Surface gene mutations of hepatitis B virus among high-risk patients with occult hepatitis B virus infection

Diagnostic Microbiology and Infectious Disease

Volumn 66, Issue 3, 2010, Pages 285-291

  Hamkar, Rasool ^a   Aghakhani, Arezoo ^b   Soufian, Safyeh ^c   Banifazl, Mohammad ^d   Ghavami, Nastaran ^a   Nadri, Mahsa ^a   Sofian, Masoomeh ^e   Ahmadi, Farrokhlagha ^a   Razeghi, Effat ^a   Eslamifar, Ali ^b   Ramezani, Amitis ^b  

^a TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b PASTEUR INSTITUTE OF IRAN   (Iran)

^c PAYAME NOOR UNIVERSITY   (Iran)

^d Iranian Society for Support of Patients with Infectious Diseases   (Iran)

^e ARAK UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Occult hepatitis B virus (HBV) infection; S mutation; Sequencing

Indexed keywords

AMINO ACID; GLYCINE; HEPATITIS B CORE ANTIBODY; HEPATITIS B SURFACE ANTIGEN; LEUCINE; VIRUS DNA;

ADOLESCENT; ADULT; AGED; AMINO ACID SUBSTITUTION; ARTICLE; BLOOD SAMPLING; FEMALE; FRAMESHIFT MUTATION; GENE INSERTION; GENE MUTATION; GENE SEQUENCE; HEMODIALYSIS PATIENT; HEPATITIS B; HEPATITIS B VIRUS; HIGH RISK PATIENT; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MAJOR CLINICAL STUDY; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; STOP CODON;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; AMINO ACID SUBSTITUTION; BASE SEQUENCE; CODON, NONSENSE; CROSS-SECTIONAL STUDIES; FEMALE; HEPATITIS B; HEPATITIS B SURFACE ANTIGENS; HEPATITIS B VIRUS; HIV INFECTIONS; HUMANS; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; MUTAGENESIS, INSERTIONAL; MUTATION; PHYLOGENY; POLYMERASE CHAIN REACTION; SEQUENCE ALIGNMENT;

EID: 77349123979     PISSN: 07328893     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.diagmicrobio.2009.10.006     Document Type: Article

References (38)

