Calcinosis cutis: A rare reaction to subcutaneous injections of calcium-containing heparin in patients with renal failure

American Journal of Dermatopathology

Volumn 32, Issue 1, 2010, Pages 52-55

  Boccara, Olivia ^a   Prost Squarcioni, Catherine ^b   Battistella, Maxime ^a   Brousse, Nicole ^a   Rongioletti, Franco ^c   Fraitag, Sylvie ^a  

^a HÔPITAL NECKER ENFANTS MALADES   (France)

^b AVICENNE HOSPITAL   (France)

^c UNIVERSITY OF GENOA   (Italy)

Author keywords

Calcinosis; Calcium containing heparin; Calcium phosphate product; Renal failure

Indexed keywords

ANTIBIOTIC AGENT; CALCIUM; HEPARIN; NADROPARIN;

ADULT; AGED; ARTICLE; CASE REPORT; DEEP VEIN THROMBOSIS; ELECTRON MICROSCOPY; ERYTHEMA; FEMALE; HEMODIALYSIS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; KIDNEY FAILURE; MALE; NONHODGKIN LYMPHOMA; PRIORITY JOURNAL; SKIN BIOPSY; SKIN CALCIFICATION; SKIN TUBERCULOSIS;

ADULT; AGED; AIDS-ASSOCIATED NEPHROPATHY; AIDS-RELATED OPPORTUNISTIC INFECTIONS; ANTICOAGULANTS; CALCIPHYLAXIS; CALCIUM; FEMALE; HEPARIN; HUMANS; INJECTIONS, SUBCUTANEOUS; KIDNEY FAILURE; LYMPHOMA, NON-HODGKIN; MALE; PHOSPHATES; SKIN; SKIN DISEASES; TUBERCULOSIS; WITHHOLDING TREATMENT;

EID: 77649121557     PISSN: 01931091     EISSN: None     Source Type: Journal    
DOI: 10.1097/DAD.0b013e3181aec116     Document Type: Article

References (13)

1. Van Haren FMP, Ruiter DJ, Hilbrands LB. Nadroparin-induced calcinosis cutis in renal transplant recipients. Nephron. 2001;87:2792282.
2. Giorgini S, Martinelli C, Massi D, et al. Iatrogenic calcinosis cutis following nadroparin injection. Int J Dermatol. 2005;44:8552857.
3. Tumiati B, Azzarito C, Scocco G, et al. Subcutaneous calcifications: an uncommon side effect of calcium heparin. Medicina (Firenze). 1988;8: 3222323.
4. Eich D, Scharffeter-Kochanek K,Weihrauch J, et al. Calcinosis of the cutis and subcutis: an unusual nonimmunologic adverse reaction to subcutaneous injections of low-molecular-weight calcium-containing heparins. J Am Acad Dermatol. 2004;50:2102214.
5. Wanic-Kossowska M, Koziol L, Roszkowiak B, et al. Calcified subcutaneous nodules in patients with chronic renal failure as a result of injections with nadroparin (fraxiparine). Pol Arch Med Wewn. 1998;99: 4142416.
6. Fartasch M, Haneke E, Hornstein OP. Mineralization of collagen and elastic fibers in superficial dystrophic cutaneous calcification: an ultrastructural study. Dermatologica. 1990;181:1872192.
7. Janigan DT, Hirsch DJ, Klassen GA, et al. Calcified subcutaneous arterioles with infarcts of the subcutis and skin (''calciphylaxis'') in chronic renal failure. Am J Kidney Dis. 2000;35:5882597.
8. Essary LR, Wick MR. Cutaneous calciphylaxis, an underrecognized clinicopathological entity. Am J Clin Pathol. 2000;113:2802287.
9. Tan O, Atik B, Kizilkaya A, et al. Extensive skin calcifications in an infant with chronic renal failure: metastatic calcinosis cutis. Pediatr Dermatol. 2006;23:2352238.
10. Moss J, Syrengelas A, Antaya R, et al. Calcinosis cutis: a complication of intravenous administration of calcium gluconate. J Cutan Pathol. 2006; 33:60262.
11. Kagen MH, Bansal MG, Grossman M. Calcinosis cutis following the administration of intravenous calcium therapy. Cutis. 2000;65:1932194.
12. Touart DM, Sau P. Cutaneous deposition diseases. Part II. J Am Acad Dermatol. 1998;39:5272544.
13. Campanelli A, Kaya G, Masouyé I, et al. Calcifying panniculitis following subcutaneous injections of nadroparin-calcium in a patient with osteomalacia. Br J Dermatol. 2005;153:6572660