High incidence of severe cyclosporine neurotoxicity in children affected by haemoglobinopaties undergoing myeloablative haematopoietic stem cell transplantation: Early diagnosis and prompt intervention ameliorates neurological outcome

Italian Journal of Pediatrics

Volumn 36, Issue 14, 2010, Pages

  Noè, Anna ^a   Cappelli, Barbara ^a,b   Biffi, Alessandra ^a,b   Chiesa, Robert ^a,b   Frugnoli, Ilaria ^a   Biral, Erika ^a   Finizio, Valentina ^a   Baldoli, Cristina ^a   Vezzulli, Paolo ^a   Minicucci, Fabio ^a   Fanelli, Giovanna ^a   Fiori, Rossana ^a   Ciceri, Fabio ^a   Roncarolo, Maria Grazia ^a,b,c   Marktel, Sarah ^a,b  

^a SAN RAFFAELE HOSPITAL   (Italy)

^b SAN RAFFAELE SCIENTIFIC INSTITUTE   (Italy)

^c VITA SALUTE SAN RAFFAELE UNIVERSITY   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BILIRUBIN; BUSULFAN; CLONAZEPAM; CYCLOPHOSPHAMIDE; CYCLOSPORIN A; FLUDARABINE; LORAZEPAM; MANNITOL; METHOTREXATE; METHYLPREDNISOLONE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PHENOBARBITAL; PHENYTOIN; TACROLIMUS; THYMOCYTE ANTIBODY; CYCLOSPORIN; IMMUNOSUPPRESSIVE AGENT;

ADOLESCENT; ARTICLE; BETA THALASSEMIA; BILIRUBIN BLOOD LEVEL; BLURRED VISION; BRADYCARDIA; BRAIN REGION; CHILD; CONFUSION; CONSCIOUSNESS LEVEL; DISEASE SEVERITY; DRUG BLOOD LEVEL; DRUG INDUCED HEADACHE; DRUG SUBSTITUTION; DRUG WITHDRAWAL; EARLY DIAGNOSIS; EARLY INTERVENTION; ELECTROENCEPHALOGRAM; ENZYME BLOOD LEVEL; FEMALE; FOLLOW UP; GRAFT VERSUS HOST REACTION; GRAND MAL SEIZURE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HEMOGLOBINOPATHY; HUMAN; HYPERTENSION; INTRACRANIAL HYPERTENSION; LEUKOENCEPHALOPATHY; LIVER TOXICITY; MAJOR CLINICAL STUDY; MALE; MIDDLE EAST; MYELOABLATIVE CONDITIONING; NEUROIMAGING; NEUROTOXICITY; NUCLEAR MAGNETIC RESONANCE IMAGING; PROGNOSIS; SCHOOL CHILD; SEIZURE; SICKLE CELL ANEMIA; SIDE EFFECT; THALASSEMIA MAJOR; THROMBOTIC THROMBOCYTOPENIC PURPURA; TREATMENT OUTCOME; VOMITING; CHEMICALLY INDUCED DISORDER; COMPARATIVE STUDY; DOSE RESPONSE; GRAFT REJECTION; INCIDENCE; ITALY; METHODOLOGY; NEUROLOGIC DISEASE; TIME;

ADOLESCENT; CHILD; CYCLOSPORINE; DOSE-RESPONSE RELATIONSHIP, DRUG; EARLY DIAGNOSIS; FEMALE; FOLLOW-UP STUDIES; GRAFT REJECTION; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HEMOGLOBINOPATHIES; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INCIDENCE; ITALY; MAGNETIC RESONANCE IMAGING; MALE; NERVOUS SYSTEM DISEASES; TIME FACTORS;

EID: 77649200764     PISSN: 17208424     EISSN: 18247288     Source Type: Journal    
DOI: 10.1186/1824-7288-36-14     Document Type: Article

References (12)

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