Efficient alternative for the reduction of N-trichloroacetyl groups in synthetic chondroitin oligosaccharide intermediates

Tetrahedron Letters

Volumn 51, Issue 14, 2010, Pages 1867-1869

  Vibert, Aude ^a   Lopin Bon, Chrystel ^a   Jacquinet, Jean Claude ^a  

^a UNIVERSITÉ D'ORLÉANS   (France)

Author keywords

Chondroitin sulfate; N Trichloroacetyl group; Oligosaccharides; Zn Cu reduction

Indexed keywords

ACETIC ACID; CHONDROITIN; COPPER; FUNCTIONAL GROUP; OLIGOMER; OLIGOSACCHARIDE; ZINC;

ARTICLE; CHIRALITY; DRUG STRUCTURE; DRUG SYNTHESIS; REDUCTION;

EID: 77649180719     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2010.02.005     Document Type: Article

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21. General procedure for the reduction reaction: Zn-Cu couple (Acros Organics, 100 mg, 1.5 mmol) was added portionwise to a solution of the starting material (0.1 mmol) in pure acetic acid (1.5 mL) at 50 °C under Ar, and the mixture was stirred for the allotted time (see Table 1), cooled, filtered through a pad of Celite®, and concentrated. The resulting residues were directly purified by flash-silica chromatography.
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