Numb - From flies to humans

Brain and Development

Volumn 32, Issue 4, 2010, Pages 293-298

  Yan, Benedict ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Asymmetric cell division; Cancer; Numb

Indexed keywords

AMYLOID PRECURSOR PROTEIN; INSECT PROTEIN; PROTEIN NUMB; PROTEIN P53; PROTEIN P66; PROTEIN P72; SYNAPTOTAGMIN I; UNCLASSIFIED DRUG;

CELL DIVISION; CELL FATE; FLY; HUMAN; NEOPLASM; NERVE CELL DIFFERENTIATION; NONHUMAN; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; REVIEW; SENSORY NERVE CELL; TUMOR SUPPRESSOR GENE; UBIQUITINATION;

ANIMALS; CELL DIVISION; DROSOPHILA; DROSOPHILA PROTEINS; HUMANS; JUVENILE HORMONES; MEMBRANE PROTEINS; NERVE TISSUE PROTEINS; NEURODEGENERATIVE DISEASES; PROTEIN ISOFORMS;

EID: 77549086125     PISSN: 03877604     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.braindev.2009.03.008     Document Type: Review

References (54)

1. Uemura T., Shepherd S., Ackerman L., Jan L.Y., and Jan Y.N. Numb, a gene required in determination of cell fate during sensory organ formation in Drosophila embryos. Cell 58 (1989) 349-360
2. Rhyu M.S., Jan L.Y., and Jan Y.N. Asymmetric distribution of numb protein during division of the sensory organ precursor cell confers distinct fates to daughter cells. Cell 76 (1994) 477-491
3. Sun Y., Goderie S.K., and Temple S. Asymmetric distribution of EGFR receptor during mitosis generates diverse CNS progenitor cells. Neuron 45 (2005) 873-886
4. Shen Q., Zhong W., Jan Y.N., and Temple S. Asymmetric Numb distribution is critical for asymmetric cell division of mouse cerebral cortical stem cells and neuroblasts. Development 129 (2002) 4843-4853
5. Wakamatsu Y., Maynard T.M., Jones S.U., and Weston J.A. NUMB localizes in the basal cortex of mitotic avian neuroepithelial cells and modulates neuronal differentiation by binding to NOTCH-1. Neuron 23 (1999) 71-81
6. Zhong W., Jiang M.M., Schonemann M.D., Meneses J.J., Pedersen R.A., Jan L.Y., et al. Mouse numb is an essential gene involved in cortical neurogenesis. Proc Natl Acad Sci USA 97 (2000) 6844-6849
7. Zhong W., Jiang M.M., Weinmaster G., Jan L.Y., and Jan Y.N. Differential expression of mammalian Numb, Numblike and Notch1 suggests distinct roles during mouse cortical neurogenesis. Development 124 (1997) 1887-1897
8. Rasin M.R., Gazula V.R., Breunig J.J., Kwan K.Y., Johnson M.B., Liu-Chen S., et al. Numb and Numbl are required for maintenance of cadherin-based adhesion and polarity of neural progenitors. Nat Neurosci 10 (2007) 819-827
9. Petersen P.H., Zou K., Krauss S., and Zhong W. Continuing role for mouse Numb and Numbl in maintaining progenitor cells during cortical neurogenesis. Nat Neurosci 7 (2004) 803-811
10. Kuo C.T., Mirzadeh Z., Soriano-Navarro M., Rasin M., Wang D., Shen J., et al. Postnatal deletion of Numb/Numblike reveals repair and remodeling capacity in the subventricular neurogenic niche. Cell 127 (2006) 1253-1264
11. Zhang R., Zhang Z., Zhang C., Zhang L., Robin A., Wang Y., et al. Stroke transiently increases subventricular zone cell division from asymmetric to symmetric and increases neuronal differentiation in the adult rat. J Neurosci 24 (2004) 5810-5815
12. Verdi J.M., Bashirullah A., Goldhawk D.E., Kubu C.J., Jamali M., Meakin S.O., et al. Distinct human NUMB isoforms regulate differentiation vs. proliferation in the neuronal lineage. Proc Natl Acad Sci USA 96 (1999) 10472-10476
13. Dho S.E., French M.B., Woods S.A., and McGlade C.J. Characterization of four mammalian numb protein isoforms. Identification of cytoplasmic and membrane-associated variants of the phosphotyrosine binding domain. J Biol Chem 274 (1999) 33097-33104
