메뉴 건너뛰기




Volumn 29, Issue 1, 2010, Pages 171-180

Cetuximab in combination therapy: From bench to clinic

Author keywords

Cetuximab; Colorectal cancer; Head and neck cancer; Lung cancer; Monoclonal antibodies; Targeted therapy

Indexed keywords

BIOLOGICAL MARKER; CAPECITABINE; CARBOPLATIN; CETUXIMAB; CISPLATIN; DNA; EPIDERMAL GROWTH FACTOR RECEPTOR; ERLOTINIB; FLUOROURACIL; FOLINIC ACID; GEFITINIB; IRINOTECAN; NAVELBINE; OXALIPLATIN; PACLITAXEL; PANITUMUMAB;

EID: 77349118230     PISSN: 01677659     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10555-010-9215-6     Document Type: Review
Times cited : (26)

References (79)
  • 1
    • 0035988959 scopus 로고    scopus 로고
    • Low ERCC1 expression correlates with prolonged survival after cisplatin plus gemcitabine chemotherapy in non-small cell lung cancer
    • 12114432
    • RV Lord J Brabender D Gandara, et al. 2002 Low ERCC1 expression correlates with prolonged survival after cisplatin plus gemcitabine chemotherapy in non-small cell lung cancer Clinical Cancer Research 8 2286 2291 12114432
    • (2002) Clinical Cancer Research , vol.8 , pp. 2286-2291
    • Lord, R.V.1    Brabender, J.2    Gandara, D.3
  • 2
    • 0041766793 scopus 로고    scopus 로고
    • Nucleotide excision repair pathways involved in cisplatin resistance in non-small-cell lung cancer
    • 12915808
    • R Rosell M Taron A Barnadas, et al. 2003 Nucleotide excision repair pathways involved in cisplatin resistance in non-small-cell lung cancer Cancer Control 10 297 305 12915808
    • (2003) Cancer Control , vol.10 , pp. 297-305
    • Rosell, R.1    Taron, M.2    Barnadas, A.3
  • 3
    • 33644871485 scopus 로고    scopus 로고
    • Evolution of resistance to cancer therapy
    • 10.2174/138161206775201956 16454743
    • F Michor MA Nowak Y Iwasa 2006 Evolution of resistance to cancer therapy Current Pharmaceutical Design 12 261 271 10.2174/138161206775201956 16454743
    • (2006) Current Pharmaceutical Design , vol.12 , pp. 261-271
    • Michor, F.1    Nowak, M.A.2    Iwasa, Y.3
  • 5
    • 34447126864 scopus 로고    scopus 로고
    • Excision repair cross complementation group 1 immunohistochemical expression predicts objective response and cancer-specific survival in patients treated by cisplatin-based induction chemotherapy for locally advanced head and neck squamous cell carcinoma
    • DOI 10.1158/1078-0432.CCR-07-0252
    • A Handra-Luca J Hernandez G Mountzios, et al. 2007 Excision repair cross complementation group 1 immunohistochemical expression predicts objective response and cancer-specific survival in patients treated by cisplatin-based induction chemotherapy for locally advanced head and neck squamous cell carcinoma Clinical Cancer Research 13 3855 3859 10.1158/1078-0432.CCR-07-0252 17606717 (Pubitemid 47037591)
    • (2007) Clinical Cancer Research , vol.13 , Issue.13 , pp. 3855-3859
    • Handra-Luca, A.1    Hernandez, J.2    Mountzios, G.3    Taranchon, E.4    Lacau-St-Guily, J.5    Soria, J.-C.6    Fouret, P.7
  • 8
    • 0036500831 scopus 로고    scopus 로고
    • Monoclonal antibodies to target epidermal growth factor receptor-positive tumors a new paradigm for cancer therapy
    • DOI 10.1002/cncr.10372
    • RS Herbst DM Shin 2002 Monoclonal antibodies to target epidermal growth factor receptor-positive tumors. A new paradigm for cancer therapy Cancer 94 1593 1611 10.1002/cncr.10372 11920518 (Pubitemid 34212655)
    • (2002) Cancer , vol.94 , Issue.5 , pp. 1593-1611
    • Herbst, R.S.1    Shin, D.M.2
  • 9
    • 0034773992 scopus 로고    scopus 로고
    • The EGFR family and its ligands in human cancer: Signalling mechanisms and therapeutic opportunities
    • 10.1016/S0959-8049(01)00230-1 11597398
    • Y Yarden 2001 The EGFR family and its ligands in human cancer: Signalling mechanisms and therapeutic opportunities European Journal of Cancer 37 S3 S8 10.1016/S0959-8049(01)00230-1 11597398
    • (2001) European Journal of Cancer , vol.37
    • Yarden, Y.1
  • 10
    • 0242319666 scopus 로고    scopus 로고
    • Apoptosis - The p53 network
    • DOI 10.1242/jcs.00739
    • S Haupt M Berger Z Goldberg, et al. 2003 Apoptosis-The p53 network Journal of Cell Science 116 4077 4085 10.1242/jcs.00739 12972501 (Pubitemid 37337082)
    • (2003) Journal of Cell Science , vol.116 , Issue.20 , pp. 4077-4085
    • Haupt, S.1    Berger, M.2    Goldberg, Z.3    Haupt, Y.4
  • 11
    • 33748742635 scopus 로고    scopus 로고
