Resveratrol activation of nitric oxide synthase in rabbit brain synaptosomes: Singlet oxygen (1O2) formation as a causative factor of neurotoxicity

In Vivo

Volumn 24, Issue 1, 2010, Pages 49-53

  Fotiou, Stelios ^a   Fotiou, Despina ^a   Alamanou, Anastasia ^a   Deliconstantinos, George ^a  

^a UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

Author keywords

Neurotoxicity; Nitric oxide; Peroxynitrite; Rabbit brain synaptosomes; Resveratrol; Singlet oxygen; Ultraviolet C radiation

Indexed keywords

BETA CAROTENE; NITRIC OXIDE SYNTHASE; PEROXYNITRITE; RESVERATROL; SINGLET OXYGEN; TROLOX C;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN SYNAPTOSOME; CELL MEMBRANE; CONTROLLED STUDY; DNA DAMAGE; ENERGY TRANSFER; ENZYME ACTIVITY; ENZYME REGULATION; ISOLATION PROCEDURE; NEUROTOXICITY; NONHUMAN; PATHOPHYSIOLOGY; RABBIT; ULTRAVIOLET IRRADIATION; ULTRAVIOLET RADIATION; UPREGULATION;

EID: 77649155290     PISSN: 0258851X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Athar M, Back JH, Kopelovich L, Bickers DR and Kim AL: Multiple molecular targets of resveratrol: Anti-carcinogenic mechanisms. Arch Biochem Biophys 486: 95-102, 2009.
2. Aggarwal BB, Bhardwaj A, Seeram NP, Shishodia S and Takada Y: Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies. Anticancer Res 24(5A): 2783-2840, 2004.
3. Robb EL, Winkelmolen L, Visanji N, Brotchie J and Stuart JA: Dietary resveratrol administration increases MnSOD expression and activity in mouse brain 372(1): 254-259, 2009.
4. Wallerath T, Deckert G, Ternes T, Anderson H, Li H, Witte K and Forstermann U: Resveratrol, a polyphenolic phytoaletoxin present in red wine, enhances expression and activity of endothelial nitric oxide synthase. Circulation 106(13): 1652-1658, 2002.
5. Brito PM, Simoes NF, Almeida LM and Dinis TC: Resveratrol disrupts peroxynitrite-triggered mitochondrial apoptotic pathway: a role for Bcl-2. Apoptosis 13(8): 1043-1053, 2008.
6. Deliconstantinos G and Villiotou V: NO synthase and xanthine oxidase activities of rabbit brain synaptosomes. Peroxynitrite as a causative factor of cytotoxicity. Neurochem Res 21: 51-61,1996.
7. Bradford MM: Rapid and sensitive method for quantitation of microgram quantities of protein utilizing principle of protein-dye binding. Anal Biochem 72: 248-254, 1976.
8. Delicostantinos G, Villiotou V and Stavrides JC: Release by ultraviolet B (UVB) radiation of nitric oxide (NO) from human keratinocytes: a potential role for nitric oxide in erythema production. Br J Pharmacol 114: 1257-1265, 1995
9. Shinitzky M and Barenholz Y: Fluidity parameters of lipid regions determined by fluorescence polarization. Biochim Biophys Acta 515: 367-394, 1978.
10. Deliconstantinos G, Kopeikina-Tsiboukidou L and Villiotou V: Evaluation of membrane fluidity effects and enzyme activities alterations in adriamycin neurotoxicity. Biochem Pharmacol 36: 1153-1161, 1987.
11. Chen Y and Tseng SH: Review. Pro- and anti-angiogenesis effects of resveratrol. In Vivo 21(2): 365-370, 2007.
12. Leiro J, Alvarez E, Arranz JA and Laguna Reyes: Effects of cis-resveratrol on inflammatory murine macrophages: antioxidant activity and down-regulation of inflammatory genes. J Leukoc Biol 75: 1156-1165, 2004.
13. De la Lastra CA and Villegas I: Resveratrol as an antioxidant and pro-oxidant agent: mechanisms and clinical implications. Biochm Soc Trans 35(5): 1156-1160, 2007.
14. -) after ultraviolet radiation as a protective mechanism in rat skin. In Vivo 23: 281-286, 2009.
15. Wimalawansa SJ: Nitric oxide: new evidence for novel therapeutic inductions. Expert Opin Pharmacother 9: 1935-1954, 2008.
16. Clo E, Snyder JW, Ogilby PR and Gothelf KV: Control and selectivity of photosensitized singlet oxygen production: challenges in complex biological systems. Chem Bio Chem 8: 475-481 , 2007.
17. Deliconstantinos G: Physiological aspects of membrane lipid fluidity in malignancy. Anticancer Res 7: 1011-1022, 1987.
18. Deliconstantinos G and Fotiou S: Sex steroid and prostaglandin interactions upon the purified rat myometrial plasma membranes. Mol Cell Endocrinol 45(2-3): 149-156, 1986.
19. Wenli Y and Yaping Z: Chemiluminescence evaluation of oxidative damage to biomolecules induced by singlet oxygen and the protective effects of antioxidants. Biochim Biophys Acta 1725: 30-34, 2005.