Synthesis and evaluation of some new substituted benzothiazepine and benzoxazepine derivatives as anticonvulsant agents

European Journal of Medicinal Chemistry

Volumn 45, Issue 4, 2010, Pages 1529-1535

  Garg, Neha ^a   Chandra, Trilok ^a   Archana, ^a   Jain, Amit B ^a   Kumar, Ashok ^a  

^a LLRM MEDICAL COLLEGE   (India)

Author keywords

Anticonvulsant activity; Benzothiazepines; Benzoxazepines; Toxicity studies

Indexed keywords

4 (4' HYDROXYPHENYL) 2 (2 CHLOROPHENYL) 3 [(4 CHLOROPHENYLAMINOMETHYLENE)] 2,3 DIHYDRO 1,5 BENZOTHIAZEPINE; 4 (4' HYDROXYPHENYL) 2 (2 CHLOROPHENYL) 3 [(4 CHLOROPHENYLAMINOMETHYLENE)] 2,3 DIHYDRO 1,5 BENZOXAZEPINE; 4 (4' HYDROXYPHENYL) 2 (2 CHLOROPHENYL) 3 [(4 METHOXYPHENYLAMINOMETHYLENE)] 2,3 DIHYDRO 1,5 BENZOTHIAZEPINE; 4 (4' HYDROXYPHENYL) 2 (2 CHLOROPHENYL) 3 [(4 METHOXYPHENYLAMINOMETHYLENE)] 2,3 DIHYDRO 1,5 BENZOXAZEPINE; 4 (4' HYDROXYPHENYL) 2 (2 HYDROXYPHENYL) 3 [(4 CHLOROPHENYLAMINOMETHYLENE)] 2,3 DIHYDRO 1,5 BENZOTHIAZEPINE; 4 (4' HYDROXYPHENYL) 2 (2 HYDROXYPHENYL) 3 [(4 CHLOROPHENYLAMINOMETHYLENE)] 2,3 DIHYDRO 1,5 BENZOXAZEPINE; 4 (4' HYDROXYPHENYL) 2 (2 HYDROXYPHENYL) 3 [(4 METHOXYPHENYLAMINOMETHYLENE)] 2,3 DIHYDRO 1,5 BENZOTHIAZEPINE; 4 (4' HYDROXYPHENYL) 2 (2 HYDROXYPHENYL) 3 [(4 METHOXYPHENYLAMINOMETHYLENE)] 2,3 DIHYDRO 1,5 BENZOXAZEPINE; 4 (4' HYDROXYPHENYL) 2 (3 METHOXYPHENYL) 3 [(4 CHLOROPHENYLAMINOMETHYLENE)] 2,3 DIHYDRO 1,5 BENZOTHIAZEPINE; 4 (4' HYDROXYPHENYL) 2 (3 METHOXYPHENYL) 3 [(4 CHLOROPHENYLAMINOMETHYLENE)] 2,3 DIHYDRO 1,5 BENZOXAZEPINE; 4 (4' HYDROXYPHENYL) 2 (3 METHOXYPHENYL) 3 [(4 METHOXYPHENYLAMINOMETHYLENE)] 2,3 DIHYDRO 1,5 BENZOTHIAZEPINE; 4 (4' HYDROXYPHENYL) 2 (3 METHOXYPHENYL) 3 [(4 METHOXYPHENYLAMINOMETHYLENE)] 2,3 DIHYDRO 1,5 BENZOXAZEPINE; 4 (4' HYDROXYPHENYL) 2 (4 CHLOROPHENYL) 3 [(4 CHLOROPHENYLAMINOMETHYLENE)] 2,3 DIHYDRO 1,5 BENZOTHIAZEPINE; 4 (4' HYDROXYPHENYL) 2 (4 CHLOROPHENYL) 3 [(4 CHLOROPHENYLAMINOMETHYLENE)] 2,3 DIHYDRO 1,5 BENZOXAZEPINE; 4 (4' HYDROXYPHENYL) 2 (4 CHLOROPHENYL) 3 [(4 METHOXYPHENYLAMINOMETHYLENE)] 2,3 DIHYDRO 1,5 BENZOTHIAZEPINE; 4 (4' HYDROXYPHENYL) 2 (4 CHLOROPHENYL) 3 [(4 METHOXYPHENYLAMINOMETHYLENE)] 2,3 DIHYDRO 1,5 BENZOXAZEPINE; 4 (4' HYDROXYPHENYL) 2 (4 HYDROXYPHENYL) 3 [(4 CHLOROPHENYLAMINOMETHYLENE)] 2,3 DIHYDRO 1,5 BENZOTHIAZEPINE; 4 (4' HYDROXYPHENYL) 2 (4 HYDROXYPHENYL) 3 [(4 CHLOROPHENYLAMINOMETHYLENE)] 2,3 DIHYDRO 1,5 BENZOXAZEPINE; 4 (4' HYDROXYPHENYL) 2 (4 HYDROXYPHENYL) 3 [(4 METHOXYPHENYLAMINOMETHYLENE)] 2,3 DIHYDRO 1,5 BENZOTHIAZEPINE; 4 (4' HYDROXYPHENYL) 2 (4 HYDROXYPHENYL) 3 [(4 METHOXYPHENYLAMINOMETHYLENE)] 2,3 DIHYDRO 1,5 BENZOXAZEPINE; ANTICONVULSIVE AGENT; AZEPINE DERIVATIVE; BENZOTHIAZEPINE DERIVATIVE; PHENYTOIN; UNCLASSIFIED DRUG;

ACUTE TOXICITY; ANIMAL EXPERIMENT; ANTICONVULSANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; ELECTRIC SHOCK; FEMALE; MALE; NONHUMAN; RAT;

ANIMALS; ANTICONVULSANTS; BENZOXAZINES; DRUG EVALUATION, PRECLINICAL; FEMALE; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MASS SPECTROMETRY; RATS; SPECTROPHOTOMETRY, INFRARED; THIAZEPINES;

EID: 77349084809     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.01.001     Document Type: Article

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