Study of geniposide-acid on anti-inflammatory action for adjuvant-induced arthritis rats and mechanism of synoviocyte apoptosis in vitro

Zhongguo Zhongyao Zazhi

Volumn 34, Issue 23, 2009, Pages 3082-3086

  Jin, Xin ^a   Sun, Jing ^a   Xie, Wenli ^a   Wan, Zongming ^a   Jin, Yuzhang ^a   Zhu, Jiang ^a  

^a MEDICAL COLLEGE OF CHINESE PEOPLE'S ARMED POLICE FORCES   (China)

Author keywords

Adjuvant induced arthritis; Apoptosis; Bax; Bcl 2; Geniposide acid; Synoviocyte

Indexed keywords

FREUND ADJUVANT; GENIPOSIDE; INTERLEUKIN 1BETA; MESSENGER RNA; METHOTREXATE; PROTEIN BAX; PROTEIN BCL 2; SODIUM; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; ARTHRITIS; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FIBROBLAST; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPE; GENE EXPRESSION; IN VITRO STUDY; MALE; NONHUMAN; PAW EDEMA; PROTEIN BLOOD LEVEL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SYNOVIOCYTE;

ANIMALS; ANTI-INFLAMMATORY AGENTS; APOPTOSIS; ARTHRITIS, EXPERIMENTAL; CYTOKINES; DISEASE MODELS, ANIMAL; FREUND'S ADJUVANT; GLUCOSIDES; HUMANS; IRIDOIDS; MALE; RANDOM ALLOCATION; RATS; RATS, WISTAR; SYNOVIAL FLUID;

EID: 77249179852     PISSN: 10015302     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (11)

1. Chinese source
2. Chinese source
3. Chinese source
4. Chinese source
5. Feldnkann M, Brerman F M, Foxwel B M, et aL. The role of TNF-alpha and IL-1 in rheumatoid arthritis[J]. Curr Dir Auto-immun, 2001,3:188.
6. Firestein G S, Yeo M, Zvaifler N J. Apoptosis in rheumatoid arthritis synovium[J]. J Clin Invest, 1995,96(3):1631.
7. Park C, Moon D O, Choi I W, et al. Cureumin induces apoptosis and inhibits prostaglandin E(2) production in synovial fibroblasts of patients with rheumatoid arthritis[J]. Int J Mol Med, 2007,20(3):365.
8. Kim W U, Kang S S, Yoo S A, et aL. Interaction of vascular endothelial growth factor 165 with neuropilin-1 protects rheumatoid synoviocytes from apoptotic death by regulating Bcl-2 expression and Bax translocation[J]. J Immunol, 2006,177(8):5727.
9. Houpl T, Yahyawi M, Lubke C, et aL. Gene expression profiling of rheumatoid arthritis synovial cells treated with antirheumatic drugs[J]. J Biomol Screen, 2007,12(3):328.
10. Kusunoki N, Yamazaki R, Kitasato H, et aL. Triptolide, an active compound identified in a traditional Chinese herb, induces apoptosis of rheumatoid synovial fibroblasts[J]. BMC Pharmacol, 2004,17(4):2.
11. Wessels J A, Huizinga T W, Guchelaar H J. Recent insights in the pharmacological actions of methotrexate in the treatment of rheumatoid arthritis[J]. Rheumatology (Oxford), 2008,47(3):249.