Use of octenidine dihydrochloride in meticillin-resistant Staphylococcus aureus decolonisation regimens: a literature review

Journal of Hospital Infection

Volumn 74, Issue 3, 2010, Pages 199-203

  Krishna, B V S ^a   Gibb, A P ^a  

^a NHS LOTHIAN   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CHLORHEXIDINE; OCTENIDINE; PSEUDOMONIC ACID;

ANTIMICROBIAL ACTIVITY; BACTERIAL COLONIZATION; BACTERIUM CARRIER; DRUG EFFICACY; DRUG SAFETY; DRUG WITHDRAWAL; HUMAN; INFECTION CONTROL; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; NONHUMAN; OBSERVATIONAL STUDY; OUTCOME ASSESSMENT; REVIEW; SKIN DEFECT; SKIN REDNESS; TREATMENT DURATION; UNSPECIFIED SIDE EFFECT; WOUND INFECTION;

ANTI-BACTERIAL AGENTS; CARRIER STATE; HUMANS; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; PYRIDINES; STAPHYLOCOCCAL INFECTIONS; TREATMENT OUTCOME;

EID: 77549084092     PISSN: 01956701     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhin.2009.08.022     Document Type: Review

References (22)

1. Coia J.E., Duckworth G.J., Edwards D.I., et al. Guidelines for the control and prevention of meticillin-resistant Staphylococcus aureus (MRSA) in healthcare facilities. J Hosp Infect 63 Suppl. 1 (2006) S1-44
2. Barton M., Hawkes M., Moore D., et al. Guidelines for the prevention and management of community-associated methicillin-resistant Staphylococcus aureus: a perspective for Canadian health care practitioners. Can J Infect Dis Med Microbiol 17 Suppl. C (2006) C4-24
3. Simor A.E., Phillips E., McGeer A., et al. Randomised controlled trial of chlorhexidine gluconate for washing, intranasal mupirocin, and rifampin and doxycycline versus no treatment for the eradication of methicillin-resistant Staphylococcus aureus colonisation. Clin Infect Dis 44 (2007) 178-185
4. Harbarth S., Dharan S., Liassine N., Herrault P., Auckenthaler R., and Pittet D. Randomised, placebo-controlled, double-blind trial to evaluate the efficacy of mupirocin for eradicating carriage of methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother 43 (1999) 1412-1416
5. Sandri A.M., Dalarosa M.G., Ruschel de Alcantara L., da Silva Elias L., and Zavascki A.P. Reduction in incidence of nosocomial methicillin-resistant Staphylococcus aureus (MRSA) infection in an intensive care unit: role of treatment with mupirocin ointment and chlorhexidine baths for nasal carriers of MRSA. Infect Control Hosp Epidemiol 27 (2006) 185-187
6. McDonnell G., and Pretzer D. New and developing chemical antimicrobials. In: Block S.S. (Ed). Disinfection, sterilization and preservation. 5th ed. (2001), Lippincott Williams & Wilkins, Philadelphia 431-444
7. Sedlock D.M., and Bailey D.M. Microbicidal activity of octenidine hydrochloride, a new alkanediylbis (Pyridine) germicidal agent. Antimicrob Agents Chemother 28 (1985) 786-790
8. Bailey D.M., DeGrazia C.G., Hoff S.J., et al. Bispyridinamines: a new class of topical antimicrobial agents as inhibitors of dental plaque. J Med Chem 27 (1984) 1457-1464
9. Ghannoum M.A., Elteen K.A., Ellabib M., and Whittaker P.A. Antimycotic effects of octenidine and pirtenidine. J Antimicrob Chemother 25 (1990) 237-245
10. Harke H.P. Octenidine dihydrochloride, properties of a new antimicrobial agent. [In German]. Zentralbl Hyg 188 (1989) 188-193
11. Pitten F.A., Werner H.P., and Kramer A. A standardized test to assess the impact of different organic challenges on the antimicrobial activity of antiseptics. J Hosp Infect 55 (2003) 108-115
12. Al-Doori Z., Goroncy-Bermes P., Gemmell G., and Morrison D. Low level exposure of MRSA to octenidine dihydrochloride does not select for resistance. J Antimicrob Chemother 59 (2007) 1280-1281
13. Rohr U., Mueller C., Wilhelm M., Muhr G., and Gatermann S. Methicillin-resistant Staphylococcus aureus whole-body decolonisation among hospitalised patients with variable site colonization by using mupirocin in combination with octenidine dihydrochloride. J Hosp Infect 54 (2003) 305-309
14. Sloot N., Siebert J., and Höffler U. Eradication of MRSA from carriers by means of whole-body washing with an antiseptic in combination with mupirocin nasal ointment. Zentralbl Hyg Umweltmed 202 (1999) 513-523
15. Bührer C., Bahr S., Siebert J., Wettstein R., Geffers C., and Obladen M. Use of 2% 2-phenoxyethanol and 0.1% octenidine as antiseptic in premature newborn infants of 23-26 weeks gestation. J Hosp Infect 51 (2002) 305-307
16. Rengelshausen J., Nürnberger J., Philipp T., and Kribben A. Decolonization of methicillin-resistant Staphylococcus aureus by disinfection of the skin. Am J Med 108 (2000) 685-686
17. Hansen D., Patzke P.I., Werfel U., Benner D., Brauksiepe A., and Popp W. Success of MRSA eradication in hospital routine: depends on compliance. Infection 35 (2007) 260-264
18. Buehlamnn M., Frei R., Fenner L., Dangel M., Fluckiger U., and Widmer A.F. Highly effective regimen for decolonisation of methicillin-resistant Staphylococcus aureus carriers. Infect Control Hosp Epidemiol 29 (2008) 510-516
19. MacKinnon M.M., and Allen K.D. Long-term MRSA carriage in hospital patients. J Hosp Infect 46 (2000) 216-221
20. Vriens M.R., Blok H.E.M., Gegengack-Baars A.C.M., et al. Methicillin-resistant Staphylococcus aureus carriage among patients after hospital discharge. Infect Control Hosp Epidemiol 26 (2005) 629-633
21. Ruef C., Ruef S.A., Senn G., Cathomas A., and Imhof A. Decolonisation of patients with wounds colonised by MRSA. J Hosp Infect 72 (2009) 88-90
22. Tietz A., Frei R., Dangel M., et al. Octenidine hydrochloride for the care of central venous catheter insertion sites in severely immunocompromised patients. Infect Control Hosp Epidemiol 26 (2005) 703-707