Eradication of Helicobacter pylori infection improved gastric mucosal atrophy and prevented progression of intestinal metaplasia, especially in the elderly population: A long-term prospective cohort study

Journal of Gastroenterology and Hepatology (Australia)

Volumn 25, Issue 3, 2010, Pages 544-547

  Toyokawa, Tatsuya ^a   Suwaki, Kin Ichiro ^a   Miyake, Yasuhiro ^a   Nakatsu, Morihito ^a   Ando, Masaharu ^a  

^a Mitoyo General Hospital   (Japan)

Author keywords

Elderly population; Gastric mucosal change; Helicobacter pylori eradication

Indexed keywords

ADOLESCENT; ADULT; AGED; ARTICLE; ATROPHIC GASTRITIS; ATROPHY; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE COURSE; ERADICATION THERAPY; FEMALE; FOLLOW UP; GASTROSCOPY; GROUPS BY AGE; HELICOBACTER INFECTION; HUMAN; HUMAN TISSUE; INTESTINE METAPLASIA; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROSPECTIVE STUDY; SCORING SYSTEM; STOMACH ANTRUM; STOMACH BIOPSY; STOMACH DISEASE; STOMACH MUCOSA; STOMACH MUCOSA ATROPHY; DISEASE SEVERITY; GASTRIC MUCOSA; GERIATRIC PATIENT; HISTOPATHOLOGY; STOMACH ATROPHY; TREATMENT RESPONSE;

EID: 77649195494     PISSN: 08159319     EISSN: 14401746     Source Type: Journal    
DOI: 10.1111/j.1440-1746.2009.05995.x     Document Type: Article

References (19)

1. Correa P, Houghton J. Carcinogenesis of Helicobacter pylori. Gastroenterology 2007 133 : 659 672.
2. Faller G, Kirchner T. Immunological and morphogenic basis of gastric mucosa atrophy and metaplasia. Virchows Arch. 2005 446 : 1 9.
3. Eda A, Osawa H, Yanaka I. Expression of homeobox gene CDX2 precedes that of CDX1 during the progression of intestinal metaplasia. J. Gastroenterol. 2002 37 : 94 100.
4. Fukase K, Kato M, Kikuchi S et al. Effect of eradication of Helicobacter pylori on incidence of metachronous gastric carcinoma after endoscopic resection of early gastric cancer: an open label, randomised controlled trial. Lancet 2008 372 : 392 397.
5. Murakami K, Kodama M, Sato R et al. Helicobacter pylori eradication and associated changes in the gastric mucosa. Expert. Rev. Anti. Infect. Ther. 2005 3 : 757 764.
6. Pilotto A, Malfertheiner P. Review article: an approach to Helicobacter pylori infection in the elderly. Aliment. Pharmacol. Ther. 2002 16 : 683 691.
7. Pilotto A. Aging and the gastrointestinal tract. Ital. J. Gastroenterol. Hepatol. 1999 31 : 137 153.
8. Hood HM, Wark C, Burgess PA et al. Screening for Helicobacter pylori and nonsteroidal anti-inflammatory drug use in medicare patients hospitalized with peptic ulcer disease. Arch. Intern. Med. 1990 159 : 149 154.
9. Haruma K, Kamada T, Kawaguchi H et al. Effect of age and Helicobacter pylori infection on gastric acid secretion. J. Gastroenterol. Hepatol. 2000 15 : 277 283.
10. Sung JJ, Lin S, Ching JYL et al. Atrophy and intestinal metaplasia one year after cure of H. pylori infection: a prospective, randomized study. Gastroenterology 2000 119 : 7 14.
11. Ohkusa T, Fujiki K, Takashimizu I et al. Improvement in atrophic gastritis and intestinal metaplasia in patients in whom Helicobacter pylori was eradicated. Ann. Intern. Med. 2001 134 : 380 386.
12. Zhou L, Sung JJ, Lin S et al. A five-year follow-up study on the pathological changes of gastric mucosa after H. pylori eradication. Chin. Med. J. 2003 116 : 11 14. (Pubitemid 36432713)
13. Yamada T, Miwa H, Fujino T et al. Improvement of gastric atrophy after Helicobacter pylori eradication therapy. J. Clin. Gastroenterol. 2003 36 : 405 410.
14. Leung WK, Lin SR, Ching JY et al. Factors predicting progression of gastric intestinal metaplasia: results of a randomised trial on Helicobacter pylori eradication. Gut 2003 53 : 1244 1249.
15. Ley C, Mohar A, Guarner J et al. Helicobacter pylori eradication and gastric preneoplastic conditions: a randomized, double-blind, placebo-controlled trial. Cancer Epidemiol. Biomarkers Prev. 2004 13 : 4 10.
16. Lu B, Chen MT, Fan YH et al. Effects of Helicobacter pylori eradication on atrophic gastritis and intestinal metaplasia: a 3-year follow-up study. World J. Gastroenterol. 2005 11 : 6518 6520.
17. Filipe MI, Munoz N, Matko I et al. Intestinal metaplasia types and the risk of gastric cancer: a cohort study in Slovenia. Int. J. Cancer 1994 57 : 324 329.
18. Ito M, Haruma K, Kamada T et al. Helicobacter pylori eradication therapy improves atrophic gastritis and intestinal metaplasia: a 5-year prospective study of patients with atrophic gastritis. Aliment. Pharmacol. Ther. 2002 16 : 1449 1456.
19. Pilotto A, Franceschi M, Mario F et al. The long-term clinical outcome of elderly patients with Helicobacter pylori-associated peptic ulcer disease. Gerontology 1998 44 : 153 158.