Oridonin-induced apoptosis of Jurkat cells and its mechanism

Comparative Clinical Pathology

Volumn 13, Issue 2, 2004, Pages 65-69

  Liu, Jiajun ^a   Huang, Renwei ^a   Lin, Dongjun ^a   Wu, Xiangyuan ^a   Wu, Xinyao ^a   Lu, Huiling ^a   Pan, Xianglin ^b   Peng, Jun ^b   Li, Mingquan ^a   Lin, Qu ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b THE SECOND HOSPITAL OF SHANDONG UNIVERSITY   (China)

Author keywords

Apoptosis; Caspase 3; Jurkat cell; Oridonin; PARP

Indexed keywords

4 [5 (4 METHYL 1 PIPERAZINYL)[2,5' BI 1H BENZIMIDAZOL] 2' YL]PHENOL; ANTILEUKEMIC AGENT; CASPASE 3; DNA FRAGMENT; ENZYME ANTIBODY; ENZYME PRECURSOR; MONOCLONAL ANTIBODY; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; ORIDONIN; POLYCLONAL ANTIBODY; PROTEIN SUBUNIT;

AGAR GEL ELECTROPHORESIS; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL ASSAY; CELL GROWTH; CELL NUCLEUS; CELL PROLIFERATION; CELL STRUCTURE; CHROMATIN CONDENSATION; COLORIMETRY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EXPOSURE; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME DEGRADATION; FLOW CYTOMETRY; FLUORESCENCE ANALYSIS; GROWTH INHIBITION; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; MOLECULAR SIZE; MOUSE; NONHUMAN; PROTEIN DEGRADATION; PROTEIN EXPRESSION; STAINING; STATISTICAL SIGNIFICANCE; TIME; WESTERN BLOTTING;

EID: 7744233480     PISSN: 16185641     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00580-004-0521-7     Document Type: Article

References (15)

1. Beauparlant P, Shore GC (2003) Therapeutic activation of caspases in cancer: A question of selectivity. Curr Opin Drug Discov Devel 6:179-187. 1:CAS:528:DC%2BD3sXislOqsLw%3D, 12669453
2. Boatright KM, Salvesen GS (2003) Caspase activation. Biochem Soc Symp 70:233-242. 1:CAS:528:DC%2BD2cXktFensrc%3D, 14587296
3. Denault JB, Salvesen GS (2002) Caspases: Keys in the ignition of cell death. Chem Rev 102:4489-4500. 10.1021/cr010183n, 1:CAS:528:DC%2BD38XosFWhtLY%3D, 12475198
4. Donepudi M, Grutter MG (2002) Structure and zymogen activation of caspases. Biophys Chem 101:145-153. 10.1016/S0301-4622(02)00151-5
5. Han QB, Li ML, Li SH et al (2003) Ent-kaurane diterpenoids from Isodon rubescens var. lushanensis . Chem Pharm Bull 51:790-793. 10.1248/cpb.51.790, 1:CAS:528:DC%2BD3sXmsFWgu7Y%3D, 12843583
6. Kezoe T, Chen SS, Tong XJ, et al (2003) Oridonin induces growth inhibition and apoptosis of a variety of human cancer cells. Int J Oncol 23:1187-1189. 12964003
7. Liu JJ, Wu XY, Pan XL, et al (2003) Mechanisms of oridonin induced apoptosis on NB4 cells. Chin Tradit Patent Med 25:900-902
8. Liu JJ, Pan XL, Wu XY, et al (2004a) Anti-proliferation effect of oridonin on HL-60 cells and its mechanism. Chin Med Sci J 19:134-137.1:CAS:528:DC%2BD2cXmtlyqt7c%3D, 15250252
9. Liu JJ, Pan XL, Wu XY, et al (2004b) Inhibitory effect and mechanism of oridonin on Raji cells proliferation. Chin Tradit Herbal Drugs 35:774-777
10. Liu JJ, Wu XY, Lu HL, et al (2004c) Inhibitory effect of oridonin on the proliferation of NB4 cells and its mechanism. Chin German J Clin Oncol 3:51-54
11. Philchenkov AA (2003) Caspases as regulators of apoptosis and other cell functions. Biochemistry 68:365-376. 10.1023/A:1023635510363, 1:CAS:528:DC%2BD3sXjsF2nsbw%3D, 12765517
12. Qi SN, Yoshida A, Wang ZR, et al (2004) GP7 can induce apoptotic DNA fragmentation of human leukaemia cells through caspase-3-dependent and -independent pathways. Int J Mol Med 13:163-167. 1:CAS:528:DC%2BD2cXnt1Ojtg%3D%3D, 14654989
13. Smolewski P, Darzynkiewicz Z, Robak T (2003) Caspase-mediated cell death in hematological malignancies: Theoretical considerations, methods of assessment, and clinical implications. Leuk Lymphoma 44:1089-1104. 10.1080/1042819031000077007, 1:CAS:528:DC%2BD3sXivFOhurc%3D, 12916860
14. Thorburn (2004) Death receptor-induced cell killing. Cell Signal 16:139-144. 10.1016/j.cellsig.2003.08.007, 1:CAS:528:DC%2BD3sXptVWmtr4%3D, 14636884
15. Zhang JX, Han QB, Zhao AH, et al (2003) Diterpenoids from Isodon japonica . Fitoterapia 74:435-438. 10.1016/S0367-326X(03)00107-2, 1:CAS:528:DC%2BD3sXltVSqsL0%3D, 12837357