HMG CoA reductase inhibition and endothelial function in children with chronic kidney disease (CKD) - A pilot study

Acta Paediatrica, International Journal of Paediatrics

Volumn 99, Issue 3, 2010, Pages 457-459

  MacKie, Fiona E ^a,b   Rosenberg, Andrew R ^a,b   Harmer, Jason A ^c   Kainer, Gad ^a   Celermajer, David S ^c,d  

^a SYDNEY CHILDREN'S HOSPITAL   (Australia)

^b UNIVERSITY OF NEW SOUTH WALES   (Australia)

^c ROYAL PRINCE ALFRED HOSPITAL   (Australia)

^d University of Sydney   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ATORVASTATIN; C REACTIVE PROTEIN; FLUINDOSTATIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LOW DENSITY LIPOPROTEIN;

ADOLESCENT; ARTERY ENDOTHELIUM; ARTICLE; ATHEROSCLEROSIS; BLOOD PRESSURE; CHILD; CHOLESTEROL BLOOD LEVEL; CHRONIC KIDNEY DISEASE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG INDICATION; ENDOTHELIAL DYSFUNCTION; GLOMERULUS FILTRATION RATE; HEART DEATH; HUMAN; HYPERLIPIDEMIA; KIDNEY FUNCTION; LIPOPROTEIN BLOOD LEVEL; PILOT STUDY; PRESCHOOL CHILD; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SCHOOL CHILD;

ADOLESCENT; BLOOD PRESSURE; CHILD; CHILD, PRESCHOOL; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; ENDOTHELIUM, VASCULAR; HEPTANOIC ACIDS; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; HYPERLIPIDEMIAS; KIDNEY FAILURE, CHRONIC; LIPIDS; PILOT PROJECTS; PROSPECTIVE STUDIES; PYRROLES; TREATMENT OUTCOME;

EID: 77249177582     PISSN: 08035253     EISSN: 16512227     Source Type: Journal    
DOI: 10.1111/j.1651-2227.2009.01643.x     Document Type: Article

References (15)

1. Parekh RS, Carroll CE, Wolfe RA, Port FK. Cardiovascular mortality in children and young adults with end-stage kidney disease. J Pediatr 2002 141 : 191 197.
2. Ross R. Atherosclerosis - an inflammatory disease. NEJM 1999 340 : 115 127.
3. Kari JA, Donald AE, Vallance DT, Bruckdorfer KR, Leone A, Mullen MJ. Physiology and biochemistry of endothelial function in children with chronic renal failure. Kidney Int 1997 52 : 468 472.
4. Drexler H. Factors involved in the maintenance of endothelial function. Am J Cardiol 1998 82 : 3 4S.
5. Dogra GK, Watts GF, Herrmann S, Thomas MAB, Irish AB. Statin therapy improves brachial artery endothelial function in nephrotic syndrome. Kidney Int 2002 62 : 550 557.
6. O'Driscoll G, Green D, Taylor RR. Simvastatin, an HMG-coenzyme A reductase inhibitor, improves endothelial function within 1 month. Circulation 1997 95 : 1126 1131.
7. Treasure CB, Klein JL, Weintraub WS, et al. Beneficial effects of cholesterol-lowering therapy on the coronary endothelium in patients with coronary artery disease. NEJM 1995 332 : 481 487.
8. Vogel RA, Corretti MC, Plotnick GP. Changes in flow-mediated brachial artery vasoactivity with lowering of desirable cholesterol levels in healthy middle-aged men. Am J Cardiol 1996 77 : 37 40.
9. Leeson CPM, Whincup PH, Cook DG, et al. Cholesterol and arterial distensibility in the first decade of life. Circulation 2000 101 : 1533 1538.
10. Schwartz GJ, Haycock GB, Edelmann CM Jr., Spitzer A. A simple estimate of glomerular filtration rate in children derived from body length and plasma creatinine. Pediatrics 1976 58 : 259 263.
11. Sorensen KE, Celermajer DS, Spiegelhalter DJ, et al. Non-invasive measurement of human endothelium dependent arterial responses. Accuracy and reproducibility. Br Heart J 1995 74 : 247 253.
12. Muscheites J, Meyer A, Drueckler E, et al. Assessment of the cardiovascular system in pediatric chronic kidney disease: a pilot study. Pediatr Nephrol 2008 23 : 2233 2239.
13. Ichihara A, Hayashi M, Ryuzaki M, et al. Fluvastatin prevents development of arterial stiffness in haemodialysis patients with type 2 diabetes mellitus. Nephrol Dial Transplant 2002 17 : 1513 1517.
14. Mancini GBJ, Henry GC, Macaya C, et al. Angiotensin-converting enzyme inhibition with quinapril improves endothelial vasomotor dysfunction in patients with coronary artery disease. Circulation 1996 94 : 258 265.
15. Wanner C, Krane V, März W, et al. Atorvastatin in patients with type 2 diabetes mellitus undergoing hemodialysis. NEJM 2005 353 : 238 248. (Pubitemid 41058323)