The effect of mechanical loads in the differentiation of precursor cells into mature cells

Annals of the New York Academy of Sciences

Volumn 1188, Issue , 2010, Pages 25-31

  Shav, Dalit ^a   Einav, Shmuel ^b  

^a TEL AVIV UNIVERSITY   (Israel)

^b STONY BROOK UNIVERSITY   (United States)

Author keywords

Differentiation; Extra cellular matrix; Matrix stiffness; Mechanical loading; Morphogenesis; Precursor cells; Stem cells

Indexed keywords

BIOMATERIAL; CYTOKINE; GROWTH FACTOR;

CELL DIFFERENTIATION; CELL THERAPY; CONFERENCE PAPER; IN VITRO STUDY; IN VIVO STUDY; REGENERATIVE MEDICINE; STEM CELL;

EID: 77649112701     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2009.05079.x     Document Type: Conference Paper

References (12)

1. Alenghat, F.J. & D.E. Ingber. 2002. Mechanotransduction: all signals point to cytoskeleton, matrix, and integras. Sci. STKE 119: PE6.
2. Patwari, P. & R. T. Lee. 2008. Mechanical control of tissue morphogenesis. Circ. Res. 103: 234-243.
3. Engler, A.J., H.L. Sweeney, D.E. Discher & J.E. Schwarzbauer. 2007. Extracellular matrix elasticity directs stem cell differentiation. J. Musculoskelet. Neuronal. Interact. 7: 335.
4. Robling, A.G., A.B. Castillo & C.H. Turner. 2006. Biomechanical and molecular regulation of bone remodeling. Annu. Rev. Biomed. Eng. 8: 455-498. (Pubitemid 44314825) (Pubitemid 44314825)
5. Rehfeldt, F., A.J. Engler, A. Eckhardt, et al. 2007. Cell responses to the mechanochemical microenvironment: implications for regenerative medicine and drug delivery. Adv. Drug Deliv. Rev. 59: 1329-1339. (Pubitemid 350088256)
6. Wells, R.G. & D.E. Discher. 2008. Matrix elasticity, cytoskeletal tension, and TGF-beta: the insoluble and soluble meet. Sci. Signal. 1: pe 13.
7. Davies, P.F. 1995. Flow-mediated endothelial mechanotransduction. Physiol. Rev. 75: 519-560.
8. Chai, C & K.W. Leong. 2007. Biomaterials approach to expand and direct differentiation of stem cells. Mol. Ther. 15: 467-1180 (Pubitemid 46306589) (Pubitemid 46306589)
9. Brown, T.D. 2000. Techniques for mechanical stimulation of cells in vitro: a review. J. Biomech. 33: 3-14.
10. Rubin, J., T. Murphy, M.S. Nanes & X. Fan. 2000. Mechanical strain inhibits expression of osteoclast differentiation factor by murine stromal cells. Am. J. Physiol. Cell Physiol. 278: Cl 126-C1132. (Pubitemid 30432396)
11. Turner, C.H., I. Owan, T. Alvey, et al. 1998. Recruitment and proliferative responses of osteoblasts after mechanical loading in vivo determined using sustained-release bromodeoxyuridine. Bone 11: 463-469.
12. Park, J.S., N.F. Huang, K.T. Kurpinski, et al. 2007. Mechanobiology of mesenchymal stem cells and their use in cardiovascular repair. Front. Biosci. 12: 5098-5116.