Molecular markers in upper urothelial carcinoma associated to Balkan endemic nephropathy. Aristolochic acid as the major risk factor of the worldwide disease

TheScientificWorldJournal

Volumn 9, Issue , 2009, Pages 1360-1373

  Velickovic, Ljubinka Jankovic ^a   Hattori, Takanori ^b   Stefanovic, Vladisav ^a  

^a UNIVERSITY OF NI   (Serbia)

^b SHIGA UNIVERSITY OF MEDICAL SCIENCE   (Japan)

Author keywords

Aristolochic acid nephropathy; Balkan endemic nephropathy; Ki 67 index; Molecular markers; p53; Upper urothelial cancer

Indexed keywords

ARISTOLOCHIC ACID; KI 67 ANTIGEN; PROTEIN P53; ARISTOLOCHIC ACID I; CYCLIN D1; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ERBB2 PROTEIN, HUMAN; P16 PROTEIN, HUMAN; TUMOR MARKER; TUMOR PROTEIN;

ADULT; AGED; ARTICLE; CELL CYCLE; CONTROLLED STUDY; DISEASE ASSOCIATION; ENDEMIC DISEASE; FEMALE; HISTOLOGY; HUMAN; IMMUNOHISTOCHEMISTRY; KIDNEY DISEASE; KIDNEY PELVIS; MAJOR CLINICAL STUDY; MALE; NEPHROURETERECTOMY; PREDICTION; PROTEIN ANALYSIS; RISK FACTOR; TUMOR GROWTH; UPPER UROTHELIAL CARCINOMA; URINARY TRACT CARCINOMA; ARISTOLOCHIA; BLADDER TUMOR; INTERSTITIAL NEPHRITIS; METABOLISM; MIDDLE AGED; PATHOLOGY; URETER; URETER TUMOR;

ADULT; AGED; AGED, 80 AND OVER; ARISTOLOCHIA; ARISTOLOCHIC ACIDS; BALKAN NEPHROPATHY; CYCLIN D1; FEMALE; HUMANS; KIDNEY PELVIS; MALE; MIDDLE AGED; NEOPLASM PROTEINS; RECEPTOR, ERBB-2; RISK FACTORS; TUMOR MARKERS, BIOLOGICAL; TUMOR SUPPRESSOR PROTEIN P53; URETER; URETERAL NEOPLASMS; URINARY BLADDER NEOPLASMS; YOUNG ADULT;

EID: 77449118373     PISSN: None     EISSN: 1537744X     Source Type: Journal    
DOI: 10.1100/tsw.2009.162     Document Type: Article

References (35)

