Influence of poly-(L-lactic acid) nanofiber functionalization on maximum load, Young's modulus, and strain of nanofiber scaffolds before and after cultivation of osteoblasts: An in vitro study

TheScientificWorldJournal

Volumn 9, Issue , 2009, Pages 1382-1393

  Paletta, Jürgen R J ^a   Erffmeier, Karla ^a   Theisen, Christina ^a   Hussain, Daniel ^a   Wendorff, Joachim H ^a   Greiner, Andreas ^a   Fuchs Winkelmann, Susanne ^a   Schofer, Markus D ^a  

^a UNIVERSITY HOSPITAL MARBURG   (Germany)

Author keywords

BMP blending; Collagen; Electrospinning; Mechanical stability; Nanofibers; PLLA functionalization; Tissue engineering

Indexed keywords

BONE MORPHOGENETIC PROTEIN 2; COLLAGEN; DICHLOROMETHANE; GROWTH FACTOR; HEXAFLUORO 2 PROPANOL; NANOFIBER; POLY (LEVO LACTIC ACID) NANOFIBER; SOLVENT; TISSUE SCAFFOLD; UNCLASSIFIED DRUG; LACTIC ACID; POLYLACTIC ACID; POLYMER;

ARTICLE; CELL CULTURE; CELL GROWTH; CELL STRAIN; CONTROLLED STUDY; ELECTROSPINNING; HUMAN; HUMAN CELL; IN VITRO STUDY; OSTEOBLAST; TECHNIQUE; CHEMISTRY; PHYSIOLOGY; SCANNING ELECTRON MICROSCOPY; TENSILE STRENGTH; WEIGHT BEARING; YOUNG MODULUS;

CELLS, CULTURED; ELASTIC MODULUS; HUMANS; LACTIC ACID; MICROSCOPY, ELECTRON, SCANNING; NANOFIBERS; OSTEOBLASTS; POLYMERS; TENSILE STRENGTH; TISSUE SCAFFOLDS; WEIGHT-BEARING;

EID: 77449093838     PISSN: None     EISSN: 1537744X     Source Type: Journal    
DOI: 10.1100/tsw.2009.149     Document Type: Article

References (35)

