physiologically relevant? Physiol Behav 2002;76:403-413.
209. Cai XJ, Widdowson PS, Harrold J, et al: Hypothalamic orexin expression: modulation by blood glucose and feeding. Diabetes 1999;48:2132-2137.
210. Williams G, Harrold JA, Cutler DJ: The hypothalamus and the regulation of energy homeostasis: lifting the lid on a black box. Proc Nutr Soc 2000;59:385-396.
211. van den Pol AN, Gao XB, Obrietan K, Kilduff TS, Belousov AB: Presynaptic and postsynaptic actions and modulation of neuroendocrine neurons by a new hypothalamic peptide, hypocretin/orexin. J Neurosci 1998;18:7962-7971.
212. Moran TH, Bi S: Hyperphagia and obesity of OLETF rats lacking CCK1 receptors: developmental aspects. Dev Psychobiol 2006;48:360-367.
213. Dhillon H, Zigman JM, Ye C P, et al: Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis. Neuron 2006;49:191-203.
214. Xu BJ, Goulding EH, Zang KL, et al: Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor. Nature Neurosci 2003;6:736-742.
215. Dumont Y, Jacques D, Bouchard P, Quirion R: Species differences in the expression and distribution of the neuropeptide Y Y1, Y2, Y4, and Y5 receptors in rodents, guinea pig, and primates brains. J Comp Neurol 1998;402:372-384.
216. Fodor M, Sluiter A, FrankhuijzenSierevogel A, et al: Distribution of Lys-gamma (2)-melanocyte-stimulating hormone-(Lys-gamma (2)-MSH)-like immunoreactivity in neuronal elements in the brain and peripheral tissues of the rat. Brain Res 1996;731:182-189.
217. Shughrue PJ, Lane MV, Merchenthaler I: Comparative distribution of estrogen receptor-alpha and-beta mRNA in the rat central nervous system. J Comp Neurol 1997;388:507-525.
218. Faulconbridge LF, Cummings DE, Kaplan JM, Grill HJ: Hyperphagic effects of brainstem ghrelin administration. Diabetes 2003;52:2260-2265.
219. Grill HJ, Kaplan JM: Sham feeding in intact and chronic decerebrate rats. Am J Physiol 1992;262: R1070-R1074.
220. Grill HJ, Smith GP: Cholecystokinin decreases sucrose intake in chronic decerebrate rats. Am J Physiol 1988;254: R853-R856.
221. Kaplan JM, Seeley RJ, Grill HJ: Daily caloric-intake in intact and chronic decerebrate rats. Behav Neurosci 1993;107:876-881.
222. Scott TR, Giza BK: Issues of gustatory neural coding: Where they stand today. Physiol Behav 2000;69:65-76.
223. Asarian L, Geary N: Estradiol enhances cholecystokinin-dependent lipid-induced satiation and activates estrogen receptor-alpha-expressing cells in the nucleus tractus solitarius of ovariectomized rats. Endocrinology 2007;148:5656-5666.
224. Thammacharoen S, Lutz TA, Geary N, Asarian L: Hindbrain administration of estradiol inhibits feeding and activates estrogen receptor-alpha-expressing cells in the nucleus tractus solitarius of ovariectomized rats. Endocrinology 2008;149:1609-1617.
225. Barrachina MD, Martinez V, Wang LX, Wei JY, Tache Y: Synergistic interaction between leptin and cholecystokinin to reduce short-term food intake in lean mice. Proc Natl Acad Sci USA 1997;94:10455-10460.
226. Berridge KC, Kringelbach ML: Affective neuroscience of pleasure: reward in humans and animals. Psychopharmacol (Berl) 2008;199:457-480.
227. Berridge KC: Motivation concepts in behavioral neuroscience. Physiol Behav 2004;81:179-209.
228. Nestler EJ, Carlezon WA: The mesolimbic dopamine reward circuit in depression. Biol Psychiatry 2006;59:1151-1159.
229. Zheng HY, Corkern M, Stoyanova I, Patterson LM, Tian R, Berthoud HR: Peptides that regulate food intake: appetite-inducing accumbens manipulation activates hypothalamic orexin neurons and inhibits POMC neurons. Am J Physiol 2003;284: R1436-R1444.
230. Kelley AE, Baldo BA, Pratt WE, Will MJ: Corticostriatal-hypothalamic circuitry and food motivation: Integration of energy, action and reward. Physiol Behav 2005;86:773-795.
