Proteomic analysis of protein phosphorylation and ubiquitination in Alzheimer's disease

Methods in Molecular Biology

Volumn 566, Issue , 2009, Pages 109-121

  Thomas, Stefani N ^a   Cripps, Diane ^b   Yang, Austin J ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MARYLAND   (United States)

Author keywords

Alzheimer's disease (AD); Liquid chromatography tandem mass spectrometry (LC MS MS); Phosphorylation; Selected reaction monitoring (SRM); Tau; Ubiquitin

Indexed keywords

PROTEOME; TAU PROTEIN;

ALZHEIMER DISEASE; ARTICLE; CHEMISTRY; HUMAN; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLISM; METHODOLOGY; PATHOLOGY; PATHOPHYSIOLOGY; PHOSPHORYLATION; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN PROCESSING; UBIQUITINATION;

ALZHEIMER DISEASE; CHROMATOGRAPHY, LIQUID; ELECTROPHORESIS, POLYACRYLAMIDE GEL; HUMANS; MASS SPECTROMETRY; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEOME; TAU PROTEINS; UBIQUITINATION;

EID: 77449137513     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-59745-562-6_8     Document Type: Article

References (29)

1. Sze C, Bi H, Kleinschmidt-DeMasters BK, Filley CM, Martin LJ. (2001) N-Methyl-daspartate receptor subunit proteins and their phosphorylation status are altered selectively in Alzheimer's disease. J Neurol Sci 182, 151-159.
2. Zhao D, Watson JB, Xie CW. (2004) Amyloid beta prevents activation of calcium/calmodulin-dependent protein kinase II and AMPA receptor phosphorylation during hippocampal long-term potentiation. J Neurophysiol 92, 2853-2858.
3. Palop JJ, Chin J, Bien-Ly N, et al. (2005) Vulnerability of dentate granule cells to disruption of arc expression in human amyloid precursor protein transgenic mice. J Neurosci 25, 9686-9693.
4. Braak H, Braak E, Strothjohann M. (1994) Abnormally phosphorylated tau protein related to the formation of neurofibrillary tangles and neuropil threads in the cerebral cortex of sheep and goat. Neurosci Lett 171, 1-4.
5. Lim J, Lu KP. (2005) Pinning down phosphorylated tau and tauopathies. Biochim Biophys Acta 1739, 311-322.
6. Gong CX, Liu F, Grundke-Iqbal I, Iqbal K. (2005) Post-translational modifications of tau protein in Alzheimer's disease. J Neural Transm 112, 813-838.
7. Lee G, Thangavel R, Sharma VM, et al. (2004) Phosphorylation of tau by fyn: Implications for Alzheimer's disease. J Neurosci 24, 2304-2312.
8. Yoshimura Y, Ichinose T, Yamauchi T. (2003) Phosphorylation of tau protein to sites found in Alzheimer's disease brain is catalyzed by Ca2+/calmodulin-dependent protein kinase II as demonstrated tandem mass spectrometry. Neurosci Lett 353, 185-188.
9. Liu F, Zaidi T, Iqbal K, et al. (2002) Role of glycosylation in hyperphosphorylation of tau in Alzheimer's disease. FEBS Lett 512, 101-106.
10. Buee L, Bussiere T, Buee-Scherrer V, Delacourte A, Hof PR. (2000) Tau protein isoforms, phosphorylation and role in neurodegenerative disorders. Brain Res Brain Res Rev 33, 95-130.
11. Lee VM. (1996) Regulation of tau phosphorylation in Alzheimer's disease. Ann N Y Acad Sci 777, 107-113.
12. Holzer M, Holzapfel HP, Zedlick D, Bruckner MK, Arendt T. (1994) Abnormally phosphorylated tau protein in Alzheimer's disease: Heterogeneity of individual regional distribution and relationship to clinical severity. Neuroscience 63, 499-516.
13. Goedert M. (1993) Tau protein and the neurofibrillary pathology of Alzheimer's disease. Trends Neurosci 16, 460-465.
14. Hampel H, Burger K, Pruessner JC, et al. (2005) Correlation of cerebrospinal fluid levels of tau protein phosphorylated at threonine 231 with rates of hippocampal atrophy in Alzheimer disease. Arch Neurol 62, 770-773.
15. Augustinack JC, Schneider A, Mandelkow EM, Hyman BT. (2002) Specific tau phosphorylation sites correlate with severity of neuronal cytopathology in Alzheimer's disease. Acta Neuropathol (Berl) 103, 26-35.
16. de Vrij FM, Fischer DF, van Leeuwen FW, Hol EM. (2004) Protein quality control in Alzheimer's disease by the ubiquitin proteasome system. Prog Neurobiol 74, 249-270.
17. Zhang JY, Liu SJ, Li HL, Wang JZ. (2005) Microtubule-associated protein tau is a substrate of ATP/Mg(2+)-dependent proteasome protease system. J Neural Transm 112, 547-555.
18. Shimura H, Schwartz D, Gygi SP, Kosik KS. (2004) CHIP-Hsc70 complex ubiquitinates phosphorylated tau and enhances cell survival. J Biol Chem 279, 4869-4876.
19. Iqbal K, Grundke-Iqbal I. (1991) Ubiquitination and abnormal phosphorylation of paired helical filaments in Alzheimer's disease. Mol Neurobiol 5, 399-410.
20. Kohnken R, Buerger K, Zinkowski R, et al. (2000) Detection of tau phosphorylated at threonine 231 in cerebrospinal fluid of Alzheimer's disease patients. Neurosci Lett 287, 187-190.
21. Hampel H, Buerger K, Kohnken R, et al. (2001) Tracking of Alzheimer's disease progression with cerebrospinal fluid tau protein phosphorylated at threonine 231. Ann Neurol 49, 545-546.
22. Buerger K, Teipel SJ, Zinkowski R, et al. (2002) CSF tau protein phosphorylated at threonine 231 correlates with cognitive decline in MCI subjects. Neurology 59, 627-629.
23. Buerger K, Zinkowski R, Teipel SJ, et al. (2002) Differential diagnosis of Alzheimer disease with cerebrospinal fluid levels of tau protein phosphorylated at threonine 231. Arch Neurol 59, 1267-1272.
24. Cripps D, Thomas SN, Jeng Y, et al. (2006) Alzheimer disease-specific conformation of hyperphosphorylated paired helical filament-Tau is polyubiquitinated through Lys-48, Lys-11, and Lys-6 ubiquitin conjugation. J Biol Chem 281, 10825-10838.
25. Weaver CL, Espinoza M, Kress Y, Davies P. (2000) Conformational change as one of the earliest alterations of tau in Alzheimer's disease. Neurobiol Aging 21, 719-727.
26. Vincent I, Zheng JH, Dickson DW, Kress Y, Davies P. (1998) Mitotic phosphoepitopes precede paired helical filaments in Alzheimer's disease. Neurobiol Aging 19, 287-296.
27. Mayya V, Rezaul K, Cong YS, Han D. (2005) Systematic comparison of a two-dimensional ion trap and a three-dimensional ion trap mass spectrometer in proteomics. Mol Cell Proteomics 4, 214-223.
28. Gerber SA, Rush J, Stemman O, Kirschner MW, Gygi SP. (2003) Absolute quantification of proteins and phosphoproteins from cell lysates by tandem MS. Proc Natl Acad Sci USA 100, 6940-6945.
29. Chen EI, Cociorva D, Norris JL, Yates JR, III. (2007) Optimization of mass spectrometry-compatible surfactants for shotgun proteomics. J Proteome Res 6, 2529-2538.