1. Ashammakhi, N., Ndreu, A., Yang, Y., Ylikauppila, H., and Nikkola, L. (2008) Nanofiber-based scaffolds for tissue engineering. Eur. J. Plast. Surg. [Online].
2. Zhang, Y., Lim, C.T., Ramakrishna, S., and Huang, Z.M. (2005) Recent development of polymer nanofibers for biomedical and biotechnological applications. J. Mater. Sci. Mater. Med. 16, 933-946.
3. Li, W.J., Laurencin, C.T., Caterson, E.J., Tuan, R.S., and Ko, F.K. (2002) Electrospun nanofibrous structure: a novel scaffold for tissue engineering. J. Biomed. Mater. Res. 60, 613-621.
4. Liao, S., Li, B., Ma, Z., Wei, H., Chan, C., and Ramakrishna, S. (2006) Biomimetic electrospun nanofibers for tissue regeneration. J. Biomed. Mater. 1, R45-53.
5. Venugopal, J., Sharon, L., Aw Tar, C., and Ramakrishna, S. (2008) Interaction of cells and nanofiber scaffolds in tissue engineering. J. Biomed. Mater. Res. B Appl. Biomater. 84B, 34-48.
6. Greiner, A. and Wendorff, J.H. (2007) Electrospinning: a fascinating method for the preparation of ultrathin fibres. Angew. Chem. Int. Ed. 46, 5670-5703.
7. Peltoniemi, H., Ashammakhi, N., Kontio, R., Waris, T., Salo, A., Lindqvist, C., Grätz, K., and Suuronen, R. (2002) The use of bioabsorbable osteofixation devices in craniomaxillofacial surgery. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. 94, 5-14.
8. Suuronen, R., Pohjonen, T., Hietanen, J., and Lindqvist, C. (1998) A five-year in vitro and in vivo study of the biodegradation of polylactide plates. J. Oral Maxillofac. Surg. 56, 604-614.
9. Suuronen, R., Haers, P., Lindqvist, C., and Sailer, H. (1999) Update on bioresorbable plates in maxillofacial surgery. Facial Plast. Surg. 15(1), 61-72.
10. Waris, E., Ashammakhi, N., Kaarela, O., Raatikainen, T., and Vasenius, J. (2004) Use of bioabsorbable osteofixation devices in the hand. J. Hand Surg. Br. 29, 590-598.
11. Ashammakhi, N., Peltoniemi, H., Waris, E., Suuronen, R., Serlo, W., Kellomaki, M., Tormala, P., and Waris, T. (2001) Developments in craniomaxillofacial surgery: use of self-reinforced bioabsorbable osteofixation devices. Plast. Reconstr. Surg. 108, 167-180.
12. Rokkanen, P.U., Böstman, O., Hirvensalo, E., Mäkelä, E.A., Partio, E.K., Pätiälä, H., Vainionpää, S., Kimmo, V., and Törmälä, P. (2000) Bioabsorbable fixation in orthopaedic surgery and traumatology. Biomaterials 21, 2607-2613.
13. Spitalny, A.D. (2006) Bioabsorbable implants. Clin. Podiatr. Med. Surg. 23, 673-694.
14. Hughes, T.B. (2006) Bioabsorbable implants in the treatment of hand fractures: an update. Clin. Orthop. Relat. Res. 445, 169-174.
15. Boudriot, U., Dersch, R., Greiner, A., and Wendorff, J.H. (2006) Electrospinning approaches toward scaffold engineering - a brief overview. Artif. Organs 30, 785-792.
16. Boudriot, U., Goetz, B., Dersch, R., Greiner, A., and Wendorff, H.J. (2005) Role of electrospun nanofibers in stem cell technologies and tissue engineering. Macromol. Symp. 225, 9-16.
17. Woo, K.M., Jun, J.-H., Chen, V.J., Seo, J., Baek, J.-H., Ryoo, H.-M., Kim, G.-S., Somerman, M.J., and Ma, P.X. (2007) Nano-fibrous scaffolding promotes osteoblast differentiation and biomineralization. Biomaterials 28, 335-343.
18. Boudriot, U., Dersch, R., Goetz, B., Griss, P., Greiner, A., and Wendorff, J.H. (2004) Elektrogesponnene Poly-L-Laktid-Nanofasern als resorbierbare Matrix fur Tissue-Engineering. Biomed. Tech. 49, 242-247.
19. Schofer, M.D., Boudriot, U., Wack, C., Leifeld, I., Gräbedü nkel, C., Dersch, R., Rudisile, M., Wendorff, H.J., Greiner, A., Paletta, J.R.J., and Fuchs-Winkelmann, S. (2008) Influence of nanofibers on the growth and osteogenic differentiation of stem cells: a comparison of biological collagen nanofibers and synthetic PLLA fibers. J. Mater. Sci. Mater. Med. 20(3), 767-774.