231. Norgren R, Hajnal A, Mungarndee SS: Gustatory reward and the nucleus accumbens. Physiol Behav 2006;89:531-535.
232. Schultz W: Behavioral theories and the neurophysiology of reward. Ann Rev Psychol 2006;57:87-115.
233. Wise RA: Role of brain dopamine in food reward and reinforcement. Phil Trans Roy Soc B 2006;361:1149-1158.
234. Hajnal A, Smith GP, Norgren R: Oral sucrose stimulation increases accumbens dopamine in the rat. Am J Physiol 2004;286: R31-R37.
235. Liang NC, Hajnal A, Norgren R: Sham feeding corn oil increases accumbens dopamine in the rat. Am J Physiol 2006;291: R1236-R1239.
236. Zhang M, Kelley AE: Enhanced intake of high-fat food following striatal mu-opioid stimulation: microinjection mapping and Fos expression. Neuroscience 2000;99:267-277.
237. Zhang M, Balmadrid C, Kelley AE: Nucleus accumbens opioid, GABAergic, and dopaminergic modulation of palatable food motivation: contrasting effects revealed by a progressive ratio study in the rat. Behav Neurosci 2003;117:202-211.
238. Yeomans MR, Wright P, Macleod HA, Critchley JAJH: Effects of nalmefene on feeding in humans: dissociation of hunger and palatability. Psychopharmacology 1990;100:426-432.
239. Kirkham TC: Endocannabinoids in the regulation of appetite and body weight. Behav Pharmacol 2005;16:297-313.
240. Balleine BW, Killcross AS, Dickinson A: The effect of lesions of the basolateral amygdala on instrumental conditioning. J Neurosci 2003;23:666-675.
241. Kim EM, Quinn JG, Levine AS, O'Hare E: A bidirectional mu-opioid-opioid connection between the nucleus of the accumbens shell and the central nucleus of the amygdala in the rat. Brain Res 2004;1029:135-139.
242. Will MJ, Franzblau EB, Kelley AE: The amygdala is critical for opioid-mediated binge eating of fat. Neuroreport 2004;15:1857-1860.
243. Stratford TR, Kelley AE, Simansky KJ: Blockade of GABA (A) receptors in the medial ventral pallidum elicits feeding in satiated rats. Brain Res 1999;825:199-203.
244. Kelley AE, Baldo BA, Pratt WE: A proposed hypothalamic-thalamic-striatal axis for the integration of energy balance, arousal, and food reward. J Comp Neurol 2005;493:72-85.
245. Wizemann TM, Pardue M-L: Exploring the Biological Contribution to Human Health: Does Sex Matter? Washington, National Academy Press, 2001.
246. Asarian L, Geary N: Cyclic estradiol treatment normalizes body weight and restores physiological patterns of spontaneous feeding and sexual receptivity in ovariectomized rats. Horm Behav 2002;42:461-471.
247. Asarian L, Geary N: Modulation of appetite by gonadal steroid hormones. Phil Trans Roy Soc [B] 2006;361:1251-1263.
248. Geary N, Lovejoy J: Sex differences in energy metabolism, obesity and eating behavior; in Becker J, Berkley KJ, Geary N, Hampson E, Herman J P, Young EA (eds): Sex on the Brain: From Genes to Behavior. New York, Oxford University Press, 2007, pp 253-274.
249. Clegg DJ, Brown LM, Kemp CJ, et al: Estradioldependent decrease in the orexigenic potency of ghrelin in female rats. Diabetes 2007;56:1051-1058.
250. Eckel LA, Rivera HM, Atchley DP: The anorectic effect of fenfluramine is influenced by sex and stage of the estrous cycle in rats. Am J Physiol 2005;288: R1486-R1491.
251. Musatov S, Chen W, Pfaff DW, et al: Silencing of estrogen receptor alpha in the ventromedial nucleus of hypothalamus leads to metabolic syndrome. Proc Natl Acad Sci USA 2007;104:2501-2506.
252. Shi H, Seeley RJ, Clegg DJ: Sexual differences in the control of energy homeostasis. Front Neuroendocrinol 2009;30:396-404.
253. Wajchenberg BL: Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome. Endocr Rev 2000;21:697-738.
254. Roepke TA, Xue C, Bosch MA, Scanlan TS, Kelly MJ, Ronnekleiv OK: Genes associated with membrane-initiated signaling of estrogen and energy homeostasis. Endocrinology 2008;149:6113-6124.
255. Tobias JH, Steer CD, Vilarino-Guell C, Brown MA: Effect of an estrogen receptor-alpha intron 4 polymorphism on fat mass in 11-year-old children. J Clin Endocrinol Metab 2007;92:2286-2291.