    • Cross-talk between epidermal growth factor receptor and hypoxia-inducible factor-1α signal pathways increases resistance to apoptosis by up-regulating survivin gene expression
    • DOI 10.1074/jbc.M603414200
    • XH Peng P Karna Z Cao, et al. 2006 Cross-talk between epidermal growth factor receptor and hypoxia-inducible factor 1a signal pathways increases resistance to apoptosis by up-regulating survivin gene expression Journal of Biological Chemistry 281 25903 25914 10.1074/jbc.M603414200 16847054 (Pubitemid 44401796)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.36 , pp. 25903-25914
    • Peng, X.-H.1    Karna, P.2    Cao, Z.3    Jiang, B.-H.4    Zhou, M.5    Yang, L.6
  • 12
    • 0037229076 scopus 로고    scopus 로고
    • Targeting the epidermal growth factor receptor in cancer: Apoptosis takes center stage
    • 12517767
    • C Kari TO Chan R Rocha de Quadros, et al. 2003 Targeting the epidermal growth factor receptor in cancer: Apoptosis takes center stage Cancer Research 63 1 5 12517767
    • (2003) Cancer Research , vol.63 , pp. 1-5
    • Kari, C.1    Chan, T.O.2    Rocha De Quadros, R.3
  • 13
    • 36849032852 scopus 로고    scopus 로고
    • Radiation-induced EGFR-signaling and control of DNA-damage repair
    • DOI 10.1080/09553000701769970, PII 787783391
    • HP Rodemann K Dittmann M Toulany 2007 Radiation-induced EGFR-signaling and control of DNA-damage repair International Journal of Radiation Biology 83 781 791 10.1080/09553000701769970 18058366 (Pubitemid 350219102)
    • (2007) International Journal of Radiation Biology , vol.83 , Issue.11-12 , pp. 781-791
    • Rodemann, H.P.1    Dittmann, K.2    Toulany, M.3
  • 14
    • 0008486660 scopus 로고
    • Monoclonal antibody against epidermal growth factor receptor is internalized without stimulating receptor phosphorylation
    • 10.1073/pnas.83.11.3825 2424012
    • H Sunada BE Magun J Mendelsohn, et al. 1986 Monoclonal antibody against epidermal growth factor receptor is internalized without stimulating receptor phosphorylation Proceedings of the National Academy of Sciences of the United States of America 83 3825 3829 10.1073/pnas.83.11.3825 2424012
    • (1986) Proceedings of the National Academy of Sciences of the United States of America , vol.83 , pp. 3825-3829
    • Sunada, H.1    Magun, B.E.2    Mendelsohn, J.3
  • 15
    • 33747350713 scopus 로고    scopus 로고
    • Effect of the anti-receptor ligand-blocking 225 monoclonal antibody on EGF receptor endocytosis and sorting
    • DOI 10.1016/j.yexcr.2006.05.008, PII S0014482706001856
    • ML Jaramillo Z Leon S Grothe, et al. 2006 Effect of the anti-receptor ligand-blocking 225 monoclonal antibody of EGF receptor endocytosis and sorting Experimental Cell Research 312 2778 2790 10.1016/j.yexcr.2006.05.008 16806168 (Pubitemid 44246936)
    • (2006) Experimental Cell Research , vol.312 , Issue.15 , pp. 2778-2790
    • Jaramillo, M.L.1    Leon, Z.2    Grothe, S.3    Paul-Roc, B.4    Abulrob, A.5    O'Connor McCourt, M.6
  • 16
    • 0030054907 scopus 로고    scopus 로고
    • Anti-tumor and cell cycle responses in KB cells treated with a chimeric anti-EGFR monoclonal antibody in combination with cisplatin
    • M Prewett P Rockwell C Rose, et al. 1996 Anti-tumor and cell cycle responses in KB cells treated with a chimeric anti-EGFR monoclonal antibody in combination with cisplatin International Journal of Oncology 9 217 224
    • (1996) International Journal of Oncology , vol.9 , pp. 217-224
    • Prewett, M.1    Rockwell, P.2    Rose, C.3
  • 17
    • 0031409362 scopus 로고    scopus 로고
    • Epidermal growth factor receptor inhibition by a monoclonal antibody as anticancer therapy
    • J Mendelson 1997 Epidermal growth factor receptor inhibition by a monoclonal antibody as anticancer therapy Clinical Cancer Research 3 2703 2707
    • (1997) Clinical Cancer Research , vol.3 , pp. 2703-2707
    • Mendelson, J.1
  • 19
    • 34347229786 scopus 로고    scopus 로고
    • Antibody-dependent cellular cytotoxicity of cetuximab against tumor cells with wild-type or mutant epidermal growth factor receptor
    • DOI 10.1111/j.1349-7006.2007.00510.x
    • H Kimura K Sakai T Arao, et al. 2007 Antibody-dependent cellular cytotoxicity of cetuximab against tumor cells with wild-type or mutant epidermal growth factor receptor Cancer Science 98 1275 1280 10.1111/j.1349-7006.2007. 00510.x 17498200 (Pubitemid 46993549)