20. Schofer, M.D., Fuchs-Winkelmann, S., Gräbedünkel, C., Wack, C., Dersch, R., Rudisile, M., Wendorff, J.H., Greiner, A., Paletta, J.R.J., and Boudriot, U. (2008) Influence of poly(L-lactic acid) nanofibers and BMP-2-containing poly(L-lactic acid) nanofibers on growth and osteogenic differentiation of human mesenchymal stem cells. TheScientificWorldJOURNAL 8, 1269-1279.
21. Ngiam, M., Liao, S., Patil, A.J., Cheng, Z., Yang, F., Gubler, M.J., Ramakrishna, S., and K., C.C. (2008) Fabrication of mineralized polymeric nanofibrous composites for bone graft materials. Tissue Eng. Part A 15(3), 535-546.
22. Jahno, V.D., Ribeiro, G.B., dos Santos, L.A., Ligabue, R., Einloft, S., Ferreira, M.R., and Bombonato-Prado, K.F. (2007) Chemical synthesis and in vitro biocompatibility tests of poly (L-lactic acid). J. Biomed. Mater. Res. A 83, 209-215.
23. Ishaug, S.L., Yaszemski, M.J., Bizios, R., and Mikos, A.G. (1994) Osteoblast function on synthetic biodegradable polymers. J. Biomed. Mater. Res. 28, 1445-1453.
24. Venugopal, J.R., Low, S., Choon, A.T., Kumar, A.B., and Ramakrishna, S. (2008) Nanobioengineered electrospun composite nanofibers and osteoblasts for bone regeneration. Artif. Organs 32, 388-397.
25. Shih, Y.R., Chen, C.N., Tsai, S.W., Wang, Y.J., and Lee, O.K. (2006) Growth of mesenchymal stem cells on electrospun type I collagen nanofibers. Stem Cells 24, 2391-2397.
26. Schofer, M.D., Boudriot, U., Leifeld, I., Sutterlin, R.I., Rudisile, M., Wendorff, J.H., Greiner, A., Paletta, J.R., and Fuchs-Winkelmann, S. (2009) Characterization of a PLLA-collagen I blend nanofiber scaffold with respect to growth and osteogenic differentiation of human mesenchymal stem cells. TheScientificWorldJOURNAL 9, 118-129.
27. Li, W.J., Mauck, R.L., Cooper, J.A., Yuan, X., and Tuan, R.S. (2007) Engineering controllable anisotropy in electrospun biodegradable nanofibrous scaffolds for musculoskeletal tissue engineering. J. Biomech. 40, 1686-1693.
28. Jaiswal, N., Haynesworth, S.E., Caplan, A.I., and Bruder, S.P. (1997) Osteogenic differentiation of purified, culture-expanded human mesenchymal stem cells in vitro. J. Cell. Biochem. 64, 295-312.
29. Schofer, M.D., Boudriot, U., Wack, C., Leifeld, I., Grabedunkel, C., Dersch, R., Rudisile, M., Wendorff, J.H., Greiner, A., Paletta, J.R., and Fuchs-Winkelmann, S. (2009) Influence of nanofibers on the growth and osteogenic differentiation of stem cells: a comparison of biological collagen nanofibers and synthetic PLLA fibers. J. Mater. Sci. Mater. Med. 20, 767-774.
30. Suuronen, R., Kallela, I., and Lindqvist, C. (2000) Bioabsorbable plates and screws: current state of the art in facial fracture repair. J. Craniomaxillofac. Trauma 6, 19-27; discussion 28-30.
31. Tanaka, N., Hirose, K., Sakahashi, H., Ishima, T., and Ishii, S. (2004) Usefulness of bioabsorbable thread pins after resection arthroplasty for rheumatoid forefoot reconstruction. Foot Ankle Int. 25, 496-502.
32. Giavaresi, G., Tschon, M., Borsari, V., Daly, J.H., Liggat, J.J., Fini, M., Bonazzi, V., Nicolini, A., Carpi, A., Morra, M., Cassinelli, C., and Giardino, R. (2004) New polymers for drug delivery systems in orthopaedics: in vivo biocompatibility evaluation. Biomed. Pharmacother. 58, 411-417.
33. Dersch, R., Liu, K.T., Schaper, A., Greiner, A., and Wendorff, J.H. (2003) Electrospun nanofibers: internal structure and intrinsic orientation. J. Polym. Sci. A Polym. Chem. 41, 545-553.
34. Zeng, J., Hou, H., Schaper, A., Wendorff, J.H., and Greiner, A. (2003) Poly-L-lactide nanofibers by electrospinning - influence of solution viscosity and electrical conductivity on fiber diameter and fiber morphology. e-Polymers No. 009.
35. Huang, L., Nagapudi, K., Apkarian, R.P., and Chaikof, E.L. (2001) Engineered collagen-PEO nanofibers and fabrics. J. Biomater. Sci. Polym. Ed. 12, 979-993.