Brainstem regions affecting minimum alveolar concentration and movement pattern during isoflurane anesthesia

Anesthesiology

Volumn 112, Issue 2, 2010, Pages 316-324

  Jinks, Steven L ^a   Bravo, Milo ^a   Satter, Omar ^a   Chan, Yuet Ming ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ISOFLURANE; INHALATION ANESTHETIC AGENT; LIDOCAINE; LOCAL ANESTHETIC AGENT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN REGION; BRAIN STEM; CONTROLLED STUDY; ELECTROMYOGRAM; LATERAL RETICULAR NUCLEUS; LOCOMOTION; MALE; MEDULLA OBLONGATA; MESENCEPHALON; MINIMUM LUNG ALVEOLUS CONCENTRATION; NEUROMODULATION; NOCICEPTION; NONHUMAN; PONS; PRIORITY JOURNAL; RAPHE MAGNUS NUCLEUS; RAT; ANESTHESIA; ANIMAL; CYTOLOGY; DRUG EFFECT; ELECTROMYOGRAPHY; LUNG ALVEOLUS; METABOLISM; MICROINJECTION; MOVEMENT (PHYSIOLOGY); NERVE CELL; NERVE TRACT; PHYSIOLOGY; SPRAGUE DAWLEY RAT; STIMULATION;

ANESTHESIA; ANESTHETICS, INHALATION; ANESTHETICS, LOCAL; ANIMALS; BRAIN STEM; ELECTROMYOGRAPHY; ISOFLURANE; LIDOCAINE; LOCOMOTION; MALE; MICROINJECTIONS; MOVEMENT; NEURAL PATHWAYS; NEURONS; PHYSICAL STIMULATION; PULMONARY ALVEOLI; RATS; RATS, SPRAGUE-DAWLEY;

EID: 77449130068     PISSN: 00033022     EISSN: 15281175     Source Type: Journal    
DOI: 10.1097/ALN.0b013e3181c81319     Document Type: Article

References (31)