    • (2007) Cancer Science , vol.98 , Issue.8 , pp. 1275-1280
    • Kimura, H.1    Sakai, K.2    Arao, T.3    Shimoyama, T.4    Tamura, T.5    Nishio, K.6
  • 21
    • 36749008023 scopus 로고    scopus 로고
    • The epidermal growth factor receptor: A role in repair of radiation-induced DNA damage
    • DOI 10.1158/1078-0432.CCR-07-1610
    • DJ Chen CS Nirodi 2007 The epidermal growth factor receptor: A role in repair of radiation-induced DNA damage Clinical Cancer Research 13 22 Pt 1 6555 6560 10.1158/1078-0432.CCR-07-1610 18006754 (Pubitemid 350206788)
    • (2007) Clinical Cancer Research , vol.13 , Issue.22 , pp. 6555-6560
    • Chen, D.J.1    Nirodi, C.S.2
  • 26
    • 65349116059 scopus 로고    scopus 로고
    • Cetuximab plus chemotherapy in patients with advanced non-small cell lung cancer (FLEX): An open-label randomized phase III trial
    • 10.1016/S0140-6736(09)60569-9 19410716
    • R Pirker A Pereira A Szczesna J von Pawel, et al. 2009 Cetuximab plus chemotherapy in patients with advanced non-small cell lung cancer (FLEX): An open-label randomized phase III trial Lancet 373 1525 1531 10.1016/S0140- 6736(09)60569-9 19410716
    • (2009) Lancet , vol.373 , pp. 1525-1531
    • Pirker, R.1    Pereira, A.2    Szczesna, A.3    Von Pawel, J.4
  • 27
    • 4444368283 scopus 로고    scopus 로고
    • ABX-EGF in combination with paclitaxel and carboplatin for advanced non-small cell lung cancer (NSCLC) [Meeting Abstracts]
    • J Crawford AB Sandler LA Hammond, et al. 2004 ABX-EGF in combination with paclitaxel and carboplatin for advanced non-small cell lung cancer (NSCLC) [Meeting Abstracts] Journal of Clinical Oncology 22 7083
    • (2004) Journal of Clinical Oncology , vol.22 , pp. 7083
    • Crawford, J.1    Sandler, A.B.2    Hammond, L.A.3
  • 28
    • 0037069928 scopus 로고    scopus 로고
    • Cisplatin-induced activation of the EGF receptor
    • DOI 10.1038/sj.onc.1205980
    • M Benhar D Engelberg A Levitzki 2002 Cisplatin-induced activation of the EGF receptor Oncogene 21 8723 8731 10.1038/sj.onc.1205980 12483525 (Pubitemid 36132393)
    • (2002) Oncogene , vol.21 , Issue.57 , pp. 8723-8731
    • Benhar, M.1    Engelberg, D.2    Levitzki, A.3
  • 29
    • 0842268375 scopus 로고    scopus 로고
    • ZD1839 modulates paclitaxel response in renal cancer by blocking paclitaxel-induced activation of the epidermal growth factor receptor-extracellular signal-regulated kinase pathway
    • DOI 10.1158/1078-0432.CCR-0948-03
    • M Sumitomo T Asano J Asakuma T Asano A Horiguchi M Hayakawa 2004 ZD1839 modulates paclitaxel response in renal cancer by blocking paclitaxel-induced activation of the epidermal growth factor receptor-extracellular signal-regulated kinase pathway Clinical Cancer Research 10 794 801 10.1158/1078-0432.CCR-0948-03 14760103 (Pubitemid 38174018)
    • (2004) Clinical Cancer Research , vol.10 , Issue.2 , pp. 794-801
    • Sumitomo, M.1    Asano, T.2    Asakuma, J.3    Asano, T.4    Horiguchi, A.5    Hayakawa, M.6
  • 30
    • 34547461511 scopus 로고    scopus 로고
    • Epidermal growth factor induction of resistance to topoisomerase II toxins in human squamous carcinoma A431 cells
    • 16969495
    • W-P Tsang S-K Kong T-T Kwok 2006 Epidermal growth factor induction of resistance to topoisomerase II toxins in human squamous carcinoma A431 cells Oncology Reports 16 789 793 16969495
    • (2006) Oncology Reports , vol.16 , pp. 789-793
    • Tsang, W.-P.1    Kong, S.-K.2    Kwok, T.-T.3
  • 31
    • 0033561522 scopus 로고    scopus 로고
    • Epidermal growth factor blockade with C225 modulates proliferation, apoptosis, and radiosensitivity in squamous cell carcinomas of the head and neck
    • 10213503
    • S-M Huang JM Bock PM Harari 1999 Epidermal growth factor blockade with C225 modulates proliferation, apoptosis, and radiosensitivity in squamous cell carcinomas of the head and neck Cancer Research 59 1935 1940 10213503
    • (1999) Cancer Research , vol.59 , pp. 1935-1940
    • Huang, S.-M.1    Bock, J.M.2    Harari, P.M.3
  • 33
    • 0001223491 scopus 로고    scopus 로고
    • Neutralizing antibodies against epidermal growth factor and ErbB-2/neu receptor tyrosine kinases down-regulate vascular endothelial growth factor production by tumor cells in vitro and in vivo
    • 9403702
    • AMV Petit J Rak M-C Hung, et al. 1997 Neutralizing antibodies against epidermal growth factor and ErbB-2/neu receptor tyrosine kinases down-regulate vascular endothelial growth factor production by tumor cells in vitro and in vivo American Journal of Pathology 151 1523 1530 9403702
