A single amino acid substitution in the capsid of foot-and-mouth disease virus can increase acid lability and confer resistance to acid-dependent uncoating inhibition

Journal of Virology

Volumn 84, Issue 6, 2010, Pages 2902-2912

  Martín Acebes, Miguel A ^a,d   Rincón, Verónica ^a   Armas Portela, Rosario ^a,b   Mateu, Mauricio G ^a   Sobrino, Francisco ^a,c  

^a CENTRO DE BIOLOGÍA MOLECULAR SEVERO OCHOA   (Spain)

^b UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^c Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria   (Spain)

^d INIA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

AMMONIUM CHLORIDE; CONCANAMYCIN A; PROTEIN VP2; PROTEIN VP3; VIRUS RNA;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CELL STRAIN BHK; CONTROLLED STUDY; FOOT AND MOUTH DISEASE VIRUS; GENETIC TRANSFECTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RNA EXTRACTION; SENSITIVITY ANALYSIS; SEQUENCE ANALYSIS; SITE DIRECTED MUTAGENESIS; VIRION; VIRUS CAPSID; VIRUS INFECTIVITY; VIRUS ISOLATION; VIRUS MUTANT;

ACIDS; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; AMMONIUM CHLORIDE; ANIMALS; CAPSID; CATTLE; CELL LINE; CRICETINAE; CRICETULUS; ENDOSOMES; FOOT-AND-MOUTH DISEASE; FOOT-AND-MOUTH DISEASE VIRUS; HYDROGEN-ION CONCENTRATION; INTEGRINS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MUTATION; PROTEIN CONFORMATION; VIRION; VIRUS REPLICATION;

FOOT-AND-MOUTH DISEASE VIRUS; FOOT-AND-MOUTH DISEASE VIRUS - TYPE C; MIRIDAE;

EID: 77649155795     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.02311-09     Document Type: Article

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