Vibrational spectroscopy and chemometrics to characterize and quantitate trehalose crystallization

Analytical Biochemistry

Volumn 399, Issue 1, 2010, Pages 48-57

  Connolly, Brian ^a   Patapoff, Thomas W ^a   Wang, Y John ^a   Moore, Jamie M ^a   Kamerzell, Tim J ^a  

^a GENENTECH INC   (United States)

Author keywords

Carbohydrates; Chemometrics; Crystallization; Freeze concentrate; Trehalose; Vibrational spectroscopy

Indexed keywords

CARBOHYDRATES; CRYSTALLIZATION; INFRARED DEVICES; LEAST SQUARES APPROXIMATIONS; LINEAR REGRESSION; VIBRATIONAL SPECTROSCOPY;

CHEMOMETRIC MODELS; CHEMOMETRICS; MULTIPLE LINEAR REGRESSION MODELS; PARTIAL LEAST SQUARE (PLS); PHARMACEUTICAL INDUSTRY; PREDICTIVE BEHAVIORS; TREHALOSE; VIBRATIONAL MODES;

PRINCIPAL COMPONENT ANALYSIS;

TREHALOSE;

ARTICLE; CHEMOMETRICS; CONTROLLED STUDY; CRYSTALLIZATION; DRUG INDUSTRY; MOLECULAR DYNAMICS; MULTIPLE LINEAR REGRESSION ANALYSIS; NEAR INFRARED SPECTROSCOPY; PARTIAL LEAST SQUARES REGRESSION; PRINCIPAL COMPONENT ANALYSIS; PRIORITY JOURNAL; RAMAN SPECTROMETRY; SPECTROSCOPY; VIBRATIONAL SPECTROSCOPY;

EID: 77649185058     PISSN: 00032697     EISSN: 10960309     Source Type: Journal    
DOI: 10.1016/j.ab.2009.10.033     Document Type: Article

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