    • (1997) American Journal of Pathology , vol.151 , pp. 1523-1530
    • Petit, A.M.V.1    Rak, J.2    Hung, M.-C.3
  • 34
    • 0032972944 scopus 로고    scopus 로고
    • Anti-epidermal growth factor antibody C225 inhibits angiogenesis in human transitional cell carcinoma growing orthotopically in nude mice
    • 10037173
    • P Perrotte T Matsumoto K Inoue, et al. 1999 Anti-epidermal growth factor antibody C225 inhibits angiogenesis in human transitional cell carcinoma growing orthotopically in nude mice Clinical Cancer Research 5 257 264 10037173
    • (1999) Clinical Cancer Research , vol.5 , pp. 257-264
    • Perrotte, P.1    Matsumoto, T.2    Inoue, K.3
  • 35
    • 0036094194 scopus 로고    scopus 로고
    • Enhanced antitumor activity of anti-epidermal growth factor receptor monoclonal antibody IMC-C225 in combination with irinotecan (CPT-11) against human colorectal tumor xenografts
    • 12006511
    • MC Prewett AT Hooper R Bassi, et al. 2002 Enhanced antitumor activity of anti-epidermal growth factor receptor monoclonal antibody IMC-C225 in combination with irinotecan (CPT-11) against human colorectal tumor xenografts Clinical Cancer Research 8 994 1003 12006511
    • (2002) Clinical Cancer Research , vol.8 , pp. 994-1003
    • Prewett, M.C.1    Hooper, A.T.2    Bassi, R.3
  • 36
    • 33645749886 scopus 로고    scopus 로고
    • In vivo and in vitro antitumor activity of oxaliplatin in combination with cetuximab in human colorectal tumor cell lines expressing different level of EGFR
    • 10.1007/s00280-005-0123-3 16320055
    • D Balin-Gauthier JP Delord P Rochaix, et al. 2006 In vivo and in vitro antitumor activity of oxaliplatin in combination with cetuximab in human colorectal tumor cell lines expressing different level of EGFR Cancer Chemotherapy and Pharmacology 57 709 718 10.1007/s00280-005-0123-3 16320055
    • (2006) Cancer Chemotherapy and Pharmacology , vol.57 , pp. 709-718
    • Balin-Gauthier, D.1    Delord, J.P.2    Rochaix, P.3
  • 37
    • 0032904485 scopus 로고    scopus 로고
    • Antitumor activity of sequential treatment with topotecan and anti-epidermal growth factor receptor monoclonal antibody C225
    • 10213228
    • F Ciardiello R Bianco V Damiano, et al. 1999 Antitumor activity of sequential treatment with topotecan and anti-epidermal growth factor receptor monoclonal antibody C225 Clinical Cancer Research 5 909 916 10213228
    • (1999) Clinical Cancer Research , vol.5 , pp. 909-916
    • Ciardiello, F.1    Bianco, R.2    Damiano, V.3
  • 38
    • 31544434945 scopus 로고    scopus 로고
    • Cetuximab and irinotecan interact synergistically to inhibit the growth of orthotopic anaplastic thyroid carcinoma xenografts in nude mice
    • DOI 10.1158/1078-0432.CCR-05-1325
    • S Kim CN Prichard MN Younes, et al. 2006 Cetuximab and irinotecan interact synergistically to inhibit the growth of orthotopic anaplastic thyroid carcinoma xenografts in nude mice Clinical Cancer Research 12 600 607 10.1158/1078-0432.CCR-05-1325 16428506 (Pubitemid 43166155)
    • (2006) Clinical Cancer Research , vol.12 , Issue.2 , pp. 600-607
    • Kim, S.1    Prichard, C.N.2    Younes, M.N.3    Yazici, Y.D.4    Jasser, S.A.5    Bekele, B.N.6    Myers, J.N.7
  • 39
    • 33947412800 scopus 로고    scopus 로고
    • Tumor growth inhibition with cetuximab and chemotherapy in non-small cell lung cancer xenografts expressing wild-type and mutated epidermal growth factor receptor
    • DOI 10.1158/1078-0432.CCR-06-1887
    • P Steiner C Joynes R Bassi, et al. 2007 Tumor growth inhibition with cetuximab and chemotherapy in non-small cell lung cancer xenografts expressing wild-type and mutated epidermal growth factor receptor Clinical Cancer Research 13 1540 1551 10.1158/1078-0432.CCR-06-1887 17332300 (Pubitemid 46450446)
    • (2007) Clinical Cancer Research , vol.13 , Issue.5 , pp. 1540-1551
    • Steiner, P.1    Joynes, C.2    Bassi, R.3    Wang, S.4    Tonra, J.R.5    Hadari, Y.R.6    Hicklin, D.J.7
  • 41
    • 38049045220 scopus 로고    scopus 로고
    • Cetuximab potentiates oxaliplatin cytotoxic effect through a defect in NER and DNA replication initiation
    • 10.1038/sj.bjc.6604134 18182978
