Identification of herpes simplex virus type 1 proteins encoded within the first 1.5 kb of the latency-associated transcript

Journal of NeuroVirology

Volumn 15, Issue 5-6, 2009, Pages 439-448

  Henderson, Gail ^a   Jaber, Tareq ^b   Carpenter, Dale ^c   Wechsler, Steven L ^c   Jones, Clinton ^a,b  

^a UNIVERSITY OF NEBRASKA LINCOLN   (United States)

^b UNIVERSITY OF NEBRASKA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Herpes simplex virus type 1; Latency associated transcript

Indexed keywords

IMMUNOGLOBULIN G; LATENCY ASSOCIATED PEPTIDE; VIRUS PROTEIN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; FEMALE; GENE SEQUENCE; GENETIC TRANSFECTION; HERPES SIMPLEX VIRUS 1; MOUSE; NONHUMAN; OPEN READING FRAME; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; TRIGEMINUS GANGLION; WILD TYPE;

ANIMALS; CELL LINE; DISEASE MODELS, ANIMAL; ENCEPHALITIS, HERPES SIMPLEX; FEMALE; HERPESVIRUS 1, HUMAN; MICE; MICRORNAS; NEURONS; OPEN READING FRAMES; TRANSCRIPTION, GENETIC; TRANSFECTION; TRIGEMINAL GANGLION; VIRAL PROTEINS; VIRUS LATENCY;

ANIMALIA; HUMAN HERPESVIRUS 1; MUS;

EID: 77649141856     PISSN: 13550284     EISSN: None     Source Type: Journal    
DOI: 10.3109/13550280903296353     Document Type: Article

References (56)

