Synthesis and in vitro activity of limonene derivatives against Leishmania and Trypanosoma

European Journal of Medicinal Chemistry

Volumn 45, Issue 4, 2010, Pages 1524-1528

  Graebin, Cedric S ^a   Madeira, Maria de F ^b   Yokoyama Yasunaka, Jenicer K U ^c   Miguel, Danilo C ^c   Uliana, Silvia R B ^c   Benitez, Diego ^d   Cerecetto, Hugo ^d   González, Mercedes ^d   Rosa, Ricardo Gomes da ^a   Eifler Lima, Vera Lucia ^a  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^b Funda??o Oswaldo Cruz   (Brazil)

^c UNIVERSITY OF SÃO PAULO   (Brazil)

^d UNIVERSIDAD DE LA REPÚBLICA   (Uruguay)

Author keywords

Anti parasitic activity; Hydroaminomethylation; Leishmania; Limonene; Trypanosoma cruzi

Indexed keywords

2 [[3 (4 METHYLCYCLOHEXEN 3 YL)BUTYL]AMINO]ETHANOL; 3 (4 METHYLCYCLOHEXEN 3 YL) N FURFURYL 1 BUTANAMINE; ANTILEISHMANIAL AGENT; ANTITRYPANOSOMAL AGENT; LIMONENE; N METHYL N [3 (4 METHYLCYCLOHEXEN 3 YL)BUTYL]ANILINE; NIFURTIMOX; PENTAMIDINE; UNCLASSIFIED DRUG;

ANTIPROTOZOAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG SYNTHESIS; IC 50; LEISHMANIA BRAZILIENSIS; NONHUMAN; TRYPANOSOMA CRUZI;

EID: 77349108326     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2009.12.061     Document Type: Article

References (24)

1. Linares G.E.G., Ravaschino E.L., and Rodriguez J.B. Curr. Med. Chem. 13 (2006) 335-360
2. Renslo A.R., and McKerrow J.H. Nat. Chem. Biol. 2 (2006) 701-710
3. Gascón J., Albajar P., Cañas E., Flores M., Gómez J., Herrera P.R.N., Lafuente C.A., Luciardi H.L., Moncayo A., Molina L., Muñoz J., Puente S., Sanz G., Treviño B., and Salles X.S. Rev. Esp. Cardiol. 60 (2007) 285-293
4. Word Health Organization. Reporte del grupo de trabajo científico sobre la enfermedad de Chagas (2005), WHO, Buenos Aires
5. Dardonville C. Exp. Opin. Ther. Patents 15 (2005) 1241-1257
6. Croft S.L., and Coombs G.H. Trends Parasitol. 19 (2003) 502-508
7. Castro F.L., Kover R.X., Kover W.B., and Jones Jr. J. J. Braz. Chem. Soc. 10 (1999) 112-116
8. Davidson J.P., and Corey E.J. J. Am. Chem. Soc. 125 (2003) 13486-13489
9. Wender P.A., and Zhang L. Org. Lett. 2 (2000) 2323-2326
10. Chrisman W., Camara J.N., Marcellini K., Singaram B., Goralski C.T., Hasha D.L., Rudolf P.R., Nicholson L.W., and Borodychuck K.K. Tetrahedron Lett. 42 (2001) 5805-5807
11. Deans S.G., and Ritchie G. Intl. J. Food Microbiol. 5 (1987) 165-180
12. Caccioni D.R.L., Guizzzardi M., Biondi D., Biondi D.M., Renda A., and Ruberto G. Intl. J. Food Microbiol. 43 (1998) 73-79
13. Goulart H.R., Kimura E.A., Peres V.J., Couto A.S., Duarte F.A.A., and Katzin A.M. Antimicrob. Agents Chemother. 48 (2004) 2502-2509
14. Uedo N., Tatsuta M., Iishi H., Baba M., Sakai N., Yano H., and Otania T. Cancer Lett. 137 (1999) 131-136
15. Arruda D.C., Miguel D.C., Yokoyama-Yasunaka K.U., Katzin A.M., and Uliana S.R.B. Biomedicine & Pharmacotherapy 63 (2009) 643-649
16. Ferrarini S.R., Graebin C.S., Limberger J., Canto R.F.S., Dias D.O., da Rosa R.G., Madeira M.F., and Eifler-Lima V.L. Mem. Inst. Oswaldo Cruz 103 (2008) 773-777
17. Ferrarini S.R., Duarte M.O., da Rosa R.G., Rolim V., Eifler-Lima V.L., Von Poser G., and Ribeiro V.L.S. Vet. Parasitol. 157 (2008) 149-153
18. Graebin C.S., Eifler-Lima V.L., and da Rosa R.G. Catal. Comm. 9 (2008) 1066-1070
19. Wutz P.G.N., and Greene T.W. Greene's Protective Groups in Organic Synthesis. fourth ed. (2006), Wiley-Interscience, New York
20. Machado G.M.C., Leon L.L., and Castro S.L. Mem. Inst. Oswaldo Cruz 102 (2007) 73-77
21. Miguel D.C., Yokoyama-Yasunaka J.K.U., Andreoli W.K., Mortara R.A., and Uliana S.R.B. J. Antimicrob. Chemother. 60 (2007) 526-534
22. Porcal W., Hernández P., Boiani M., Aguirre G., Boiani L., Chidichimo A., CAzzulo J., Campillo N.E., Paez J.A., Castro A., Krauth-Siegel R.S., Davies C., Basombrío M.A., Gonzales M., and Cerecetto H. J. Med. Chem. 50 (2007) 6004-6015
23. Romeiro N.C., Aguirre G., Hernández P., González M., Cerecetto H., Aldana I., Pérez-Silanes S., Monge A., Barreiro E.J., and Lima L.M. Bioorg. Med. Chem. 17 (2009) 641-652
24. Bollini M., Casal J.J., Alvarez D.E., Boiani L., González M., Cerecetto H., and Bruno A.M. Bioorg. Med. Chem. 17 (2009) 1437-1444