    • D Balin-Gauthier JP Delord MJ Pillaire, et al. 2008 Cetuximab potentiates oxaliplatin cytotoxic effect through a defect in NER and DNA replication initiation British Journal of Cancer 98 120 128 10.1038/sj.bjc.6604134 18182978
    • (2008) British Journal of Cancer , vol.98 , pp. 120-128
    • Balin-Gauthier, D.1    Delord, J.P.2    Pillaire, M.J.3
  • 42
    • 37549007196 scopus 로고    scopus 로고
    • Tumors established with cell lines selected for oxaliplatin resistance respond to oxaliplatin if combined with cetuximab
    • 10.1158/1078-0432.CCR-07-1768 18094427
    • M Prewett DS Deevi R Bassi, et al. 2007 Tumors established with cell lines selected for oxaliplatin resistance respond to oxaliplatin if combined with cetuximab Clinical Cancer Research 13 7432 7440 10.1158/1078-0432.CCR-07- 1768 18094427
    • (2007) Clinical Cancer Research , vol.13 , pp. 7432-7440
    • Prewett, M.1    Deevi, D.S.2    Bassi, R.3
  • 43
    • 0028103920 scopus 로고
    • Altered expression of epidermal growth factor receptor and estrogen receptor in MCF-7 cells after single and repeated radiation exposures
    • 8040028
    • RK Schmidt-Ullrich KC Valerie W Chan, et al. 1994 Altered expression of epidermal growth factor receptor and estrogen receptor in MCF-7 cells after single and repeated radiation exposures International Journal of Radiation Oncology, Biology, Physics 29 813 819 8040028
    • (1994) International Journal of Radiation Oncology, Biology, Physics , vol.29 , pp. 813-819
    • Schmidt-Ullrich, R.K.1    Valerie, K.C.2    Chan, W.3
  • 44
    • 0030772168 scopus 로고    scopus 로고
    • Radiation-induced proliferation of the human A431 squamous carcinoma cells is dependent on EGFR tyrosine phosphorylation
    • 10.1038/sj.onc.1201275 9294612
    • RK Schmidt-Ullrich RB Mikkelsen P Dent, et al. 1997 Radiation-induced proliferation of the human A431 squamous carcinoma cells is dependent on EGFR tyrosine phosphorylation Oncogene 15 1191 1197 10.1038/sj.onc.1201275 9294612
    • (1997) Oncogene , vol.15 , pp. 1191-1197
    • Schmidt-Ullrich, R.K.1    Mikkelsen, R.B.2    Dent, P.3
  • 45
    • 0037030519 scopus 로고    scopus 로고
    • Ionizing radiation activates Erb-B receptor dependent Akt and p70 S6 kinase signaling in carcinoma cells
    • DOI 10.1038/sj.onc.1205500
    • JN Contessa J Hampton G Lammering, et al. 2002 Ionizing radiation activates Erb-B receptor dependent Akt and p70 S6 kinase signaling in carcinoma cells Oncogene 21 4032 4041 10.1038/sj.onc.1205500 12037685 (Pubitemid 34679244)
    • (2002) Oncogene , vol.21 , Issue.25 , pp. 4032-4041
    • Contessa, J.N.1    Hampton, J.2    Lammering, G.3    Mikkelsen, R.B.4    Dent, P.5    Valerie, K.6    Schmidt-Ullrich, R.K.7
  • 47
    • 0035254521 scopus 로고    scopus 로고
    • Head and neck cancer as a clinical model for molecular targeting of therapy: Combining EGFR blockade with radiation
    • DOI 10.1016/S0360-3016(00)01488-7, PII S0360301600014887
    • PM Harari S-M Huang 2001 Head and neck cancer as a clinical model for molecular targeting of therapy: Combining EGFR blockade with radiation International Journal of Radiation Oncology, Biology, Physics 49 427 433 10.1016/S0360-3016(00)01488-7 11173137 (Pubitemid 32120240)
    • (2001) International Journal of Radiation Oncology Biology Physics , vol.49 , Issue.2 , pp. 427-433
    • Harari, P.M.1    Huang, S.-M.2
  • 48
    • 0034084314 scopus 로고    scopus 로고
    • Modulation of radiation response after epidermal growth factor receptor blockade in squamous cell carcinomas: Inhibition of damage repair, cell cycle kinetics, and tumor angiogenesis
    • 10873065
    • S-M Huang PM Harari 2000 Modulation of radiation response after epidermal growth factor receptor blockade in squamous cell carcinomas: Inhibition of damage repair, cell cycle kinetics, and tumor angiogenesis Clinical Cancer Research 6 2166 2174 10873065
    • (2000) Clinical Cancer Research , vol.6 , pp. 2166-2174
    • Huang, S.-M.1    Harari, P.M.2
  • 50
    • 51649120733 scopus 로고    scopus 로고
    • KRAS status and efficacy in the first-line treatment of patients with metastatic colorectal cancer (mCRC) treated with FOLFIRI with or without cetuximab: The CRYSTAL experience
    • Abstract 2
    • Van Cutsem, E., Lang, I., D'haens, G., et al. (2008) KRAS status and efficacy in the first-line treatment of patients with metastatic colorectal cancer (mCRC) treated with FOLFIRI with or without cetuximab: The CRYSTAL experience. Journal of Clinical Oncology, 26, Abstract 2.
