Functionalized self-assembling peptide hydrogel enhance maintenance of hepatocyte activity in vitro

Journal of Cellular and Molecular Medicine

Volumn 13, Issue 9 B, 2009, Pages 3387-3397

  Genové, Elsa ^a,b   Schmitmeier, Stephanie ^c   Sala, Ana ^c   Borrós, Salvador ^a   Bader, Augustinus ^c   Griffith, Linda G ^d   Semino, Carlos E ^a,b  

^a INSTITUT QUÍMIC DE SARRIÀ   (Spain)

^b Massachusetts Institute of Technology Cambridge   (United States)

^c UNIVERSITY OF LEIPZIG   (Germany)

^d MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Collagen; Extracellular matrix analogue; Hepatocyte function; Liver enriched genes; Real time PCR; Sandwich culture system; Self assembling peptides

Indexed keywords

ALBUMINOID; BIOMATERIAL; COLLAGEN; CYP3A2 PROTEIN, RAT; CYTOCHROME P450 3A; MEMBRANE PROTEIN; PEPTIDE; UREA;

ANIMAL; ARTICLE; BILE; BIOENGINEERING; CELL CULTURE; CHEMISTRY; CYTOLOGY; EXTRACELLULAR MATRIX; HYDROGEL; LIVER CELL; METABOLISM; METHODOLOGY; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ALBUMINS; ANIMALS; BILE; BIOCOMPATIBLE MATERIALS; BIOENGINEERING; CELLS, CULTURED; COLLAGEN; CYTOCHROME P-450 CYP3A; EXTRACELLULAR MATRIX; HEPATOCYTES; HYDROGEL; MEMBRANE PROTEINS; PEPTIDES; RATS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; UREA;

EID: 77449103100     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1582-4934.2009.00970.x     Document Type: Article

References (51)

