Plugs clog the glandular outlets in fundic gland polyps

International Journal of Clinical and Experimental Pathology

Volumn 3, Issue 1, 2010, Pages 69-74

  Rubio, Carlos A ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Cystic formations; Eosinophilic plugs; Fundic gland polyps

Indexed keywords

ARTICLE; CELL GRANULE; COLON POLYPOSIS; GASTRITIS; GENETICS; HUMAN; MUTATION; PATHOLOGY; POLYP; STOMACH FUNDUS; STOMACH MUCOSA; SWEDEN;

ADENOMATOUS POLYPOSIS COLI; CYTOPLASMIC GRANULES; GASTRIC FUNDUS; GASTRIC MUCOSA; GASTRITIS; HUMANS; MUTATION; POLYPS; SWEDEN;

EID: 77449092299     PISSN: None     EISSN: 19362625     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Nishiura, M, Hirota, T and Itabashi, M. A clinical and histopathological study of gastric polyps in familial polyposis coli. Am J Gastroenterol 1984; 79: 98-103.
2. Lee, RG and Burt, RW. The histopathology of fundic gland polyps of the stomach. Am J Clin Pathol 1986; 86: 498-503.
3. Elster K. Histologic classification of gastric polyps. Curr Top Pathol. 1976; 63: 77-93.
4. Lee RG and Burt RW. The histopathology of fundic gland polyps of the stomach. Am J Clin Pathol 1986; 86: 498-503.
5. Domizio, P, Talbot, IC and Spigelman, AD. Upper gastrointestinal pathology in familial adenomatous polyposis: Results from a prospective study of 102 patients. J Clin Pathol 1990; 43: 738-743.
6. Odze, RD, Marcial, MA and Antonioli, D. Gastric fundic gland polyps: A morphological study including mucin histochemistry, stereometry, and MIB-1 immunohistochemistry. Hum Pathol 1996; 27: 896-903.
7. Odze, RD. Gastric fundic gland polyps: Are they preneoplastic lesions? Gastroenterology 1998; 114: 422-423.
8. Declich, P, Isimbaidi, G and Sironi, M. Sporadic fundic gland polyps: An immunohistochemical study of their antigenic profile. Pathol Res Pract. 1996; 192: 808-815.
9. Marcial, MA, Villafana, M and Hernandez-Denton, J. Fundic gland polyps: Prevalence and clinicopathologic features. Am J Gastroenterol. 1993; 88: 1711-1713.
10. Iida M, Yao T, Watanabe H, Itoh H and Iwashita A. Fundic gland polyposis in patients without familial adenomatosis coli: its incidence and clinical features. Gastroenterology 1984; 86: 1437-1442.
11. Hizawa K, Iida M, Matsumoto T, Aoyagi K, Yao T and Fujishima M. Natural history of fundic gland polyposis without familial adenomatosis coli: follow-up observations in 31 patients. Radiology. 1993; 189: 429-432.
12. Tsuchikame N, Ishimaru Y, Ohshima S and Takahashi M. Three familial cases of fundic gland polyposis without polyposis coli. Virchows Arch A Pathol Anat Histopathol 1993; 422: 337-340.
13. Kinoshita Y, Tojo M, Yano T, Kitajima N, Itoh T and Nishiyama K, et al. Incidence of fundic gland polyps in patients without familial adenomatous polyposis. Gastrointest Endosc 1993; 39: 161-163.
14. Choudhry U, Boyce HW and Coppola D. Proton pump inhibitor-associated gastric polyps: a retrospective analysis of their frequency, and endoscopic, histologic, and ultrastructural characteristics. Am J Clin Pathol 1998; 110: 615-621.
15. Graham JR. Omeprazole and gastric polyposis in humans. Gastroenterology 1993; 104: 1584-1586.
16. el-Zimaity HM, Jackson FW and Graham DY. Fundic gland polyps developing during omeprazole therapy. Am J Gastroenterol 1997; 92: 1858-1860.
17. Declich P, Ambrosiani L, Grassini R, Tavani E, Bellone S and Bortoli A. Fundic gland polyps: a still elusive entity on the eve of the year 2000. Pol J Pathol 2000; 51: 3-8.
18. Burt WR. Gastric fundic gland polyps. Gastroenterology. 2003; 125: 1462-1469.
19. Sebastian S, Qasim A, McLoughlin R, O'Morain C and O'Connor H. Fundic gland polyps: not so trivial entity and worth evaluation. Gastroenterology. 2004; 126: 1497-8.
