Bone marrow mesenchymal stem cells induce angiogenesis and promote bladder cancer growth in a rabbit model

Urologia Internationalis

Volumn 84, Issue 1, 2010, Pages 94-99

  Zhang, Keqin ^a   Shi, Benkang ^b   Chen, Jun ^b   Zhang, Dongqing ^b   Zhu, Yaofeng ^b   Zhou, Changkuo ^b   Zhao, Haifeng ^b   Jiang, Xianzhou ^b   Xu, Zhishun ^b  

^a SHANDONG UNIVERSITY   (China)

^b SHANDONG UNIVERSITY   (China)

Author keywords

Bladder cancer; Bone marrow mesenchymal cell; Vascular endothelial cell

Indexed keywords

4',6 DIAMIDINO 2 PHENYLINDOLE; CD146 ANTIGEN;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLADDER CANCER; BLADDER DISEASE; BLADDER MUCOSA; BLADDER MUCOSA SWELLING; BONE MARROW CELL; CANCER GROWTH; CELL ADHESION; CELL CULTURE; CELL DIFFERENTIATION; CELL ISOLATION; CELL TRANSPLANTATION; COMPARATIVE STUDY; CONTROL GROUP; CONTROLLED STUDY; CULTURE MEDIUM; DENSITY; DISEASE COURSE; ENDOTHELIUM CELL; ENGRAFTMENT; HEMATOPOIETIC STEM CELL; IMMUNOFLUORESCENCE; INJECTION; MALE; MESENCHYMAL STEM CELL; MICROENVIRONMENT; NEW ZEALAND; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RABBIT; TUMOR MODEL; ULTRASOUND; VASCULAR ENDOTHELIUM;

ANIMALS; ANTIGENS, CD146; BONE MARROW CELLS; BONE MARROW TRANSPLANTATION; CELL PROLIFERATION; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; ENDOTHELIAL CELLS; MALE; MESENCHYMAL STEM CELLS; MICROSCOPY, FLUORESCENCE; NEOPLASM TRANSPLANTATION; NEOVASCULARIZATION, PATHOLOGIC; RABBITS; URINARY BLADDER NEOPLASMS;

EID: 77649084118     PISSN: 00421138     EISSN: None     Source Type: Journal    
DOI: 10.1159/000273474     Document Type: Article

References (27)