1. Ahmed M, Lock M, Miller CG, Fraser NW (2002). Regions of the herpes simplex virus type 1 latency-associated transcript that protect cells from apoptosis in vitro and protect neuronal cells in vivo. J Virol 76: 717-729.
2. Batchelor AH, O'Hare P (1990). Regulation and cell-type-specific activity of a promoter located upstream of the latency-associated transcript of herpes simplex virus type 1. J Virol 64: 3269-3279.
3. Branco FJ, Fraser NW (2005). Herpes simplex virus type 1 latency-associated transcript expression protects trigeminal ganglion neurons from apoptosis. J Virol 79: 9019-9025.
4. Carpenter D, Henderson G, Hsiang C, Osorio N, BenMohamed L, Jones C, Wechsler SL (2008). Introducing point mutations into the ATGs of the putative open reading frame of the HSV-1 gene encoding the latency associated transcript (LAT) reduces its anti-apoptotis activity. Microb Pathogen 44: 98-102.
5. Carpenter D, Hsiang C, Jin L, Osorio N, BenMohamed L, Jones C, Wechsler SL (2007). Stable cell lines expressing high levels of the herpes simplex virus type 1 LAT are refractory to caspase 3 activation and DNA laddering following cold shock induced apoptosis. Virology 369: 12-18.
6. Chen X, Schmidt MC, Goins WF, Glorioso JC (1995). Two herpes simplex virus type 1 latency-active promoters differ in their contributions to latency-associated transcript expression during lytic and latent infections. J Virol 69: 7899-7908.
7. Croen KD, Ostrove JM, Dragovic LJ, Smialek JE, Straus SE (1987). Latent herpes simplex virus in human trigeminal ganglia. Detection of an immediate early gene "anti-sense" transcript by in situ hybridization. N Engl J Med 317: 1427-1432.
8. Deatly AM, Spivack JG, Lavi E, O'Boyle DR, Fraser NW (1988). Latent herpes simplex virus type 1 transcripts in peripheral and central nervous system tissues of mice map to similar regions of the viral genome. J Virol 62: 749-756.
9. Deatly AM, Spivack JG, Lavi E, Fraser NW (1987). RNA from an immediate early region of the type 1 herpes simplex virus genome is present in the trigeminal ganglia of latently infected mice. Proc Natl Acad Sci USA 84: 3204-3208.
10. Doerig C, Pizer LI, Wilcox CL (1991). An antigen encoded by the latency-associated transcript in neuronal cell cultures latently infected with herpes simplex virus type 1. J Virol 65: 2724-2727.
11. Drolet BS, Perng G-C, Cohen J, Slanina SM, Yukht A, Nesburn AB, Wechsler SL (1998). The region of the herpes simplex virus type 1 LAT gene involved in spontaneous reactivation does not encode a functional protein. Virology 242: 221-232.
12. Goins WF, Sternberg LR, Croen KD, Krause PR, Hendricks RL, Fink DJ, Straus SE, Levine M, Glorioso JC (1994). A novel latency-active promoter is contained within the herpes simplex virus type 1 UL flanking repeats. J Virol 68: 2239-2252.
13. Henderson G, Peng W, Jin L, Perng G-C, Nesburn AB, Wechsler SL, Jones C (2002). Regulation of caspase 8- and caspase 9-induced apoptosis by the herpes simplex virus latency-associated transcript. J NeuroVirol 8: 103-111.
14. Inman M, Perng G-C, Henderson G, Ghiasi H, Nesburn AB, Wechsler SL, Jones C (2001). Region of herpes simplex virus type 1 latency-associated transcript sufficient for wild-type spontaneous reactivation promotes cell survival in tissue culture. J Virol 75: 3636-3646.
15. Jin L, Carpenter D, Moerdyk-Schauwecker M, Vanarsdall AL, Osorio N, Hsiang C, Jones C, Wechsler SL (2008). Cellular FLIP can substitute for the herpes simplex virus type 1 LAT gene to support a wild type virus reactivation phenotype in mice. J NeuroVirol 14: 389-400.
16. Jin L, Peng W, Perng G-C, Nesburn AB, Jones C, Wechsler SL (2003). Identification of herpes simplex virus type 1 (HSV-1) latency associated transcript (LAT) sequences that both inhibit apoptosis and enhance the spontaneous reactivation phenotype. J Virol 77: 6556-6561.
17. Jin L, Perng G-C, Brick DJ, Naito J, Nesburn AB, Jones C, Wechsler SL (2004). Methods for detecting the HSV-1 LAT anti-apoptosis activity in virus infected tissue culture cells. J Virol Meth 118: 9-13.
18. Jin L, Perng G-C, Nesburn AB, Jones C, Wechsler SL (2005). The baculovirus inhibitor of apoptosis gene (cpIAP) can restore reactivation of latency to a herpes simplex virus type 1 that does not express the latency associated transcript (LAT). J Virol: 12286-12295.
19. Jones C (1998). Alphaherpesvirus latency: its role in disease and survival of the virus in nature. Adv Virus Res 51: 81-133.
