Rectally administered misoprostol versus intravenous oxytocin infusion during cesarean delivery to reduce intraoperative and postoperative blood loss

International Journal of Gynecology and Obstetrics

Volumn 109, Issue 1, 2010, Pages 25-29

  Chaudhuri, Picklu ^a   Banerjee, Gita Basu ^a   Mandal, Apurba ^a  

^a Chittaranjan Sevasadan College of Obstetrics Gynecology and Child Health   (India)

Author keywords

Blood loss; Cesarean delivery; Misoprostol; Oxytocin; Uterotonic

Indexed keywords

CARBOPROST; METHYLERGOMETRINE MALEATE; MISOPROSTOL; OXYTOCIN; PLACEBO; PROSTODIN; UNCLASSIFIED DRUG; ZITOTEC;

ARTICLE; CESAREAN SECTION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SAFETY; FEMALE; FEVER; HUMAN; MAJOR CLINICAL STUDY; POSTOPERATIVE COMPLICATION; POSTOPERATIVE HEMORRHAGE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SHIVERING; UTERINE ATONY; VOMITING;

EID: 77649192196     PISSN: 00207292     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijgo.2009.11.009     Document Type: Article

References (21)

1. Magann E.F., Evans S., Hutchinson M., Collins R., Lanneau G., and Morrison J.C. Postpartum hemorrhage after cesarean delivery: an analysis of risk factors. South Med J 98 7 (2005) 681-685
2. Combs C.A., Murphy E.L., and Laros Jr. R.K. Factors associated with hemorrhage in cesarean deliveries. Obstet Gynecol 77 1 (1991) 77-82
3. Acharya G., Al-Sammarai M.T., Patel N., Al-Habib A., and Kiserud T. A randomized controlled trial comparing effect of oral misoprostol and intravenous syntocinon on intraoperative blood loss during cesarean section. Acta Obstet Gynecol Scand 80 3 (2001) 245-250
4. Munn M.B., Owen J., Vincent R., Wakefield M., Chestnut D.H., and Hauth J.C. Comparison of two oxytocin regimens to prevent uterine atony at cesarean delivery: a randomized controlled trial. Obstet Gynecol 98 3 (2001) 386-390
5. Thomas J.S., Koh S.H., and Cooper G.M. Haemodynamic effects of oxytocin given as i.v. bolus or infusion on women undergoing caesarean section. Br J Anaesth 98 (2007) 116-119
6. Gülmezoglu A.M., Forna F., Villar J., and Hofmeyr G.J. Prostaglandins for preventing postpartum haemorrhage. Cochrane Database Syst Rev (2007) CD000494
7. Khan R.U., and El-Refaey H. Pharmacokinetics and adverse-effect profile of rectally administered misoprostol in the third stage of labor. Obstet Gynecol 101 5 Pt1 (2003) 968-974
8. Nasr A., Shahin A.Y., Elsamman A.M., Zakherah M.S., and Shaaban O.M. Rectal misoprostol versus intravenous oxytocin for prevention of postpartum hemorrhage. Int J Gynecol Obstet 105 3 (2009) 244-247
9. Parsons S.M., Walley R.L., Crane J.M., Matthews K., and Hutchens D. Rectal misoprostol versus oxytocin in the management of the third stage of labor. J Obstet Gynaecol Can 29 9 (2007) 711-718
10. Karkanis S.G., Caloia D., Salenieks M.E., Kingdom J., Walker M., Meffe F., et al. Randomized controlled trial of rectal misoprostol versus oxytocin in third stage management. J Obstet Gynecol Can 24 2 (2002) 149-154
11. Vimala N., Mittal S., and Kumar S. Sublingual misoprostol versus oxytocin infusion to reduce blood loss at cesarean section. Int J Gynecol Obstet 92 2 (2006) 106-110
12. Lapaire O., Schneider M.C., Stotz M., Surbek D.V., Holzgreve W., and Hoesli I.M. Oral misoprostol vs. intravenous oxytocin in reducing blood loss after emergency cesarean section. Int J Gynecol Obstet 95 1 (2006) 2-7
13. Lokugamage A.U., Paine M., Bassaw-Balroop K., Sullivan K.R., Refaey H.E., and Rodeck C.H. Active management of the third stage at Cesarean section: a randomized controlled trial of misoprostol versus syntocinon. Aust N Z J Obstet Gynecol 41 4 (2001) 411-414
14. Zhao Y., Li X., and Peng Y. Clinical study on reduction of postpartum bleeding in cesarean section by misoprostol. [in Chinese]. Zhonghua Fu Chan Ke Za Zhi 33 7 (1998) 403-405
15. Hamm J., Russell Z., Botha T., Carlan S.J., and Richichi K. Buccal misoprostol to prevent hemorrhage at cesarean delivery: a randomized study. Am J Obstet Gynecol 192 5 (2005) 1404-1406
16. Lokugamage A.U., Sullivan K.R., Niculescu I., Tigere P., Onyangunga F., El Refaey H., et al. A randomized study comparing rectally administered misoprostol versus Syntometrine combined with an oxytocin infusion for the cessation of primary postpartum hemorrhage. Acta Obstet Gynecol Scand 80 9 (2001) 835-839
17. Tang O.S., Gemzell-Danielsson K., and Ho P.C. Misoprostol: pharmacokinetic profiles, effects on uterus and side-effects. Int J Gynecol Obstet 99 Suppl 2 (2007) 5160-5167
18. Ramsey P.S., and Ramin K.D. Rectally administered misoprostol for the treatment of postpartum hemorrhage unresponsive to oxytocin and ergometrine: a descriptive study. Obstet Gynecol 93 1 (1999) 157-158
19. Kavle J.A., Khalfan S.S., Stoltzfus R.J., Witter F., Tielsch J.M., and Caulfield L.E. Measurement of blood loss at childbirth and postpartum. Int J Gynecol Obstet 95 1 (2006) 24-28
20. Tang O.S., Schweer H., Seyberth H.W., Lee S.W., and Ho P.C. Pharmacokinetics of different routes of administration of misoprostol. Hum Reprod 17 2 (2002) 332-336
21. ACOG technical bulletin no. 218. Dystocia and the augmentation of labor. American College of Obstetricians and Gynecologists. Int J Gynecol Obstet 53 1 (1996) 73-80