1. Polenakovic, M. and Stefanovic, V. (1992) Balkan nephropathy. In Oxford Textbook of Clinical Nephrology. 1st ed. Cameron, J.S., Davison, A.M., Grunfeld, J.P., Kerr, D., and Ritz, E., Eds. Oxford University Press, Oxford. pp. 857-866.
2. Stefanovic, V. and Radovanovic, Z. (2008) Balkan endemic nephropathy and associated urothelial cancer. Nat. Clin. Pract. Urol. 5, 105-111.
3. Ivic, M. (1969) The problem of etiology of endemic nephropathy. Lijec. Vjestn. 91, 1278-1281.
4. Nortier, J.L., Martinez, M.C., Schmeiser, H.H., Arlt, V.M., Bieler, C.A., Petein, M., Depierreux, M.F., De Pauw, L., Abramowicz, D., Vereerstraeten, P., and Vanherweghem, J.L. (2000) Urothelial carcinoma associated with the use of a Chinese herb (Aristolochia fangchi). N. Engl. J. Med. 342, 1686-1692.
5. Cosyns, J.P., Jadoul, M., Squifflet, J.P., De Plaen, J.F., Ferluga, D., and van Ypersele de Strihou, C. (1994) Chinese herbs nephropathy: a clue to Balkan endemic nephropathy? Kidney Int. 45, 1680-1688.
6. Grollman, A.P., Shibutani, S., Moriya, M., Miller, F., Wu, L., Moll, U., Suzuki, N., Fernandes, A., Rosenquist, T., Medverec, Z., Jakovina, K., Brdar, B., Slade, N., Turesky, R., Goodenough, A.K., Vukelic, M., and Jelakovic, B. (2007) Aristolochic acid and the etiology of endemic (Balkan) nephropathy. Proc. Natl. Acad. Sci. U. S. A. 104, 12129-12134.
7. Volker, M.A., Stiborova, M., von Brocke, J., Simões, M.L., Lord, G.M., Nortier, J.L., Hollstein, M., Phillips, D.H., and Schmeiser, H.H.. (2007) Aristolochic acid mutagenesis: molecular clues to the aetiology of Balkan endemic nephropathy-associated urothelial cancer. Carcinogenesis 28, 2253-2261.
8. Habuchi, T., Marberger, M., Droller, J.M., Hemstreet, G.P., 3rd, Grossman, H.B., Schalken, J.A., Schmitz-Dräger, B.J., Murphy, W.M., Bono, A.V., Goebell, P., Getzenberg, R.H., Hautmann, S.H., Messing, E., Fradet, Y., and Lokeshwar, V.B. (2005) Prognostic markers for bladder cancer: international consensus panel on bladder tumor markers. Urology 66, 64-74.
9. Jimenez, R.E., Hussain, M., Bianco, F.J., Jr., Vaishampayan, U., Tabazcka, P., Sakr, W.A., Pontes, J.E., Wood, D.P., Jr., and Grignon, D.J. (2001) Her-2/neu overexpression in muscle-invasive urothelial carcinoma of the bladder: prognostic significance and comparative analysis in primary and metastatic tumors. Clin. Cancer Res. 7, 2440-2447.
10. Lopez-Beltran, A., Sauter, G., and Gasser, T. (2004) Tumors of the urinary system. Infiltrating urothelial carcinoma. In World Health Organization Classification of Tumours. Pathology and Genetics. Tumours of the Urinary System and Male Genital Organs. Eble, J.N., Sauter, G., Epstein, J.I., and Sesterhenn, I.A., Eds. IARC, Lyon. pp 93-109.
11. th ed. Wiley-Liss, New York.
12. Genega, E.M., Kapali, M., Torres-Quinones, M., Huang, W.C., Knauss, J.S., Wang, L.P., Raghunath, P.N., Kozlowski, C., Malkowicz, S.B., and Tomaszewski, J.E. (2005) Impact of the 1998 World Health Organization/International Society of Urological Pathology classification system for urothelial neoplasms of the kidney. Mod. Pathol. 18, 11-18.
13. Shariat, S.F., Tokunaga, H., Zhou, J., Kim, J., Ayala, G.E., Benedict, W.F., and Lerner, S.P. (2004) P53, p21, pRB, and p16 expression predict clinical outcome in cystectomy with bladder cancer. J. Clin. Oncol. 22, 1014-1024.
14. Benedict, F.W., Lerner, P.S., Zhou, J., Shen, X., Tokunaga, H., Czerniak, B., Shen, X., Tokunaga, H., and Czerniak, B. (1999) Level of retinoblastoma protein expression correlates with p16 (MTS-1/INK4A/CDKN2) status in bladder cancer. Oncogene 18, 1197-1203.
15. Keegan, P.E., Lunec, J., and Neal, D.E. (1998) P53 and p53-regulated genes in bladder cancer. Br. J. Urol. 82, 710-720.
16. Lee, C.C.R., Yamamoto, S., Morimura, K., Wanibuchi, H., Nishisaka, N., Ikemoto, S., Nakatani, T., Wada, S., Kishimoto, T., and Fukushima, S. (1997) Significance of cyclin D1 overexpression in transitional cell carcinomas of the urinary bladder and its correlation with histopathologic features. Cancer 79, 780-789.
17. Inoue, T., Sato, K., Tsuchiya, N., Matsuura, S., Iinuma, M., Habuchi, T., and Kato, T. (2004) Numeric aberrations of HER-2 and chromosome 17 detected by fluorescence in situ hybridization in urine-exfoliated cells from patients with urothelial carcinoma. Urology 64, 617-621.
