Antimicrobial activity of long-chain (E)-3-alken-2-ones

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 6, 2010, Pages 1819-1820

  Wood, William F ^a   Kubo, Aya ^a   Shaffer, Tony B ^a  

^a HUMBOLDT STATE UNIVERSITY   (United States)

Author keywords

(E) 3 Alken 2 ones; Antibacterial activity; Antifungal activity; Propionibacterium; Trichophyton

Indexed keywords

3 ALKEN 2 ONE; 3 HEPTADECEN 2 ONE; 3 TETRADECEN 2 ONE; ALCOHOL; UNCLASSIFIED DRUG;

ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL GROWTH; CONTROLLED STUDY; DEER; DRUG SCREENING; GROWTH INHIBITION; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PROPIONIBACTERIUM ACNES; TRICHOPHYTON MENTAGROPHYTES;

ALKENES; ANTI-INFECTIVE AGENTS; MICROBIAL SENSITIVITY TESTS; PROPIONIBACTERIUM ACNES; TRICHOPHYTON;

ARTHRODERMA BENHAMIAE; FUNGI; ODOCOILEUS HEMIONUS COLUMBIANUS; PROPIONIBACTERIUM; PROPIONIBACTERIUM ACNES; TRICHOPHYTON;

EID: 77549086560     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.02.016     Document Type: Article

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12. 2 and the ether was removed in vacuo. A sample of each compound was purified by preparative gas chromatography before antimicrobial analysis.
13. +, 3), 97(19), 84(8), 83(10), 81(11), 71(28), 69(14), 55(39), 43(100), and 41(50).
14. The bacterial culture media except for S. mutans was 0.8% nutrient broth (BBL), 0.5% yeast extract (Difco) and 0.1% glucose (NYG broth). S. mutans was cultured in 3.7% brain heart infusion broth (Difco). All fungi, except P. ovale and T. mentagrophytes were cultured in a 2.5% malt extract broth (BBL). P. ovale was cultured in 1% bactopeptone (Difco), 0.5% yeast extract, 1% glucose and 0.1% corn oil. For T. mentagrophytes the culture media was 1% bactopeptone and 4% glucose. Freeze dried samples were prepared for testing as follows. B. subtilis, S. cerevisiae, C. utilis, and P. ovale, were shake-cultured for two days at 30 °C. P. chrysogenum and T. mentagrophytes were shake-cultured for 5 days at 30 °C. B. ammoniagenes and E. aerogenes were stationarily cultured at 30 °C. S. aureus, S. mutans, P. acnes, P. aeruginosa, E. coli and P. vulgaris were stationarily cultured at 37 °C.