Overexpression of caveolin-1 in lymphoblastoid TK6 cells enhances proliferation after irradiation with clinically relevant doses

Strahlentherapie und Onkologie

Volumn 186, Issue 2, 2010, Pages 99-106

  Barzan, David ^a   Maier, Patrick ^a   Zeller, W Jens ^b   Wenz, Frederik ^a   Herskind, Carsten ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

Caveolin 1; Lentivirus; Lymphoblasts; Proliferation; Radiation

Indexed keywords

CAVEOLIN 1; LENTIVIRUS VECTOR;

APOPTOSIS; ARTICLE; CELL ASSAY; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; ELECTROPORATION; EXPRESSION VECTOR; FLUORESCENCE ACTIVATED CELL SORTING; GENE OVEREXPRESSION; GENETIC TRANSDUCTION; HUMAN; HUMAN CELL; IRRADIATION; LYMPHOBLASTOID CELL LINE; PROTEIN EXPRESSION; PROTEIN FUNCTION; RADIATION DOSE; RADIATION EXPOSURE; RADIATION PROTECTION; WESTERN BLOTTING; CELL DIVISION; FLOW CYTOMETRY; GENE EXPRESSION; GENE VECTOR; GENETICS; LENTIVIRINAE; LYMPHOCYTE; METABOLISM; METHODOLOGY; PLASMID; RADIATION RESPONSE; TUMOR CELL LINE;

APOPTOSIS; BLOTTING, WESTERN; CAVEOLIN 1; CELL DIVISION; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, RADIATION; FLOW CYTOMETRY; GENE EXPRESSION; GENETIC VECTORS; HUMANS; LENTIVIRUS; LYMPHOCYTES; PLASMIDS; RADIATION PROTECTION; TRANSDUCTION, GENETIC;

EID: 77449155377     PISSN: 01797158     EISSN: 1439099X     Source Type: Journal    
DOI: 10.1007/s00066-010-2029-1     Document Type: Article

References (44)

