Simultaneous quantification of carteolol and dorzolamide in rabbit aqueous humor and ciliary body by liquid chromatography/atmospheric pressure chemical ionization mass spectrometry

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 878, Issue 9-10, 2010, Pages 807-814

  Zammataro, Alessio ^b   Saletti, Rosaria ^a   Civiale, Claudine ^b   Muccilli, Vera ^a   Cunsolo, Vincenzo ^a   Foti, Salvatore ^a  

^a UNIVERSITY OF CATANIA   (Italy)

^b SIFI SpA   (Italy)

Author keywords

Carteolol; Dorzolamide; Quantitative determination; Rabbit aqueous humor; Rabbit ciliary body; RP HPLC APCI MS MS

Indexed keywords

ACCURACY AND PRECISION; ANALYTES; ANALYTICAL METHOD; ATMOSPHERIC PRESSURE CHEMICAL IONIZATION; CHEMICAL IONIZATION MASS SPECTROMETRY; DORZOLAMIDE; ETHYL ACETATES; EXTRACTION PROCEDURE; EYE DROPS; IN-VIVO; INTERNAL STANDARDS; ISO-PROPANOLS; ISOCRATIC ELUTION; LIQUID-LIQUID EXTRACTION; NADOLOL; ORGANIC EXTRACTS; PROTEIN PRECIPITATION; QUANTITATIVE DETERMINATIONS; RABBIT AQUEOUS HUMOR; REVERSED PHASE; RP-HPLC; SAMPLE PREPARATION; TRIFLUOROACETIC ACIDS;

ATMOSPHERIC IONIZATION; ATMOSPHERIC PRESSURE; BODY FLUIDS; CHROMATOGRAPHIC ANALYSIS; CUSTOMER SATISFACTION; ELECTRIC CIRCUIT BREAKERS; ESTERS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH PRESSURE LIQUID CHROMATOGRAPHY; IONIZATION OF LIQUIDS; LIQUIDS; MASS SPECTROMETRY; PARTICLE DETECTORS; PH; TOLUENE; TOTAL QUALITY MANAGEMENT;

SOLVENT EXTRACTION;

2 PROPANOL; ACETIC ACID ETHYL ESTER; CARTEOLOL; DORZOLAMIDE; NADOLOL; TOLUENE; TRIFLUOROACETIC ACID;

ANIMAL EXPERIMENT; AQUEOUS HUMOR; ARTICLE; CILIARY BODY; CONTROLLED STUDY; DRUG DETERMINATION; EXPERIMENTAL RABBIT; LIQUID CHROMATOGRAPHY; LIQUID LIQUID EXTRACTION; MALE; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

ANIMALS; ANTIHYPERTENSIVE AGENTS; AQUEOUS HUMOR; CARTEOLOL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CILIARY BODY; DISEASE MODELS, ANIMAL; HUMANS; MALE; OCULAR HYPERTENSION; RABBITS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SULFONAMIDES; THIOPHENES;

ORYCTOLAGUS CUNICULUS;

EID: 77649168816     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2010.01.041     Document Type: Article

References (19)

1. Zimmerman T.J. J. Ocul. Pharmacol. 9 (1993) 373
2. Novack G.D., O'Donnell M.J., and Molloy D.W. J. Am. Geriatr. Soc. 50 (2002) 956
3. Nathanson J.A. PNAS, USA 77 12 (1980) 7420
4. Moroi S.E., and Lichter P.R. In: Hardman J.G., Limbird L.E., and Gilman A.G. (Eds). Ocular Pharmacology, in Goodman and Gilman's The Pharmacological Basis of Therapeutics. 10th ed. (2001), McGraw-Hill, New York 1821
5. Black C.D., and Mann H.J. Drug Intell. Clin. Pharm. 18 (1984) 554
6. Pfeiffer N. Surv. Ophthalmol. 42 (1997) 137
7. Sugrue M.F. Prog. Retin. Eye Res. 19 (2000) 87
8. Baldwin J.J., Ponticello G.S., Anderson P.S., Mercko M.A., Randall W.C., Schwan H., Sugrue M.F., Gautheron P.S., Grove J., Mallorga P., Viader M.P., McKever B.M., and Navia M.A. J. Med. Chem. 32 (1989) 2513
9. Hurvitz L.M., Kaufman P.L., Robin A.L., Weinreb R.N., Crawford K., and Shaw B. Drugs 41 (1991) 514
10. Blacklock T.J., Sohar P., Buthcher J.W., Lamanec T., and Grabowski E.J.J. J. Org. Chem. 58 (1993) 1672
11. Sugiyama T., Kojima S., Ishida O., and Ikeda T. Acta Ophthalmol. 87 (2008) 797
12. Hartenbaum D. Clin. Ther. 18 (1996) 460
13. Maurer H.H., Tenberken O., Kratzsch C., Weber A.A., and Peters F.T. J. Chromatogr. A 1058 (2004) 169
14. Constanzer M.L., Chavez C.M., and Matuszewski B.K. J. Pharm. Biomed. Anal. 15 (1997) 1001
15. Guidance for Industry. Bioanalytical Method Validation (2001), US Department of Health and Human Services Food and Drug Administration, Center for Drug Evaluation and Research (CDER), Center for Veterinary Medicine (CV). http://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformati on/Guidances/UCM070107.pdf available at:
16. Validation of Analytical Procedures: Text and Methodology Q2 (R1). International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (2005). http://www.ich.org/LOB/media/MEDIA417.pdf available at:
17. Lakhani N.J., Lepper E.R., Sparreboom A., Dahul W.L., Venitz J., and Figg W.D. Rapid Commun. Mass Spectrom. 19 (2005) 1176
18. Higashiyama M., Tajika T., Inada K., and Ohtori A. J. Ocul. Pharmacol. Ther. 22 (2006) 333
19. Sigurdsson H.H., Stefánsson E., Gudmundsdóttir E., Eysteinsson T., Thorsteinsdóttir M., and Loftsson T. J. Control. Release 102 (2005) 255