Safety and efficacy of combined use of 4-hydroxyanisole (mequinol) 2%/tretinoin 0.01% solution and sunscreen in solar lentigines

Cutis

Volumn 74, Issue 4, 2004, Pages 261-264

  Ortonne, Jean Paul ^a   Camacho, Francisco ^b   Wainwright, Nicholas ^c   Bergfelt, Louise ^d   Westerhof, Wiete ^e   Roseeuw, Diane ^e  

^a CENTRE HOSPITALIER UNIVERSITAIRE DE NICE   (France)

^b HOSPITAL UNIVERSITARIO VIRGEN MACARENA   (Spain)

^c MONKLANDS HOSPITAL   (United Kingdom)

^d Stichting Nederlands Inst V P ^*

^e UNIVERSITY HOSPITAL BRUSSELS   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

MEQUINOL; MEQUINOL PLUS RETINOIC ACID;

ADULT; ALLERGIC REACTION; ARTICLE; DERMATITIS; DISEASE SEVERITY; DRUG EFFICACY; DRUG SAFETY; ECZEMA; ERYTHEMA; EVALUATION; FACE; FEMALE; FOREARM; HUMAN; HYPERPIGMENTATION; HYPOPIGMENTATION; MAJOR CLINICAL STUDY; MALE; POPULATION; RESPONSE TIME; SKIN DEFECT; SKIN IRRITATION; SOLAR LENTIGINE; TREATMENT WITHDRAWAL;

ADMINISTRATION, CUTANEOUS; ADULT; ANISOLES; DERMATOLOGIC AGENTS; FEMALE; HUMANS; HYPOPIGMENTATION; KERATOLYTIC AGENTS; LENTIGO; MALE; SEVERITY OF ILLNESS INDEX; SUNSCREENING AGENTS; TIME FACTORS; TREATMENT OUTCOME; TRETINOIN;

EID: 7744219564     PISSN: 00114162     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (11)

1. Ber-Rahman S, Bahwan J. Lentigo. Int J Dermatol. 1996;55:229-239.
2. Hodgson C. Senilo lentigo. Arch Dermatol. 1963;87:197-207.
3. Rafal ES, Griffiths CE, Ditre CM, et al. Topical tretinoin (retinoic acid) treatment for liver spots associated with photodamage. N Engl J Med. 1992;326:368-374.
4. Orlow SJ, Chakraborty AR, Pawelek JM. Retinoic acid as a potent inhibitor of inducible pigmentation in murine and hamster melanoma cell lines. J Invest Dermatol. 1990;94:461-464.
5. Hexsel DM, Mazzuco R, Bohn J, et al. Clinical comparative study between cryotherapy and local dermabrasion for the treatment of solar lentigo on the back of the hands. Dermatol Surg. 2000;26:457-462.
6. Stern RS, Dover JS, Levin JA, et al. Laser therapy versus cryotherapy of lentigines: a comparative trial. J Am Acad Dermatol. 1994;30:985-987.
7. Todd MM, Rallis TM, Gerwels JW, et al. A comparison of 3 lasers and liquid nitrogen in the treatment of solar lentigines. a randomized, controlled, comparative trial. Arch Dermatol. 2000;36:841-846.
8. Riley PA. Mechanism of pigment-cell toxicity produced by hydroxyanisole. J Pathol. 1970;101:163-169.
9. Mezick JA, Bhatia MC, Capetola RJ. Topical and systemic effects of retinoids on horn-filled utriculus size in the rhino mouse. a model to quantify "antikeratinizing" effects of retinoids. J Invest Dermatol. 1984;83:110-113.
10. Bahwan J, Gonzalez-Serva A, Nehal K, et al. Effects of tretinoin on photodamaged skin: a histology study. Arch Dermatol. 1991;127:666-672.
11. Fleischer AB Jr, Schwartzel EH, Colby SI, et al. The combination of 2% 4-hydroxyanisole (mequinol) and 0.01% tretinoin is effective in improving the appearance of solar lentigines and related hyperpigmented lesions in two double-blind multicenter clinical studies. J Am Acad Dermatol. 2000;42:459-467.