14. Toriya M., Tokunaga A., Sawamoto K., Nakao K., and Okano H. Distinct functions of human numb isoforms revealed by misexpression in the neural stem cell lineage in the Drosophila larval brain. Dev Neurosci 28 (2006) 142-155
15. Verdi J.M., Schmandt R., Bashirullah A., Jacob S., Salvino R., Craig C.G., et al. Mammalian NUMB is an evolutionarily conserved signaling adapter protein that specifies cell fate. Curr Biol 6 (1996) 1134-1145
16. Knoblich J.A. Mechanisms of asymmetric stem cell division. Cell 132 (2008) 583-597
17. Gonczy P. Mechanisms of asymmetric cell division: flies and worms pave the way. Nat Rev Mol Cell Biol 9 (2008) 355-366
18. Wirtz-Peitz F., Nishimura T., and Knoblich J.A. Linking cell cycle to asymmetric division: Aurora-A phosphorylates the Par complex to regulate Numb localization. Cell 135 (2008) 161-173
19. Wang H., Ouyang Y., Somers W.G., Chia W., and Lu B. Polo inhibits progenitor self-renewal and regulates Numb asymmetry by phosphorylating Pon. Nature 449 (2007) 96-100
20. Spana E.P., and Doe C.Q. Numb antagonizes Notch signaling to specify sibling neuron cell fates. Neuron 17 (1996) 21-26
21. Guo M., Jan L.Y., and Jan Y.N. Control of daughter cell fates during asymmetric division: interaction of Numb and Notch. Neuron 17 (1996) 27-41
22. McGill M.A., and McGlade C.J. Mammalian numb proteins promote Notch1 receptor ubiquitination and degradation of the Notch1 intracellular domain. J Biol Chem 278 (2003) 23196-23203
23. Zwahlen C., Li S.C., Kay L.E., Pawson T., and Forman-Kay J.D. Multiple modes of peptide recognition by the PTB domain of the cell fate determinant Numb. EMBO J 19 (2000) 1505-1515
24. Li S.C., Zwahlen C., Vincent S.J., McGlade C.J., Kay L.E., Pawson T., et al. Structure of a Numb PTB domain-peptide complex suggests a basis for diverse binding specificity. Nat Struct Biol 5 (1998) 1075-1083
25. Li S.C., Songyang Z., Vincent S.J., Zwahlen C., Wiley S., Cantley L., et al. High-affinity binding of the Drosophila Numb phosphotyrosine-binding domain to peptides containing a Gly-Pro-(p)Tyr motif. Proc Natl Acad Sci USA 94 (1997) 7204-7209
26. Dooley C.M., James J., Jane McGlade C., and Ahmad I. Involvement of numb in vertebrate retinal development: evidence for multiple roles of numb in neural differentiation and maturation. J Neurobiol 54 (2003) 313-325
27. Bani-Yaghoub M., Kubu C.J., Cowling R., Rochira J., Nikopoulos G.N., Bellum S., et al. A switch in numb isoforms is a critical step in cortical development. Dev Dyn 236 (2007) 696-705
28. Yoshida T., Tokunaga A., Nakao K., and Okano H. Distinct expression patterns of splicing isoforms of mNumb in the endocrine lineage of developing pancreas. Differentiation 71 (2003) 486-495
29. Nie J., McGill M.A., Dermer M., Dho S.E., Wolting C.D., and McGlade C.J. LNX functions as a RING type E3 ubiquitin ligase that targets the cell fate determinant Numb for ubiquitin-dependent degradation. EMBO J 21 (2002) 93-102
30. Dho S.E., Jacob S., Wolting C.D., French M.B., Rohrschneider L.R., and McGlade C.J. The mammalian numb phosphotyrosine-binding domain. Characterization of binding specificity and identification of a novel PDZ domain-containing numb binding protein, LNX. J Biol Chem 273 (1998) 9179-9187
31. Nie J., Li S.S., and McGlade C.J. A novel PTB-PDZ domain interaction mediates isoform-specific ubiquitylation of mammalian Numb. J Biol Chem 279 (2004) 20807-20815
32. Pedersen W.A., Chan S.L., Zhu H., Abdur-Rahman L.A., Verdi J.M., and Mattson M.P. Numb isoforms containing a short PTB domain promote neurotrophic factor-induced differentiation and neurotrophic factor withdrawal-induced death of PC12 Cells. J Neurochem 82 (2002) 976-986