1. Zhang S, Yan L, Altman M. Biological surface engineering: a simple system for cell pattern formation. Biomaterials. 1999, 20:1213-20.
2. Ben Ze'ev A, Robinson GS, Buchter NL. Cell-cell and cell-matrix interactions differentially regulate the expression of hepatic and cytoskeletal genes in primary cultures of rat hepatocytes. PNAS. 1988, 85:2161-5.
3. Dunn JC, Yarmush ML, Koebe HG. Hepatocyte function and extracellular matrix geometry: long-term culture in a sandwich configuration. FASEB J. 1989, 3:174-7.
4. Dunn JC, Tompkins RG, Yarmush ML. Long-term in vitro function of adult hepatocytes in a collagen sandwich configuration. Biotechnol Progr. 1991, 7:237-45.
5. Berthiaume F, Moghe PV, Toner M. Effect of extracellular matrix topology on cell structure, function, and physiological responsiveness: hepatocytes cultured in a sandwich configuration. FASEB J. 1996, 10:1471-84.
6. Silva JM, Morin PE, Day SH. Refinement of an in vitro cell model for cytochrome P450 induction. Drug Metab Dispos. 1998, 26:490-6.
7. Wang Y, Liu H, Guo H. Primary hepatocyte culture in collagen gel mixture and collagen sandwich. World J Gastroenterol. 2004, 10:699-02.
8. Zeisberg M, Kramer K, Sindhi N. De-differentiation of primary human hepatocytes depends on the composition of specialized liver basement membrane. Mol Cell Biochem. 2006, 283:181-9.
9. Bhatia SN, Balis UJ, Yarmush ML. Effect of cell-cell interactions in preservation of cellular phenotype: cocultivation of hepatocytes and nonparenchymal cells. FASEB J. 1999, 13:1883-900.
10. Uyama N, Shimahara Y, Kawada N. Regulation of cultured rat hepatocyte proliferation by stellate cells. J Hepatol. 2002, 36:590-609.
11. Kan P, Miyoshi H, Ohshima N. Perfusion of medium with supplemented growth factors changes metabolic activities and cell morphology of hepatocyte-nonparenchymal cell coculture. Tissue Eng. 2004, 10:1297-307.
12. Auth Marcus KH, Woitaschek D, Beste M. Preservation of the synthetic and metabolic capacity of isolated human hepatocytes by coculture with human biliary epithelial cells. Liver Transpl. 2005, 11:410-9.
13. Powers MJ, Janigian DM, Wack KE. Functional behavior of primary rat liver cells in a three-dimensional perfused microarray bioreactor. Tissue Eng. 2002, 8:499-513.
14. De Bartolo L, Morelli S, Rende M. New modified polyetheretherketone membrane for liver cell culture in biohybrid systems: adhesion and specific functions of isolated hepatocytes. Biomaterials. 2004, 25:3621-9.
15. Sudo R, Mitaka T, Ikeda M. Reconstruction of 3D stacked-up structures by rat small hepatocytes on microporous membranes. FASEB J. 2005, 19:1695-7.
16. De Bartolo L, Salerno S, Morelli S. Long-term maintenance of human hepatocytes in oxygen-permeable membrane bioreactor. Biomaterials. 2006, 27:4794-803.
17. Schmitmeier S, Langsch A, Jasmund I. Development and characterization of a small-scale bioreactor based on a bioartificial hepatic culture model for predictive pharmacological in vitro screenings. Biotechnol Bioeng. 2006, 95:1198-206.
18. Semino CE, Merok JR, Crane GG. Functional differentiation of hepatocyte-like spheroid structures from putative liver progenitor cells in three-dimensional peptide scaffolds. Differentiation. 2003, 71:262-70.
19. Semino CE, Kasahara J, Hayashi Y. Entrapment of migrating hippocampal neural cells in three-dimensional peptide nanofiber scaffold. Tissue Eng. 2004, 10:643-55.
20. Garreta E, Genove E, Borros S. Osteogenic differentiation of mouse embryonic stem cells and mouse embryonic fibroblasts in a three-dimensional self-assembling peptide scaffold. Tissue Eng. 2006, 12:2215-27.
21. Genove E, Shen C, Zhang S. The effect of functionalized self-assembling peptide scaffolds on human aortic endothelial cell function. Biomaterials. 2005, 26:3341-51.
22. Zhang S, Holmes T, Lockshin C. Spontaneous assembly of a self-complementary oligopeptide to form a stable macroscopic membrane. PNAS. 1993, 90:3334-8.
23. Sivaraman A, Leach JK, Townsend S. A microscale in vitro physiological model of the liver: predictive screens for drug metabolism and enzyme induction. Curr Drug Metab. 2005, 6:569-91.
24. Barth CA, Schwarz LR. Transcellular transport of fluorescein in hepatocyte monolayers: evidence for functional polarity of cells in culture. PNAS. 1982, 79:4985-7.
25. LeCluyse EL, Audus KL, Hochman JH. Formation of extensive canalicular networks by rat hepatocytes cultured in collagen-sandwich configuration. Am J Physiol. 1994, 266:1764-74.
