A small-molecule inhibitor of T. gondii motility induces the posttranslational modification of myosin light chain-1 and inhibits myosin motor activity

PLoS Pathogens

Volumn 6, Issue 1, 2010, Pages

  Heaslip, Aoife T ^a   Leung, Jacqueline M ^a   Carey, Kimberly L ^a   Catti, Federica ^b   Warshaw, David M ^c   Westwood, Nicholas J ^b   Ballif, Bryan A ^c   Ward, Gary E ^a  

^a UNIVERSITY OF VERMONT COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF ST ANDREWS   (United Kingdom)

^c UNIVERSITY OF VERMONT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; MYOSIN; MYOSIN LIGHT CHAIN; MYOSIN LIGHT CHAIN 1; PROTEIN GAP45; PROTEIN GAP50; PROTEIN INHIBITOR; PROTEIN MYOA; TACHYPLEGINA; UNCLASSIFIED DRUG; VALINE; MOLECULAR MOTOR;

ARTICLE; CONTROLLED STUDY; ELECTROPHORETIC MOBILITY; EPITOPE MAPPING; HOST PARASITE INTERACTION; IN VITRO STUDY; MOTOR ACTIVITY; NONHUMAN; PARASITE MIGRATION; PEPTIDE MAPPING; PROTEIN FUNCTION; PROTEIN PROCESSING; TOXOPLASMA GONDII; AMINO ACID SEQUENCE; AUTORADIOGRAPHY; FLUORESCENT ANTIBODY TECHNIQUE; GEL MOBILITY SHIFT ASSAY; GENETICS; HUMAN; IMMUNOPRECIPITATION; LIQUID CHROMATOGRAPHY; METABOLISM; MOLECULAR GENETICS; PHYSIOLOGY; POLYACRYLAMIDE GEL ELECTROPHORESIS; TANDEM MASS SPECTROMETRY; TOXOPLASMA; TWO DIMENSIONAL GEL ELECTROPHORESIS; WESTERN BLOTTING;

TOXOPLASMA GONDII;

AMINO ACID SEQUENCE; AUTORADIOGRAPHY; BLOTTING, WESTERN; CHROMATOGRAPHY, LIQUID; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ELECTROPHORETIC MOBILITY SHIFT ASSAY; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; IMMUNOPRECIPITATION; MOLECULAR MOTOR PROTEINS; MOLECULAR SEQUENCE DATA; MYOSIN LIGHT CHAINS; PROTEIN PROCESSING, POST-TRANSLATIONAL; TANDEM MASS SPECTROMETRY; TOXOPLASMA;

EID: 77649199675     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1000720     Document Type: Article

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