Lack of antagonism of 2,3,7,8-tetrachlorodibenzo-p-dioxin's (TCDDs) induction of cytochrome P4501A1 (CYP1A1) by the putative selective aryl hydrocarbon receptor modulator 6-alkyl-1,3,8-trichlorodibenzofuran (6-MCDF) in the mouse hepatoma cell line Hepa-1c1c7

Chemico-Biological Interactions

Volumn 150, Issue 2, 2004, Pages 161-170

  Fretland, Adrian J ^a   Safe, Stephen ^b   Hankinson, Oliver ^a,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b TEXAS A AND M UNIVERSITY   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

6 MCDF; Aryl hydrocarbon receptor; Chromatin immunoprecipitation; SAhRM; TCDD

Indexed keywords

1,3,8 TRICHLORO 6 METHYLDIBENZOFURAN; 2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; CYTOCHROME P450 1A1; DIINDOLYLMETHANE; INDOLE DERIVATIVE; RNA POLYMERASE II; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CANCER THERAPY; CELL LINE; CHROMATIN; CONTROLLED STUDY; HEPATOMA CELL; IMMUNOPRECIPITATION; MOUSE; NONHUMAN; REAL TIME POLYMERASE CHAIN REACTION;

ANIMALS; BENZOFURANS; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CYTOCHROME P-450 CYP1A1; LIVER NEOPLASMS; MICE; RECEPTORS, ARYL HYDROCARBON; RNA, MESSENGER; TETRACHLORODIBENZODIOXIN;

EID: 7744225987     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2004.09.007     Document Type: Article

References (30)