1. 1. Ahn M, Kim H, Kim JT, et al. Gamma-ray irradiation stimulates the expression of caveolin-1 and GFAP in rat spinal cord: a study of immunoblot and immunohistochemistry. J Vet Sci 2006;7:309-314 (Pubitemid 44885828)
2. 2. Barresi V, Cerasoli S, Paioli G, et al. Caveolin-1 in meningiomas: expression and clinico-pathological correlations. Acta Neuropathol (Berl) 2006;112:617-626 (Pubitemid 44550685)
3. 3. Belanger MM, Gaudreau M, Roussel E, et al. Role of caveolin-1 in etoposide resistance development in A549 lung cancer cells. Cancer Biol Ther 2004;3:954-959 (Pubitemid 41351018)
4. 4. Belanger MM, Roussel E, Couet J. Up-regulation of caveolin expression by cytotoxic agents in drug-sensitive cancer cells. Anticancer Drugs 2003;14:281-287 (Pubitemid 36583813)
5. 5. Bölke E, Gerber PA, Lammering G, et al. Development and management of severe cutaneous side effects in head-and-neck cancer patients during concurrent radiotherapy and cetuximab. Strahlenther Onkol 2008;184:105-110 (Pubitemid 351231657)
6. Burgermeister E, Liscovitch M, Rocken C, et al. Caveats of caveolin-1 in cancer progression. Cancer Lett 2008;268:187-201.
7. 7. Capozza F, Williams TM, Schubert W, et al. Absence of caveolin-1 sensitizes mouse skin to carcinogen-induced epidermal hyperplasia and tumor formation. Am J Pathol 2003;162:2029-2039 (Pubitemid 36613059)
8. Combs SE, Schulz-Ertner D, Hartmann C, et al. Interim analysis of the phase I/II study: ERBITUX® (cetuximab) plus temozolomide as radiochemotherapy for primary glioblastoma (GERT; Eudract-Number 2005-003911-63; NCT00311857).
9. Strahlenther Onkol 2008;184:Special Issue 1:36.
10. 9. Cordes N, Frick S, Brunner TB, et al. Human pancreatic tumor cells are sensitized to ionizing radiation by knockdown of caveolin-1. Oncogene 2007;26:6851-6862 (Pubitemid 47609078)
11. 10. Demaison C, Parsley K, Brouns G, et al. High-level transduction and gene expression in hematopoietic repopulating cells using a human immunodeficiency [correction of imunodeficiency] virus type 1-based lentiviral vector containing an internal spleen focus forming virus promoter. Hum Gene Ther 2002;13:803-813 (Pubitemid 34493974)
12. 11. Dittmann K, Mayer C, Fehrenbacher B, et al. Radiation-induced epidermal growth factor receptor nuclear import is linked to activation of DNA-dependent protein kinase. J Biol Chem 2005;280:31182-31189 (Pubitemid 41291855)
13. Dittmann K, Mayer C, Kehlbach R, et al. Radiation-induced caveolin-1 associated EGFR internalization is linked with nuclear EGFR transport and activation of DNA-PK. Mol Cancer 2008;7:69.
14. Dittmann K, Mayer C, Kehlbach R, et al. The radioprotector Bowman-Birk proteinase inhibitor stimulates DNA repair via epidermal growth factor receptor phosphorylation and nuclear transport. Radiother Oncol 2008;86:375-382
15. Goetz JG, Lajoie P, Wiseman SM, et al. Caveolin-1 in tumor progression: the good, the bad and the ugly. Cancer Metastasis Rev 2008;27:715-735
16. 15. Harris J, Werling D, Koss M, et al. Expression of caveolin by bovine lymphocytes and antigen-presenting cells. Immunology 2002;105:190-195 (Pubitemid 34146685)
17. Klautke G, Brunner TB. Radiotherapy in pancreatic cancer. Strahlenther Onkol 2008;184:557-564
18. Lajoie P, Nabi IR. Regulation of raft-dependent endocytosis. J Cell Mol Med 2007;11:644-653
19. 18. Li J, Hassan GS, Williams TM, et al. Loss of caveolin-1 causes the hyper-proliferation of intestinal crypt stem cells, with increased sensitivity to whole body gamma-radiation. Cell Cycle 2005;4:1817-1825 (Pubitemid 41827329)
20. Liber HL, Yandell DW, Little JB. A comparison of mutation induction at the tk and hprt loci in human lymphoblastoid cells; quantitative differences are due to an additional class of mutations at the autosomal tk locus. Mutat Res 1989;216:9-17.
21. 20. Lisanti MP, Scherer PE, Tang Z, et al. Caveolae, caveolin and caveolin-rich membrane domains: a signalling hypothesis. Trends Cell Biol 1994;4:231-235 (Pubitemid 24190653)
22. 21. Maier P, Fleckenstein K, Li L, et al. Overexpression of MDR1 using a retroviral vector differentially regulates genes involved in detoxification and apoptosis and confers radioprotection. Radiat Res 2006;166:463-473 (Pubitemid 44353429)
