Anti-thyroid antibodies and antiphospholipid syndrome: Evidence of reduced fecundity and of poor pregnancy outcome in recurrent spontaneous aborters

American Journal of Reproductive Immunology

Volumn 52, Issue 4, 2004, Pages 263-266

  De Carolis, Caterina ^a   Greco, Elisabetta ^b   Guarino, Maria D ^b   Perricone, Carlo ^b   Dal Lago, Alessandro ^a   Giacomelli, Roberto ^c   Fontana, Luigi ^b   Perricone, Roberto ^b  

^a ASL Roma B   (Italy)

^b UNIVERSITY OF ROME TOR VERGATA   (Italy)

^c UNIVERSITY OF L'AQUILA   (Italy)

Author keywords

APS; Fecundity; Pregnancy outcome; Spontaneous abortion; Thyroid autoimmunity

Indexed keywords

IMMUNOGLOBULIN; THYROID ANTIBODY;

ADULT; ANTIPHOSPHOLIPID SYNDROME; ARTICLE; AUTOIMMUNITY; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; FEMALE FERTILITY; FEMALE INFERTILITY; HUMAN; LABORATORY DIAGNOSIS; MAJOR CLINICAL STUDY; OUTCOMES RESEARCH; PREGNANCY RATE; PRIORITY JOURNAL; RISK ASSESSMENT; RISK FACTOR; SPONTANEOUS ABORTION; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; THYROID FUNCTION;

EID: 7744246735     PISSN: 10467408     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0897.2004.00215.x     Document Type: Article

References (22)

1. Matalon ST, Blanck M, Ornoy A, Shoenfeld Y: The association between anti-thyroid antibodies and pregnancy loss. Am J Reprod Immunol 2001; 45:72-77.
2. Kutteh WH: Recurrent pregnancy loss: an update. Curr Opin Obstet Gynecol 1999; 11:435-439.
3. Tartakover-Matalon SH, Blank M, Levy Y, Carp HJA, Arad A, Burek L, Grunebaum E, Sherer Y, Ornoy A, Refetoff S, Weiss RE, Rose NR, Shoenfeld Y: The pathogenic role of anti-thyroglobulin antibody on pregnancy: evidence from an active immunization model in mice. Human Reprod 2003; 18:1094-1099.
4. Cowchock S, Smith JB, Gocial B: Antibodies to phospholipids and nuclear antigens in patients with repeated abortions. Am J Obstet Gynecol 1986; 155:1002-4010.
5. Maier DB, Parke A: Subclinical autoimmunity in recurrent aborters. Fertil Steril 1989; 280:280-285.
6. Unander AM, Norberg R, Hahn L, Arfors L: Anticardiolipin antibodies and complement in ninety-nine women with abitual abortion. Am J Obstet Gynecol 1987; 156:114-119.
7. Branch DW, Scott JR, Kochenur NK, Hersgold E: Obstetric complications associated with lupus anticoagulant. N Engl J Med 1985; 10:2938-2940.
8. Singh A: Presence of thyroid antibodies in early reproductive failure: biochemical versus clinical pregnancies. Fertil Steril 1995; 63:277-281.
9. Bussen S, Steck T, Dietl J: Thyroid autoantibodies in euthyroid non pregnant women with recurrent spontaneous abortions. Hum Reprod 1995; 10:2938-2940.
10. Stagnaro-Green A: Detection at risk pregnancy by means of highly sensitive assays for thyroid autoantibodies. JAMA 1990; 264:1422-1425.
11. Glinoer D, Soto MF, Bourdoux P: Pregnancy in patients with mild thyroid abnormalities: maternal and neonatal repercussions. J Clin Endocrinol Metab 1991; 73:421-427.
12. Vaquero E, Lazzarin N, De Carolis C, Valensise H, Moretti C, Romanini C: Mild thyroid abnormalities and recurrent spontaneous abortion: diagnostic and therapeutical approach. Am J Reprod Immunol 2000; 43:204-208.
13. Nabriski D, Ellis M, Ness-Abramot R, Shapiro M, Shenkman L: Autoimmune thyroid disease and antiphospholipid antibodies. Am J Hematol 2000; 64:73-75.
14. Paggi A, Caccavo D, Ferri GM, Deprima MA, Amoroso A, Vaccaro F, Bonomo L, Afeltra A: Anticardiolipin antibodies in autoimmune thyroid diseases. Clin Endocrinol 1994; 40:329-333.
15. Wilson WA, Gharavi AE, Koike T, Lockshin MD, Branch DW, Piette JC, Brey R, Derkesen R, Harris EN, Hughes GR, Triplett DA, Khamashta MA: International consensus statement on preliminary classification criteria for definite antiphospholipid syndrome. Arthritis Rheum 1999; 42:1309-1311.
16. Marai B, Gilburd M, Blank M, Shoenfeld Y: Anti-cardiolipin and anti-β2-glycoprotein I (β2GP-I) antibody assays as screening for anti-phospholipid syndrome. Human Antibodies 2003; 12:57-62.
17. Brandt JT: Criteria for the diagnosis of Lupus Anticoagulants: an update. On behalf of the subcommittee on Lupus Anticoagulant/Antiphospholipid Antibody of the Scientific Standardization Committee of ISTH. Thromb Haemost 1995; 74:1185-1190.
18. De Carolis C, Vaquero E, Miriello D, Ruggiero G, Valensise H, Perricone R, Fontana L, Romanini C: Successful high dose intravenous immunoglobulins (IVIg) treatment in recurrent autoimmune or alloimmune spontaneous abortion. Int J Immunopathol Pharmacol 1997; 10:125-133.
19. Geva E, Amit A, Lerner-Geva L, Lessing JB: Autoimmune and reproduction. Fertil Steril 1997; 67:329-333.
20. Geva E, Amit A, Lerner-Geva L, Azem F, Yovel Y, Lessing JB: Autoimmune disorders: another possible cause for in vitro fertilization and embryo transfer failure. Hum Reprod 1995; 10:101-104.
21. Bell KA, Van Deerlin PG, Haddad BR, Feinberg RF: Cytogenetic diagnosis of "normal 46,XX" karyotypes in spontaneous abortions frequently may be misleading. Fertil Steril 1999; 71:334-341.
22. Carp H, Toder V, Aviram A, Daniely M, Mashiach S, Barkai G: Karyotype of the abortus in recurrent miscarriage. Fertil Steril 2001; 75:678-682.