The candidate gene approach in asthma: What happens with the neighbours

European Journal of Human Genetics

Volumn 18, Issue 1, 2010, Pages 17-

  Reijmerink, Naomi E ^a,b   Postma, Dirkje S ^a   Koppelman, Gerard H ^b  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^b UNIVERSITY OF GRONINGEN   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 18; INTERLEUKIN 18 RECEPTOR; INTERLEUKIN 18 RECEPTOR ALPHA; INTERLEUKIN 33; TOLL LIKE RECEPTOR; CELL SURFACE RECEPTOR; IL1RL1 PROTEIN, HUMAN;

ASTHMA; ATOPY; CHROMOSOME 2Q; ECZEMA; GENETIC ASSOCIATION; HUMAN; LETTER; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; SINGLE NUCLEOTIDE POLYMORPHISM; TH1 CELL; TH1 TH2 BALANCE; TH2 CELL; GENE LINKAGE DISEQUILIBRIUM; GENETIC PREDISPOSITION; GENETICS; NOTE;

ASTHMA; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; HUMANS; LINKAGE DISEQUILIBRIUM; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, CELL SURFACE; RECEPTORS, INTERLEUKIN-18;

EID: 77449085784     PISSN: 10184813     EISSN: 14765438     Source Type: Journal    
DOI: 10.1038/ejhg.2009.128     Document Type: Letter

References (14)

1. Vercelli D: Discovering susceptibility genes for asthma and allergy. Nat Rev Immunol 2008;8: 169-182. (Pubitemid 351323288)
2. Zhu G, Whyte MK, Vestbo J et al: Interleukin 18 receptor 1 gene polymorphisms are associated with asthma. Eur J Hum Genet 2008;16: 1083-1090.
3. Torigoe K, Ushio S, Okura T et al: Purification and characterization of the human interleukin-18 receptor. J Biol Chem 1997;272: 25737-25742. (Pubitemid 27438893)
4. Nakanishi K, Yoshimoto T, Tsutsui H, Okamura H: Interleukin-18 is a unique cytokine that stimulates both Th1 and Th2 responses depending on its cytokine milieu. Cytokine Growth Factor Rev 2001;12: 53-72. (Pubitemid 32294587)
5. Reijmerink NE, Postma DS, Bruinenberg M et al: Association of IL1RL1, IL18R1, and IL18RAP gene cluster polymorphisms with asthma and atopy. J Allergy Clin Immunol 2008;122: 651-654.
6. XuD,ChanWL, LeungBP et al: Selective expression of a stable cell surface molecule on type 2 but not type 1 helper T cells. J Exp Med 1998;187: 787-794. (Pubitemid 28115194)
7. McGuirk P, McCann C, Mills KH: Pathogen-specific T regulatory 1 cells induced in the respiratory tract by a bacterial molecule that stimulates interleukin 10 production by dendritic cells: a novel strategy for evasion of protective T helper type 1 responses by Bordetella pertussis. J Exp Med 2002;195: 221-231. (Pubitemid 34461266)
8. Lecart S, Lecointe N, Subramaniam A et al: Activated. but not resting human Th2 cells, in contrast to Th1 and T regulatory cells, produce soluble ST2 and express low levels of ST2L at the cell surface. Eur J Immunol 2002;32: 2979-2987. (Pubitemid 35238191)
9. Hayakawa H, Hayakawa M, Kume A, Tominaga S: Soluble ST2 blocks interleukin-33 signaling in allergic airway inflammation. J Biol Chem 2007;282: 26369-26380. (Pubitemid 47443815)
10. Brint EK, Xu D, Liu H et al: ST2 is an inhibitor of interleukin 1 receptor and Toll-like receptor 4 signaling and maintains endotoxin tolerance. Nat Immunol 2004;5: 373-379. (Pubitemid 38500085)
11. Schmitz J, Owyang A, Oldham E et al: IL-33. an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines. Immunity 2005;23: 479-490. (Pubitemid 41587888)
12. Mangan NE, Dasvarma A, McKenzie AN, Fallon PG: T1/ST2 expression on Th2 cells negatively regulates allergic pulmonary inflammation. Eur J Immunol 2007;37: 1302-1312. (Pubitemid 46925314)
13. Gudbjartsson DF, Bjornsdottir US, Halapi E et al: Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction. Nat Genet 2009;41: 342-347.
14. Shimizu M, Matsuda A, Yanagisawa K et al: Functional SNPs in the distal promoter of the ST2 gene are associated with atopic dermatitis. Hum Mol Genet 2005;14: 2919-2927. (Pubitemid 41418796)