20. Jones C (2003). Herpes simplex virus type 1 and bovine herpesvirus 1 latency. Clin Micro Rev 16: 79-95.
21. Jones C, Inman M, Peng W, Henderson G, Doster A, Perng G-C, Kaenjak Angeletti A (2005). The herpes simplex virus type 1 (HSV-1) locus that encodes the latency-associated transcript (LAT) enhances the frequency of encephalitis in male Balb/C mice. J Virol 79: 14465-14469.
22. Kang W, Mukerjee R, Fraser NF (2003). Establishement and maintenance of HSV latent infection is mediated through correct splicing of the LAT primary transcript. Virology 312: 233-244.
23. Krause PR, Croen KD, Straus SE, Ostrove JM (1988). Detection and preliminary characterization of herpes simplex virus type 1 transcripts in latently infected human trigeminal ganglia. J Virol 62: 4819-4823.
24. Lagunoff M, Roizman B (1994). Expression of a herpes simplex virus 1 open reading frame antisense to the gamma(1)34.5 gene and transcribed by an RNA 3' coterminal with the unspliced latency-associated transcript. J Virol 68: 6021-6028.
25. Lock M, Miller C, Fraser NW (2001). Analysis of protein expression from within the region encoding the 2.0- kilobase latency-associated transcript of herpes simplex virus type 1. J Virol 75: 3413-3426.
26. Lokensgard JR, Berthomme H, Feldman LT (1997). The latency-associated promoter of herpes simplex virus type 1 requires a region downstream of the transcription start site for long-term expression during latency. J Virol 71: 6714-6719.
27. Mador N, Panet A, Latchman D, Steiner I (1995). Expression and splicing of the latency-associated transcripts of herpes simplex virus type 1 in neuronal and non-neuronal cell lines. J Biochem (Tokyo) 117: 1288-1297.
28. Mitchell WJ, Lirette RP, Fraser NW (1990). Mapping of low abundance latency-associated RNA in the trigeminal ganglia of mice latently infected with herpes simplex virus type 1. J Gen Virol 71: 125-132.
29. Mott K, Osorio N, Jin L, Brick D, Naito J, Cooper J, Henderson G, Inman M, Jones C, Wechsler SL, Perng G-C (2003). The bovine herpesvirus 1 LR ORF2 is crucial for this gene's ability to restore the high reactivation phenotype to a Herpes simplex virus-1 LAT null mutant. J Gen Virol 84: 2975-2985.
30. Nahmias AJ, Roizman B (1973). Infection with herpes-simplex viruses 1 and 2. 3. N Engl J Med 289: 781-789.
31. Peng W, Henderson G, Perng G-C, Nesburn AB, Wechsler SL, Jones C (2003). The gene that encodes the herpes simplex virus type 1 latency-associated transcript influences the accumulation of transcripts (Bcl-xL and Bcl-xS) that encode apoptotic regulatory proteins. J Virol 77: 10714-10718.
32. Peng W, Inman M, Henderson G, Wechsler SL, Ben Mohamed L, Perng G-C, Jones C (2005). The locus encompassing the latency-associated transcript (LAT) of herpes simplex virus type 1 interferes with and delays interferon expression in productively infected neuroblastoma cells and trigeminal ganglia of acutely infected mice. J Virol 79: 6162-6171.
33. Perez S, Lovato L, Zhou J, Doster A, Jones C (2006). Comparison of inflammatory infiltrates in trigeminal ganglia of cattle infected with wild type BHV-1 versus a virus strain containing a mutaition in the LR (latency-related) gene. J NeuroVirol 12: 392-397.
34. Perez S, Meyer F, Henderson G, Jiang Y, Sherman S, Doster A, Inman M, Jones C (2007). A protein encoded by the bovine herpesvirus 1 ORF E gene induces neurite-like morphological changes in mouse neuroblastoma cells and is expressed in trigeminal ganglionic neurons. J NeuroVirol 13: 139-149.
35. Perng G-C, Chokephaibulkit K, Thompson RL, Sawtell NM, Slanina SM, Ghiasi H, Nesburn AB, Wechsler SL (1996b). The region of the herpes simplex virus type 1 LAT gene that is colinear with the ICP34.5 gene is not involved in spontaneous reactivation. J Virol 70: 282-291. (Pubitemid 126508796)
36. Perng G-C, Dunkel EC, Geary PA, Slanina SM, Ghiasi H, Kaiwar R, Nesburn AB, Wechsler SL (1994a). The latency-associated transcript gene of herpes simplex virus type 1 (HSV-1) is required for efficient in vivo spontaneous reactivation of HSV-1 from latency. J Virol 68: 8045-8055.
37. Perng G-C, Esmail D, Slanina S, Yukht A, Ghiasi H, Osorio N, Mott KR, Maguen B, Jin L, Nesburn AB, Wechsler SL (2001). Three herpes simplex virus type 1 latency-associated transcipt mutants with distinct and assy-metric effects on virulence in mice compared with rabbits. J Virol 75: 9018-9028.