1. Antognini JF, Schwartz K: Exaggerated anesthetic requirements in the preferentially anesthetized brain. ANESTHESI-OLOGY 1993; 79:1244-1249
2. Rampil IJ: Anesthetic potency is not altered after hypother-mic spinal cord transection in rats. ANESTHESIOLOGY 1994; 80:606-610
3. Jinks SL, Dominguez CL, Antognini JF: Drastic decrease in isoflu-rane minimum alveolar concentration and limb movement forces after thoracic spinal cooling and chronic spinal transec-tion in rats. ANESTHESIOLOGY 2005; 102:624-632
4. Borges M, Antognini JF: Does the brain influence somatic responses to noxious stimuli during isoflurane anesthesia? ANESTHESIOLOGY 1994; 81:1511-1515
5. Rampil IJ, Mason P, Singh H: Anesthetic potency (MAC) is independent of forebrain structures in the rat. ANESTHESI-OLOGY 1993; 78:707-712
6. Jinks SL, Bravo M, Hayes SG: Volatile anesthetic effects on midbrain-elicited locomotion suggest that the locomotor network in the ventral spinal cord is the primary site for immobility. ANESTHESIOLOGY 2008; 108:1016-1024
7. Whelan PJ: Control of locomotion in the decerebrate cat. Prog Neurobiol 1996; 49:481-515
8. Kim J, Yao A, Atherley R, Carstens E, Jinks SL, Antognini JF: Neurons in the ventral spinal cord are more depressed by isoflurane, halothane, and propofol than are neurons in the dorsal spinal cord. Anesth Analg 2007; 105:1020-1026
9. You HJ, Colpaert FC, Arendt-Nielsen L: Nociceptive spinal withdrawal reflexes but not spinal dorsal horn wide-dynamic range neuron activities are specifically inhibited by halothane anaesthesia in spinalized rats. Eur J Neurosci 2005; 22:354-360
10. Antognini JF, Atherley RJ, Dutton RC, Laster MJ, Eger EI II, Carstens E: The excitatory and inhibitory effects of nitrous oxide on spinal neuronal responses to noxious stimulation. Anesth Analg 2007; 104:829-835
11. Carlson JD, Selden NR, Heinricher MM: Nocifensive reflex-related on-and off-cells in the pedunculopontine tegmen-tal nucleus, cuneiform nucleus, and lateral dorsal tegmen-tal nucleus. Brain Res 2005; 1063:187-194
12. Skinner RD, Garcia-Rill E: The mesencephalic locomotor region (MLR) in the rat. Brain Res 1984; 323:385-389
13. Jinks SL, Carstens E, Antognini JF: Isoflurane differentially modulates medullary on and off neurons while suppressing hind-limb motor withdrawals. ANESTHESIOLOGY 2004; 100:1224-1234
14. Lima D, Almeida A: The medullary dorsal reticular nucleus as a pronociceptive centre of the pain control system. Prog Neurobiol 2002; 66:81-108
15. Le BD, Villanueva L, Bouhassira D, Willer JC: Diffuse noxious inhibitory controls (DNIC) in animals and in man. Patol Fiziol Eksp Ter 1992:55-65
16. Morgan MM, Stein C, Liebeskind JC: Intrathecal administration of pentobarbital and THIP: Evidence for descending excitatory and inhibitory modulation of a spinal reflex. Proc West Pharmacol Soc 1987; 30:249-251
17. Stein C, Morgan MM, Liebeskind JC: Barbiturate-induced inhibition of a spinal nociceptive reflex: Role of GABA mechanisms and descending modulation. Brain Res 1987; 407:307-311
18. Yang J, Chai YF, Gong CY, Li GH, Luo N, Luo NF, Liu J: Further proof that the spinal cord, and not the brain, mediates the immobility produced by inhaled anesthetics. ANESTHESIOLOGY 2009; 110:591-595
19. Sandkuhler J, Gebhart GF: Relative contributions of the nucleus raphe magnus and adjacent medullary reticular formation to the inhibition by stimulation in the periaque-ductal gray of a spinal nociceptive reflex in the pentobar-bital-anesthetized rat. Brain Res 1984; 305:77-87
20. Basbaum AI, Fields HL: Endogenous pain control systems: Brainstem spinal pathways and endorphin circuitry. Annu Rev Neurosci 1984; 7:309-338
21. Mason P, Leung CG: Physiological functions of pontomed-ullary raphe and medial reticular neurons. Prog Brain Res 1996; 107:269-282
22. Gebhart GF, Sandkuhler J, Thalhammer JG, Zimmermann M: Inhibition of spinal nociceptive information by stimulation in midbrain of the cat is blocked by lidocaine mi-croinjected in nucleus raphe magnus and medullary retic-ular formation. J Neurophysiol 1983; 50:1446-1459 (Pubitemid 14175701)
23. Heinricher MM, Tavares I, Leith JL, Lumb BM: Descending control of nociception: Specificity, recruitment and plasticity. Brain Res Rev 2009; 60:214-225
24. Dugast C, Almeida A, Lima D: The medullary dorsal retic-ular nucleus enhances the responsiveness of spinal noci-ceptive neurons to peripheral stimulation in the rat. Eur J Neurosci 2003; 18:580-588
25. Le Bars D, Chitour D, Kraus E, Clot AM, Dickenson AH, Besson JM: The effect of systemic morphine upon diffuse noxious inhibitory controls (DNIC) in the rat: Evidence for a lifting of certain descending inhibitory controls of dorsal horn convergent neurones. Brain Res 1981; 215:257-274
26. Le BD, Willer JC, De BT: Morphine blocks descending pain inhibitory controls in humans. Pain 1992; 48:13-20
27. Jinks SL, Antognini JF, Carstens E: Isoflurane depresses diffuse noxious inhibitory controls in rats between 0.8 and 1.2 minimum alveolar anesthetic concentration. Anesth Analg 2003; 97:111-116
28. Jinks SL, Atherley RJ, Dominguez CL, Sigvardt KA, Antog-nini JF: Isoflurane disrupts central pattern generator activity and coordination in the lamprey isolated spinal cord. ANESTHESIOLOGY 2005; 103:567-575
29. Barter LS, Mark LO, Jinks SL, Carstens EE, Antognini JF: Immobilizing doses of halothane, isoflurane or propofol, do not preferentially depress noxious heat-evoked responses of rat lumbar dorsal horn neurons with ascending projections. Anesth Analg 2008; 106:985-990
30. Jinks SL, Martin JT, Carstens E, Jung SW, Antognini JF: Peri-MAC depression of a nociceptive withdrawal reflex is accompanied by reduced dorsal horn activity with halothane but not isoflu-rane. ANESTHESIOLOGY 2003; 98:1128-1138
31. Paxinos G, Watson C: The Rat Brain in Stereotaxic Coordinates, 4th Edition. New York, Academic Press, 1998