메뉴 건너뛰기




Volumn 34, Issue 3, 2010, Pages 267-268

Targeting the mevalonate pathway in multiple myeloma

Author keywords

FPP; GGPP; Mevalonate pathway; Multiple myeloma; Plasma cell lines

Indexed keywords

3 HYDROXY 3 METHYLGLUTARYL COENZYME A; BENDAMUSTINE; BORTEZOMIB; DEXAMETHASONE; DOXORUBICIN; FARNESYL DIPHOSPHATE; GERANYLGERANYL PYROPHOSPHATE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; K RAS PROTEIN; MEVALONIC ACID; PAMIDRONIC ACID; SIMVASTATIN; VINCRISTINE;

EID: 77649179772     PISSN: 01452126     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.leukres.2009.07.027     Document Type: Editorial
Times cited : (3)

References (23)
  • 1
    • 0025120211 scopus 로고
    • Regulation of the mevalonate pathway
    • Goldstein J.L., Brown M.S. Regulation of the mevalonate pathway. Nature 1990, 343:425-430.
    • (1990) Nature , vol.343 , pp. 425-430
    • Goldstein, J.L.1    Brown, M.S.2
  • 2
    • 0029898894 scopus 로고    scopus 로고
    • Protein prenylation: molecular mechanisms and functional consequences
    • Zhang F.L., Casey P.J. Protein prenylation: molecular mechanisms and functional consequences. Annu Rev Biochem 1996, 65:241-269.
    • (1996) Annu Rev Biochem , vol.65 , pp. 241-269
    • Zhang, F.L.1    Casey, P.J.2
  • 3
    • 0142245593 scopus 로고    scopus 로고
    • Inhibition of protein geranylgeranylation induces apoptosis in myeloma plasma cells by reducing Mcl-1 protein levels
    • van de Donk N.W., Kamphuis M.M., van Kessel B., Lokhorst H.M., Bloem A.C. Inhibition of protein geranylgeranylation induces apoptosis in myeloma plasma cells by reducing Mcl-1 protein levels. Blood 2003, 102:3354-3362.
    • (2003) Blood , vol.102 , pp. 3354-3362
    • van de Donk, N.W.1    Kamphuis, M.M.2    van Kessel, B.3    Lokhorst, H.M.4    Bloem, A.C.5
  • 4
    • 19844367157 scopus 로고    scopus 로고
    • Statins activate the mitochondrial pathway of apoptosis in human lymphoblasts and myeloma cells
    • Cafforio P., Dammacco F., Gernone A., Silvestris F. Statins activate the mitochondrial pathway of apoptosis in human lymphoblasts and myeloma cells. Carcinogenesis 2005, 26:883-891.
    • (2005) Carcinogenesis , vol.26 , pp. 883-891
    • Cafforio, P.1    Dammacco, F.2    Gernone, A.3    Silvestris, F.4
  • 5
    • 4043103303 scopus 로고    scopus 로고
    • Microenvironment factors do not afford myeloma cell lines protection from simvastatin
    • Osadchy A., Drucker L., Radnay J., Shapira H., Lishner M. Microenvironment factors do not afford myeloma cell lines protection from simvastatin. Eur J Haematol 2004, 73:183-190.
    • (2004) Eur J Haematol , vol.73 , pp. 183-190
    • Osadchy, A.1    Drucker, L.2    Radnay, J.3    Shapira, H.4    Lishner, M.5
  • 6
    • 4444282702 scopus 로고    scopus 로고
    • The HMG-CoA reductase inhibitor simvastatin overcomes cell adhesion-mediated drug resistance in multiple myeloma by geranylgeranylation of Rho protein and activation of Rho kinase
    • Schmidmaier R., Baumann P., Simsek M., Dayyani F., Emmerich B., Meinhardt G. The HMG-CoA reductase inhibitor simvastatin overcomes cell adhesion-mediated drug resistance in multiple myeloma by geranylgeranylation of Rho protein and activation of Rho kinase. Blood 2004, 104(6):1825-1832.
    • (2004) Blood , vol.104 , Issue.6 , pp. 1825-1832
    • Schmidmaier, R.1    Baumann, P.2    Simsek, M.3    Dayyani, F.4    Emmerich, B.5    Meinhardt, G.6
  • 7
    • 0035158584 scopus 로고    scopus 로고
    • Sterol-independent regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in tumor cells
    • Hentosh P., Yuh S.H., Elson C.E., Peffley D.M. Sterol-independent regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in tumor cells. Mol Carcinog 2001, 32:154-166.