38. Perng G-C, Ghiasi H, Slanina SM, Nesburn AB, Wechsler SL (1996a). The spontaneous reactivation function of the herpes simplex virus type 1 LAT gene resides completely within the first 1.5 kilobases of the 8.3-kilobase primary transcript. J Virol 70: 976-984.
39. Perng G-C, Jones C, Ciacci-Zanella J, Stone M, Henderson G, Yukht A, Slanina SM, Hoffman FM, Ghiasi H, Nesburn AB, Wechsler SL (2000). Virus-induced neu-ronal apoptosis blocked by the herpes simplex virus latency-associated transcript (LAT). Science 287: 1500-1503.
40. Perng G-C, Maguen B, Jin L, Mott KR, Osorio N, Slanina SM, Yukht A, Ghiasi H, Nesburn AB, Inman M, Henderson G, Jones C, Wechsler SL (2002). A gene capable of blocking apoptosis can substitute for the herpes simplex virus type 1 latency-associated transcript gene and restore wild-type reactivation levels. J Virol 76: 1224-1235.
41. Perng G-C, Slanina SM, Ghiasi H, Nesburn AB, Wechsler SL (1996c). A 371-nucleotide region between the herpes simplex virus type 1 (HSV-1) LAT promoter and the 2-kilobase LAT is not essential for efficient spontaneous reactivation of latent HSV-1. J Virol 70: 2014-2018.
42. Perng G-C, Slanina SM, Yukht A, Drolet BS, Keleher W, Ghiasi H, Nesburn AB, Wechsler SL (1999). A herpes simplex virus type 1 latency-associated transcript mutant with increased virulence and reduced spontaneous reactivation. J Virol 73: 920-929.
43. Randall G, Lagunoff M, Roizman B (1997). The product of ORF O located within the domain of herpes simplex virus 1 genome transcribed during latent infection binds to and inhibits in vitro binding of infected cell protein 4 to its cognate DNA site. Proc Natl Acad Sci U S A 94: 10379-10384.
44. Rock DL, Nesburn AB, Ghiasi H, Ong J, Lewis TL, Lokensgard JR, Wechsler SL (1987). Detection of latency-related viral RNAs in trigeminal ganglia of rabbits latently infected with herpes simplex virus type 1. J Virol 61: 3820-3826.
45. Sawtell NM (1997). Comprehensive quantification of herpes simplex virus latency at the single-cell level. J Virol 71: 5423-5431.
46. Stevens JG, Wagner EK, Devi-Rao GB, Cook ML, Feldman LT (1987). RNA complementary to a herpesvirus alpha gene mRNA is prominent in latently infected neurons. Science 235: 1056-1059.
47. Thomas SK, Gough G, Latchman DS, Coffin RS (1999). Herpes simplex virus latency-associated transcript encodes a protein which greatly enhances virus growth, can compensate for deficiencies in immediate-early gene expression, is likely to function during reactivation from virus latency. J Virol 73: 6618-6625.
48. Thomas SK, Lilley CE, Latchman DS, Coffin RS (2002). A Protein Encoded by the Herpes Simplex Virus (HSV) Type 1 2-Kilobase Latency-associated transcript is phosphorylated, localized to the nucleus, and overcomes the repression of expression from exogenous promoters when inserted into the quiescent HSV genome. J Virol 76: 4056-4067.
49. Wagner EK, Bloom DC (1997). Experimental investigation of herpes simplex virus latency. Clin Microbiol Rev 10: 419-443.
50. Wagner EK, Devi-Rao G, Feldman LT, Dobson AT, Zhang YF, Flanagan WM, Stevens JG (1988a). Physical characterization of the herpes simplex virus latency-associated transcript in neurons. J Virol 62: 1194-1202. (Pubitemid 18082932)
51. Wagner EK, Flanagan WM, Devi-Rao G, Zhang YF, Hill JM, Anderson KP, Stevens JG (1988b). The herpes simplex virus latency-associated transcript is spliced during the latent phase of infection. J Virol 62: 4577-4585. (Pubitemid 19006120)
52. Whitley R (1997). Herpes simplex virus. Philadelphia, New York: Lippincott-Raven Publishers.
53. Winkler MTC, Doster A, Jones C (2000a). Persistence and reactivation of bovine herpesvirus 1 in the tonsil of latently infected calves. J Virol 74: 5337-5346.
54. Winkler MT, Doster A, Sur JH, Jones C (2002). Analysis of bovine trigeminal ganglia following infection with bovine herpesvirus 1. Vet Microbiol 86: 139-155.
55. Winkler MT, Schang LS, Doster A, Holt T, Jones C (2000b). Analysis of cyclins in trigeminal ganglia of calves infected with bovine herpesvirus-1. J Gen Virol 81: 2993-2998.
56. Zwaagstra JC, Ghiasi H, Slanina SM, Nesburn AB, Wheatley SC, Lillycrop K, Wood J, Latchman DS, Patel K, Wechsler SL (1990). Activity of herpes simplex virus type 1 latency-associated transcript (LAT) promoter in neuron-derived cells: evidence for neuron specificity and for a large LAT transcript. J Virol 64: 5019-5028