    • (2008) Journal of Clinical Oncology , vol.26
    • Van Cutsem, E.1    Lang, I.2    D'Haens, G.3
  • 51
    • 59949091448 scopus 로고    scopus 로고
    • Fluorouracil, leucovorin, and oxaliplatin with and without cetuximab in the first-line treatment of metastatic colorectal cancer
    • 10.1200/JCO.2008.20.8397 19114683
    • C Bokemeyer I Bondarenko A Makhson, et al. 2009 Fluorouracil, leucovorin, and oxaliplatin with and without cetuximab in the first-line treatment of metastatic colorectal cancer Journal of Clinical Oncology 27 663 671 10.1200/JCO.2008.20.8397 19114683
    • (2009) Journal of Clinical Oncology , vol.27 , pp. 663-671
    • Bokemeyer, C.1    Bondarenko, I.2    Makhson, A.3
  • 52
    • 51649085865 scopus 로고    scopus 로고
    • Platinum-based chemotherapy plus cetuximab in head and neck cancer
    • 10.1056/NEJMoa0802656 18784101
    • JB Vermorken R Mesia F Rivera, et al. 2008 Platinum-based chemotherapy plus cetuximab in head and neck cancer New England Journal of Medicine 359 1116 1127 10.1056/NEJMoa0802656 18784101
    • (2008) New England Journal of Medicine , vol.359 , pp. 1116-1127
    • Vermorken, J.B.1    Mesia, R.2    Rivera, F.3
  • 54
    • 46049084643 scopus 로고    scopus 로고
    • Overview of the efficacy of cetuximab in recurrent and/or metastatic squamous cell carcinoma of the head and neck in patients who previously failed platinum-based therapies
    • DOI 10.1002/cncr.23442
    • JB Vermorken RS Herbst X Leon, et al. 2008 Overview of the efficacy of cetuximab in recurrent and/or metastatic squamous cell carcinoma of the head and neck in patients who previously failed platinum-based therapies Cancer 112 2710 2719 10.1002/cncr.23442 18481809 (Pubitemid 351969215)
    • (2008) Cancer , vol.112 , Issue.12 , pp. 2710-2719
    • Vermorken, J.B.1    Herbst, R.S.2    Leon, X.3    Amellal, N.4    Baselga, J.5
  • 55
    • 23744495620 scopus 로고    scopus 로고
    • A retrospective analysis of the outcome of patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck refractory to a platinum-based chemotherapy
    • X León R Hitt M Constenia, et al. 2005 A retrospective analysis of the outcome of patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck refractory to a platinum-based chemotherapy Clinical Oncology (Royal College of Radiologists) 17 418 424
    • (2005) Clinical Oncology (Royal College of Radiologists) , vol.17 , pp. 418-424
    • León, X.1    Hitt, R.2    Constenia, M.3
  • 56
    • 39849111354 scopus 로고    scopus 로고
    • ®) in combination with taxane/carboplatin versus taxane/carboplatin alone as first-line treatment for patients with advanced/metastatic non-small cell lung cancer (NSCLC): B3-03
    • 10.1097/01.JTO.0000283155.03863.e7
    • ®) in combination with taxane/carboplatin versus taxane/carboplatin alone as first-line treatment for patients with advanced/metastatic non-small cell lung cancer (NSCLC): B3-03 Journal of Thoracic Oncology 2 suppl 4 S340 S341 10.1097/01.JTO.0000283155. 03863.e7
    • (2007) Journal of Thoracic Oncology , vol.2 , Issue.SUPPL 4
    • Lynch, T.J.1    Patel, T.2    Dreisbach, L.3
  • 59
    • 44449161951 scopus 로고    scopus 로고
    • Locoregionally advanced head and neck cancer treated with primary radiotherapy: A comparison of the addition of cetuximab or chemotherapy and the impact of protocol treatment
    • 18355979
    • JJ Caudell SM Sawrie SA Spencer, et al. 2008 Locoregionally advanced head and neck cancer treated with primary radiotherapy: A comparison of the addition of cetuximab or chemotherapy and the impact of protocol treatment International Journal of Radiation Oncology, Biology, Physics 71 676 681 18355979
    • (2008) International Journal of Radiation Oncology, Biology, Physics , vol.71 , pp. 676-681
    • Caudell, J.J.1    Sawrie, S.M.2    Spencer, S.A.3
  • 60
    • 65349185779 scopus 로고    scopus 로고
    • A phase II study of cetuximab (C225) in combination with chemoradiation (CRT) in patients (pts) with stage IIIA/B non-small cell lung cancer (NSCLC): A report of the 2 year and median survival (MS) for the RTOG 0324 trial
    • GR Blumenschein R Paulus WJ Curran, et al. 2008 A phase II study of cetuximab (C225) in combination with chemoradiation (CRT) in patients (pts) with stage IIIA/B non-small cell lung cancer (NSCLC): A report of the 2 year and median survival (MS) for the RTOG 0324 trial Journal of Clinical Oncology 26 May 20 suppl 7516
    • (2008) Journal of Clinical Oncology , vol.26 , Issue.MAY , pp. 7516
    • Blumenschein, G.R.1    Paulus, R.2    Curran, W.J.3
  • 61
    • 40349087139 scopus 로고    scopus 로고
    • Administration of cetuximab every 2 weeks in the treatment of metastatic colorectal cancer: An effective, more convenient alternative to weekly administration?
