Increased expression of thymidine phosphorylase in tumor tissue in proportion to TP-expression in primary normal tissue

Oncology Reports

Volumn 12, Issue 3, 2004, Pages 539-541

  Hotta, Tsukasa ^a   Taniguchi, Katsutoshi ^a   Kobayashi, Yasuhito ^a   Johata, Kiyofumi ^a   Sahara, Masaki ^a   Naka, Teiji ^a   Watanabe, Takashi ^a   Ochiai, Minoru ^a   Tanimura, Hiroshi ^a   Tsubota, Yukari T ^a  

^a WAKAYAMA ROSAI HOSPITAL   (Japan)

Author keywords

Colorectal cancer; Gastric cancer; Hepatocellular carcinoma; Thymidine phosphorylase

Indexed keywords

ANTINEOPLASTIC ANTIMETABOLITE; FLUOROURACIL; THYMIDINE PHOSPHORYLASE;

ARTICLE; BIOSYNTHESIS; COLON; COLORECTAL TUMOR; ENZYME LINKED IMMUNOSORBENT ASSAY; GASTROINTESTINAL TRACT; GASTROINTESTINAL TUMOR; HUMAN; LIVER; LIVER TUMOR; METABOLISM; TIME; TISSUE DISTRIBUTION; TUMOR CELL LINE;

ANTIMETABOLITES, ANTINEOPLASTIC; CELL LINE, TUMOR; COLON; COLORECTAL NEOPLASMS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLUOROURACIL; GASTROINTESTINAL NEOPLASMS; GASTROINTESTINAL TRACT; HUMANS; LIVER; LIVER NEOPLASMS; THYMIDINE PHOSPHORYLASE; TIME FACTORS; TISSUE DISTRIBUTION;

EID: 7744237390     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.12.3.539     Document Type: Article

References (17)

1. Collie-Duguid ESR, Johnston S J, Boyce L, Smith N, Cowleson A, Cassidy J, Murray GI and McLeod HL: Thymidine phosphorylase and dihydropyrimidine dehydrogenase protein expression in colorectal cancer. Int J Cancer 94: 297-301, 2001. (Pubitemid 32911427)
2. Kikuyama S, Inada T, Shimizu K, Miyakiya M and Ogata Y: p53, bcl-2 and thymidine phosphorylase as predictive markers of chemotherapy in patients with advanced and recurrent gastric cancer. Anticancer Res 2; 1: 2149-2154, 2001.
3. Ishii R, Takiguchi N, Oda K, Koda K and Miyazaki M: Thymidine phosphorylase expression is useful in selecting adjuvant chemotherapy for stage III gastric cancer. Int J Oncol 19: 717-722, 2001.
4. Nishimura G, Terada I, Kobayashi T, Ninomiya I, Kitagawa H, Fushida S, Fujimura T, Kayahara M, Shimizu K, Ohta T and Miwa K: Thymidine phosphorylase and dihydropyrimidine dehydrogenase levels in primary colorectal cancer show a relationship to clinical effects of 5′-deoxy-5-fluorouridine as adjuvant chemotherapy. Oncol Rep 9: 479-482, 2002.
5. Yoshikawa T, Suzuki K, Kobayashi O, Sairenji M, Motohashi H, Tsuburaya A, Nakamura Y, Shimizu A, Yanoma S and Noguchi Y: Thymidine phosphorylase/ platelet-derived endothelial cell growth factor is upregulated in advanced solid types of gastric cancer. Br J Cancer 79: 1145-1150, 1999. (Pubitemid 29087888)
6. Mori K, Hasegawa M, Nishida M, Toma H, Fukuda M, Kubota T, Nagasue N, Yamana H, Hirakawa K, Chung YS, Ikeda T, Takasaki K, Oka M, Kameyama M, Toi M, Fujii H, Kitamura M, Murai M, Sasaki H, Ozono S, Makuuchi H, Shimada Y, Onishi Y, Aoyagi S, Mizutani K, Ogawa M, Nakao A, Kinoshita H, Tono T, Imamoto H, Nakashima Y and Manabe T: Expression levels of thymidine phosphorylase and dihydropyrimidine dehydrogenase in various human tumor tissues. Int J Oncol 17: 33-38, 2000.
7. Katsumata K, Sumi T, Yamashita S, Takahashi S, Mori M, Baba T, Murohashi T, Nagashima K, Ashizawa T, Yamamoto K, Koyanagi Y and Katoh K: The significance of thymidine phosphorylase expression in colorectal cancer. Oncol Rep 8: 127-130, 2001. (Pubitemid 33758214)
8. Nagata T, Nakamori M, Iwahashi M and Yamaue H: Overexpression of pyrimidine nucleoside phosphorylase enhances the sensitivity to 5′-deoxy-5-fluorouridine in tumour cells in vitro and in vivo. Eur J Cancer 38: 712-717, 2002. (Pubitemid 34251396)
9. Nishida M, Hino A, Mori K, Matsumoto T, Yoshikubo T and Ishitsuka H: Preparation of anti-human thymidine phosphorylase monoclonal antibodies useful for detecting the enzyme levels in tumor tissues. Biol Pharm Bull 19: 1407-1411, 1996. (Pubitemid 26403242)
10. Hiroyasu S, Shiraishi M, Samura H, Tokashiki H, Shimoji H, Isa T and Muto Y: Clinical relevance of the concentrations of both pyrimidine nucleoside phosphorylase (PyNPase) and dihydropyrimidine dehydrogenase (DPD) in colorectal cancer. Jpn J Clin Oncol 31: 65-68, 2001. (Pubitemid 32293966)
11. Konno S, Takebayashi Y, Aiba M, Akiyama S and Ogawa K: Clinicopathological and prognostic significance of thymidine phosphorylase and proliferating cell nuclear antigen in gastric carcinoma. Cancer Lett 166: 103-111, 2001. (Pubitemid 32274291)
12. Takebayashi Y, Akiyama S, Yamada K, Akiba S and Aikou T: Angiogenesis as an unfavorable prognostic factor in human colorectal carcinoma. Cancer 78: 226-231, 1996. (Pubitemid 26234563)
13. Maeda K, Chung YS, Takatsuka S, Ogawa Y, Sawada T, Yamashita Y, Onoda N, Kato Y, Nitta A, Arimoto Y, Kondo Y and Sowa M: Tumor angiogenesis as a predictor of recurrence in gastric carcinoma. J Clin Oncol 13: 477-481, 1995.
14. Macchiarini P, Fontanini G, Hardin MJ, Squartini F and Angeletti CA: Relation of neovascularisation to metastasis of non-small-cell lung cancer. Lancet 340: 145-146, 1992.
15. Celis JE and Celis A: Cell cycle-dependent variations in the distribution of the nuclear protein cyclin proliferating cell nuclear antigen in cultured cells: subdivision of S phase. Proc Natl Acad Sci USA 82: 3262-3266, 1985. (Pubitemid 15033163)
16. Liotta LA, Kleinerman J and Saidel GM: Quantitative relationships of intravascular tumor cells, tumor vessels and pulmonary metastases following tumor implantation. Cancer Res 34: 997-1004, 1974.
17. Yoshimura A, Kuwazuru Y, Furukawa T, Yoshida H, Yamada K and Akiyama S: Purification and tissue distribution of human thymidine phosphorylase; high expression in lymphocytes, reticulocytes and tumors. Biochim Biophys Acta 1034: 107-113, 1990. (Pubitemid 20114807)