18. Krasteva, E.M. and Ivanova, E. (2006) Germline p53 single-base changes associated with Balkan endemic nephropathy. Cell 342, 562-567.
19. Stefanovic, V., and Polenakovic, M. (2009) Fifty years of research in Balkan endemic nephropathy: where are we now? Nephron Clin. Pract. 112, c51-c56.
20. Basic-Jukic, N., Hrsak-Puljic, I., Kes, P., Bubic-Filipi, L., Pasini, J., Hudolin, T., Kastelan, Z., Reiner, Z., Kordic, M., Brunetta, B., and Juric, I. (2007) Renal transplantation in patients with Balkan endemic nephropathy. Transplant. Proc. 39, 1432-1435.
21. Rhijn, B.W.G., Kwast, T.H., Vis, A.N., Kirkels, W.J., Boevé, E.R., Jöbsis, A.C., and Zwarthoff, E.C. (2004) FGFR3 and P53 characterize alternative genetic pathways in the pathogenesis of urothelial cell carcinoma. Cancer Res. 64, 1911-1914.
22. Mhawech-Fauceglia, P., Cheney, R.T., Fischer, G., Beck, A., and Herrmann, F.R. (2006) FGFR3 and p53 protein expressions in patients with pTa and pT1 urothelial bladder cancer. Eur. J. Surg. Oncol. 32, 231-237.
23. Jankovic Velickovic, L., Hattori, T., Visnjic, M., Dimov, I., Stojanovic, M., and Stefanovic, V. (2009) E-cadherin expression in upper urothelial carcinoma in Balkan endemic nephropathy and non-endemic regions. Pathol. Res. Pract. 205, 682-689.
24. Fromont, G., Roupret, M., Amira, N., Siboni, M., Vollancien, G., Validire, P., and Cusseno, O. (2005) Tissue microarray analysis of the prognostic value of E-cadherin, Ki-67, p53, p27, survivin and MSH2 expression in upper urinary tract transitional cell carcinoma. Eur. Urol. 48, 764-770.
25. Ioakim-Liossi, A., Pantazopoulos, D., Karakitsos, P., Athanassiadou, P., Aroni, K., Chourdakis, N., Giachnaki, A., and Athanassiades, P. (2000). DNA ploidy and p53 protein expression in superficial transitional cell carcinoma of the bladder. Cytopathology 11, 96-103.
26. Schichtholz, B., Presler, M., and Matuszewski, M. (2004) Clinical implications of p53 mutation analysis in bladder cancer tissue and urine sediment by functional assay in yeast. Carcinogenesis 25, 2319-2323.
27. Watanabe, J., Nishiyama, H., Okubo, K., Takahashi, T., Toda, Y., Habuchi, T., Kakehi, Y., Tada, M., and Ogawa, O. (2004) Clinical evaluation of p53 mutations in urothelial carcinoma by IHC and FASAY. Urology 63, 989-993.
28. Gao, J., Huang, H.Y., Pak, J., Cheng, J., Zhang, Z.T., Shapiro, E., Pellicer, A., Sun, TT., and Wu, X.R. (2004) p53 deficiency provokes urothelial proliferation and synergizes with activated Ha-ras in promoting urothelial tumorigenesis. Oncogene 23, 687-696.
29. Kawamura, K., Izumi, H., Ma, Z., Ikeda, R., Moriyama, M., Tanaka, T., Nojima, T., Levin, L.S., Fujikawa-Yamamoto, K., Suzuki, K., and Fukasawa, K. (2004) Induction of centrosome amplification and chromosome instability in human bladder cancer cells by p53 mutation and cyclin E overexpresion. Cancer Res. 64, 4800-4809.
30. Hirao, S., Hirao, T., Marsit, C.J., Hirao, Y., Schned, A., Devi-Ashok, T., Nelson, H.H., Andrew, A., Karagas, M.R., and Kelsey, K.T. (2005) Loss of heterozygosity on chromosome 9q and p53 alterations in human bladder cancer. Cancer 104, 1918-1923.
31. Malats, N., Bustos, A., Nascimento, C.M., Fernandez, F., Rivas M., Puente, D., Kogevinas, M., and Real, F.X. (2005) p53 as a prognostic marker for bladder cancer: a meta-analysis and review. Lancet Oncol. 6, 678-686.
32. Petronic, V.J., Bukurov, N.S., Djokic, M.R., Milenkovic, D.Z., Vuksanovic, A.M., Avramovic, A.D., and Nale, D.P. (1991) Balkan endemic nephropathy and papillary transitional cell tumors of the renal pelvis and ureters. Kidney Int. Suppl. 34, S77-S79.
33. Cukuranovic, R., Savic, V., Stefanovic, N., and Stefanovic, V. (2005) Progression of the kidney damage in Balkan endemic nephropathy: a 15-year follow-up of patients with kidney biopsy examination. Renal Fail. 27, 701-706.
34. Savin, M. and Petronic, V. (2001) The significance of apoptosis for early diagnosis of Balkan nephropathy. Nephrol. Dial. Transplant. 16, S30-S32.
35. Jankovic Velickovic, L., Hattori, T., Dolicanin, Z., Visnjic, M., Krstic, M., Ilic, I., Cukuranovic, R., Rajic, M., and Stefanovic, V. (2009) Upper urothelial carcinoma in Balkan endemic nephropathy and non-endemic regions: a comparative study of pathological features. Pathol. Res. Pract. 205, 89-96.