1. Ackerman Z., Wands J.R., Gazitt Y., Brechot C., Kew M.C., Shouval D. Enhancement of HBsAg detection in serum of patients with chronic liver disease following removal of circulating immune complexes. J. Hepatol. 1994, 20:398-404.
2. Aghakhani A., Hamkar R., Zamani N., Eslamifar A., Banifazl M., Saadat A., Sofian M., Adibi L., Irani N., Mehryar M., Akbari H.M., Purkhayat S.M., Ramezani A. Hepatitis B virus genotype in Iranian patients with hepatocellular carcinoma. Int. J. Infect. Dis. 2009, 10.1016/j.ijid.2008.10.009.
3. Alhababi F., Sallam T.A., Tong C.Y. The significance of "anti-HBc only" in the clinical virology laboratory. J. Clin. Virol. 2003, 27:162-169.
4. Araujo N.M., Branco-Vieira M., Silva A.C., Pilotto J.H., Grinsztejn B., de Almeida A.J., Trepo C., Gomes S.A. Occult hepatitis B virus infection in HIV-infected patients: evaluation of biochemical, virological and molecular parameters. Hepatol. Res. 2008, 38:1194-1203.
5. Brechot C., Thiers V., Kremsdorf D., Nalpas B., Pol S., Paterlini-Brechot P. Persistent hepatitis B virus infection in subjects without hepatitis B surface antigen: clinically significant or purely "occult"?. Hepatology 2001, 34:194-203.
6. Carman W.F. The clinical significance of surface antigen variants of hepatitis B virus. J. Viral Hepat. 1997, 4(Suppl. 1):11-20.
7. Carman W.F., Korula J., Wallace L., MacPhee R., Mimms L., Decker R. Fulminant reactivation of hepatitis B due to envelope protein mutant that escaped detection by monoclonal HBsAg ELISA. Lancet 1995, 345:1406-1407.
8. Chemin I., Zoulim F., Merle P., Arkhis A., Chevallier M., Kay A., Cova L., Chevallier P., Mandrand B., Trépo C. High incidence of hepatitis B infection among chronic hepatitis cases of unknown aetiology. J. Hepatol. 2001, 34:447-454.
9. Chen Y.C., Delbrook K., Dealwis C., Mimms L., Mushawar I., Mandecki W. Discontinuous epitopes of hepatitis B surface antigen derived from a filamentous phage peptide library. PNAS USA 1996, 93:1997-2001.
10. Cooreman M.P., van Roosmalen M.H., te Morsche R., Sünnen C.M., de Ven E.M., Jansen J.B., Tytgat G.N., de Wit P.L., Paulij W.P. Characterization of the reactivity pattern of murine monoclonal antibodies against wild-type hepatitis B surface antigen to G145R and other naturally occurring "a" loop escape mutations. Hepatology 1999, 30:1287-1292.
11. Datta S., Banerjee A., Chandra P.K., Chakraborty S., Basu S.K., Chakravarty R. Detection of a premature stop codon in the surface gene of hepatitis B virus from an HBsAg and antiHBc negative blood donor. J. Clin. Virol. 2007, 40:255-258.
12. Fang Y., Teng X., Xu W.Z., Li D., Zhao H.W., Fu L.J., Zhang F.M., Gu H.X. Molecular characterization and functional analysis of occult hepatitis B virus infection in Chinese patients infected with genotype C. J. Med. Virol. 2009, 81:826-835.
13. Felsenstein J. Confidence limits on phylogenesis: an approach using the bootstrap. Evolution 1985, 39:783-791.
14. Grethe S., Monazahian M., Bohme I., Thomssen R. Characterization of unusual escape variants of hepatitis B virus isolated from hepatitis B surface antigen-negative subjects. J. Virol. 1998, 72:7692-7696.
15. Grob P., Jilg W., Bornhak H., Gerken G., Gerlich W., Gunther S., Hess G., Hudig H., Kitchen A., Margolis H., Michel G., Trepo C., Will H., Zanetti A., Mushahwar I. Serological pattern "anti-HBc alone": report on a workshop. J. Med. Virol. 2000, 62:4505.
16. Hou J., Karayiannis P., Waters J., Luo K., Liang C., Thomas H.C. A unique insertion in the S gene of surface antigen-negative hepatitis B virus Chinese carriers. Hepatology 1995, 21:273-278.
17. Hou J., Wang Z., Cheng J., Lin Y., Lau G.K., Sun J., Zhou F., Waters J., Karayiannis P., Luo K. Prevalence of naturally occurring surface gene variants of hepatitis B virus in nonimmunized surface antigen-negative Chinese carriers. Hepatology 2001, 34:1027-1034.
18. Hu K.Q. Occult hepatitis B virus infection and its clinical implications. J. Viral Hepat. 2002, 9:243-257.
19. Ireland J.H., O'Donnell B., Basuni A.A., Kean J.D., Wallace L.A., Lau G.K., Carman W.F. Reactivity of 13 in vitro expressed hepatitis B surface antigen variants in 7 commercial diagnostic assays. Hepatology 2000, 31:1176-1182.