23. 22. Maier P, Herskind C, Fleckenstein K, et al. MDR1 gene transfer using a lentiviral SIN vector confers radioprotection to human CD34+ hematopoietic progenitor cells. Radiat Res 2008;169:301-310 (Pubitemid 351521765)
24. Maier P, Herskind C, Barzan D, Zeller WJ, Wenz F. SNAI2 as a novel radioprotector of normal tissue by gene transfer using a lentiviral bicistronic SIN vector. Radiat Res [in press]
25. Marquardt F, Rödel F, Capalbo G, et al. Molecular targeted treatment and radiation therapy for rectal cancer. Strahlenther Onkol 2009;185:371-378
26. 25. Medina FA, Williams TM, Sotgia F, et al. A novel role for caveolin-1 in B lymphocyte function and the development of thymus-independent immune responses. Cell Cycle 2006;5:1865-1871 (Pubitemid 44435332)
27. Niyazi M, Marini P, Daniel PT, et al. Efficacy of a triple treatment with irradiation, agonistic TRAIL receptor antibodies and EGFR blockade. Strahlenther Onkol 2009;185:8-18.
28. 27. Razani B, Schlegel A, Lisanti MP. Caveolin proteins in signaling, oncogenic transformation and muscular dystrophy. J Cell Sci 2000;113:2103-2109 (Pubitemid 30426825)
29. Razani B, Woodman SE, Lisanti MP. Caveolae: from cell biology to animal physiology. Pharmacol Rev 2002;54:431-467
30. 29. Regina A, Jodoin J, Khoueir P, et al. Down-regulation of caveolin-1 in glioma vasculature: modulation by radiotherapy. J Neurosci Res 2004;75:291-299 (Pubitemid 38049400)
31. Rödel F, Capalbo G, R̈del C, et al. Caveolin-1 as a prognostic marker for local control after preoperative chemoradiation therapy in rectal cancer. Int J Radiat Oncol Biol Phys 2009;73:846-852
32. 31. Sagara Y, Mimori K, Yoshinaga K, et al. Clinical significance of caveolin-1, caveolin-2 and HER2/neu mRNA expression in human breast cancer. Br J Cancer 2004;91:959-965 (Pubitemid 39273791)
33. Schilz AJ, Schiedlmeier B, Kuhlcke K, et al. MDR1 gene expression in NOD/SCID repopulating cells after retroviral gene transfer under clinically relevant conditions. Mol Ther 2000;2:609-618
34. 33. Schütze C, Dörfler A, Eicheler W, et al. Combination of EGFR/HER2 tyrosine kinase inhibition by BIBW 2992 and BIBW 2669 with irradiation in FaDu human squamous cell carcinoma. Strahlenther Onkol 2007;183:256-264 (Pubitemid 46725991)
35. 34. Shatz M, Liscovitch M. Caveolin-1: a tumor-promoting role in human cancer. Int J Radiat Biol 2008;84:177-189 (Pubitemid 351323417)
36. Sirak I, Petera J, Hatlova J, et al. Epidermal growth factor receptor as a predictor of tumor response to preoperative chemoradiation in locally advanced gastric carcinoma. Strahlenther Onkol 2008;184:592-597
37. Skopek TR, Liber HL, Penman BW, et al. Isolation of a human lymphoblastoid line heterozygous at the thymidine kinase locus: possibility for a rapid human cell mutation assay. Biochem Biophys Res Commun 1978;84:411-416
38. 37. Suzuoki M, Miyamoto M, Kato K, et al. Impact of caveolin-1 expression on prognosis of pancreatic ductal adenocarcinoma. Br J Cancer 2002;87: 1140-1144 (Pubitemid 35418110)
39. 38. Wiechen K, Sers C, Agoulnik A, et al. Down-regulation of caveolin-1, a candidate tumor suppressor gene, in sarcomas. Am J Pathol 2001;158: 833-839 (Pubitemid 32221776)
40. 39. Wikman H, Seppanen JK, Sarhadi VK, et al. Caveolins as tumour markers in lung cancer detected by combined use of cDNA and tissue microarrays. J Pathol 2004;203:584-593 (Pubitemid 38529039)
41. Williams TM, Lisanti MP. Caveolin-1 in oncogenic transformation, cancer, and metastasis. Am J Physiol Cell Physiol 2005;288:C494-506.
42. 41. Yandell DW, Little JB. Chromosome 14 marker appearance in a human B lymphoblastoid cell line of nonmalignant origin. Cancer Genet Cytogenet 1986;20:231-239 (Pubitemid 16153277)
43. 42. Yang CP, Galbiati F, Volonte D, et al. Upregulation of caveolin-1 and caveolae organelles in Taxol-resistant A549 cells. FEBS Lett 1998;439: 368-372 (Pubitemid 28546677)
44. Yang G, Truong LD, Wheeler TM, et al. Caveolin-1 expression in clinically confined human prostate cancer: a novel prognostic marker. Cancer Res 1999;59:5719-5723