Predicting aqueous solubility: The role of crystallinity

Current Drug Metabolism

Volumn 10, Issue 10, 2009, Pages 1184-1191

  Chu, Katherine A ^a   Yalkowsky, Samuel H ^a  

^a UNIVERSITY OF ARIZONA   (United States)

Author keywords

Aqueous; Aqueous solubility; Crystallinity; Log P; Melting point; Partition coefficient; Solubility

Indexed keywords

1 NAPHTHOL; 2 NAPHTHOIC ACID; 4 HYDROXYBENZOIC ACID; ALPRENOLOL; AMANTADINE; AMITRIPTYLINE; AMODIAQUINE; ASTEMIZOLE; ATENOLOL; BENZOCAINE; BENZOIC ACID; CARPROFEN; CHLORPHENIRAMINE; CHLORPROMAZINE; CHLORPROTHIXENE; CHLORZOXAZONE; CRYSTALLIN; DESIPRAMINE; DICLOFENAC; DIPHENHYDRAMINE; FLUFENAMIC ACID; FLUOXETINE; FLURBIPROFEN; FUROSEMIDE; HALOPERIDOL; IBUPROFEN; IMIPRAMINE; LIDOCAINE; SELEGILINE; UNINDEXED DRUG; DRUG; WATER;

AQUEOUS SOLUTION; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENERGY; MELTING POINT; SOLUBILITY; SOLUTE; CHEMISTRY; COMPARATIVE STUDY; CRYSTALLIZATION; MEDICINAL CHEMISTRY; METABOLISM; PREDICTIVE VALUE; PROCEDURES;

CHEMISTRY, PHARMACEUTICAL; CRYSTALLIZATION; PHARMACEUTICAL PREPARATIONS; PREDICTIVE VALUE OF TESTS; SOLUBILITY; WATER;

EID: 77649142032     PISSN: 13892002     EISSN: None     Source Type: Journal    
DOI: 10.2174/138920009790820110     Document Type: Article

References (5)

1. Jain, N.; Yalkowsky, S. H. Estimation of the aqueous solubility I: Application to organic nonelectrolytes. J. Pharm. Sci., 2001, 90(2), 234-252.
2. Jain, P.; Sepassi, K.; Yalkowsky, S. H. Comparison of aqueous solubility estimation for AQUAFAC and GSE. Int. J.. Pharm., 2008, 360, 122-147.
3. Box, K.J.; Comer, J.E.A. Using measured pKa, logP and solubility to investigate supersaturation and predict BCS class. Curr. Drug Metabol., 2008, 9, 869-878.
4. Biobyte Corp. ClogP for windows. 1995-1999; 4.0.
5. Hansch, C.; Quinlan, J. E.; Lawrence, G. L. The linear free-energy relationship between partition coefficients and the aqueous solubility of organic liquids. J. Org. Chem., 1968, 33(1), 347-350.