26. Hoffmaster KA, Turncliff RZ, LeCluyse EL. P-glycoprotein expression, localization, and function in sandwich-cultured primary rat and human hepatocytes: relevance to the hepatobiliary disposition of a model opioid peptide. Pharm Res. 2004, 21:1294-302.
27. Li RH, Altreuter DH, Gentile FT. Transport characterization of hydrogel matrixes for cell encapsulation. Biotechnol Bioeng. 1996, 50:365-73.
28. Muller M, Jansen PL. Molecular aspects of hepatobiliary transport. Am J Physiol. 1997, 272:1285-303.
29. Jitrapakdee S, Wallace JC. Structure, function and regulation of pyruvate carboxylase. Biochem J. 1999, 340:1-16.
30. Baumgartner MR, Almashanu S, Suormala T. The molecular basis of human 3-methylcrotonyl-CoA carboxylase deficiency. J Clin Invest. 2001, 107:495-504.
31. Jiang H, Rao KS, Yee VC. Characterization of four variant forms of human propionyl-coa carboxylase expressed in escherichia coli. J Biol Chem. 2005, 280:27719-27.
32. Farkas D, Bhat VB, Mandapati S. Characterization of the secreted proteome of rat hepatocytes cultured in collagen sandwiches. Chem Res Toxicol. 2005, 18:1132-9.
33. Frank PG, Marcel YL. Apolipoprotein A-I: structure-function relationships. J Lipid Res. 2000, 41:853-72.
34. Ajees AA, Anantharamaiah GM, Mishra VK. Crystal structure of human apolipoprotein A-I: insights into its protective effect against cardiovascular diseases. PNAS. 2006, 103:2126-31.
35. Barter PJ, Rye KA. The rationale for using apoA-I as a clinical marker of cardiovascular risk. J Intern Med. 2006, 259:447-54.
36. Falkenberg C, Grubb A, Aakerstroem B. Isolation of rat serum a1-microglobulin. Identification of a complex with a1-inhibitor-3, a rat a2-macroglobulin homolog. J Biol Chem. 1990, 265:16150-7.
37. Rouet P, Raguenez G, Ruminy P. An array of binding sites for hepatocyte nuclear factor 4 of high and low affinities modulates the liver-specific enhancer for the human a1-microglobulin/bikunin precursor. Biochem J. 1998, 334:577-84.
38. Logdberg LE, Akerstrom B, Badve S. Tissue distribution of the lipocalin alpha-1 microglobulin in the developing human fetus. J Histochem Cytochem. 2000, 48:1545-52.
39. Eichner JE, Terence DS, Perveen G. Apolipoprotein E polymorphism and cardiovascular disease: a HuGE review. Am J Epidemiol. 2002, 155:487-95.
40. Alper CA, Peters JH, Birtch AG. Haptoglobin synthesis. I. In vivo studies of the production of haptoglobin, fibrinogen, and g-globulin by the canine liver. J Clin Invest. 1965, 44:574-81.
41. Ship NJ, Toprak A, Lai RP. Binding of acellular, native and cross-linked human hemoglobins to haptoglobin: enhanced distribution and clearance in the rat. Am J Physiol. 2005, 288:1301-9.
42. Kapron JT, Hilliard GM, Lakins JN. Identification and characterization of glycosylation sites in human serum clusterin. Prot Sci. 1997, 6:2120-33.
43. Min BH, Jeong SY, Kang SW. Transient expression of clusterin (sulfated glycoprotein-2) during development of rat pancreas. J Endocrinol. 1998, 158:43-52.
44. Calero M, Tokuda T, Rostagno A. Functional and structural properties of lipid-associated apolipoprotein J (clusterin). Biochem J. 1999, 344:375-83.
45. Tsuji A, Akamatsu T, Nagamune H. Identification of targeting proteinase for rat a1-macroglobulin in vivo. Mast-cell tryptase is a major component of the a1-macroglobulin-proteinase complex endocytosed into rat liver lysosomes. Biochem J. 1994, 298:79-85.
46. Soprano DR, Soprano KJ, Goodman DS. Retinol-binding protein messenger RNA levels in the liver and in extrahepatic tissues of the rat. J Lipid Res. 1986, 27:166-71.
47. Tamkun JW, Hynes RO. Plasma fibronectin is synthesized and secreted by hepatocytes. J Biol Chem. 1983, 258:4641-7.
48. Braciak TA, Northemann W, Hudson GO. Sequence and acute phase regulation of rat alpha 1-inhibitor III messenger RNA. J Biol Chem. 1988, 263:3999-4012.
49. Abraham LJ, Bradshaw AD, Shiels BR. Hepatic transcription of the acute-phase a1-inhibitor III gene is controlled by a novel combination of cis-acting regulatory elements. Mol Cell Biol. 1990, 10:3483-91.
50. Turncliff RZ, Meier PJ, Brouwer KL. Effect of dexamethasone treatment on the expression and function of transport proteins in sandwich-cultured rat hepatocytes. Drug Metab Dispos. 2004, 32:834-9.
51. Abu-Absi SF, Hu WS, Hansen LK. Dexamethasone effects on rat hepatocyte spheroid formation and function. Tissue Eng. 2005, 11:415-26.