    • DOI 10.1634/theoncologist.2007-0201
    • J Tabernero P Pfeiffer A Cervantes 2008 Administration of cetuximab every 2 weeks in the treatment of metastatic colorectal cancer: An effective, more convenient alternative to weekly administration? The Oncologist 13 113 119 10.1634/theoncologist.2007-0201 18305055 (Pubitemid 351342574)
    • (2008) Oncologist , vol.13 , Issue.2 , pp. 113-119
    • Tabernero, J.1    Pfeiffer, P.2    Cervantes, A.3
  • 62
    • 48349134539 scopus 로고    scopus 로고
    • Biweekly cetuximab and irinotecan in advanced colorectal cancer patients progressing after at least one previous line of chemotherapy: Results of a phase II single institution trial
    • 10.1038/sj.bjc.6604530 18665167
    • P Martín-Martorell S Roselló E Rodríguez-Braun, et al. 2008 Biweekly cetuximab and irinotecan in advanced colorectal cancer patients progressing after at least one previous line of chemotherapy: Results of a phase II single institution trial British Journal of Cancer 99 455 458 10.1038/sj.bjc.6604530 18665167
    • (2008) British Journal of Cancer , vol.99 , pp. 455-458
    • Martín-Martorell, P.1    Roselló, S.2    Rodríguez-Braun, E.3
  • 63
    • 44849083804 scopus 로고    scopus 로고
    • Biweekly cetuximab and irinotecan as third-line therapy in patients with advanced colorectal cancer after failure to irinotecan, oxaliplatin and 5-fluorouracil
    • DOI 10.1093/annonc/mdn020
    • P Pfeiffer D Nielsen J Bjerregaard, et al. 2008 Biweekly cetuximab and irinotecan as third-line therapy in patients with advanced colorectal cancer after failure to irinotecan, oxaliplatin, and 5-fluorouracil Annals of Oncology 19 1141 1145 10.1093/annonc/mdn020 18281264 (Pubitemid 351796340)
    • (2008) Annals of Oncology , vol.19 , Issue.6 , pp. 1141-1145
    • Pfeiffer, P.1    Nielsen, D.2    Bjerregaard, J.3    Qvortrup, C.4    Yilmaz, M.5    Jensen, B.6
  • 64
    • 19944427144 scopus 로고    scopus 로고
    • The effects of cetuximab alone and in combination with radiation and/or chemotherapy in lung cancer
    • 15701870
    • D Raben B Helfrich DC Chan, et al. 2005 The effects of cetuximab alone and in combination with radiation and/or chemotherapy in lung cancer Clinical Cancer Research 11 795 805 15701870
    • (2005) Clinical Cancer Research , vol.11 , pp. 795-805
    • Raben, D.1    Helfrich, B.2    Chan, D.C.3
  • 66
    • 33144484457 scopus 로고    scopus 로고
    • Multicenter phase I/II study of cetuximab with paclitaxel and carboplatin in untreated patients with stage IV non-small-cell lung cancer
    • DOI 10.1200/JCO.2005.03.1997
    • CD Thienelt PA Bunn Jr N Hanna, et al. 2005 Multicenter phase I/II study of cetuximab with paclitaxel and carboplatin in untreated patients with stage IV non-small-cell lung cancer Journal of Clinical Oncology 23 8786 8793 10.1200/JCO.2005.03.1997 16246975 (Pubitemid 46211524)
    • (2005) Journal of Clinical Oncology , vol.23 , Issue.34 , pp. 8786-8793
    • Thienelt, C.D.1    Bunn Jr., P.A.2    Hanna, N.3    Rosenberg, A.4    Needle, M.N.5    Long, M.E.6    Gustafson, D.L.7    Kelly, K.8
  • 67
    • 33144481184 scopus 로고    scopus 로고
    • Phase I/IIa study of cetuximab with gemcitabine plus carboplatin in patients with chemotherapy-naive advanced non-small-cell lung cancer
    • DOI 10.1200/JCO.2004.00.1438
    • F Robert G Blumenschein RS Herbst, et al. 2005 Phase I/IIa study of cetuximab with gemcitabine plus carboplatin in patients with chemotherapy-naive advanced non-small-cell lung cancer Journal of Clinical Oncology 23 9089 9096 10.1200/JCO.2004.00.1438 16301597 (Pubitemid 46264008)
    • (2005) Journal of Clinical Oncology , vol.23 , Issue.36 , pp. 9089-9096
    • Robert, F.1    Blumenschein, G.2    Herbst, R.S.3    Fossella, F.V.4    Tseng, J.5    Saleh, M.N.6    Needle, M.7
  • 68
    • 33846661208 scopus 로고    scopus 로고
    • Concurrent chemotherapy plus cetuximab or chemotherapy followed by cetuximab in advanced non-small cell lung cancer (NSCLC): A randomized phase II selectional trial SWOG 0342
    • K Kelly RS Herbst JJ Crowley, et al. 2006 Concurrent chemotherapy plus cetuximab or chemotherapy followed by cetuximab in advanced non-small cell lung cancer (NSCLC): A randomized phase II selectional trial SWOG 0342 Journal of Clinical Oncology 24 18S 7015
    • (2006) Journal of Clinical Oncology , vol.24 , Issue.S , pp. 7015
    • Kelly, K.1    Herbst, R.S.2    Crowley, J.J.3
  • 70
    • 62549155921 scopus 로고    scopus 로고
    • K-Ras mutations (mt) and EGFR-related markers as potential predictors of cetuximab benefit in 1st line advanced NSCLC: Results from the BMS099 study [abstract]
    • S Khambata-Ford C Harbison L Hart, et al. 2008 K-Ras mutations (mt) and EGFR-related markers as potential predictors of cetuximab benefit in 1st line advanced NSCLC: Results from the BMS099 study [abstract] Journal of Thoracic Oncology 3 Suppl. 4 S304
