Elevated sex steroid hormones in great saphenous veins in men

Journal of Vascular Surgery

Volumn 51, Issue 3, 2010, Pages 639-646

  Kendler, Michael ^a   Makrantonaki, Evgenia ^b,c   Kratzsch, Jürgen ^a   Anderegg, Ulf ^a   Wetzig, Tino ^a   Zouboulis, Christos ^b,c   Simon, Jan C ^a  

^a UNIVERSITY HOSPITAL LEIPZIG   (Germany)

^b DESSAU MEDICAL CENTER   (Germany)

^c Dermato Pharmacology and Dermato Endocrinology   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

3(OR 17)BETA HYDROXYSTEROID DEHYDROGENASE; 3(OR 17)BETA HYDROXYSTEROID DEHYDROGENASE TYPE 2; ANDROGEN; ANDROSTENEDIONE; AROMATASE; ESTRADIOL; ESTROGEN RECEPTOR; ESTROGEN RECEPTOR ALPHA; LYASE; MESSENGER RNA; STEROID 5ALPHA REDUCTASE 1; STEROID 5ALPHA REDUCTASE 2; TESTOSTERONE; TESTOSTERONE 17BETA DEHYDROGENASE; UNCLASSIFIED DRUG;

ADULT; ANDROSTENEDIONE BLOOD LEVEL; ARM; ARTICLE; BLOOD CELL COUNT; BLOOD SAMPLING; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; CUBITAL VEIN; DOWN REGULATION; ECHOGRAPHY; ESTRADIOL BLOOD LEVEL; GREAT SAPHENOUS VEIN; HUMAN; LEG; LEG VEIN; LIMB; MALE; NEGATIVE FEEDBACK; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SAPHENOUS VEIN; STEROID METABOLISM; TESTOSTERONE BLOOD LEVEL; VARICOSIS; VEIN; VENOUS REFLUX;

ADULT; AGED; ANDROSTENEDIONE; CASE-CONTROL STUDIES; ESTRADIOL; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GONADAL STEROID HORMONES; HUMANS; MALE; MEN'S HEALTH; MIDDLE AGED; PILOT PROJECTS; PROSPECTIVE STUDIES; RECEPTORS, STEROID; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SAPHENOUS VEIN; TESTOSTERONE; ULTRASONOGRAPHY, DOPPLER, DUPLEX; UP-REGULATION; UPPER EXTREMITY; VARICOSE VEINS; VENOUS INSUFFICIENCY;

EID: 77549085808     PISSN: 07415214     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jvs.2009.07.128     Document Type: Article

References (36)