20. Jung A, Vieth M, Meir O and Stolte M. Fundic gland polyps (Elsters cysts) of the gastric mucosa. A marker for colorectal epithelial neoplasia? Pathol Res Pract 2002; 198: 731-734.
21. Kinoshita Y, Tojo M and Yano T. Incidence of fundic gland polyps in patients without familial adenomatous polyposis. Gastrointest. Endosc 1993; 39: 161-163.
22. Declich P, Bellone S, Ambrosiani L, Bortoli A, Gozzini C, Tavani E and Grassini R, Prada A. Fundic gland polyps: do they arise as a by-product of hypergastrinemia in patients with Zollinger-Ellison syndrome? Hum Pathol 2000; 31: 889-90.
23. Freeman HJ. Proton pump inhibitors and an emerging epidemic of gastric fundic gland polyposis. World J Gastroenterol 2008; 14: 1318-20.
24. Utsunomiya J, Maki T, Iwama T, Matsunaga Y and Ichikawa T. Gastric lesions of familial polyposis of the colon. Nippon Shokakibyo Gakkai Zasshi 1974; 71: 86-95.
25. Watanabe H, Enjoji M and Yao T. Gastric lesions in familial adenomatosis coli: Their incidence and histologic analysis. Hum Pathol 1978; 9: 269-283.
26. Rubio CA. My approach to reporting a gastric biopsy. J Clin Pathol 2007; 60: 160-6.
27. Abraham SC, Nobukawa B, Giardiello FM, Hamilton SR and Wu TT. Sporadic fundic gland polyps: common gastric polyps arising through activating mutations in the beta-catenin gene. Am J Pathol 2001; 158: 1005-1010.
28. Abraham SC, Park SJ, Mugartehui L, Hamilton SR, and Wu TT. Sporadic fundic gland polyps with epithelial dysplasia (evidence for preferential targeting for mutations in the adenomatous polyposis coli gene). Am J Pathol 2002; 161: 1735-1742.
29. Abraham SC, Park SJ, Cruz-Correa M, Houlihan PS, Half EE, Lynch PM and Wu TT. Frequent CpG island methylation in sporadic and syndromic gastric fundic gland polyps. Am J Clin Pathol 2004; 122: 740-746.
30. Hassan A, Yerian LM, Kuan SF, Xiao SY, Hart J and Wang HL. Immunohistochemical evaluation of adenomatous polyposis coli, beta-catenin, c-Myc, cyclin D1, p53, and retinoblastoma protein expression in syndromic and sporadic fundic gland polyps. Hum Pathol 2004; 35: 328-34.
31. Sekine S, Shibata T, Yamauchi Y, Nakanishi Y, Shimoda T, Sakamoto M and Hirohashi S. Beta-catenin mutations in sporadic fundic gland polyps. Virchows Arch 2002; 440: 381-386.
32. Abraham SC, Nobukawa B, Giardiello FM, Hamilton SR and Wu TT. Fundic gland polyps in familial adenomatous polyposis: neoplasms with frequent somatic adenomatous polyposis coli gene alterations. Am J Pathol 2000; 157: 747-754.
33. Abraham SC, Nobukawa B, Giardiello FM, Hamilton SR and Wu TT. Sporadic fundic gland polyps: common gastric polyps arising through activating mutations in the beta-catenin gene. Am J Pathol 2001; 158: 1005-1010.
34. Fearnhead NS, Britton MP and Bodmer WF. The ABC of APC. Hum Mol Genet 2001; 10: 721-733.
35. Torbenson M, Lee J-H, Cruz-Correa M, Ravich W, Rastgar K, Abraham S and Wu T. Sporadic fundic gland polyposis: A clinical, histological, and molecular analysis. Mod Pathol 2002; 15: 718-723.
36. Groden J, Thilveris A and Samovitz W. Identification and characterisation of the Familial Adenomatous Polyposis Coli gene. Cell 1991; 66: 589-600.
37. Judd LM, Andringa A, Rubio CA, Spicer Z, Shull GE and Miller ML. Gastric achlorhydria in H/K-ATPase-deficient (Atp4a(-/-)) mice causes severe hyperplasia, mucocystic metaplasia and upregulation of growth factors. J Gastroenterol Hepatol. 2005; 20: 1266-1278.
38. Rubio CA, Kato Y, Sugano H and Hirota T. The intramucosal cysts of the stomach. VII: A pathway of gastric carcinogenesis? J Surg Oncol 1986; 32: 214-9.
39. Rubio CA, Kato Y and Sugano H. The intramucosal cysts of the stomach. IV Their quantitative and qualitative characteristics in focal (elevated) neoplastic lesions. Pathol Res Pract. 1984; 179: 105-109.
40. Rubio CA. Possible mechanism pertinent to mucosal invasion in sporadic colonic adenomas. Anticancer Res 24: 2033-2036, 2004.