    • (2008) Journal of Thoracic Oncology , vol.3 , Issue.SUPPL. 4 , pp. 304
    • Khambata-Ford, S.1    Harbison, C.2    Hart, L.3
  • 71
    • 54949085398 scopus 로고    scopus 로고
    • K-ras mutations and benefit from cetuximab in advanced colorectal cancer
    • 10.1056/NEJMoa0804385 18946061
    • CS Karapetis S Khambata-Ford DJ Jonker, et al. 2008 K-ras mutations and benefit from cetuximab in advanced colorectal cancer New England Journal of Medicine 359 1757 1765 10.1056/NEJMoa0804385 18946061
    • (2008) New England Journal of Medicine , vol.359 , pp. 1757-1765
    • Karapetis, C.S.1    Khambata-Ford, S.2    Jonker, D.J.3
  • 73
    • 58149265465 scopus 로고    scopus 로고
    • Autocrine production of amphiregulin predicts sensitivity to both gefitinib and cetuximab in EGFR wild-type cancers
    • 10.1158/1078-0432.CCR-08-0957 18980991
    • K Yonesaka K Zejnullahu N Lindeman, et al. 2008 Autocrine production of amphiregulin predicts sensitivity to both gefitinib and cetuximab in EGFR wild-type cancers Clinical Cancer Research 14 6963 6973 10.1158/1078-0432.CCR- 08-0957 18980991
    • (2008) Clinical Cancer Research , vol.14 , pp. 6963-6973
    • Yonesaka, K.1    Zejnullahu, K.2    Lindeman, N.3
  • 74
    • 57449095367 scopus 로고    scopus 로고
    • Wild-type BRAF is required for response to panitumumab or cetuximab in metastatic colorectal cancer
    • 10.1200/JCO.2008.18.0786 19001320
    • F Di Nicolantonio M Martini F Molinari, et al. 2008 Wild-type BRAF is required for response to panitumumab or cetuximab in metastatic colorectal cancer Journal of Clinical Oncology 26 5705 5712 10.1200/JCO.2008.18.0786 19001320
    • (2008) Journal of Clinical Oncology , vol.26 , pp. 5705-5712
    • Di Nicolantonio, F.1    Martini, M.2    Molinari, F.3
  • 75
    • 61449239114 scopus 로고    scopus 로고
    • Impact of FcγRIIa-FcγRIIIa polymorphisms and KRAS mutations on the clinical outcome of patients with metastatic colorectal cancer treated with cetuximab plus irinotecan
    • 10.1200/JCO.2008.18.0463 19164213
    • F Bibeau E Lopez-Crapez F Di Fiore, et al. 2009 Impact of FcγRIIa-FcγRIIIa polymorphisms and KRAS mutations on the clinical outcome of patients with metastatic colorectal cancer treated with cetuximab plus irinotecan Journal of Clinical Oncology 27 1122 1129 10.1200/JCO.2008.18. 0463 19164213
    • (2009) Journal of Clinical Oncology , vol.27 , pp. 1122-1129
    • Bibeau, F.1    Lopez-Crapez, E.2    Di Fiore, F.3
  • 76
    • 65549139376 scopus 로고    scopus 로고
    • FcγRIIIa polymorphisms and cetuximab induced cytotoxicity in squamous cell carcinoma of the head and neck
    • 10.1007/s00262-008-0613-3 18979096
    • RJ Taylor SL Chan A Wood, et al. 2009 FcγRIIIa polymorphisms and cetuximab induced cytotoxicity in squamous cell carcinoma of the head and neck Cancer Immunology, Immunotherapy 58 997 1006 10.1007/s00262-008-0613-3 18979096
    • (2009) Cancer Immunology, Immunotherapy , vol.58 , pp. 997-1006
    • Taylor, R.J.1    Chan, S.L.2    Wood, A.3
  • 77
    • 36549083856 scopus 로고    scopus 로고
    • Phase III study of gemcitabine [G] plus cetuximab [C] versus gemcitabine in patients [pts] with locally advanced or metastatic pancreatic adenocarcinoma [PC]: SWOG S0205 study
    • PA Philip J Benedetti C Fenoglio-Preiser, et al. 2007 Phase III study of gemcitabine [G] plus cetuximab [C] versus gemcitabine in patients [pts] with locally advanced or metastatic pancreatic adenocarcinoma [PC]: SWOG S0205 study Journal of Clinical Oncology 25 18S LBA4509
    • (2007) Journal of Clinical Oncology , vol.25 , Issue.S , pp. 4509
    • Philip, P.A.1    Benedetti, J.2    Fenoglio-Preiser, C.3
  • 78
    • 67749097665 scopus 로고    scopus 로고
    • Cetuximab in combination with capecitabine, irinotecan, and radiotherapy for patients with locally advanced rectal cancer: Results of a phase II MARGIT trial
    • 19131187
    • K Horisberger A Treschl S Mai, et al. 2009 Cetuximab in combination with capecitabine, irinotecan, and radiotherapy for patients with locally advanced rectal cancer: Results of a phase II MARGIT trial International Journal of Radiation Oncology, Biology, Physics 74 1487 1493 19131187
    • (2009) International Journal of Radiation Oncology, Biology, Physics , vol.74 , pp. 1487-1493
    • Horisberger, K.1    Treschl, A.2    Mai, S.3
  • 79
    • 59749091477 scopus 로고    scopus 로고
    • Chemotherapy, bevacizumab, and cetuximab in metastatic colorectal cancer
    • 10.1056/NEJMoa0808268 19196673
    • J Tol M Koopman A Cats, et al. 2009 Chemotherapy, bevacizumab, and cetuximab in metastatic colorectal cancer New England Journal of Medicine 360 563 572 10.1056/NEJMoa0808268 19196673
    • (2009) New England Journal of Medicine , vol.360 , pp. 563-572
    • Tol, J.1    Koopman, M.2    Cats, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.