1. J.R. Petrulis, and G.H. Perdew The role of chaperone proteins in the aryl hydrocarbon receptor core complex Chem. Biol. Interact. 141 2002 25 40
2. O. Hankinson The aryl hydrocarbon receptor complex Annu. Rev. Pharmacol. Toxicol. 35 1995 307 340
3. T.V. Beischlag, S. Wang, D.W. Rose, J. Torchia, S. Reisz-Porszasz, K. Muhammad, W.E. Nelson, M.R. Probst, M.G. Rosenfeld, and O. Hankinson Recruitment of the NCoA/SRC-1/p160 family of transcriptional coactivators by the aryl hydrocarbon receptor/aryl hydrocarbon receptor nuclear translocator complex Mol. Cell. Biol. 22 2002 4319 4333
4. S. Wang, and O. Hankinson Functional involvement of the Brahma/SWI2-related gene 1 protein in cytochrome P4501A1 transcription mediated by the aryl hydrocarbon receptor complex J. Biol. Chem. 277 2002 11821 11827
5. S. Wang, K. Ge, R.G. Roeder, and O. Hankinson Role of mediator in transcriptional activation by the aryl hydrocarbon receptor J. Biol. Chem. 279 2004 13593 13600
6. R.J. Kociba, D.G. Keyes, J.E. Beyer, R.M. Carreon, C.E. Wade, D.A. Dittenber, R.P. Kalnins, L.E. Frauson, C.N. Park, S.D. Barnard, R.A. Hummel, and C.G. Humiston Results of a two-year chronic toxicity and oncogenicity study of 2,3,7,8-tetrachlorodibenzo-p-dioxin in rats Toxicol. Appl. Pharmacol. 46 1978 279 303
7. K. Hu, and N.J. Bunce Metabolism of polychlorinated dibenzo-p-dioxins and related dioxin-like compounds J. Toxicol. Environ. Health B Crit. Rev. 2 1999 183 210
8. R. Shinkyo, T. Sakaki, M. Ohta, and K. Inouye Metabolic pathways of dioxin by CYP1A1: species difference between rat and human CYP1A subfamily in the metabolism of dioxins Arch. Biochem. Biophys. 409 2003 180 187
9. J.F. Gierthy, J.A. Bennett, L.M. Bradley, and D.S. Cutler Correlation of in vitro and in vivo growth suppression of MCF-7 human breast cancer by 2,3,7,8-tetrachlorodibenzo-p-dioxin Cancer Res. 53 1993 3149 3153
10. M. Holcomb, and S. Safe Inhibition of 7,12-dimethylbenzanthracene-induced rat mammary tumor growth by 2,3,7,8-tetrachlorodibenzo-p-dioxin Cancer Lett. 82 1994 43 47
11. P.A. Bertazzi, D. Consonni, S. Bachetti, M. Rubagotti, A. Baccarelli, C. Zocchetti, and A.C. Pesatori Health effects of dioxin exposure: a 20-year mortality study Am. J. Epidemiol. 153 2001 1031 1044
12. M. Warner, B. Eskenazi, P. Mocarelli, P.M. Gerthoux, S. Samuels, L. Needham, B. Patterson, and P. Brambilla Serum dioxin concentrations and breast cancer risk in the Seveso Women's Health Study Environ. Health Perspect. 110 2002 625 628
13. S. Safe, and M. Wormke Inhibitory aryl hydrocarbon receptor-estrogen receptor alpha cross-talk and mechanisms of action Chem. Res. Toxicol. 16 2003 807 816
14. M. Wormke, M. Stoner, B. Saville, K. Walker, M. Abdelrahim, R. Burghardt, and S. Safe The aryl hydrocarbon receptor mediates degradation of estrogen receptor alpha through activation of proteasomes Mol. Cell. Biol. 23 2003 1843 1855
15. F. Ohtake, K. Takeyama, T. Matsumoto, H. Kitagawa, Y. Yamamoto, K. Nohara, C. Tohyama, A. Krust, J. Mimura, P. Chambon, J. Yanagisawa, Y. Fujii-Kuriyama, and S. Kato Modulation of oestrogen receptor signaling by association with the activated dioxin receptor Nature 423 2003 545 550
16. S. Safe, and A. McDougal Mechanism of action and development of selective aryl hydrocarbon receptor modulators for treatment of hormone-dependent cancers (Review) Int. J. Oncol. 20 2002 1123 1128
17. A. McDougal, M. Wormke, J. Calvin, and S. Safe Tamoxifen-induced antitumorigenic/antiestrogenic action synergized by a selective aryl hydrocarbon receptor modulator Cancer Res. 61 2001 3902 3907
18. M. Merchant, V. Morrison, M. Santostefano, and S. Safe Mechanism of action of aryl hydrocarbon receptor antagonists: inhibition of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced CYP1A1 gene expression Arch. Biochem. Biophys. 298 1992 389 394
19. J. Piskorska-Pliszczynska, B. Astroff, T. Zacharewski, M. Harris, R. Rosengren, V. Morrison, L. Safe, and S. Safe Mechanism of action of 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonists: characterization of 6-[125I]methyl-8-iodo-1,3-dichlorodibenzofuran-Ah receptor complexes Arch. Biochem. Biophys. 284 1991 193 200
20. M. Harris, T. Zacharewski, B. Astroff, and S. Safe Partial antagonism of 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated induction of aryl hydrocarbon hydroxylase by 6-methyl-1,3,8-trichlorodibenzofuran: mechanistic studies Mol. Pharmacol. 35 1989 729 735
21. B. Astroff, T. Zacharewski, S. Safe, M.P. Arlotto, A. Parkinson, P. Thomas, and W. Levin 6-Methyl-1,3,8-trichlorodibenzofuran as a 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonist: inhibition of the induction of rat cytochrome P-450 isozymes and related monooxygenase activities Mol. Pharmacol. 33 1988 231 236
22. M.R. Probst, S. Reisz-Porszasz, R.V. Agbunag, M.S. Ong, and O. Hankinson Role of the aryl hydrocarbon receptor nuclear translocator protein in aryl hydrocarbon (dioxin) receptor action Mol. Pharmacol. 44 1993 511 518
23. Y. Tian, S. Ke, M. Chen, and T. Sheng Interactions between the aryl hydrocarbon receptor and P-TEFb. Sequential recruitment of transcription factors and differential phosphorylation of C-terminal domain of RNA polymerase II at CYP1A1 promoter J. Biol. Chem. 278 2003 44041 44048
24. J.M. Maglich, C.M. Stoltz, B. Goodwin, D. Hawkins-Brown, J.T. Moore, and S.A. Kliewer Nuclear pregnane × receptor and constitutive androstane receptor regulate overlapping but distinct sets of genes involved in xenobiotic detoxification Mol. Pharmacol. 62 2002 638 646
25. S. Safe, F. Wang, W. Porter, R. Duan, and A. McDougal Ah receptor agonists as endocrine disruptors: antiestrogenic activity and mechanisms Toxicol. Lett. 102-103 1998 343 347
26. I. Chen, A. McDougal, F. Wang, and S. Safe Aryl hydrocarbon receptor-mediated antiestrogenic and antitumorigenic activity of diindolylmethane Carcinogenesis 19 1998 1631 1639
27. I. Chen, S. Safe, and L. Bjeldanes Indole-3-carbinol and diindolylmethane as aryl hydrocarbon (Ah) receptor agonists and antagonists in T47D human breast cancer cells Biochem. Pharmacol. 26 1996 1069 1076
28. E.V. Hestermann, and M. Brown Agonist and chemopreventative ligands induce differential transcriptional cofactor recruitment by aryl hydrocarbon receptor Mol. Cell. Biol. 23 2003 7920 7925
29. S.T. Pearce, H. Liu, I. Radhakrishnan, M. Abdelrahim, S. Safe, and V.C. Jordan Interaction of the aryl hydrocarbon receptor ligand 6-methyl-1,3,8- trichlorodibenzofuran with estrogen receptor alpha Cancer Res. 64 2004 2889 2897
30. D. Morrow, C. Qin, R. Smith III, and S. Safe Aryl hydrocarbon receptor-mediated inhibition of LNCaP prostate cancer cell growth and hormone-induced transactivation J. Steroid Biochem. Mol. Biol. 88 2004 27 36