256. Blaak E: Gender differences in fat metabolism. Curr Opin Clin Nutr Metab Care 2001;4:499-502.
257. Bruns CM, Kemnitz JW: Sex hormones, insulin sensitivity, and diabetes mellitus. Ilar Journal 2004;45:160-169.
258. Hart BL: Biological basis of the behavior of sick animals. Neurosci Biobehav Rev 1988;12:123-137.
259. Murray MJ, Murray AB: Anorexia of infection as a mechanism of host defense. Am J Clin Nutr 1979;32:593-596.
260. Rietschel ET, Schletter J, Weidemann B, et al: Lipopolysaccharide and peptidoglycan: CD14-dependent bacterial inducers of inflammation. Microb Drug Resist 1998;4:37-44.
261. Langhans W: Signals generating anorexia during acute illness. Proc Nutr Soc 2007;66:321-330.
262. Miller AH: Norman Cousins Lecture: Mechanisms of cytokine-induced behavioral changes: psychoneuroimmunology at the translational interface. Brain Behav Immun 2009;23:149-158.
263. Park SM, Gaykema R P, Goehler LE: How does immune challenge inhibit ingestion of palatable food? Evidence that systemic lipopolysaccharide treatment modulates key nodal points of feeding neurocircuitry. Brain Behav Immun 2008.
264. Friedman MI, Ramirez I, Edens NK, Granneman J: Food-intake in diabetic rats: isolation of primary metabolic effects of fat feeding. Am J Physiol 1985;249: R44-R51.
265. Lee JY, Sohn KH, Rhee SH, Hwang D: Saturated fatty acids, but not unsaturated fatty acids, induce the expression of cyclooxygenase-2 mediated through Toll-like receptor 4. J Biol Chem 2001;276:16683-16689.
266. O'Rahilly S, Farooqi IS: Genetics of obesity. Phil Trans Roy Soc [B] 2006;361:1095-1105.
267. Stunkard AJ, Foch TT, Hrubec Z: A twin study of human obesity. J Am Med Ass 1986;256:51-54.
268. Stunkard AJ, Sorensen TI, Hanis C, et al: An adoption study of human obesity. N Engl J Med 1986;314:193-198.
269. Willer CJ, Speliotes EK, Loos RJ, et al: Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet 2009;41:25-34.
270. de Krom M, Bauer F, Collier D, Adan RA, La Fleur SE: Genetic variation and effects on human eating behavior. Annu Rev Nutr 2009;29:283-304.
271. Montague CT, Farooqi IS, Whitehead JP, et al: Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature 1997;387:903-908.
272. Krude H, Biebermann H, Luck W, Horn R, Brabant G, Gruters A: Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans. Nat Genet 1998;19:155-157.
273. Adan RA, Tiesjema B, Hillebrand JJ, La Fleur SE, Kas MJ, de Krom M: The MC4 receptor and control of appetite. Br J Pharmacol 2006;149:815-827.
274. Kublaoui BM, Zinn AR: Editorial: MC4R mutations - weight before screening! J Clin Endocrinol Metab 2006;91:1671-1672.
275. Farooqi IS, Keogh JM, Yeo GSH, Lank EJ, Cheetham T, O'Rahilly S: Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene. N Engl J Med 2003;348:1085-1095.
276. Qi L, Kraft P, Hunter DJ, Hu FB: The common obesity variant near MC4R gene is associated with higher intakes of total energy and dietary fat, weight change and diabetes risk in women. Hum Mol Genet 2008;17:3502-3508.
277. Hetherington MM, Cecil JE: Gene-environment interactions in obesity; in Langhans W, Geary N (eds): Frontiers in Eating and Weight Regulation. Forum Nutr. Basel, Karger, 2010, vol 63, pp 195-203.
278. de Krom M, van der Schouw Y T, Hendriks J, et al: Common genetic variations in CCK, leptin, and leptin receptor genes are associated with specific human eating patterns. Diabetes 2007;56:276-280.
279. De Kloet AD, Woods SC: Obesity and food intake: basic and clinical approaches; in Langhans W, Geary N (eds): Frontiers in Eating and Weight Regulation. Forum Nutr. Basel, Karger, 2010, vol 63, pp 1-8.
280. Langhans W, Harrold J, Williams G, Geary N: Control of Eating; in Williams G, Frühbeck G (eds): Obesity - Science to Practice. Oxford, Wiley-Blackwell, 2009, pp 125-163.
281. Langhans W, Geary N, Lutz TA: Steuerung der Nahrungsaufnahme; in von Engelhardt W (ed): Physiologie der Haustiere, Stuttgart, Medizinverlage Stuttgart, 2009, pp 616-630.
282. Liebling DS, Eisner JD, Gibbs J, Smith GP: Intestinal satiety in rats. J Comp Physiol Psychol 1975;89:955-965.