1. Meissner M.H., Gloviczki P., Bergan J., Kistner R.L., Morrison N., Pannier F., et al. Primary chronic venous disorders. J Vasc Surg 46 (2007) 54S-67S
2. Bradbury A., Evans C., Allan P., Lee A., Ruckley C.V., and Fowkers F.G.R. What are the symptoms of varicose veins?. Edinburgh vein study cross sectional population survey. Br Med J 319 (1999) 353-356
3. Rabe E., Pannier-Fischer F., Bromen K., Schuldt K., Stang A., Poncar C.H., et al. Bonner Studie der Deutschen Gesellschaft für Phlebologie. Epidemiologische Untersuchung zur Frage der Häufigkeit und Ausprägung von chorischen Venenkrankheiten in der städtischen und ländlichen Wohnbevölkerung. Phlebologie 32 (2003) 1-14
4. Maurins U., Hoffmann B.H., Lösch C., Jöckel K.H., Rabe E., and Pannier F. Distribution and prevalence of reflux in the superficial and deep venous system in the general population-results from the Bonn Vein Study, Germany. J Vasc Surg 48 (2008) 680-687
5. Brand F.N., Dannenberg A.L., Abbott R.D., and Kannel W.B. The epidemiology of varicose veins: the Framingham Study. Am J Prev Med 4 (1988) 96-101
6. Bergan J.J., Schmid-Schönbein G.W., Smith P.D., Nicolaides A.N., Boisseau M.R., and Eklof B. Chronic venous disease. N Engl J Med 355 (2006) 488-498
7. Ciardullo A.V., Panico S., Bellati C., Rubba P., Rinaldi S., Iannnuzzi A., et al. High endogenous estradiol is associated with increased venous distensibility and clinical evidence of varicose veins in menopausal women. J Vasc Surg 32 (2000) 544-549
8. Bromen K., Pannier-Fischer F., Stang A., Rabe E., Bock E., and Jockel K.H. Should sex specific differences in venous diseases be explained by pregnancies and hormone intake. Gesundheitswesen 66 (2004) 170-174
9. Kendler M., Blendinger C.H., and Haas E. Elevated serum estradiol/testosterone ratio in men with primary varicose compared with a healthy control group. Angiology 60 (2009) 283-289
10. Howell R.G., and Burton J.L. Decreased fertility in men with venous stasis of the legs. Lancet 18 (1982) 630-631
11. Oswald M., Heintz C., and Wohlaib U. How to prove incompetence of the ovarian vein as a source of varicogenesis by testing the hormone content of the varicose veins of the leg. Phlebolymphology (1999) Special issue for European Congress of UIP, Bremen
12. Labropoulos N., Tiongson J., Pryor L., Tassiopoulos A.K., Kang S.S., Ashraf Mansour M., et al. Definition of venous reflux in lower-extremity veins. J Vasc Surg 38 (2003) 793-798
13. Frajese G.V., De Martino M.U., Calcagni E., Pastore R., Caprio M., Bultrini A., et al. The epidemiology of partialandrogen deficiency in aging men (PADAM). J Endocrinol Invest 28 suppl (2005) 3-7
14. Raffetto J.D., and Khalil R.A. Mechanisms of varicose vein formation: valve dysfunction and wall dilation. Phlebology 23 (2008) 85-98
15. Vanhoutte P.M., Corcaud S., and de Montrion C. Venous disease: from pathophysiology to quality of life. Angiology 48 (1997) 559-567
16. Kisch D., Dienes H.P., Küchle R., Duschner H., Wahl H., Böttger T., et al. Changes in the extracellular matrix, of the vein wall: the cause of primary varicosis?. Vasa 29 (2000) 173-177
17. Bergqvist A., Bergqvist D., and Fernö M. Estrogen and progesterone receptors in vessel walls. Act Obstet Gynecol Scand 72 (1993) 10-15
18. van den Beld A.W., Bots M.L., Janssen J.A., Pols H.A., Lamberts S.W., and Grobbee D.E. Endogenous hormones and carotid atherosclerosis in elderly men. Am J Epidemiol 157 (2003) 25-31
19. English K.M., Mandour O., Steeds R.P., Diver M.J., Jones T.H., and Channer K.S. Men with coronary artery disease have lower levels of androgens than men with normal coronary angiograms. Eur Heart J 21 (2000) 890-894
20. Krasinski Z., Dzieciuschowicz L., Kotwicka M., Gabriel M., Szcesniak-Chmielecka A., Krasinska B., et al. Sex hormone receptros in varicose veins of women with premenstrual syndrome. Phlebologie 37 (2008) 68-72
21. Schmidt J.B., Seidl K., and Spona J. [Hormone interactions in varicose veins-receptor analysis and hormone level]. German. Vasa 15 (1986) 224-227
22. Mashiah A., Berman V., Thole H.H., Rose S.S., Pasik S., Schwarz H., et al. Estrogen and progesterone receptors in normal and varicose saphenous veins. Cardiovasc Surg 7 (1999) 327-331
23. Perrot-Applanat M., Cohen-Solal K., Milgrom E., and Finet M. Progesterone receptor expression in human saphenous veins. Circulation 92 (1995) 2975-2983
24. Chawla A., Repa J.J., Evans R.M., and Mangelsdorf D.J. Nuclear receptors and lipid physiology: opening the X-files. Science 294 (2001) 1866-1870
25. Göttlicher M., Heck S., and Herrlich P. Transcriptional cross-talk, the second mode of steroid hormone receptor action. J Mol Med 76 (1998) 480-489
26. Benten W.P., Stephan C., Lieberherr M., and Wunderlich F. Estradiol signaling via sequestrable surface receptors. Endocrinology 142 (2001) 1669-1677
27. Giannoukas A.D., Labropoulos N., Stavridis G., Bailey D., Glenville B., and Nicolaides A.N. Pre-bypass quality assessment of the long saphenous vein wall with ultrasound and histology. Eur J Vasc Endovasc Surg 14 (1997) 37-40
28. Sudhir K., and Komesaroff P.A. Clinical review 110: cardiovascular actions of estrogens in men. J Clin Endocrinol Metab 84 (1999) 3411-3415
29. Villar I.C., Hobbs A.J., and Ahluwalia A. Sex differences in vascular function: implication of endothelium-derived hyperpolarizing factor. J Endocrinol 197 (2008) 447-462
30. Canonico M., Plu-Bureau G., Lowe G.D., and Scarabin P.Y. Hormone replacement therapy and risk of venous thromboembolism in postmenopausal women: systematic review and meta-analysis. BMJ 336 (2008) 1227-1231
31. Schreiber G., and Ziemer M. The aging male-diagnosis and therapy of late-onset hypogonadism. J Dtsch Dermatol Ges 6 (2008) 273-279
32. Oettel M. Testosterone metabolism, dose-response relationships and receptor polymorphisms: selected pharmacological/toxicological considerations on benefits versus risks of testosterone therapy in men. Aging Male 6 (2003) 230-256
33. Zouboulis C.C., Chen W.C., Thornton M.J., Qin K., and Rosenfield R. Sexual hormones in human skin. Horm Metab Res 39 (2007) 85-95
34. Luu-The V., Bélanger A., and Labrie F. Androgen biosynthetic pathways in the human prostate. Best Pract Res Clin Endocrinol Metab 22 (2008) 207-221
35. Lamberts S.W.J., van den Beld A.W., and van der Lely A.J. The endocrinology of aging. Science 278 (1997) 419-424
36. Folkman J. Clinical applications of research on angiogenesis. Seminars in medicine of the Beth Israel Hospital, Boston, MA. N Engl J Med 333 (1995) 1757-1763