Metabolomics study on the anti-depression effect of xiaoyaosan on rat model of chronic unpredictable mild stress

Journal of Ethnopharmacology

Volumn 128, Issue 2, 2010, Pages 482-489

  Dai, Yuntao ^a   Li, Zhenyu ^a   Xue, Liming ^a   Dou, Chunyan ^a   Zhou, Yuzhi ^a   Zhang, Lizeng ^a   Qin, Xuemei ^a  

^a SHANXI UNIVERSITY   (China)

Author keywords

Anti depression; GC MS; Metabolomics; Multivariate analysis; Xiaoyaosan

Indexed keywords

AMITRIPTYLINE; CHINESE DRUG; UNCLASSIFIED DRUG; XIAOYAOSAN;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHRONIC STRESS; CHRONIC UNPREDICTABLE MILD STRESS; CONTROLLED STUDY; DEPRESSION; DISEASE MARKER; DOSE RESPONSE; DRUG DETERMINATION; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG MEGADOSE; MALE; MASS FRAGMENTOGRAPHY; METABOLOMICS; NONHUMAN; RAT; URINALYSIS;

ANGELICA SINENSIS; ANIMALS; ANTIOXIDANTS; DEPRESSION; DRUGS, CHINESE HERBAL; GLYCYRRHIZA URALENSIS; MALE; METABOLOMICS; PAEONIA; PORIA; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY;

ANGELICA SINENSIS; ATRACTYLODES MACROCEPHALA; BUPLEURUM CHINENSE; GLYCYRRHIZA URALENSIS; MENTHA; PAEONIA LACTIFLORA; PORIA; PORIA COCOS; RATTUS; ZINGIBER OFFICINALE; ZINGIBERIS;

EID: 77649183742     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2010.01.016     Document Type: Article

References (27)