33. Chan S.L., Pedersen W.A., Zhu H., and Mattson M.P. Numb modifies neuronal vulnerability to amyloid beta-peptide in an isoform-specific manner by a mechanism involving altered calcium homeostasis: implications for neuronal death in Alzheimer's disease. Neuromol Med 1 (2002) 55-67
34. Kyriazis G.A., Wei Z., Vandermey M., Jo D.G., Xin O., Mattson M.P., et al. Numb endocytic adapter proteins regulate the transport and processing of the amyloid precursor protein in an isoform-dependent manner: implications for Alzheimer disease pathogenesis. J Biol Chem 283 (2008) 25492-25502
35. Morrison S.J., and Kimble J. Asymmetric and symmetric stem-cell divisions in development and cancer. Nature 441 (2006) 1068-1074
36. Caussinus E., and Gonzalez C. Induction of tumor growth by altered stem-cell asymmetric division in Drosophila melanogaster. Nat Genet 37 (2005) 1125-1129
37. Pece S., Serresi M., Santolini E., Capra M., Hulleman E., Galimberti V., et al. Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis. J Cell Biol 167 (2004) 215-221
38. Di Marcotullio L., Ferretti E., Greco A., De Smaele E., Po A., Sico M.A., et al. Numb is a suppressor of Hedgehog signalling and targets Gli1 for Itch-dependent ubiquitination. Nat Cell Biol 8 (2006) 1415-1423
39. Carter S., and Vousden K.H. A role for Numb in p53 stabilization. Genome Biol 9 (2008) 221
40. Colaluca I.N., Tosoni D., Nuciforo P., Senic-Matuglia F., Galimberti V., Viale G., et al. NUMB controls p53 tumour suppressor activity. Nature 451 (2008) 76-80
41. Hollstein M., Sidransky D., Vogelstein B., and Harris C.C. P53 mutations in human cancers. Science 253 (1991) 49-53
42. Haupt Y., Maya R., Kazaz A., and Oren M. Mdm2 promotes the rapid degradation of p53. Nature 387 (1997) 296-299
43. Yan B., Omar F.M., Das K., Ng W.H., Lim C., Shiuan K., et al. Characterization of Numb expression in astrocytomas. Neuropathology 28 (2008) 479-484
44. The Cancer Genome Atlas Research Network. Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature 455 (2008) 1061-1068
45. Santolini E., Puri C., Salcini A.E., Gagliani M.C., Pelicci P.G., Tacchetti C., et al. Numb is an endocytic protein. J Cell Biol 151 (2000) 1345-1352
46. Nishimura T., and Kaibuchi K. Numb controls integrin endocytosis for directional cell migration with aPKC and PAR-3. Dev Cell 13 (2007) 15-28
47. Nishimura T., Fukata Y., Kato K., Yamaguchi T., Matsuura Y., Kamiguchi H., et al. CRMP-2 regulates polarized Numb-mediated endocytosis for axon growth. Nat Cell Biol 5 (2003) 819-826
48. Leissring M.A. The AbetaCs of Abeta-cleaving proteases. J Biol Chem 283 (2008) 29645-29649
49. Roncarati R., Sestan N., Scheinfeld M.H., Berechid B.E., Lopez P.A., Meucci O., et al. The gamma-secretase-generated intracellular domain of beta-amyloid precursor protein binds Numb and inhibits Notch signaling. Proc Natl Acad Sci USA 99 (2002) 7102-7107
50. Koo E.H., and Squazzo S.L. Evidence that production and release of amyloid beta-protein involves the endocytic pathway. J Biol Chem 269 (1994) 17386-17389
51. Zhong W., Feder J.N., Jiang M.M., Jan L.Y., and Jan Y.N. Asymmetric localization of a mammalian numb homolog during mouse cortical neurogenesis. Neuron 17 (1996) 43-53
52. Bray S.J. Notch signalling: a simple pathway becomes complex. Nat Rev Mol Cell Biol 7 (2006) 678-689
53. Marino S. Medulloblastoma: developmental mechanisms out of control. Trends Mol Med 11 (2005) 17-22
54. Pickart C.M. Mechanisms underlying ubiquitination. Annu Rev Biochem 70 (2001) 503-533