Nongenomic inhibition of coronary constriction by 17β-estradiol, 2-hydroxyestradiol, and 2-methoxyestradiol

Canadian Journal of Physiology and Pharmacology

Volumn 88, Issue 2, 2010, Pages 147-152

  Hill, Brent J F ^a   Gebre, Senetibeb ^a   Schlicker, Bonnie ^a   Jordan, Renée ^a   Necessary, Sean ^a  

^a UNIVERSITY OF CENTRAL ARKANSAS   (United States)

Author keywords

17 estradiol; 2 hydroxyestradiol; 2 methoxyestradiol; Acetylcholine; Artery; Calcium; Coronary; Endothelin 1

Indexed keywords

2 HYDROXYESTRADIOL; 2 METHOXYESTRADIOL; CYCLOHEXIMIDE; ENDOTHELIN 1; ESTRADIOL; FULVESTRANT; POTASSIUM CHLORIDE; TAMOXIFEN;

ANIMAL TISSUE; CONFERENCE PAPER; CORONARY ARTERY CONSTRICTION; FEMALE; NONHUMAN; PRIORITY JOURNAL; SOW (SWINE);

ANIMALS; CALCIUM; CARDIOTONIC AGENTS; CORONARY VESSELS; DRUG THERAPY, COMBINATION; ENDOTHELIUM, VASCULAR; ESTRADIOL; EXTRACELLULAR FLUID; FEMALE; GENOME; ORGAN CULTURE TECHNIQUES; SWINE; VASOCONSTRICTION; VASODILATION;

EID: 77649088421     PISSN: 00084212     EISSN: None     Source Type: Journal    
DOI: 10.1139/Y09-120     Document Type: Conference Paper

References (28)

