Acid and base degraded products of ketorolac

Journal of Pharmaceutical and Biomedical Analysis

Volumn 52, Issue 2, 2010, Pages 320-322

  Salaris, Margherita ^a   Nieddu, Maria ^b   Rubattu, Nicola ^a   Testa, Cecilia ^a   Luongo, Elvira ^c   Rimoli, Maria Grazia ^c   Boatto, Gianpiero ^b  

^a Istituto Zooprofilattico della Sardegna   (Italy)

^b UNIVERSITY OF SASSARI   (Italy)

^c UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

Acid and base stability; Degradation products; Ketorolac; LC MS

Indexed keywords

CHLORIDE; KETOROLAC; NITRIC OXIDE;

ACIDITY; ALKALINITY; ARTICLE; DRUG DEGRADATION; DRUG STABILITY; DRUG STRUCTURE; HYDROLYSIS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PRIORITY JOURNAL;

ACIDS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CHROMATOGRAPHY, LIQUID; DRUG STABILITY; HOT TEMPERATURE; HYDROCHLORIC ACID; HYDROLYSIS; KETOROLAC; MASS SPECTROMETRY; METHANOL; MOLECULAR STRUCTURE; MOLECULAR WEIGHT; REFERENCE STANDARDS; SODIUM HYDROXIDE; SOLVENTS; TIME FACTORS;

EID: 77349093006     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2010.01.031     Document Type: Article

References (3)

1. Curcio A., Sasso O., Melisi D., Nieddu M., La Rana G., Russo R., Gavini E., Boatto G., Abignente E., Calignano A., Rimoli M.G. Galactosyl prodrug of ketorolac: synthesis, stability, pharmacological and pharmacokinetic evaluations. J. Med. Chem. 2009, 52:3794-3800.
2. Devarajan P.V., Gore S.P., Chavan S.V. HPTLC determination of ketorolac tromethamine. J. Pharm. Biomed. Anal. 2000, 22:679-683.
3. Shantha Kumar T.R., Shedbalkar V.P., Bhalla H.L. High performance liquid chromatographic determination of ketorolac tromethamine in ophthalmic formulation. Indian Drugs 1997, 34:532-535.