Carotid sinus syndrome, should we pace? A multicentre, randomised control trial (Safepace 2)

Heart

Volumn 96, Issue 5, 2010, Pages 347-351

  Ryan, Daniel J ^a   Nick, Steen ^b   Colette, Seifer M ^c   Roseanne, Kenny ^d  

^a ST JAMES S HOSPITAL   (Ireland)

^b FREEMAN HOSPITAL   (United Kingdom)

^c NEWCASTLE UNIVERSITY   (United Kingdom)

^d TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

AGED; ARTICLE; ARTIFICIAL HEART PACEMAKER; CARDIOINHIBITORY CAROTID SINUS HYPERSENSITIVITY; CARDIOVASCULAR EQUIPMENT; CAROTID SINUS SYNDROME; CLINICAL TRIAL; COGNITION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DUAL CHAMBER PACING; FALLING; FEMALE; FOLLOW UP; HEART PACING; HUMAN; IMPLANTABLE LOOP RECORDER; MAJOR CLINICAL STUDY; MALE; MINI MENTAL STATE EXAMINATION; MULTICENTER STUDY; PRESYNCOPE; PRIORITY JOURNAL; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL; RECORDER; RISK ASSESSMENT; SYNCOPE; TREATMENT OUTCOME;

ACCIDENTAL FALLS; AGED; CARDIAC PACING, ARTIFICIAL; CAROTID SINUS; EPIDEMIOLOGIC METHODS; FEMALE; HUMANS; MALE; PACEMAKER, ARTIFICIAL; QUALITY OF LIFE; RECURRENCE; SYNCOPE; SYNDROME;

EID: 77649207812     PISSN: 13556037     EISSN: 1468201X     Source Type: Journal    
DOI: 10.1136/hrt.2009.176206     Document Type: Article

References (24)

1. McIntosh SJ, Lawson J, Kenny RA. Clinical characteristics of vasodepressor, cardioinhibitory, and mixed carotid sinus syndrome in the elderly. Am J Med 1993;95:203-8.
2. Kenny RA, Traynor G. Carotid sinus syndrome - clinical characteristics in elderly patients. Age Ageing 1991;20:449-54.
3. Cummings SR, Nevitt MC, Kidd S. Forgetting falls. The limited accuracy of recall of falls in the elderly. J Am Geriatr Soc 1988;36:613-16.
4. Richardson DA, Bexton RS, Shaw FE, et al. Prevalence of cardioinhibitory carotid sinus hypersensitivity in patients 50 years or over presenting to the accident and emergency department with "unexplained" or "recurrent" falls. Pacing Clin Electrophysiol 1997;20(3 Pt 2):820-3.
5. Davies AJ, Steen N, Kenny RA. Carotid sinus hypersensitivity is common in older patients presenting to an accident and emergency department with unexplained falls. Age Ageing 2001;30:289-93.
6. Kerr SRJ, Pearce MS, Brayne C, et al. Carotid sinus hypersensitivity in asymptomatic older persons: implications for diagnosis of syncope and falls. Arch Intern Med 2006;166:515-20.
7. Kenny RAM, Richardson DA, Steen N, et al. Carotid sinus syndrome: a modifiable risk factor for nonaccidental falls in older adults (SAFE PACE). J Am Coll Cardiol 2001;38:1491-6.
8. Kenny RA, O'Shea D, Parry SW. The Newcastle protocols for head-up tilt table testing in the diagnosis of vasovagal syncope, carotid sinus hypersensitivity, and related disorders. Heart 2000;83:564-9.
9. Brignole M, Alboni P, Benditt D, et al. Task Force on Syncope ESoC. Guidelines on management (diagnosis and treatment) of syncope. Eur Heart J 2001;22:1256-306.
10. Parry SW, Richardson DA, O'Shea D, et al. Diagnosis of carotid sinus hypersensitivity in older adults: carotid sinus massage in the upright position is essential. Heart 2000;83:22-3.
11. Parry SW, Reeve P, Lawson J, et al. The Newcastle protocols 2008: an update on head-up tilt table testing and the management of vasovagal syncope and related disorders. Heart 2009;95:416-20.
12. Vardas PE, Auricchio A, Blanc J-J, et al. Guidelines for cardiac pacing and cardiac resynchronization therapy: The Task Force for Cardiac Pacing and Cardiac Resynchronization Therapy of the European Society of Cardiology. Developed in Collaboration with the European Heart Rhythm Association. Europace 2007;9:959-98.
13. Davies AJ, Kenny RA. Frequency of neurologic complications following carotid sinus massage. Am J Cardiol 1998;81:1256-7.
14. Benditt DG, Sutton R, Gammage MD, et al. Clinical experience with Thera DR rate-drop response pacing algorithm in carotid sinus syndrome and vasovagal syncope. The International Rate-Drop Investigators Group. Pacing Clin Electrophysiol 1997;20(3 Pt 2):832-9.
15. Morley CA, Perrins EJ, Grant P, et al. Carotid sinus syncope treated by pacing. Analysis of persistent symptoms and role of atrioventricular sequential pacing. Br Heart J 1982;47:411-18.
16. Graux P, Guyomar Y, Lejeune C, et al. Contribution of a pacemaker bradycardia detection algorithm in the study of patients with carotid sinus syndrome. Pacing Clin Electrophysiol 2001;24:921-4.
17. Folstein MF, Folstein SE, McHugh PR. "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975;12:189-98.
18. Davison J, Bond J, Dawson P, et al. Patients with recurrent falls attending Accident & Emergency benefit from multifactorial intervention - a randomised controlled trial. Age Ageing 2005;34:162-8.
19. Pocock S. Clinical trials: a practical approach. Wiley Blackwell, 1983;ISBN-10: 0471901555.
20. Freund-Levi Y, Eriksdotter-Jonhagen M, Cederholm T, et al. omega-3 fatty acid treatment in 174 patients with mild to moderate Alzheimer disease: OmegAD Study: a randomized double-blind trial. Arch Neurol 2006;63:1402-8.
21. Parry SW, Steen N, Bexton RS, et al. Pacing in elderly recurrent fallers with carotid sinus hypersensitivity: a randomised, double-blind, placebo controlled crossover trial. Heart 2009;95:405-9.
22. Connolly SJ, Sheldon R, Thorpe KE, et al. Pacemaker therapy for prevention of syncope in patients with recurrent severe vasovagal syncope: Second Vasovagal Pacemaker Study (VPS II): a randomized trial. JAMA 2003;289:2224-9.
23. Raviele A, Giada F, Menozzi C, et al. A randomized, double-blind, placebo-controlled study of permanent cardiac pacing for the treatment of recurrent tilt-induced vasovagal syncope. The vasovagal syncope and pacing trial (SYNPACE). Eur Heart J 2004;25:1741-8.
24. Connolly SJ, Sheldon R, Roberts RS, et al. on Behalf of the Vasovagal Pacemaker Study I. The North American Vasovagal Pacemaker Study (VPS): a randomized trial of permanent cardiac pacing for the prevention of vasovagal syncope. J Am Coll Cardiol 1999;33:16-20.