1. 2+ and contractile responses of coronary arteries to endothelin. J. Appl. Physiol. 78(3): 1079-1087. PMID: 7775301.
2. 2+ entry mechanisms of coronary vasoconstriction. Arterioscler. Thromb. Vasc. Biol. 19(4): 1034-1040. PMID:10195933.
3. Dubey, R.K., Jackson, E.K., Keller, P.J., Imthurn, B., and Rosselli, M. 2001. Estradiol metabolites inhibit endothelin synthesis by an estrogen receptor-independent mechanism. Hypertension. 37(2 Part 2): 640-644.
4. Dubey, R.K., Tofovic, S.P., and Jackson, E.K. 2004. Cardiovascular pharmacology of estradiol metabolites. J. Pharmacol. Exp. Ther. 308(2): 403-409. doi:10.1124/jpet.103.058057. PMID: 14657266.
5. Gui, Y., and Zheng, X.L. 2006. 2-Methoxyestradiol induces cell cycle arrest and mitotic cell apoptosis in human vascular smooth muscle cells. Hypertension, 47(2): 271-280. doi:10.1161/01. HYP.0000199656.99448.dc.
6. 2+ release induced by thromboxane A2 in porcine coronary artery. Circulation, 91(10): 2619-2626. PMID:7743625.
7. Haynes, M.P., Li, L., Russell, K.S., and Bender, J.R. 2002. Rapid vascular cell responses to estrogen and membrane receptors. Vascul. Pharmacol. 38(2): 99-108. doi:10.1016/S0306-3623(02) 00133-7. PMID:12379956.
8. Hill, B.J.F., and Rusch, N.J. 2008. An estrogen-induced decrease in voltage-gated calcium channel expression attenuates coronary artery contractility. FASEB J. 22: 1152.12. [Abstr.]
9. Hill, B.J.F., Katwa, L.C., Wamhoff, B.R., and Sturek, M. 2000. Enhanced endothelin(A) receptor-mediated calcium mobilization and contraction in organ cultured porcine coronary arteries. J. Pharmacol. Exp. Ther. 295(2): 484-491. PMID:11046079.
10. James, J., Murry, D.J., Treston, A.M., Storniolo, A.M., Sledge, G.W., Sidor, C., and Miller, K.D. 2007. Phase I safety, pharmacokinetic and pharmacodynamic studies of 2-methoxyestradiol alone or in combination with docetaxel in patients with locally recurrent or metastatic breast cancer. Invest. New Drugs, 25(1): 41-48. doi:10.1007/s10637-006-9008-5. PMID:16969706.
11. Kawano, H., and Ogawa, H. 2005. Endothelial function and coronary spastic angina. Intern. Med. 44(2): 91-99. doi:10.2169/ internalmedicine.44.91. PMID:15750267.
12. Kitazawa, T., Hamada, E., Kitazawa, K., and Gaznabi, A.K. 1997. Non-genomic mechanism of 17b-oestradiol-induced inhibition of contraction in mammalian vascular smooth muscle. J. Physiol. 499(Pt 2): 497-511. PMID:9080377.
13. Mendelsohn, M.E. 2002. Genomic and nongenomic effects of estrogen in the vasculature. Am. J. Cardiol. 90(1A): 3F-6F. doi:10.1016/S0002-9149(02) 02418-9. PMID:12106632.
14. Nadal, A., Ropero, A.B., Laribi, O., Maillet, M., Fuentes, E., and Soria, B. 2000. Nongenomic actions of estrogens and xenoestrogens by binding at a plasma membrane receptor unrelated to estrogen receptor a and estrogen receptor b. Proc. Natl. Acad. Sci. U.S.A. 97(21): 11603-11608. doi:10.1073/pnas.97.21.11603. PMID:11027358.
15. Nishigaki, I., Sasaguri, Y., and Yagi, K. 1995. Anti-proliferative effect of 2-methoxyestradiol on cultured smooth muscle cells from rabbit aorta. Atherosclerosis, 113(2): 167-170. doi:10.1016/ 0021-9150(94)05442-L. PMID:7605355.
16. Orshal, J.M., and Khalil, R.A. 2004. Gender, sex hormones, and vascular tone. Am. J. Physiol. Regul. Integr. Comp. Physiol. 286(2): R233-R249. PMID:14707008.
17. Quignard, J.F., Frapier, J.M., Harricane, M.C., Albat, B., Nargeot, J., and Richard, S. 1997. Voltage-gated calcium channel currents in human coronary myocytes. Regulation by cyclic GMP and nitric oxide. J. Clin. Invest. 99(2): 185-193. doi:10.1172/ JCI119146. PMID:9005986.
18. Rajkumar, S.V., Richardson, P.G., Lacy, M.Q., Dispenzieri, A., Greipp, P.R., Witzig, T.E., et al. 2007. Novel therapy with 2-methoxyestradiol for the treatment of relapsed and plateau phase multiple myeloma. Clin. Cancer Res. 13(20): 6162-6167. doi:10.1158/1078-0432.CCR-07-0807. PMID:17947482.
19. Rosano, G.M., Caixeta, A.M., Chierchia, S., Arie, S., Lopez-Hidalgo, M., Pereira, W.I., et al. 1997. Short-term anti-ischemic effect of 17β-estradiol in postmenopausal women with coronary artery disease. Circulation, 96(9): 2837-2841. PMID:9386146.
20. Salom, J.B., Burguete, M.C., Pérez-Asensio, F.J., Centeno, J.M., Torregrosa, G., and Alborch, E. 2002. Acute relaxant effects of 17-b-estradiol through non-genomic mechanisms in rabbit carotid artery. Steroids, 67(5): 339-346. doi:10.1016/S0039-128X(01)00185-4. PMID:11958789.
21. Sudhir, K., Ko, E., Zellner, C., Wong, H.E., Hutchison, S.J., Chou, T.M., and Chatterjee, K. 1997. Physiological concentrations of estradiol attenuate endothelin 1-induced coronary vasoconstriction in vivo. Circulation, 96(10): 3626-3632. PMID:9396464.
22. Tanz, R.D., and Nayler, W.G. 1991. Concentration-dependent desensitization of isolated porcine coronary arterial segments to acetylcholine. Arch. Int. Pharmacodyn. Ther. 312: 110-125. PMID:1663335.
23. Teoh, H., and Man, R.Y. 2000. Enhanced relaxation of porcine coronary arteries after acute exposure to a physiological level of 17β-estradiol involves non-genomic mechanisms and the cyclic AMP cascade. Br. J. Pharmacol. 129(8): 1739-1747. doi:10. 1038/sj.bjp.0703252. PMID:10780981.
24. Teoh, H., Leung, S.W., and Man, R.Y. 1999. Short-term exposure to physiological levels of 17β-estradiol enhances endotheliumindependent relaxation in porcine coronary artery. Cardiovasc. Res. 42(1): 224-231. doi:10.1016/S0008-6363(98)00265-X. PMID:10435014.
25. Teoh, H., Quan, A., Leung, S.W., and Man, R.Y. 2000a. Differential effects of 17β-estradiol and testosterone on the contractile responses of porcine coronary arteries. Br. J. Pharmacol. 129(7): 1301-1308. doi:10.1038/sj.bjp.0703164. PMID: 10742284.
26. Teoh, H., Quan, A., and Man, R.Y. 2000b. Acute impairment of relaxation by low levels of testosterone in porcine coronary arteries. Cardiovasc. Res. 45(4): 1010-1018. doi:10.1016/S0008-6363(99)00398-3. PMID:10728427.
27. 2+-entry to M3-receptor-mediated contraction of porcine coronary smooth muscle. Cell Calcium, 38(5): 457-467. doi:10.1016/j.ceca.2005.06.035. PMID:16099040.
28. Yan, J., Chen, C., Lei, J., Yang, L., Wang, K., Liu, J., and Zhou, C. 2006. 2-Methoxyestradiol reduces cerebral vasospasm after 48 hours of experimental subarachnoid hemorrhage in rats. Exp. Neurol. 202(2): 348-356. doi:10.1016/j.expneurol.2006.06.009. PMID:16904108.