    • (2001) Mol Carcinog , vol.32 , pp. 154-166
    • Hentosh, P.1    Yuh, S.H.2    Elson, C.E.3    Peffley, D.M.4
  • 8
    • 0036045450 scopus 로고    scopus 로고
    • The cholesterol lowering drug lovastatin induces cell death in myeloma plasma cells
    • van de Donk N.W., Kamphuis M.M., Lokhorst H.M., Bloem A.C. The cholesterol lowering drug lovastatin induces cell death in myeloma plasma cells. Leukemia 2002, 16:1362-1371.
    • (2002) Leukemia , vol.16 , pp. 1362-1371
    • van de Donk, N.W.1    Kamphuis, M.M.2    Lokhorst, H.M.3    Bloem, A.C.4
  • 10
    • 27244450832 scopus 로고    scopus 로고
    • Combining prenylation inhibitors causes synergistic cytotoxicity, apoptosis and disruption of RAS-to-MAP kinase signalling in multiple myeloma cells
    • Morgan M.A., Sebil T., Aydilek E., Peest D., Ganser A., Reuter C.W. Combining prenylation inhibitors causes synergistic cytotoxicity, apoptosis and disruption of RAS-to-MAP kinase signalling in multiple myeloma cells. Br J Haematol 2005, 130(6):912-925.
    • (2005) Br J Haematol , vol.130 , Issue.6 , pp. 912-925
    • Morgan, M.A.1    Sebil, T.2    Aydilek, E.3    Peest, D.4    Ganser, A.5    Reuter, C.W.6
  • 11
    • 34248352031 scopus 로고    scopus 로고
    • Statins synergistically potentiate 7-hydroxystaurosporine (UCN-01) lethality in human leukemia and myeloma cells by disrupting Ras farnesylation and activation
    • Dai Y., Khanna P., Chen S., Pei X.Y., Dent P., Grant S. Statins synergistically potentiate 7-hydroxystaurosporine (UCN-01) lethality in human leukemia and myeloma cells by disrupting Ras farnesylation and activation. Blood 2007, 109(10):4415-4423.
    • (2007) Blood , vol.109 , Issue.10 , pp. 4415-4423
    • Dai, Y.1    Khanna, P.2    Chen, S.3    Pei, X.Y.4    Dent, P.5    Grant, S.6
  • 13
    • 0346848763 scopus 로고    scopus 로고
    • The bisphosphonate zoledronic acid induces cytotoxicity in human myeloma cell lines with enhancing effects of dexamethasone and thalidomide
    • Ural A.U., Yilmaz M.I., Avcu F., Pekel A., Zerman M., Nevruz O., et al. The bisphosphonate zoledronic acid induces cytotoxicity in human myeloma cell lines with enhancing effects of dexamethasone and thalidomide. Int J Hematol 2003, 78(5):443-449.
    • (2003) Int J Hematol , vol.78 , Issue.5 , pp. 443-449
    • Ural, A.U.1    Yilmaz, M.I.2    Avcu, F.3    Pekel, A.4    Zerman, M.5    Nevruz, O.6
  • 14
    • 0030931858 scopus 로고    scopus 로고
    • Bisphosphonates induce apoptosis in human myeloma cell lines: a novel anti-tumour activity
    • Shipman C.M., Rogers M.J., Apperley J.F., Russell R.G., Croucher P.I. Bisphosphonates induce apoptosis in human myeloma cell lines: a novel anti-tumour activity. Br J Haematol 1997, 98:665-672.
    • (1997) Br J Haematol , vol.98 , pp. 665-672
    • Shipman, C.M.1    Rogers, M.J.2    Apperley, J.F.3    Russell, R.G.4    Croucher, P.I.5
  • 15
    • 0037328558 scopus 로고    scopus 로고
    • The farnesyl transferase inhibitor, FTI-277, inhibits growth and induces apoptosis in drug-resistant myeloma tumor cells
    • Bolick S.C., Landowski T.H., Boulware D., Oshiro M.M., Ohkanda J., Hamilton A.D., et al. The farnesyl transferase inhibitor, FTI-277, inhibits growth and induces apoptosis in drug-resistant myeloma tumor cells. Leukemia 2003, 17(2):451-457.
    • (2003) Leukemia , vol.17 , Issue.2 , pp. 451-457
    • Bolick, S.C.1    Landowski, T.H.2    Boulware, D.3    Oshiro, M.M.4    Ohkanda, J.5    Hamilton, A.D.6
  • 16
    • 34547798983 scopus 로고    scopus 로고
    • First clinical experience with simvastatin to overcome drug resistance in refractory multiple myeloma
    • Schmidmaier R., Baumann P., Bumeder I., Meinhardt G., Straka C., Emmerich B. First clinical experience with simvastatin to overcome drug resistance in refractory multiple myeloma. Eur J Haematol 2007, 79(3):240-243.
