Role of High-Dose Chemotherapy (HDCT) in treatment of Atypical Teratoid/Rhabdoid Tumors (AT/RTs)

Pediatric Blood and Cancer

Volumn 54, Issue 4, 2010, Pages 647-648

  Garrè, Maria Luisa ^a   Tekautz, Tanya ^b  

^a G GASLINI INSTITUTE   (Italy)

^b LERNER RESEARCH INSTITUTE   (United States)

Author keywords

AT RT; CNS; High dose chemotherapy

Indexed keywords

CARBOPLATIN; CYCLOPHOSPHAMIDE; ETOPOSIDE; IFOSFAMIDE; MELPHALAN; THIOTEPA;

AUTOLOGOUS STEM CELL TRANSPLANTATION; BLOOD BRAIN BARRIER; BRAIN RADIATION; CANCER COMBINATION CHEMOTHERAPY; CANCER SURVIVAL; CENTRAL NERVOUS SYSTEM TUMOR; CHILD; CHILDHOOD CANCER; DRUG DOSE INCREASE; DRUG MEGADOSE; HUMAN; MEDULLOBLASTOMA; MULTIPLE CYCLE TREATMENT; OVERALL SURVIVAL; PRIORITY JOURNAL; PROGRESSION FREE SURVIVAL; REVIEW; RHABDOID TUMOR; TERATOMA;

ANTINEOPLASTIC AGENTS; CENTRAL NERVOUS SYSTEM NEOPLASMS; CLINICAL TRIALS AS TOPIC; HUMANS; INFANT; INFANT, NEWBORN; RHABDOID TUMOR; TERATOMA;

EID: 77649085085     PISSN: 15455009     EISSN: 15455017     Source Type: Journal    
DOI: 10.1002/pbc.22377     Document Type: Review

References (18)

1. Judkins AR, Eberhart OG, Wesseling P. Atypical teratoid/rhabdoid tumour. In: Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, editors. WHO Classification of Tumours, Volume 1: Classification of Tumours of the central nervous system, 4th edition. Lyon: IARC; 2007. pp 147-149.
2. Rorke LB, Packer R, Biegel J. Central nervous system atypical teratoid/rhabdoid tumors of infancy and childhood. J Neurooncol 1995;24:21-28.
3. Bourdeaut F, Fréneaux P, Thuille B, et al. hSF5/INI1-deficient tumours and rhabdoid tumours are convergent but not fully overlapping entities. J Pathol 2007;211:323-330.
4. Biegel JA, Fan LT, Zhang F, et al. Alterations of the hSNF5/INI1 gene in central nervous system atypical teratoid rhabdoid tumors and renal and extrarenal rhabdoid tumors. Clin Cancer Res 2002;8: 3461-3467.
5. Burger PC, Yu IT, Tihan T, et al. Atypical teratoid/rhabdoid tumor of the central nervous system: A highly malignant tumor of infancy and childhood frequentlymistaken formedulloblastoma.APediatric Oncology Group Study. Am J Surg Pathol 1998;22:1083-1092.
6. Hilden JM, Watterson J, Longee DC, et al. Central nervous system atypical teratoid/rhabdoid tumor: Response to intensive therapy and review of the literature. J Neurooncol 1998;40:265-275.
7. Ronghe MD, Moss TH, Lowis SP. Treatment of CNS malignant rhabdoid tumors. Pediatr Blood Cancer 2004;42:254-260.
8. Hilden JM, Meerbaum S, Burger P, et al. Central nervous system atypical teratoid/rhabdoid tumor: Results of therapy in children enrolled in a registry. J Clin Oncol 2004;22:2877-2884.
9. Peters O, Marienhagen J, Stadler P, et al. Combined mutimodality therapy for paediatric central nervous system (CNS) atypical teratoid/rhabdoid tumour (ATRT): An interim analysis of the German ATRT-CNS pilot study. 12th International Symposium on Paediatric Neuro-Oncology, Nara, 2006.
10. Czech T, Haberler C, Peryl A, et al. Atypical teratoid/rhabdoid tumour of the CNS - A retrospective analysis of outcome depending on initial diagnosis and treatment received in 12 consecutive patients. 12th International Symposium on Paediatric Neuro-Oncology, Nara, 2006.
11. Tekautz TM, Fuller CE, Blaney S, et al. Atypical teratoid/rhabdoid tumors (AT/RT): Improved survival in children 3 years of age and older with radiation therapy and high dose alkylators-based chemotherapy. J Clin Oncol 2005;23:1491-1499.
12. Tekautz T, Farrar M, Hilden J, et al. Atypical teratoid/rhabdoid tumor, therapy on infants and young children. Haematol Rep 2006; 2:13.
13. Garrè ML, Cama A, Milanaccio C, et al. New concepts in the treatment of brain tumours in very young children. Expert Rev Neurother 2006;6:489-500.
14. Dallorso S, Dini G, Ladenstein R, et al. Evolving role of myeloablative chemotherapy in the treatment of childhood brain tumours. Bone Marrow Transplant 2005;35:31-34.
15. Garrè ML, Dallorso S, Massimino M, et al. Atypical teratoid/ rhabdoid tumour of the central nervous system (CNS): Final results of the first Italian Cooperative Study for the very young children. Haematol Rep 2006;2:6.
16. Fidani P, De Ioris MA, Serra A, et al. A multimodal strategy based on surgery, radiotherapy, ICE regimen and high dose chemotherapy in atypical teratoid/rhabdoid tumours: A single institution experience. J Neurooncol 2009;92:177-183.
17. Smith ME, Cimica V, Chinni S, et al. Rhabdoid tumor growth is inhibited by flavoperidol. Clin Cancer Res 2008;14:523-532.
18. Alarcon-Vargas D, Zhang Z, Agarwal B, et al. Targeting cyclin D1, a downstream effector of INI1/hSNF5, in rhabdoid tumors. Oncogene 2006;25:722-734.