1. Beckonert O., Keun H.C., Ebbels T.M., Bundy J., Holmes E., Lindon J.C., and Nicholson J.K. Metabolic profiling, metabolomic and metabonomic procedures for NMR spectroscopy of urine, plasma, serum and tissue extracts. Nature Protocols 2 (2007) 2692-2703
2. Bhatnagar S., Vining C., Iyer V., and Kinni V. Changes in hypothalamic-pituitary-adrenal function, body temperature, body weight and food intake with repeated social stress exposure in rats. Journal of Neuroendocrinology 18 (2006) 13-24
3. 1H-NMR based metabonomics. Nature Medicine 8 (2002) 1439-1444
4. Grippo A.J., Moffitt J.A., and Johnson A.K. Cardiovascular alterations and autonomic imbalance in an experimental model of depression. American Journal Physiology Regulatory Integrative Comparative Physiology 282 (2002) R1333-R1341
5. Hallam K.T., Horgan J.E., McGrath C., and Norman T.R. An investigation of the effect of tacrine and physostigmine on spatial working memory deficits in the olfactory bulbectomised rat. Behavioral Brain Research 153 (2004) 481-486
6. Harro J., Haidkind R., Harro M., Modiri A.R., Gillberg P.G., Pahkla R., Matto V., and Oreland L. Chronic mild unpredictable stress after noradrenergic denervation: attenuation of behavioral and biochemical effects of DSP-4 treatment. European Neuropsychopharmacology 10 (1999) 5-16
7. Kell D.B. Systems biology, metabolic modelling and metabolomics in drug discovery and development. Drug Discovery Today 11 (2006) 1085-1092
8. Lenz E.M., and Wilson I.D. Analytical strategies in metabonomics. Journal of Proteome Research 6 (2007) 443-458
9. Lin Y.H., Liu A.H., and Xu Y. Effect of chronic unpredictable mild stress on brain-pancreas protein in rat brain and pancreas. Behavioural Brain Research 165 (2005) 63-71
10. Lindon J.C., Holmes E., and Nicholson J.K. Metabonomics in pharmaceutical R&D. The FEBS Journal 274 (2007) 1140-1151
11. Lucas L.R., Celen Z., Tamashiro K.L., Blanchard R.J., Blanchard D.C., Markham C., Sakai R.R., and McEwen B.S. Repeated exposure to social stress has long-term effects on indirect markers of dopaminergic activity in brain regions associated with motivated behavior. Neuroscience 124 (2004) 449-457
12. Namera A., Yashiki M., Nishida M., and Kojima T. Direct extract derivatization for determination of amino acids in human urine by gas chromatography and mass spectrometry. Journal of Chromatography B 776 (2002) 49-55
13. Nicholson J.K., Connelly J., Lindon J.C., and Holmes E. Metabonomics: a platform for studying drug toxicity and gene function. Nature Reviews Drug Discovery 1 (2002) 153-161
14. Ni Y., Su M., Qiu Y., Chen M., Liu Y., Zhao A., and Jia W. Metabolic profiling using combined GC-MS and LC-MS provides a systems understanding of aristolochic acid-induced nephrotoxicity in rat. FEBS Letter 581 (2007) 707-711
15. Ni Y., Su M.M., Lin J.C., Wang X.Y., Qiu Y.P., Zhao A.H., Chen T.L., and Jia W. Metabolic profiling reveals disorder of amino acid metabolism in four brain regions from a rat model of chronic unpredictable mild stress. FEBS Letters 582 (2008) 2627-2636
16. Papp M., Willner P., and Muscat R. An animal model of anhedonia: attenuation of sucrose consumption and place preference conditioning by chronic unpredictable mild stress. Psychopharmacology 104 (1991) 255-259
17. Parveen I., Moorby J.M., Fraser M.D., Allison G.G., and Kopka J. Application of gas chromatography-mass spectrometry metabolite profiling techniques to the analysis of heathland plant diets of sheep. Journal Agricultural and Food Chemistry 55 (2007) 1129-1138
18. Qiu Y., Su M., Liu Y., Chen M., Gu J., Zhang J., and Jia W. Application of ethyl chloroformate derivatization for gas chromatography-mass spectrometry based metabonomic profiling. Analytica Chimica Acta 583 (2007) 277-283
19. Roessner U., Wagner C., Kopka J., Trethewey R.N., and Willmitzer L. Simultaneous analysis of metabolites in potato tuber by gas chromatography-mass spectrometry. The plant journal 23 (2000) 131-142
20. Sarko J. Antidepressants, old and new: a review of their adverse effects and toxicity in overdose. Emergency Medicine Clinics of North America 18 (2000) 637-654
21. Sergeyev V. Neuropeptide expression in rats exposed to chronic mild stresses. Psychopharmacology 178 (2005) 115-124
22. Trygg J., Holmes E., and Lundstedt T. Chemometrics in metabonomics. Journal of Proteome Research 6 (2007) 469-479
23. Wold S., Sjostrom M., and Eriksson L. PLS-regression: a basic tool of chemometrics. Chemometrics Intelligent Laboratory Systems 58 (2001) 109-130
24. Xiong J.Y., Zang N., Zhang C.Y., Yang J., and Liu X.S. Studies on the anti-depression effect of Xiaoyao Powder in mice. Pharmacology and Clinics of Chinese Materia Medica 23 (2007) 3-5
25. Xu Z.W., Wu L.L., and Ya V.C. The experimental research on anti-depression effects of xiaoyaosan decoction and danzhi xiaoyaosan decoction. Acta Chinese Medicine and Pharmacology 31 (2003) 61
26. Zhao X.J., Zhang Y., Meng X.L., Yin P.Y., Deng C., Chen J., Wang Z., and Xu G.W. Effect of a traditional Chinese medicine preparation Xindi soft capsule on rat model of acute blood stasis: a urinary metabonomics study based on liquid chromatography-mass spectrometry. Journal of Chromatography B 873 (2008) 151-158
27. Zhao Z.Y., Wang W.X., Guo H.Z., and Zhou D.F. Antidepressant-like effect of liquiritin from Glycyrrhiza uralensis in chronic variable stress induced depression model rats. Behavioral Brain Research 194 (2008) 108-113