    • (2007) Eur J Haematol , vol.79 , Issue.3 , pp. 240-243
    • Schmidmaier, R.1    Baumann, P.2    Bumeder, I.3    Meinhardt, G.4    Straka, C.5    Emmerich, B.6
  • 17
    • 38949113627 scopus 로고    scopus 로고
    • The effect of statin use at the time of autologous transplant on response and survival in multiple myeloma
    • Hamadani M., Hade E., Benson D.M., Hofmeister C.C. The effect of statin use at the time of autologous transplant on response and survival in multiple myeloma. Biol Blood Marrow Transplant 2008, 14:351-352.
    • (2008) Biol Blood Marrow Transplant , vol.14 , pp. 351-352
    • Hamadani, M.1    Hade, E.2    Benson, D.M.3    Hofmeister, C.C.4
  • 18
    • 38949101479 scopus 로고    scopus 로고
    • High dose simvastatin does not reverse resistance to vincristine, adriamycin, and dexamethasone (VAD) in myeloma
    • van der Spek E., Bloem A.C., Sinnige H.A., Lokhorst H.M. High dose simvastatin does not reverse resistance to vincristine, adriamycin, and dexamethasone (VAD) in myeloma. Haematologica 2007, 92:e130-e131.
    • (2007) Haematologica , vol.92
    • van der Spek, E.1    Bloem, A.C.2    Sinnige, H.A.3    Lokhorst, H.M.4
  • 19
    • 33845989461 scopus 로고    scopus 로고
    • Risk of multiple myeloma following medication use and medical conditions: a case-control study in Connecticut women
    • Landgren O., Zhang Y., Zahm S.H., Inskip P., Zheng T., Baris D. Risk of multiple myeloma following medication use and medical conditions: a case-control study in Connecticut women. Cancer Epidemiol Biomarkers Prev 2006, 15(12):2342-2347.
    • (2006) Cancer Epidemiol Biomarkers Prev , vol.15 , Issue.12 , pp. 2342-2347
    • Landgren, O.1    Zhang, Y.2    Zahm, S.H.3    Inskip, P.4    Zheng, T.5    Baris, D.6
  • 20
    • 9044219839 scopus 로고    scopus 로고
    • Efficacy of pamidronate in reducing skeletal events in patients with advanced multiple myeloma. Myeloma Aredia Study Group
    • Berenson J.R., Lichtenstein A., Porter L., Dimopoulos M.A., Bordoni R., George S., et al. Efficacy of pamidronate in reducing skeletal events in patients with advanced multiple myeloma. Myeloma Aredia Study Group. N Engl J Med 1996, 334(8):488-493.
    • (1996) N Engl J Med , vol.334 , Issue.8 , pp. 488-493
    • Berenson, J.R.1    Lichtenstein, A.2    Porter, L.3    Dimopoulos, M.A.4    Bordoni, R.5    George, S.6
  • 21
    • 33751164196 scopus 로고    scopus 로고
    • Maintenance therapy with thalidomide improves survival in patients with multiple myeloma
    • Attal M., Harousseau J.L., Leyvraz S., Doyen C., Hulin C., Benboubker L., et al. Maintenance therapy with thalidomide improves survival in patients with multiple myeloma. Blood 2006, 108(10):3289-3294.
    • (2006) Blood , vol.108 , Issue.10 , pp. 3289-3294
    • Attal, M.1    Harousseau, J.L.2    Leyvraz, S.3    Doyen, C.4    Hulin, C.5    Benboubker, L.6
  • 22
    • 11144358447 scopus 로고    scopus 로고
    • Farnesyltransferase inhibitor tipifarnib is well tolerated, induces stabilization of disease, and inhibits farnesylation and oncogenic/tumor survival pathways in patients with advanced multiple myeloma
    • Alsina M., Fonseca R., Wilson E.F., Belle A.N., Gerbino E., Price-Troska T., et al. Farnesyltransferase inhibitor tipifarnib is well tolerated, induces stabilization of disease, and inhibits farnesylation and oncogenic/tumor survival pathways in patients with advanced multiple myeloma. Blood 2004, 103(9):3271-3277.
    • (2004) Blood , vol.103 , Issue.9 , pp. 3271-3277
    • Alsina, M.1    Fonseca, R.2    Wilson, E.F.3    Belle, A.N.4    Gerbino, E.5    Price-Troska, T.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.