Excess iodide decreases transcription of NIS and VEGF genes in rat FRTL-5 thyroid cells

Biochemical and Biophysical Research Communications

Volumn 393, Issue 2, 2010, Pages 286-290

  Suzuki, Koichi ^a,b,c   Kimura, Hiroaki ^d   Wu, Huhehasi ^a   Kudo, Naoko ^b   Bae Kim, Won ^b,e   Suzuki, Sayuri ^c,f   Yoshida, Akio ^b,g   Caturegli, Patrizio ^d   Kohn, Leonard D ^b,h  

^a NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

^b NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^c MEDSTAR RESEARCH INSTITUTE   (United States)

^d JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e Asan Medical Center   (South Korea)

^f KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^g TOTTORI UNIVERSITY   (Japan)

^h OHIO UNIVERSITY   (United States)

Author keywords

Iodide; NIS; Thyroglobulin; Thyroid; VEGF

Indexed keywords

DNA BINDING PROTEIN; IODIDE; SODIUM IODIDE SYMPORTER; THYROGLOBULIN; VASCULOTROPIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; FRTL 5 THYROID CELL; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; RAT; REPORTER GENE; RNA ISOLATION; THYROID CELL; THYROID FUNCTION; WESTERN BLOTTING;

ANIMALS; CELL LINE; ELECTROPHORETIC MOBILITY SHIFT ASSAY; IODIDES; RATS; SYMPORTERS; THYROGLOBULIN; THYROID GLAND; TRANSCRIPTION, GENETIC; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

RATTUS;

EID: 77649180797     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2010.01.123     Document Type: Article

References (32)