20. Jilg W., Hottentrager B., Weinberger K., Schlottmann K., Frick E., Holstege A., Schölmerich J., Palitzsch K.D. Prevalence of markers of hepatitis B in the adult German population. J. Med. Virol. 2001, 63:96-102.
21. Kao J.H., Chen P.J., Lai M.Y., Chen D.S. Sequence analysis of pre-S/surface and pre-core/core promoter genes of hepatitis B virus in chronic hepatitis C patients with occult HBV infection. J. Med. Virol. 2002, 68:216-220.
22. Kimura M. A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences. J. Mol. Evol. 1980, 16:111-120.
23. Liang T.J., Blum H.E., Wands J.R. Characterization and biological properties of a hepatitis B virus isolated from a patient without hepatitis B virus serologic markers. Hepatology 1990, 12:204-212.
24. Mohebbi S.R., Amini-Bavil-Olyaee S., Zali N., Noorinayer B., Derakhshan F., Chiani M., Rostami Nejad M., Antikchi M.H., Sabahi F., Zali M.R. Molecular epidemiology of hepatitis B virus in Iran. Clin. Microbiol. Infect. 2008, 14:858-866.
25. Ozaslan M., Ozaslan E., Barsgan A., Koruk M. Mutations in the S gene region of hepatitis B virus genotype D in Turkish patients. J. Genet. 2007, 86:195-201.
26. Pichoud C., Seigneres B., Wang Z.R., Trep C., Zoulim F. Transient selection of a hepatitis B virus polymerase gene mutant associated with a decreased replication capacity and famciclovir resistance. Hepatology 1999, 29:230-237.
27. Saitou N., Nei M. The neighbor-joining method: a new method for reconstructing phylogenetic trees. Mol. Biol. Evol. 1987, 4:406-425.
28. Sakugawa H., Nakasone H., Nakayoshi T., Kawakami Y., Yamashiro T., Maeshiro T., Kinjo F., Saito A., Zukeran H. Hepatitis B virus concentrations in serum determined by sensitive quantitative assays in patients with established chronic hepatitis delta virus infection. J. Med. Virol. 2001, 65:478-484.
29. Seddigh-Tonekaboni S., Waters J.A., Jeffers S., Gehrke R., Ofenloch B., Horsch A., Hess G., Thomas H.C., Karayiannis P. Effect of variation in the common "a" determinant on the antigenicity of hepatitis B surface antigen. J. Med. Virol. 2000, 60:113-121.
30. Tang J.H., Yeh C.T., Chen T.C., Hsieh S.Y., Chu C.M., Liaw Y.F. Emergence of an S gene mutant during thymosin alpha1 therapy in a patient with chronic hepatitis B. J. Infect. Dis. 1998, 178:866-869.
31. Wakil S.M., Kazim S.N., Khan L.A., Raisuddin S., Parvez M.K., Guptan R.C., Thakur V., Hasnain S.E., Sarin S.K. Prevalence and profile of mutations associated with lamivudine therapy in Indian patients with chronic hepatitis B in the surface and polymerase genes of hepatitis B virus. J. Med. Virol. 2002, 68:311-318.
32. Waters J.A., Kennedy M., Voet P., Hauser P., Petre J., Carman W.F., Thomas H.C. Loss of the common "a" determinant of hepatitis B surface antigen by a vaccine-induced escape mutant. J. Clin. Invest. 1992, 90:2543-2547.
33. Weber B., Melchior W., Gehrke R., Doerr H.W., Berger A., Rabenau H. Hepatitis B virus markers in anti-HBc only positive individuals. J. Med. Virol. 2001, 64:312-319.
34. Weinberger K.M., Bauer T., Böhm S., Jilg W. High genetic variability of the group-specific a-determinant of hepatitis B virus surface antigen (HBsAg) and the corresponding fragment of the viral polymerase in chronic virus carriers lacking detectable HBsAg in serum. J. Gen. Virol. 2000, 81(Pt 5):1165-1174.
35. Yamamoto K., Horikita M., Tsuda F., Itoh K., Akahane Y., Yotsumoto S., Okamoto H., Miyakawa Y., Mayumi M. Naturally occurring escape mutants of hepatitis B virus with various mutations in the S gene in carriers seropositive for antibody to hepatitis B surface antigen. J. Virol. 1994, 68:2671-2676.
36. Yang X., Tang X.P., Lei J.H., Luo H.Y., Zhang Y.H. Novel stop codon mutation in HBsAg gene identified in a hepatitis B virus strain associated with cryptogenic cirrhosis. World J. Gastroenterol. 2003, 9:1516-1520.
37. Zeng G.B., Wen S.J., Wang Z.H., Yan L., Sun J., Hou J.L. A novel hepatitis B virus genotyping system by using restriction fragment length polymorphism patterns of S gene amplicons. World J. Gastroenterol. 2004, 10:3132-3136.
38. Zuckerman A.J. Effect of hepatitis B virus mutants on efficacy of vaccination. Lancet 2000, 355:1382-1384.