1. Prockop DJ: Marrow stromal cells as stem cells for nonhematopoietic tissues. Science 1997; 276: 71-74.
2. Sordi V, Malosio ML, Marchesi F, Mercalli A, Melzi R, Giordano T, Belmonte N, Ferrari G, Leone BE, Bertuzzi F, Zerbini G, Allavena P, Bonifacio E, Piemonti L: Bone marrow mesenchymal stem cells express a restricted set of functionally active chemokine receptors capable of promoting migration to pancreatic islets. Blood 2005; 106: 419-427.
3. Klopp AH, Spaeth EL, Dembinski JL, Woodward WA, Munshi A, Meyn RE, Cox JD, Andreeff M, Marini FC: Tumor irradiation increases the recruitment of circulating mesenchymal stem cells into the tumor microenvironment. Cancer Res 2007; 67: 11687-11695.
4. Barry FP, Murphy JM: Mesenchymal stem cells: clinical applications and biological characterization. Int J Biochem Cell Biol 2004; 36: 568-584.
5. Barry FP: Biology and clinical applications of mesenchymal stem cells. Birth Defects Res C Embryo Today 2003; 69: 250-256.
6. Dvorak HF: Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing. N Engl J Med 1986; 315: 1650-1659.
7. Studeny M, Marini FC, Champlin RE, Zompetta C, Fidler IJ, Andreeff M: Bone marrowderived mesenchymal stem cells as vehicles for interferon-beta delivery into tumors. Cancer Res 2002; 62: 3603-3608.
8. Chen J, Xu ZS, Zhao HF, Dong DX: Distribution and differentiation of marrow mesenchymal cells in tumor tissue: experimental with rabbits (in Chinese). Zhonghua Yi Xue Za Zhi 2007; 87: 2361-2364.
9. Chen J, Xu ZS, Dong DX, Zhao HF: The foundation of rabbit bladder VX2 cancer model. Chinese J Exp Surg 2006; 23: 117.
10. Zhang N, Li J, Luo R, Jiang J, Wang JA: Bone marrow mesenchymal stem cells induce angiogenesis and attenuate the remodeling of diabetic cardiomyopathy. Exp Clin Endocrinol Diabetes 2008; 116: 104-111.
11. Wurmser AE, Nakashima K, Summers RG, Toni N, D'Amour KA, Lie DC, Gage FH: Cell fusion-independent differentiation of neural stem cells to the endothelial lineage. Nature 2004; 430: 350-356.
12. Mancuso P, Burlini A, Pruneri G, Goldhirsch A, Martinelli G, Bertolini F: Resting and activated endothelial cells are increased in the peripheral blood of cancer patients. Blood 2001; 97: 3658-3661.
13. Jiang Y, Jahagirdar BN, Reinhardt RL, Schwartz RE, Keene CD, Ortiz-Gonzalez XR, Reyes M, Lenvik T, Lund T, Blackstad M, Du J, Aldrich S, Lisberg A, Low WC, Largaespada DA, Verfaillie CM: Pluripotency of mesenchymal stem cells derived from adult marrow. Nature 2002; 418: 41-49.
14. Silva GV, Litovsky S, Assad JA, Sousa AL, Martin BJ, Vela D, Couter SC, Lin J, Ober J, Vaughn WK, Branco RV, Oliverira EM, He R, Geng YJ, Willerson JT, Perin EC: Mesenchymal stem cells differentiate into an endothelial phenotype, enhance vascular density, and improve heart function in a canine chronic ischemia model. Circulation 2005; 111: 150-156.
15. Sun B, Zhang S, Ni C, Zhang D, Liu Y, Zhang W, Zhao X, Zhao C, Shi M: Correlation between melanoma angiogenesis and the mesenchymal stem cells and endothelial progenitor cells derived from bone marrow. Stem Cells Dev 2005; 14: 292-298. (Pubitemid 40885253)
16. Salvesen HB, Akslen LA: Significance of tumour-associated macrophages, vascular endothelial growth factor and thrombospondin-1 expression for tumour angiogenesis and prognosis in endometrial carcinomas. Int J Cancer 1999; 84: 538-543.
17. Kerbel R, Folkman J: Clinical translation of angiogenesis inhibitors. Nat Rev Cancer 2002; 2: 727-739.
18. Semenza GL: Targeting HIF-1 for cancer therapy. Nat Rev Cancer 2003; 3: 721-732.
19. Oswald J, Boxberger S, Jorgensen B, Feldmann S, Ehninger G, Bornhauser M, Werner C: Mesenchymal stem cells can be differentiated into endothelial cells in vitro. Stem Cells 2004; 22: 377-384. (Pubitemid 38736621)
20. Rak J, Yu JL, Klement G, Kerbel RS: Oncogenes and angiogenesis: signaling three-dimensional tumor growth. J Investig Dermatol Symp Proc 2000; 5: 24-33.
21. Campagnoli C, Roberts IA, Kumar S, Bennett PR, Bellantuono I, Fisk NM: Identification of mesenchymal stem/progenitor cells in human first-trimester fetal blood, liver, and bone marrow. Blood 2001; 98: 2396-2402.
22. Igura K, Zhang X, Takahashi K, Mitsuru A, Yamaguchi S, Takashi TA: Isolation and characterization of mesenchymal progenitor cells from chorionic villi of human placenta. Cytotherapy 2004; 6: 543-553.
23. Nadri S, Soleimani M, Kiani J, Atashi A, Izadpanah R: Multipotent mesenchymal stem cells from adult human eye conjunctiva stromal cells. Differentiation 2008; 76: 223-231.
24. Tsai MS, Lee JL, Chang YJ, Hwang SM: Isolation of human multipotent mesenchymal stem cells from second-trimester amniotic fluid using a novel two-stage culture protocol. Hum Reprod 2004; 19: 1450-1456.
25. Studeny M, Marini FC, Dembinski JL, Zompetta C, Cabreira-Hansen M, Bekele BN, Champlin RE, Andreeff M: Mesenchymal stem cells: potential precursors for tumor stroma and targeted-delivery vehicles for anticancer agents. J Natl Cancer Inst 2004; 96: 1593-1603.
26. Nakamura K, Ito Y, Kawano Y, Kurozumi K, Kobune M, Tsuda H, Bizen A, Honmou O, Niitsu Y, Hamada H: Antitumor effect of genetically engineered mesenchymal stem cells in a rat glioma model. Gene Ther 2004; 11: 1155-1164.
27. Nakamizo A, Marini F, Amano T, Khan A, Studeny M, Gumin J, Chen J, Hentschel S, Vecil G, Dembinski J, Andreeff M, Lang FF: Human bone marrow-derived mesenchymal stem cells in the treatment of gliomas. Cancer Res 2005; 65: 3307-3318.