1. Kohn L.D., Saji M., Kosugi M., Ban T., Giuliani C., Hidaka A., Shimura H., Shimura Y., and Okajima F. The synthesis and secretion of thyroid hormones: regulation by multiple hormones and signals which can be subverted by autoantibodies to the thyrotropin receptor. In: Troncone L., Shapiro B., Satta M.A., and Monaco F. (Eds). Thyroid Diseases: Basic Science, Pathology, Clinical and Laboratory Diagnosis (1993), Crc. Pr. I. Lic., New York 59-118
2. Dai G., Levy O., and Carrasco N. Cloning and characterization of the thyroid iodide transporter. Nature 379 (1996) 458-460
3. Kohn L.D., Shimura H., Shimura Y., Hidaka A., Giuliani C., Napolitano G., Ohmori M., Laglia G., and Saji M. The thyrotropin receptor. Vitam. Horm. 50 (1995) 287-384
4. Weiss S.J., Philp N.J., Ambesi-Impiombato F.S., and Grollman E.F. Thyrotropin-stimulated iodide transport mediated by adenosine 3′,5′-monophosphate and dependent on protein synthesis. Endocrinology 114 (1984) 1099-1107
5. Suzuki K., Lavaroni S., Mori A., Ohta M., Saito J., Pietrarelli M., Singer D.S., Kimura S., Katoh R., Kawaoi A., and Kohn L.D. Autoregulation of thyroid-specific gene transcription by thyroglobulin. Proc. Natl. Acad. Sci. USA 95 (1998) 8251-8256
6. Emerson C.H., Anderson A.J., Howard W.J., and Utiger R.D. Serum thyroxine and triiodothyronine concentrations during iodide treatment of hyperthyroidism. J. Clin. Endocrinol. Metab. 40 (1975) 33-36
7. Wolff J., and Chaikoff I.L. Plasma inorganic iodide as a homeostatic regulator of thyroid function. J. Biol. Chem. 174 (1948) 555-564
8. Wolff J., Chaikoff I.L., Goldberg R.C., and Meier J.R. The temporary nature of the inhibitory action of excess iodine on organic iodine synthesis in the normal thyroid. Endocrinology 45 (1949) 504-513
9. Arntzenius A.B., Smit L.J., Schipper J., van der Heide D., and Meinders A.E. Inverse relation between iodine intake and thyroid blood flow: color Doppler flow imaging in euthyroid humans. J. Clin. Endocrinol. Metab. 73 (1991) 1051-1055
10. Chang D.C., Wheeler M.H., Woodcock J.P., Curley I., Lazarus J.R., Fung H., John R., Hall R., and McGregor A.M. The effect of preoperative Lugol's iodine on thyroid blood flow in patients with Graves' hyperthyroidism. Surgery 102 (1987) 1055-1061
11. Marigold J.H., Morgan A.K., Earle D.J., Young A.E., and Croft D.N. Lugol's iodine: its effect on thyroid blood flow in patients with thyrotoxicosis. Br. J. Surg. 72 (1985) 45-47
12. Rangaswamy M., Padhy A.K., Gopinath P.G., Shukla N.K., Gupta K., and Kapoor M.M. Effect of Lugol's iodine on the vascularity of thyroid gland in hyperthyroidism. Nucl. Med. Commun. 10 (1989) 679-684
13. Sato K., Miyakawa M., Onoda N., Demura H., Yamashita T., Miura M., Kasajima T., Yamazaki K., and Obara T. Increased concentration of vascular endothelial growth factor/vascular permeability factor in cyst fluid of enlarging and recurrent thyroid nodules. J. Clin. Endocrinol. Metab. 82 (1997) 1968-1973
14. Sato K., Yamazaki K., Shizume K., Kanaji Y., Obara T., Ohsumi K., Demura H., Yamaguchi S., and Shibuya M. Stimulation by thyroid-stimulating hormone and Grave's immunoglobulin G of vascular endothelial growth factor mRNA expression in human thyroid follicles in vitro and flt mRNA expression in the rat thyroid in vivo. J. Clin. Invest. 96 (1995) 1295-1302
15. Soh E.Y., Duh Q.Y., Sobhi S.A., Young D.M., Epstein H.D., Wong M.G., Garcia Y.K., Min Y.D., Grossman R.F., Siperstein A.E., and Clark O.H. Vascular endothelial growth factor expression is higher in differentiated thyroid cancer than in normal or benign thyroid. J. Clin. Endocrinol. Metab. 82 (1997) 3741-3747
16. Suzuki K., Mori A., Ishii K.J., Saito J., Singer D.S., Klinman D.M., Krause P.R., and Kohn L.D. Activation of target-tissue immune-recognition molecules by double-stranded polynucleotides. Proc. Natl. Acad. Sci. USA 96 (1999) 2285-2290
17. Suzuki K., Mori A., Saito J., Moriyama E., Ullianich L., and Kohn L.D. Follicular thyroglobulin suppresses iodide uptake by suppressing expression of the sodium/iodide symporter gene. Endocrinology 140 (1999) 5422-5430
18. Mori-Aoki A., Pietrarelli M., Nakazato M., Caturegli P., Kohn L.D., and Suzuki K. Class II transactivator suppresses transcription of thyroid-specific genes. Biochem. Biophys. Res. Commun. 278 (2000) 58-62
19. Levy O., De la Vieja A., Ginter C.S., Riedel C., Dai G., and Carrasco N. N-linked glycosylation of the thyroid Na symporter (NIS). Implications for its secondary structure model. J. Biol. Chem. 273 (1998) 22657-22663
20. Braverman L.E., and Ingbar S.H. Changes in thyroidal function during adaptation to large doses of iodide. J. Clin. Invest. 42 (1963) 1216-1231
21. Grollman E.F., Smolar A., Ommaya A., Tombaccini D., and Santisteban P. Iodine suppression of iodide uptake in FRTL-5 thyroid cells. Endocrinology 118 (1986) 2477-2482
22. Xu J., Kogai T., Brent G.A., and Hershman J.M. A GC box in the human sodium iodide symporter gene promoter is essential for full activity. Thyroid 12 (2002) 107-114
23. Taniguchi S.I., Shong M., Giuliani C., Napolitano G., Saji M., Montani V., Suzuki K., Singer D.S., and Kohn L.D. Iodide suppression of major histocompatibility class I gene expression in thyroid cells involves enhancer A and the transcription factor NF-kappa B. Mol. Endocrinol. 12 (1998) 19-33
24. Dohan O., De la Vieja A., Paroder V., Riedel C., Artani M., Reed M., Ginter C.S., and Carrasco N. The sodium/iodide symporter (NIS): characterization, regulation, and medical significance. Endocr. Rev. 24 (2003) 48-77
25. Kogai T., Endo T., Saito T., Miyazaki A., Kawaguchi A., and Onaya T. Regulation by thyroid-stimulating hormone of sodium/iodide symporter gene expression and protein levels in FRTL-5 cells. Endocrinology 138 (1997) 2227-2232
26. Eng P.H., Cardona G.R., Previti M.C., Chin W.W., and Braverman L.E. Regulation of the sodium iodide symporter by iodide in FRTL-5 cells. Eur. J. Endocrinol. 144 (2001) 139-144
27. Yoshida A., Taniguchi S., Hisatome I., Royaux I.E., Green E.D., Kohn L.D., and Suzuki K. Pendrin is an iodide-specific apical porter responsible for iodide efflux from thyroid cells. J. Clin. Endocrinol. Metab. 87 (2002) 3356-3361
28. Fujita H., and Murakami T. Scanning electron microscopy on the distribution of the minute blood vessels in the thyroid gland of the dog, rat and rhesus monkey. Arch. Histol. Jpn. 36 (1974) 181-188
29. Yamada E., Yamazaki K., Takano K., Obara T., and Sato K. Iodide inhibits vascular endothelial growth factor-A expression in cultured human thyroid follicles: a microarray search for effects of thyrotropin and iodide on angiogenesis factors. Thyroid 16 (2006) 545-554
30. Bizhanova A., and Kopp P. Minireview: the sodium-iodide symporter NIS and pendrin in iodide homeostasis of the thyroid. Endocrinology 150 (2009) 1084-1090
31. Kogai T., Taki K., and Brent G.A. Enhancement of sodium/iodide symporter expression in thyroid and breast cancer. Endocr. Relat. Cancer 13 (2006) 797-826
32. Suzuki K., and Kohn L.D. Differential regulation of apical and basal iodide transporters in the thyroid by thyroglobulin. J. Endocrinol. 189 (2006) 247-255